Stéphane Mancini
@stephanemancini.bsky.social
INSERM Research Director, passionate about Science, Immunology, Hematology, lymphocytes, leukemia, microenvironment. Keen on cytometry, imaging, bioinformatics
Pinned
Signals from the bone marrow B cell niches shape pre-leukemic fate in murine B cell acute lymphoblastic leukemia
The bone marrow (BM) microenvironment plays a key role in supporting B cell development. In acute lymphoblastic leukemia (B-ALL), the acquisition of oncogenic driver mutations blocks B cell differenti...
www.biorxiv.org
So happy to share the latest preprint of the lab, with Marjorie Delahaye as the main actor of this great story. This work demonstrates that the bone marrow microenvironment can imprint (pre-)leukemic cell fate and influence the acquisition of secondary mutations
Honoured to be part of the summit in immuno-oncology in Yerevan 🇦🇲. Warm welcome from everyone here, such a great pleasure. And what a stunning view! 🤩
October 16, 2025 at 5:25 AM
Honoured to be part of the summit in immuno-oncology in Yerevan 🇦🇲. Warm welcome from everyone here, such a great pleasure. And what a stunning view! 🤩
Reposted by Stéphane Mancini
Thanks to @lindemileslab.bsky.social and @challenlab.bsky.social (& team) for writing our first commentary for @isehsociety.bsky.social journal Experimental Hematology! Two recent papers on Clonal Hematopoiesis- want to learn more? Read the link here 👇🏻
Excited to see the first commentary in Experimental Hematology (@isehsociety.bsky.social)! Kudos to Aishwarya, Linde @lindemileslab.bsky.social, and Grant @challenlab.bsky.social for highlighting recent papers in Exp Hem on cell-extrinsic factors in Tet2-mutant clonal hematopoiesis!! bit.ly/4k3pEAI
Cell-extrinsic factors contribute toward myeloid-biased expansion in Tet2-mutant clonal hematopoiesis
Hematopoietic stem cells (HSCs) acquire somatic mutations throughout life, with the
frequency of mutational incidence increasing with age [1]. Occasionally, certain mutations
confer a fitness advantag...
bit.ly
May 23, 2025 at 9:47 PM
Thanks to @lindemileslab.bsky.social and @challenlab.bsky.social (& team) for writing our first commentary for @isehsociety.bsky.social journal Experimental Hematology! Two recent papers on Clonal Hematopoiesis- want to learn more? Read the link here 👇🏻
Such a great day yesterday spent with fantastic people doing amazing science, here in sunny #Glasgow. Thank you so much @keeshanlab.bsky.social for the kind invitation. I can’t wait starting new projects with all of you!
May 23, 2025 at 5:33 AM
Such a great day yesterday spent with fantastic people doing amazing science, here in sunny #Glasgow. Thank you so much @keeshanlab.bsky.social for the kind invitation. I can’t wait starting new projects with all of you!
Reposted by Stéphane Mancini
🚨🦠🔬 Last month to register to the EMBO workshop on Adaptive Immunity in Barrier Tissues.
📍 Where: Basel, Switzerland
📅 When: 26th–29th August 2025
📝 Registration deadline: 30th May 2025
Childcare support & travel grants from @embo.org and @efis-immunology.bsky.social
#EMBOBarrierTissues
📍 Where: Basel, Switzerland
📅 When: 26th–29th August 2025
📝 Registration deadline: 30th May 2025
Childcare support & travel grants from @embo.org and @efis-immunology.bsky.social
#EMBOBarrierTissues
Adaptive immunity in barrier tissues
Immune responses lie at the heart of almost every aspect of human health, including host responses to infection, autoimmunity, cancer, metabolism and aging. While adaptive immune responses by B and T…
meetings.embo.org
April 30, 2025 at 3:04 PM
🚨🦠🔬 Last month to register to the EMBO workshop on Adaptive Immunity in Barrier Tissues.
📍 Where: Basel, Switzerland
📅 When: 26th–29th August 2025
📝 Registration deadline: 30th May 2025
Childcare support & travel grants from @embo.org and @efis-immunology.bsky.social
#EMBOBarrierTissues
📍 Where: Basel, Switzerland
📅 When: 26th–29th August 2025
📝 Registration deadline: 30th May 2025
Childcare support & travel grants from @embo.org and @efis-immunology.bsky.social
#EMBOBarrierTissues
Reposted by Stéphane Mancini
We're pleased to announce that Dr Ari Melnick has been appointed new Director of the Josep Carreras Institute.
Dr Melnick will lead IJC in our mission to advance #research in #leukaemia and other malignant blood diseases.
