Lightnews — Scholar-powered news

Uli Steidl @steidluli.bsky.social · 4d

‪Thank you! I am deeply honored and grateful to the scientific community at ISEH for receiving this award! All the brilliant, fearless, and hard-working former and current lab members who I have had the privilege to work with are the true stars here! 😊🤩 Thank you all! 🙏

Keisuke Ito @keisukeito-lab.bsky.social · 11d

Huge congratulations to Uli @steidluli.bsky.social on receiving the McCulloch & Till Award 2025 @isehsociety.bsky.social in Kumamoto, Japan!! @einsteinmededu.bsky.social #ISEH2025

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Reposted by Uli Steidl

Elizabeth McKenna @elizsmckenna.bsky.social · 7d

Now online in Cancer Discovery @aacrjournals.bsky.social: Elevated Clonal Hematopoiesis in 9/11 First Responders Has Distinct Age-Related Patterns and Relies on IL1RAP for Clonal Expansion doi.org/10.1158/2159...

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Reposted by Uli Steidl

Mick Milsom @milsommick.bsky.social · 8d

Surprising finding that standard chemo renders AML resistant to subsequent treatment with menin inhibitors. Published in @isehsociety.bsky.social journal Exp. Hem.: www.exphem.org/article/S030...

Upfront Menin-inhibitor resistance in multiply pretreated leukemias

10% of acute leukemias carry rearrangements of the KMT2A gene (Mixed-Lineage Leukemia-1, MLL-1). More than 80 fusion partners have been identified, and differences in fusion partner have been linked t...

www.exphem.org

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Uli Steidl @steidluli.bsky.social · Sep 1

Thank you, Ann!

Ann Mullally @mullallylab.bsky.social · Aug 28

Interesting, looking forward to reading this, congrats to all!

Uli Steidl @steidluli.bsky.social · Sep 1

Thank you, Julio!

Aguirre-Ghiso Lab @jaguirreghisolab.bsky.social · Sep 1

Congrats to Shoichiro Takeishi, @steidluli.bsky.social @gritsmanlab.bsky.social and co-authors on this fascinating discovery! @cdi-einstein.bsky.social @einsteincellbio.bsky.social

Cancer Dormancy Institute @ Einstein @cdi-einstein.bsky.social · Sep 1

New findings by CDI members @steidluli.bsky.social @gritsmanlab.bsky.social et al.,reveal how HSC numbers are controlled by both systemic & local (niche) mechanisms, primarily regulated by thrombopoietin, even with increased niche capacity. Congrats to all! www.nature.com/articles/s41...

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Reposted by Uli Steidl

Kira Gritsman @gritsmanlab.bsky.social · Aug 28

Happy to contribute to this exciting project just published in @nature.com led by the amazing Shoichiro Takeishi in a fantastic collaboration with @steidluli.bsky.social - check out this thread 🩸 🧬

Uli Steidl @steidluli.bsky.social · Aug 28

Please check out this thread on our latest paper in
@nature.com on HSC pool size regulation. rdcu.be/eCJLe
Phenomenal collaboration with @gritsmanlab.bsky.social, and driven by the outstanding Shoichiro Takeishi! @einsteincellbio.bsky.social
@einsteinmededu.bsky.social (1/6)

Haematopoietic stem cell number is not solely defined by niche availability

Nature - Haematopoietic stem cell numbers are restricted at both systemic and local levels.

rdcu.be

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Uli Steidl @steidluli.bsky.social · Aug 28

Recruiters watch out! Shoichiro is entering the faculty job market right now...

Uli Steidl @steidluli.bsky.social · Aug 28

Please check out this thread on our latest paper in
@nature.com on HSC pool size regulation. rdcu.be/eCJLe
Phenomenal collaboration with @gritsmanlab.bsky.social, and driven by the outstanding Shoichiro Takeishi! @einsteincellbio.bsky.social
@einsteinmededu.bsky.social (1/6)

Haematopoietic stem cell number is not solely defined by niche availability

Nature - Haematopoietic stem cell numbers are restricted at both systemic and local levels.

rdcu.be

Uli Steidl @steidluli.bsky.social · Aug 28

We also found that thrombopoietin has a pivotal role in determining total HSC numbers in the body, even in the context of increased niche availability. Our study provides new insights into stem cell number regulation and opens avenues of investigation into various fields. (6/6)

Uli Steidl @steidluli.bsky.social · Aug 28

Moreover, HSC numbers in transplanted wild-type femurs did not exceed physiological levels when HSCs were mobilized from defective endogenous niches to the periphery, indicating that HSC numbers are constrained at the local level as well. (5/6)

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Uli Steidl @steidluli.bsky.social · Aug 28

