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Reposted by Stefan Mundlos

Juliane Glaser @julianeg.bsky.social · Jul 24

So happy to see the illustration of our work featured on the cover of @natgenet.nature.com 😍
It represents digits desintegrating into viral like particles. Thank you so much @annaamonaco.bsky.social for making this design!

Nature Genetics @natgenet.nature.com · Jul 24

💫The July issue of @natgenet.nature.com is out!

Featuring:

✅retrotransposons in limb malformation and cancer
✅single-cell Micro-C
✅long-term effects of chemotherapy on normal blood cells
✅blood regulatory variation map in South Africans

And more!

⬇️

www.nature.com/ng/volumes/5...

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Reposted by Stefan Mundlos

Ariadna Morales @ariadnamorales.bsky.social · Jul 23

So happy to see this paper out in @natecoevo.nature.com. Huge congrats to the whole team, and especially to @fany-real.bsky.social, @dariloops.bsky.social, @stemundi.bsky.social, Magdalena Schindler & Christian Feregrino. Ever wondered how bats develop wings from their hands? 🦇 Enjoy the read ;) 👇

Fany M. Real @fany-real.bsky.social · Jul 17

Thrilled to see our revised preprint now published in Nature Ecology & Evolution!
If you’re curious about how to build a bat wing by re-using existing gene programs, check out the link or the tutorial below. Big congratulations to all co-authors!! Thanks to reviewers!

www.nature.com/articles/s41...

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Stefan Mundlos @stemundi.bsky.social · Jul 24

Our comparative single-cell study on limb development in bats vs. mice reveals insights how evolution can produce massive changes by just changing the expression of a few TFs 😱
www.nature.com/articles/s41...

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Stefan Mundlos @stemundi.bsky.social · Jul 24

Congratulations, Anna! It really looks fantastic!

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Stefan Mundlos @stemundi.bsky.social · Jul 24

Our really exciting bat work got published. This was a fantastic effort by @fany-real.bsky.social, @dariloops.bsky.social, Magdalena Schindler and Christian Feregrino. Many thanks to all our collaborators! who made this possible!!!
www.nature.com/articles/s41...

Comparative single-cell analyses reveal evolutionary repurposing of a conserved gene programme in bat wing development - Nature Ecology & Evolution

Single-cell comparison of developing bat and mouse limbs reveals conservation of cell populations and gene expression patterns, and suggests repurposing of genes involved in proximal limb development ...

www.nature.com

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Stefan Mundlos @stemundi.bsky.social · Jul 24

Our first paper in Naturre Ecology & Evolution - it won't be the last. Essential insights in bat wing development and how evolution achieves such drastic morphological changes:
www.nature.com/articles/s41...

Comparative single-cell analyses reveal evolutionary repurposing of a conserved gene programme in bat wing development - Nature Ecology & Evolution

Single-cell comparison of developing bat and mouse limbs reveals conservation of cell populations and gene expression patterns, and suggests repurposing of genes involved in proximal limb development ...

www.nature.com

Stefan Mundlos @stemundi.bsky.social · Jul 24

Our first bat story is out! What turns a limb into a wing? Evolution's most impressive adaptation. The massive difference is achieved by small changes and the re-purposing of existing pathways - the principle of parsimony! Meis2 gene, normally expressed in proximal limb gets expressed distally.

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Stefan Mundlos @stemundi.bsky.social · Jul 24

50-70% of cases for WGS remain undiagnosed. Searching for an explanation? Read this article by Glaser et al. Activation of endogenous retroviruses can induce cell death in the embry. You can detect virus-like particles in these cell in EM! www.nature.com/ng/volumes/5...

Nature Genetics - An endogenous retrovirus causes limb malformation

Activation of a long terminal repeat retrotransposon inserted upstream of the Fgf8 gene produces viral-like particles that cause limb malformation in...

www.nature.com

Stefan Mundlos @stemundi.bsky.social · Jul 24

Our new story in Nature Genetics: endogenous retroviruses can produce viral-like particles in the embryo resulting in apoptosis and congenital malformation. If this would happen in human, it wouldn't leave a trace. No WGS or other analysis would identify this. www.nature.com/articles/s41...