Read the full release here: www.carrerasresearch.org/en/news/dr-a...
Dr Melnick will lead IJC in our mission to advance #research in #leukaemia and other malignant blood diseases.
Read the full release here: www.carrerasresearch.org/en/news/dr-a...
April 22, 2025 at 2:05 PM
We're pleased to announce that Dr Ari Melnick has been appointed new Director of the Josep Carreras Institute.
Dr Melnick will lead IJC in our mission to advance #research in #leukaemia and other malignant blood diseases.
Read the full release here: www.carrerasresearch.org/en/news/dr-a...
Dr Melnick will lead IJC in our mission to advance #research in #leukaemia and other malignant blood diseases.
Read the full release here: www.carrerasresearch.org/en/news/dr-a...
Reposted by Stéphane Mancini
Extremely happy to share our study on the regulation of HSCs in the context of myocardial infarction published in Nature Cell Biology! Driven by two amazing scientists in my lab - Jasmin and Maricarmen and co-led with the awesome cardiologist Timo! Huge thanks also to all our collaborators 👏🏻👏🏻
New research by the @ninacabezas.bsky.social lab & collaborators from @uniklinik-fr.bsky.social.
A vitamin A metabolite may offer a targeted therapeutic strategy for heart attack patients by regulating HSCs to minimize excessive inflammation and preserve long-term heart function.
A vitamin A metabolite may offer a targeted therapeutic strategy for heart attack patients by regulating HSCs to minimize excessive inflammation and preserve long-term heart function.
Healing a broken heart
A vitamin A metabolite, 4-oxo-retinoic acid, can regulate the activity of hematopoietic stem cells and thereby reduce inflammation after a heart attack, ultimately improving heart function in the long...
www.ie-freiburg.mpg.de
April 2, 2025 at 2:32 PM
Extremely happy to share our study on the regulation of HSCs in the context of myocardial infarction published in Nature Cell Biology! Driven by two amazing scientists in my lab - Jasmin and Maricarmen and co-led with the awesome cardiologist Timo! Huge thanks also to all our collaborators 👏🏻👏🏻
Reposted by Stéphane Mancini
The vaccine against Shingles helps protect against dementia, results of a natural experiment, adding to prior evidence
"implications are profound"
New @nature.com
www.nature.com/articles/d41...
nature.com/articles/s41...
"implications are profound"
New @nature.com
www.nature.com/articles/d41...
nature.com/articles/s41...
A natural experiment on the effect of herpes zoster vaccination on dementia - Nature
Using a natural experiment that avoids common bias concerns, this study finds that the live-attenuated shingles vaccine reduced the probability of a new dementia diagnosis within a follow-up period of...
nature.com
April 2, 2025 at 3:29 PM
The vaccine against Shingles helps protect against dementia, results of a natural experiment, adding to prior evidence
"implications are profound"
New @nature.com
www.nature.com/articles/d41...
nature.com/articles/s41...
"implications are profound"
New @nature.com
www.nature.com/articles/d41...
nature.com/articles/s41...
Reposted by Stéphane Mancini
Licenciements, coupe de budgets, de nombreux scientifiques américains subissent de plein fouet les nouvelles directives de Donald Trump. Une réforme brutale en forme de purge contre tous ceux qui oseraient continuer leurs dans les secteurs qui dérangent.
charliehebdo.fr/2025...
charliehebdo.fr/2025...
« On entend dire plein de choses » : aux États-Unis, terreur sur la recherche universitaire
Ils sont partout. Selon le nouveau locataire de la Maison-Blanche, les universités américaines ne seraient plus qu’un vaste repaire de gauchistes « wokes », que dis-je, de néobolcheviques aux cheveux bleus. C’est la panique morale au pays des cow-boys. Mais qu’ils soient rassurés, après avoir capitalisé sur le fantasme de l’ennemi de l’intérieur durant toute […]
charliehebdo.fr
March 13, 2025 at 6:15 PM
Licenciements, coupe de budgets, de nombreux scientifiques américains subissent de plein fouet les nouvelles directives de Donald Trump. Une réforme brutale en forme de purge contre tous ceux qui oseraient continuer leurs dans les secteurs qui dérangent.
charliehebdo.fr/2025...
charliehebdo.fr/2025...
Reposted by Stéphane Mancini
Check out the #ExpHem Special Issue, Making Blood: Mechanisms of Early Hematopoietic Development from guest editors Elaine Dzierzak and Anna Bigas➡️ www.exphem.org/content/edit...
March 12, 2025 at 8:00 PM
Check out the #ExpHem Special Issue, Making Blood: Mechanisms of Early Hematopoietic Development from guest editors Elaine Dzierzak and Anna Bigas➡️ www.exphem.org/content/edit...
