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Reposted by Stéphane Mancini

Louise Purton @louisepurton.bsky.social · May 23

Thanks to @lindemileslab.bsky.social and @challenlab.bsky.social (& team) for writing our first commentary for @isehsociety.bsky.social journal Experimental Hematology! Two recent papers on Clonal Hematopoiesis- want to learn more? Read the link here 👇🏻

Keisuke Ito @keisukeito-lab.bsky.social · May 23

Excited to see the first commentary in Experimental Hematology (@isehsociety.bsky.social)! Kudos to Aishwarya, Linde ‪@lindemileslab.bsky.social, and Grant @challenlab.bsky.social for highlighting recent papers in Exp Hem on cell-extrinsic factors in Tet2-mutant clonal hematopoiesis!! bit.ly/4k3pEAI

Cell-extrinsic factors contribute toward myeloid-biased expansion in Tet2-mutant clonal hematopoiesis

Hematopoietic stem cells (HSCs) acquire somatic mutations throughout life, with the frequency of mutational incidence increasing with age [1]. Occasionally, certain mutations confer a fitness advantag...

bit.ly

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Stéphane Mancini @stephanemancini.bsky.social · May 23

Such a great day yesterday spent with fantastic people doing amazing science, here in sunny #Glasgow. Thank you so much @keeshanlab.bsky.social for the kind invitation. I can’t wait starting new projects with all of you!

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Mauro Gaya @maurogaya.bsky.social · Apr 30

🚨🦠🔬 Last month to register to the EMBO workshop on Adaptive Immunity in Barrier Tissues.

📍 Where: Basel, Switzerland
📅 When: 26th–29th August 2025
📝 Registration deadline: 30th May 2025

Childcare support & travel grants from @embo.org and @efis-immunology.bsky.social

#EMBOBarrierTissues

Adaptive immunity in barrier tissues

Immune responses lie at the heart of almost every aspect of human health, including host responses to infection, autoimmunity, cancer, metabolism and aging. While adaptive immune responses by B and T…

meetings.embo.org

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Josep Carreras Leukaemia Research Institute @carrerasijc.bsky.social · Apr 22

We're pleased to announce that Dr Ari Melnick has been appointed new Director of the Josep Carreras Institute.

Dr Melnick will lead IJC in our mission to advance #research in #leukaemia and other malignant blood diseases.

Read the full release here: www.carrerasresearch.org/en/news/dr-a...

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Nina Cabezas-Wallscheid @ninacabezas.bsky.social · Apr 2

Extremely happy to share our study on the regulation of HSCs in the context of myocardial infarction published in Nature Cell Biology! Driven by two amazing scientists in my lab - Jasmin and Maricarmen and co-led with the awesome cardiologist Timo! Huge thanks also to all our collaborators 👏🏻👏🏻

Max Planck Institute of Immunobiology and Epigenetics @mpi-ie.bsky.social · Apr 2

New research by the @ninacabezas.bsky.social lab & collaborators from @uniklinik-fr.bsky.social.

A vitamin A metabolite may offer a targeted therapeutic strategy for heart attack patients by regulating HSCs to minimize excessive inflammation and preserve long-term heart function.

Healing a broken heart

A vitamin A metabolite, 4-oxo-retinoic acid, can regulate the activity of hematopoietic stem cells and thereby reduce inflammation after a heart attack, ultimately improving heart function in the long...

www.ie-freiburg.mpg.de

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Eric Topol @erictopol.bsky.social · Apr 2

The vaccine against Shingles helps protect against dementia, results of a natural experiment, adding to prior evidence
"implications are profound"
New @nature.com
www.nature.com/articles/d41...
nature.com/articles/s41...

A natural experiment on the effect of herpes zoster vaccination on dementia - Nature

Using a natural experiment that avoids common bias concerns, this study finds that the live-attenuated shingles vaccine reduced the probability of a new dementia diagnosis within a follow-up period of...

nature.com

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Stéphane Mancini @stephanemancini.bsky.social · Mar 21

How can something like that happen in the USA? Worrying ☹️

www.theguardian.com/us-news/2025...