Enhancer adoption by an LTR retrotransposon generates viral-like particles, causing developmental limb phenotypes - Nature Genetics

Activation of an LTR retrotransposon inserted upstream of the Fgf8 gene produces viral-like particles in the mouse developing limb, triggering apoptosis and causing limb malformation. This phenotype c...

www.nature.com

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Stefan Mundlos @stemundi.bsky.social · Jul 24

Nature Genetics' new issue is out: Our project is on the cover: An endogenous retrovirus causes limb malformation. Juliane's great scientific work and Anna's cover design!

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Reposted by Stefan Mundlos

Anna A Monaco @annaamonaco.bsky.social · Jul 23

Pretty surreal to see my artwork on the cover of Nature Genetics! Big congrats to @julianeg.bsky.social, @stemundi.bsky.social and the others, and thank you Juliane for letting me help bring your research to life visually.

www.nature.com/ng/volumes/5...

The cover of Nature Genetics July 2025 issue. Digital art of a mouse paw skeletal prep on dark background, digits I to IV disintegrating into viral particles. A caption says “An endogenous retrovirus causes limb malformation”.

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Stefan Mundlos @stemundi.bsky.social · May 15

Genome comparisons identify gene flow events between three species of right whales and the bowhead whale. Evidence of historical trans-equatorial migration during ancient glacial cycles. Beautiful work by BaiWei Lo in the lab together with Paolo Franchini: Genome Biology and Evolution, in press.

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Max Planck Institute for Molecular Genetics @molgen.mpg.de · May 14

Nuage Therapeutics, co-founded by our group leader Denes Hnisz was highlighted in recent Nature Spotlight article: www.nature.com/articles/d42...

Find out more about work in the Hnisz lab: www.molgen.mpg.de/3857230/tran...

@irbbarcelona.org @xsalvatella1.bsky.social

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Stefan Mundlos @stemundi.bsky.social · May 13

A genetic study on Korean divers renowned for their remarkable diving abilities. They identified SNPs, one associated significantly with RBC count. Hematological variation is believed to provide additional oxygen capacity during diving. COOL!
www.cell.com/cell-reports...

Genetic and training adaptations in the Haenyeo divers of Jeju, Korea

Aguilar-Gómez et al. find evidence of evolutionary adaptation with potential relevance to breath-hold diving in the Haenyeo divers of Korea. Genetic variants under selection in this population may hel...

www.cell.com

Reposted by Stefan Mundlos

Mike Robson @drmrobson.bsky.social · May 8

The Robson lab's second paper! A truly fun collaboration with an unexpected and important finding - progenitors reconfigure 3D genomes organisation to commission loci for future cell fates. A heroic amount of work from a rockstar team.

Konrad Chudzik @konrad-chudzik.bsky.social · May 8

🚨 Preprint 🚨
Ever wondered how cells prepare their genomes to enable new cell-fates? In this team up with the Kind lab, we show that genes are repositioned in the nucleus to get ready for future activation and tissue formation. Read 🧵👇 to find out how and when this happens!

doi.org/10.1101/2025...

Reconfiguration of genome-lamina interactions marks the commissioning of limb cell-fates

Diverse forms of heterochromatin block inappropriate transcription and safeguard differentiation and cell identity. Yet, how and when heterochromatin is reconfigured to facilitate changes in cell-fate...

www.biorxiv.org

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Stefan Mundlos @stemundi.bsky.social · May 9

www.biorxiv.org/content/10.1...

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Reposted by Stefan Mundlos

Konrad Chudzik @konrad-chudzik.bsky.social · May 8

Thanks also to the @stemundi.bsky.social lab where this work started and the Robson lab where it was finished! Last, my amazing supervisor @drmrobson.bsky.social who devised the inducible DamID mouse and spearheaded the project!