‘I hate to predict things’: Trump doesn’t rule out US recession amid trade tariffs
Ah ah! 😂 That’s why he has been so successful in sinking daddy’s fortune. Well now the problem is that he is sinking the US and the whole world ☹️
Ah ah! 😂 That’s why he has been so successful in sinking daddy’s fortune. Well now the problem is that he is sinking the US and the whole world ☹️
March 10, 2025 at 6:07 AM
‘I hate to predict things’: Trump doesn’t rule out US recession amid trade tariffs
Ah ah! 😂 That’s why he has been so successful in sinking daddy’s fortune. Well now the problem is that he is sinking the US and the whole world ☹️
Ah ah! 😂 That’s why he has been so successful in sinking daddy’s fortune. Well now the problem is that he is sinking the US and the whole world ☹️
Will our leaders be able to react and ensure that France once again becomes the land of enlightenment? That would mean 3% of GDP for research, not for guns and pain
March 8, 2025 at 6:56 AM
Will our leaders be able to react and ensure that France once again becomes the land of enlightenment? That would mean 3% of GDP for research, not for guns and pain
Reposted by Stéphane Mancini
Reposted by Stéphane Mancini
US President Donald Trump is taking a wrecking ball to science and to international institutions. The global research community must take a stand against these attacks.
https://go.nature.com/4kd1vIu
https://go.nature.com/4kd1vIu
Trump 2.0: an assault on science anywhere is an assault on science everywhere
US President Donald Trump is taking a wrecking ball to science and to international institutions. The global research community must take a stand against these attacks.
go.nature.com
February 25, 2025 at 9:53 PM
US President Donald Trump is taking a wrecking ball to science and to international institutions. The global research community must take a stand against these attacks.
https://go.nature.com/4kd1vIu
https://go.nature.com/4kd1vIu
Reposted by Stéphane Mancini
As the world of science wakes up to modern fascism, it's worth remembering older generations who stood up for humanity in much harsher circumstances. Jacques Monod worked actively for the resistance in WWII, while pursuing early stages of his research in occupied Paris. @standupforscifr.bsky.social
February 26, 2025 at 5:40 PM
As the world of science wakes up to modern fascism, it's worth remembering older generations who stood up for humanity in much harsher circumstances. Jacques Monod worked actively for the resistance in WWII, while pursuing early stages of his research in occupied Paris. @standupforscifr.bsky.social
Reposted by Stéphane Mancini
Bring your samples into focus! A new version of the #Cellpose cell boundary mapping tool, developed at @hhmijanelia.bsky.social by @computingnature.bsky.social and @marius10p.bsky.social, now works on less-than-perfect microscopy images that are noisy, blurry, or undersampled.
Newest version of Cellpose can spot cell boundaries even in cloudy conditions
Picking out individual cells in distorted microscopy images is now as easy as clicking a button. A new version of Cellpose – the popular tool that maps the boundaries of diverse cells in microscopy
buff.ly
February 17, 2025 at 1:42 PM
Bring your samples into focus! A new version of the #Cellpose cell boundary mapping tool, developed at @hhmijanelia.bsky.social by @computingnature.bsky.social and @marius10p.bsky.social, now works on less-than-perfect microscopy images that are noisy, blurry, or undersampled.
So happy to share the latest preprint of the lab, with Marjorie Delahaye as the main actor of this great story. This work demonstrates that the bone marrow microenvironment can imprint (pre-)leukemic cell fate and influence the acquisition of secondary mutations
Signals from the bone marrow B cell niches shape pre-leukemic fate in murine B cell acute lymphoblastic leukemia
The bone marrow (BM) microenvironment plays a key role in supporting B cell development. In acute lymphoblastic leukemia (B-ALL), the acquisition of oncogenic driver mutations blocks B cell differenti...
www.biorxiv.org
February 17, 2025 at 11:19 PM
So happy to share the latest preprint of the lab, with Marjorie Delahaye as the main actor of this great story. This work demonstrates that the bone marrow microenvironment can imprint (pre-)leukemic cell fate and influence the acquisition of secondary mutations
Great presentation of Marjorie Delahaye, post doc in my team at the #ESHMICRO2025. Now part of the panel of specialists together with great names in the field. Proud of you!
February 17, 2025 at 6:07 PM
Great presentation of Marjorie Delahaye, post doc in my team at the #ESHMICRO2025. Now part of the panel of specialists together with great names in the field. Proud of you!