French scientist denied US entry after phone messages critical of Trump found

France’s research minister said the scientist was traveling to Houston for a conference when his phone was searched

www.theguardian.com

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Charlie Hebdo @charliehebdo.fr · Mar 13

Licenciements, coupe de budgets, de nombreux scientifiques américains subissent de plein fouet les nouvelles directives de Donald Trump. Une réforme brutale en forme de purge contre tous ceux qui oseraient continuer leurs dans les secteurs qui dérangent.
charliehebdo.fr/2025...

« On entend dire plein de choses » : aux États-Unis, terreur sur la recherche universitaire

Ils sont partout. Selon le nouveau locataire de la Maison-Blanche, les universités américaines ne seraient plus qu’un vaste repaire de gauchistes « wokes », que dis-je, de néobolcheviques aux cheveux bleus. C’est la panique morale au pays des cow-boys. Mais qu’ils soient rassurés, après avoir capitalisé sur le fantasme de l’ennemi de l’intérieur durant toute […]

charliehebdo.fr

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ISEH - International Society for Experimental Hematology @isehsociety.bsky.social · Mar 12

Check out the #ExpHem Special Issue, Making Blood: Mechanisms of Early Hematopoietic Development from guest editors Elaine Dzierzak and Anna Bigas➡️ www.exphem.org/content/edit...

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Stéphane Mancini @stephanemancini.bsky.social · Mar 10

www.theguardian.com/us-news/2025...

‘I hate to predict things’: Trump doesn’t rule out US recession amid trade tariffs

President downplays recent stock market volatility that followed his ducking and weaving over tariff policy

www.theguardian.com

Stéphane Mancini @stephanemancini.bsky.social · Mar 10

‘I hate to predict things’: Trump doesn’t rule out US recession amid trade tariffs
Ah ah! 😂 That’s why he has been so successful in sinking daddy’s fortune. Well now the problem is that he is sinking the US and the whole world ☹️

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Stéphane Mancini @stephanemancini.bsky.social · Mar 8

Will our leaders be able to react and ensure that France once again becomes the land of enlightenment? That would mean 3% of GDP for research, not for guns and pain

Charlie Hebdo @charliehebdo.fr · Mar 7

Le dessin du jour, par Juin

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Eric Chevet @ericchevet.bsky.social · Mar 8

www.ouest-france.fr/bretagne/ren...

En solidarité avec leurs homologues américains ciblés par Trump, les scientifiques réunis à Rennes

En réaction à l’offensive menée par l’administration Trump contre le monde de la recherche aux États-Unis, la communauté scientifique française a témoigné de sa solidarité, en multipliant les rassembl...

www.ouest-france.fr

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Nature @nature.com · Feb 25

US President Donald Trump is taking a wrecking ball to science and to international institutions. The global research community must take a stand against these attacks.

https://go.nature.com/4kd1vIu

Trump 2.0: an assault on science anywhere is an assault on science everywhere

US President Donald Trump is taking a wrecking ball to science and to international institutions. The global research community must take a stand against these attacks.

go.nature.com

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Michalis Averof @michalis-averof.bsky.social · Feb 26

As the world of science wakes up to modern fascism, it's worth remembering older generations who stood up for humanity in much harsher circumstances. Jacques Monod worked actively for the resistance in WWII, while pursuing early stages of his research in occupied Paris. @standupforscifr.bsky.social

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HHMI @hhmi.org · Feb 17

Bring your samples into focus! A new version of the #Cellpose cell boundary mapping tool, developed at @hhmijanelia.bsky.social by @computingnature.bsky.social and @marius10p.bsky.social, now works on less-than-perfect microscopy images that are noisy, blurry, or undersampled.