To test this, we developed a femur-transplantation system, enabling us to increase HSC niche cells without adding HSCs. Surprisingly, adding niches did not increase the total HSC numbers in the body, revealing the presence of systemic mechanism(s) that limits HSC numbers. (4/6)

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Uli Steidl @steidluli.bsky.social · Aug 28

We and others have previously identified several HSC niche components, including mesenchymal stem cells in the bone marrow. However, their numbers significantly exceed HSC numbers, leading us to hypothesize that other regulatory mechanisms govern HSC numbers. (3/6)

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Uli Steidl @steidluli.bsky.social · Aug 28

HSCs play a major role in blood cell production, making the regulation of HSC numbers a central question in stem cell biology. A model from the 1970s suggested that HSC numbers are determined locally by the availability of their bone marrow microenvironments, or niches. (2/6)

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Uli Steidl @steidluli.bsky.social · Aug 28

Please check out this thread on our latest paper in
@nature.com on HSC pool size regulation. rdcu.be/eCJLe
Phenomenal collaboration with @gritsmanlab.bsky.social, and driven by the outstanding Shoichiro Takeishi! @einsteincellbio.bsky.social
@einsteinmededu.bsky.social (1/6)

Haematopoietic stem cell number is not solely defined by niche availability

Nature - Haematopoietic stem cell numbers are restricted at both systemic and local levels.

rdcu.be

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Reposted by Uli Steidl

ernstlaboratory.bsky.social @ernstlaboratory.bsky.social · Jul 21

The Myeloid Workshop is back in ASH! Please contact the organizers if you have an exciting story that will not be out by December they are: Zuzana Tothova ,
@ernstlaboratory.bsky.social
@steidluli.bsky.social
@ericpietras.bsky.social
@kathrinbernt.bsky.social
@gritsmanlab.bsky.social

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Reposted by Uli Steidl

ISEH - International Society for Experimental Hematology @isehsociety.bsky.social · Jun 12

Continuing our interview spotlight series is the 2025 McCulloch and Till Awardee @steidluli.bsky.social‬ Dr. Steidl discusses his current work, career inspirations and more. Watch part III on www.simplyblood.org

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Reposted by Uli Steidl

NYCTrainKUHR @nyctrainkuhr.bsky.social · May 22

Our trainees had a truly enriching experience at #KUHRTN2025 at Emory, Atlanta! They gained insights into career development, received valuable advice, and enjoyed connecting with field leaders and peers from across the country. bit.ly/3H529IZ
@steidluli.bsky.social @gritsmanlab.bsky.social

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Uli Steidl @steidluli.bsky.social · May 7

Thank you, Ann!

Uli Steidl @steidluli.bsky.social · May 7

Thank you! And proud to be part of this outstanding institute under the leadership of @jaguirreghisolab.bsky.social

Cancer Dormancy Institute @ Einstein @cdi-einstein.bsky.social · May 7

Congrats @steidluli.bsky.social proud to have you at CDI!

Aguirre-Ghiso Lab @jaguirreghisolab.bsky.social · May 6

What a great pleasure to witness Uli Steidl @steidluli.bsky.social receiving the The 2025 Marshall Horwitz Faculty Prize for Excellence in Research. Honored to have him as a friend, colleague and Chair @einsteincellbio.bsky.social
Congrats !!!

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Uli Steidl @steidluli.bsky.social · May 7

Thank you, Julio! The feelings are absolutely mutual. Grateful for your friendship, input, and support!

Aguirre-Ghiso Lab @jaguirreghisolab.bsky.social · May 6

What a great pleasure to witness Uli Steidl @steidluli.bsky.social receiving the The 2025 Marshall Horwitz Faculty Prize for Excellence in Research. Honored to have him as a friend, colleague and Chair @einsteincellbio.bsky.social
Congrats !!!

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Uli Steidl @steidluli.bsky.social · May 3

Thanks so much, Daniel!

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Uli Steidl @steidluli.bsky.social · Apr 30

Thank you, Divij!

Uli Steidl @steidluli.bsky.social · Apr 30

Thank you, Ravi!

Uli Steidl @steidluli.bsky.social · Apr 30

I am incredibly humbled being elected into the AAP. Grateful to all the highly dedicated former and current team members and collaborators who enabled the scientific progress that led to this big honor! Also a huge thank you to my nominator and long-standing role model @jdlicht.bsky.social !

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Uli Steidl @steidluli.bsky.social · Apr 25

Thank you, Julio!

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Uli Steidl @steidluli.bsky.social · Apr 12

Congrats, Fia and Lindsay!!

Lindsay LaFave @lindsaylafave.bsky.social · Apr 8

Huge congrats to talented graduate student Fia Stratton on receiving the NSF GRFP today! So proud and excited to see all the incredible science you'll do — well deserved! @einsteincellbio.bsky.social @einsteinmededu.bsky.social

Fia holding a cake with a sign that says congratulations

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