ESH haematological tumour microenvironment is just starting! #ESHMICRO2025. So great to be here in London after a two-year wait
February 16, 2025 at 3:08 PM
ESH haematological tumour microenvironment is just starting! #ESHMICRO2025. So great to be here in London after a two-year wait
You've been murdered, who do you want on the case?
February 15, 2025 at 1:41 PM
You've been murdered, who do you want on the case?
Reposted by Stéphane Mancini
1, 2, 3, 4.
"Electronic lab notebooks, despite their popularity, are stored in proprietary formats, incur a recurrent cost, tend to become defunct over time, and have poor interoperability with each other"
journals.plos.org/plosbiology/...
"Electronic lab notebooks, despite their popularity, are stored in proprietary formats, incur a recurrent cost, tend to become defunct over time, and have poor interoperability with each other"
journals.plos.org/plosbiology/...
GitHub enables collaborative and reproducible laboratory research
GitHub, a platform widely used in software development, offers a robust framework for documenting all activities of laboratory research projects. This Community Page highlights the benefits of, and pr...
journals.plos.org
February 15, 2025 at 12:18 PM
1, 2, 3, 4.
"Electronic lab notebooks, despite their popularity, are stored in proprietary formats, incur a recurrent cost, tend to become defunct over time, and have poor interoperability with each other"
journals.plos.org/plosbiology/...
"Electronic lab notebooks, despite their popularity, are stored in proprietary formats, incur a recurrent cost, tend to become defunct over time, and have poor interoperability with each other"
journals.plos.org/plosbiology/...
Reposted by Stéphane Mancini
New pre-print from Thomas Höfer, Daniel Hübschmann, @haas_lab and myself, with first authors @Esther_RCorrea @FloGrunschlager and Tamar Nizharadze doi.org/10.1101/2025... @DKFZ @NCT_HD @ChariteBerlin @hi_stem_lab BIH & MDC
A kinetics-based model of hematopoiesis reveals extrinsic regulation of skewed lineage output from stem cells
Residing at the top of the hematopoietic hierarchy, long-term hematopoietic stem cells (HSCs) are capable of self-renewal and sustained blood cell regeneration. Over the past decades, single-cell and ...
doi.org
February 5, 2025 at 10:55 AM
New pre-print from Thomas Höfer, Daniel Hübschmann, @haas_lab and myself, with first authors @Esther_RCorrea @FloGrunschlager and Tamar Nizharadze doi.org/10.1101/2025... @DKFZ @NCT_HD @ChariteBerlin @hi_stem_lab BIH & MDC
Reposted by Stéphane Mancini
World Cancer Day
@uiccofficial.bsky.social
oncodaily.com/blog/world-c...
#Cancer #OncoDaily #Oncology #UICC #UnitedByUnique #Health #WorldCancerDay #Medicine
@uiccofficial.bsky.social
oncodaily.com/blog/world-c...
#Cancer #OncoDaily #Oncology #UICC #UnitedByUnique #Health #WorldCancerDay #Medicine
World Cancer Day - OncoDaily
World Cancer Day / cancer, OncoDaily, Oncology, UICC, United By Unique, World Cancer Day
oncodaily.com
February 4, 2025 at 4:58 PM
Reposted by Stéphane Mancini
🎉 We’re excited to share our latest research on FLT3-targeted antibody-drug conjugates (ADCs) as a promising strategy to eliminate leukemic stem cells in AML! 🚀🔬Many thanks to all involved in this great BMBF-funded project #leukemia #PDXmodels
📖Read more here: www.nature.com/articles/s41...
📖Read more here: www.nature.com/articles/s41...
Effective eradication of acute myeloid leukemia stem cells with FLT3-directed antibody-drug conjugates - Leukemia
Leukemia - Effective eradication of acute myeloid leukemia stem cells with FLT3-directed antibody-drug conjugates
www.nature.com
February 3, 2025 at 3:33 PM
🎉 We’re excited to share our latest research on FLT3-targeted antibody-drug conjugates (ADCs) as a promising strategy to eliminate leukemic stem cells in AML! 🚀🔬Many thanks to all involved in this great BMBF-funded project #leukemia #PDXmodels
📖Read more here: www.nature.com/articles/s41...
📖Read more here: www.nature.com/articles/s41...
You are a scientist and want to expend your scientific network? You are interested in the research held in Rennes? Please share!
Another starter pack for scientists in Rennes go.bsky.app/DqtR5Bq still missing many -- if you want to be added to the list please contact me -- @stephanemancini.bsky.social @leborgne.bsky.social @iscr-rennes.bsky.social @osurennes.bsky.social please diffuse in your institutes
February 3, 2025 at 4:35 PM
You are a scientist and want to expend your scientific network? You are interested in the research held in Rennes? Please share!