Newest version of Cellpose can spot cell boundaries even in cloudy conditions

Picking out individual cells in distorted microscopy images is now as easy as clicking a button. A new version of Cellpose – the popular tool that maps the boundaries of diverse cells in microscopy

buff.ly

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Stéphane Mancini @stephanemancini.bsky.social · Feb 17

So happy to share the latest preprint of the lab, with Marjorie Delahaye as the main actor of this great story. This work demonstrates that the bone marrow microenvironment can imprint (pre-)leukemic cell fate and influence the acquisition of secondary mutations

Signals from the bone marrow B cell niches shape pre-leukemic fate in murine B cell acute lymphoblastic leukemia

The bone marrow (BM) microenvironment plays a key role in supporting B cell development. In acute lymphoblastic leukemia (B-ALL), the acquisition of oncogenic driver mutations blocks B cell differenti...

www.biorxiv.org

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Stéphane Mancini @stephanemancini.bsky.social · Feb 17

Great presentation of Marjorie Delahaye, post doc in my team at the #ESHMICRO2025. Now part of the panel of specialists together with great names in the field. Proud of you!

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Stéphane Mancini @stephanemancini.bsky.social · Feb 16

ESH haematological tumour microenvironment is just starting! #ESHMICRO2025. So great to be here in London after a two-year wait

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Stéphane Mancini @stephanemancini.bsky.social · Feb 15

You've been murdered, who do you want on the case?

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Thiago Carvalho @cyrilpedia.bsky.social · Feb 15

1, 2, 3, 4.
"Electronic lab notebooks, despite their popularity, are stored in proprietary formats, incur a recurrent cost, tend to become defunct over time, and have poor interoperability with each other"
journals.plos.org/plosbiology/...

GitHub enables collaborative and reproducible laboratory research

GitHub, a platform widely used in software development, offers a robust framework for documenting all activities of laboratory research projects. This Community Page highlights the benefits of, and pr...

journals.plos.org

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Mick Milsom @milsommick.bsky.social · Feb 5

New pre-print from Thomas Höfer, Daniel Hübschmann, @haas_lab and myself, with first authors @Esther_RCorrea @FloGrunschlager and Tamar Nizharadze doi.org/10.1101/2025... @DKFZ @NCT_HD @ChariteBerlin @hi_stem_lab BIH & MDC

A kinetics-based model of hematopoiesis reveals extrinsic regulation of skewed lineage output from stem cells

Residing at the top of the hematopoietic hierarchy, long-term hematopoietic stem cells (HSCs) are capable of self-renewal and sustained blood cell regeneration. Over the past decades, single-cell and ...

doi.org

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OncoDaily @oncodaily.bsky.social · Feb 4

World Cancer Day
@uiccofficial.bsky.social

oncodaily.com/blog/world-c...

#Cancer #OncoDaily #Oncology #UICC #UnitedByUnique #Health #WorldCancerDay #Medicine

World Cancer Day - OncoDaily

World Cancer Day / cancer, OncoDaily, Oncology, UICC, United By Unique, World Cancer Day

oncodaily.com

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Jeremias Lab @jeremiaslab.bsky.social · Feb 3

🎉 We’re excited to share our latest research on FLT3-targeted antibody-drug conjugates (ADCs) as a promising strategy to eliminate leukemic stem cells in AML! 🚀🔬Many thanks to all involved in this great BMBF-funded project #leukemia #PDXmodels

📖Read more here: www.nature.com/articles/s41...

Effective eradication of acute myeloid leukemia stem cells with FLT3-directed antibody-drug conjugates - Leukemia

Leukemia - Effective eradication of acute myeloid leukemia stem cells with FLT3-directed antibody-drug conjugates

www.nature.com

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Stéphane Mancini @stephanemancini.bsky.social · Feb 3

You are a scientist and want to expend your scientific network? You are interested in the research held in Rennes? Please share!

Eric Chevet @ericchevet.bsky.social · Feb 3

Another starter pack for scientists in Rennes go.bsky.app/DqtR5Bq still missing many -- if you want to be added to the list please contact me -- @stephanemancini.bsky.social @leborgne.bsky.social @iscr-rennes.bsky.social @osurennes.bsky.social please diffuse in your institutes

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