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Stefan Mundlos @stemundi.bsky.social · May 9

Fantastic work - groundbreaking, important!

Konrad Chudzik @konrad-chudzik.bsky.social · May 8

🚨 Preprint 🚨
Ever wondered how cells prepare their genomes to enable new cell-fates? In this team up with the Kind lab, we show that genes are repositioned in the nucleus to get ready for future activation and tissue formation. Read 🧵👇 to find out how and when this happens!

doi.org/10.1101/2025...

Reconfiguration of genome-lamina interactions marks the commissioning of limb cell-fates

Diverse forms of heterochromatin block inappropriate transcription and safeguard differentiation and cell identity. Yet, how and when heterochromatin is reconfigured to facilitate changes in cell-fate...

www.biorxiv.org

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Stefan Mundlos @stemundi.bsky.social · May 9

This is an important paper: genome-lamina interactions are selectively released in early multipotent progenitors preceding gene expression, suggesting it primes regulatory domains for future potential activation. Fantastic collboration of Robson/Kind/Mundlos labs.

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Stefan Mundlos @stemundi.bsky.social · May 9

Our new study on whale genomics by BaiWei Lo together with Paolo Franchini. Evidence of historical trans-equatorial migration impacted by glacial cycles and connectivity of bowhead whale populations between the North Pacific right whale, the Southern right whale and the North Atlantic right whale.

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Juliane Glaser @julianeg.bsky.social · May 7

Beautiful work 🤩

Cedric Feschotte @cedricfeschotte.bsky.social · Apr 30

💥🥳 At long last, our latest paper is out!

Gag proteins of endogenous retroviruses are required for zebrafish development

www.pnas.org/doi/10.1073/...

Led heroically by Sylvia Chang & @jonowells.bsky.social

A study which has changed the way I think of #transposons! No less! 🧵 1/n

Gag proteins encoded by endogenous retroviruses are required for zebrafish development | PNAS

Transposable elements (TEs) make up the bulk of eukaryotic genomes and examples abound of TE-derived sequences repurposed for organismal function. ...

www.pnas.org

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Reposted by Stefan Mundlos

Iana V. Kim @ianakim.bsky.social · May 7

I’m very excited to share our work on the early evolution of animal regulatory genome architecture - the main project of my postdoc, carried out across two wonderful and inspirational labs of @arnausebe.bsky.social and @mamartirenom.bsky.social. www.nature.com/articles/s41...

Chromatin loops are an ancestral hallmark of the animal regulatory genome - Nature

The physical organization of the genome in non-bilaterian animals and their closest unicellular relatives is characterized; comparative analysis shows chromatin looping is a conserved feature of ...

www.nature.com

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Stefan Mundlos @stemundi.bsky.social · May 8

thanks a lot to you too! Hope we can continue this in the future!

Reposted by Stefan Mundlos

Rada-Iglesias Lab @radaiglesiaslab.bsky.social · May 3

Really proud of Michaela Bartusel, who initiated this work while being a PhD in our lab. Michaela never gave up and, together with the great guidance of my friend and former colleague Eliezer Calo, made some very interesting findings regarding the genetic basis of orofacial clefting.

American Society of Human Genetics (ASHG) @geneticssociety.bsky.social · May 2

Non-syndromic orofacial clefts (OFCs) are common birth defects with unclear molecular causes. @ajhgnews.bsky.social latest article studies an OFC-associated risk locus & implicates tRNA splicing defects that cause ribosome stalling & neural crest cell dysfunction: www.cell.com/ajhg/abstrac... #ASHG

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Alfonso Martinez Arias @amartinezarias.bsky.social · May 4

Just published the new edition of “Principles of Development’ from now called “Wolpert’s Principles of Development’ to honour his memory and the origin of this textbooks that aims at distilling the, sometimes elusive, principles underlying animal and plant development shorturl.at/LrOxn

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