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Steve Reilly

@stevereilly.bsky.social

83 followers 96 following 9 posts

Assistant Professor of Genetics @ Yale. Studying how variation in cis-regulatory-elements impacts evolution, complex traits, and more! http://reilly-lab.com

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Reposted by Steve Reilly

Noonan Lab @noonanlab.bsky.social · Aug 13

Yale has established a new PhD program in Human Genome Sciences and will be accepting applications this fall. We are also searching for an Associate Director of Student Services (a PhD-level position).

Learn more here:
medicine.yale.edu/bbs/tracks/h...

careers.yale.edu/us/en/job/YU...

Human Genome Sciences

The overall goal of the Human Genome Sciences (HGS) track is to train the next generation of scientists in the areas of human genomics, genetics, and

medicine.yale.edu

Steve Reilly @stevereilly.bsky.social · Jun 10

After spending tons of time rebutting our trainee's grant termination.. this response doesn't suggest a 'careful assessment'

There aren't mechanisms that support mid-PhD trainees, so theres nothing to apply to, even though it scored in the top % of all apps.
Not to mention the demotivation.
Ugh.

Reposted by Steve Reilly

Darío Lupiáñez @dariloops.bsky.social · May 9

🧠 MPRA + AI to decipher rules of enhancer grammar.

I wrote some thoughts about the fantastic and inspiring work by Robert Frömel & colleagues from @larsplus.bsky.social lab at @crg.eu @upf.edu 👏👏👏

sciencemediacentre.es/en/design-dn...

Design DNA fragments that control genes in mammalian cells with AI

A team from the Centre for Genomic Regulation (CRG) and Pompeu Fabra University (UPF) in Barcelona has developed an artificial intelligence tool capable of designing regulatory sequences for genes that do not exist in nature. When introduced into cells, these enhancers can increase or decrease gene activity in a specific way depending on the type of cell targeted. According to the authors, ‘the potential applications are enormous. It's like writing software, but for biology.’ The results are published in the journal Cell.

sciencemediacentre.es

Reposted by Steve Reilly

Jeremy Berg @jeremymberg.bsky.social · May 6

As a follow-up to the Kaiser interview, here is my exchange with Dr. Bhattacharya starting Sunday evening...

1/n

A letter from Jeremy Berg to NIH Director Jayanta Bhattacharya about the need to award grants promptly.

Reposted by Steve Reilly

Ryan Tewhey @tewhey.bsky.social · Apr 29

Proud to share our lab’s first student preprint!🚀@j-c-butts.bsky.social, @alwaysrong.bsky.social, @sagergosai.bsky.social leveraged our MPRA models to predict variant effects, providing scores for the complete catalog of human variation. Grateful for another fun collab with @stevereilly.bsky.social.

John Butts @j-c-butts.bsky.social · Apr 23

Excited to share our MPAC preprint, a scalable ensemble of ML models for genome-wide non-coding variant effect prediction and our findings from 575M predictions across databases including @ukbiobank.bsky.social, GTEx, ClinVar, COSMIC, and @gnomad-project.bsky.social
www.biorxiv.org/content/10.1...

bioRxiv - the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution

https://www.biorxiv.org/content/10.1101/2025.04.16.648420v1\

Steve Reilly @stevereilly.bsky.social · Apr 25

20% of the US population is rural, but certainly not 20% of scientists are. Not fostering scientists from these places certainly DOES reduce our knowledge, reduces our health, and reduces scientific inquiry.

OOF.

Steve Reilly @stevereilly.bsky.social · Apr 25

"Research based on artificial and non-scientific categories, including amorphous equity objectives, are antithetical to the scientific inquiry, do nothing to expand our knowledge of living systems, provide low returns on investment, and do not enhance health, lengthen life, or reduce illness"

Steve Reilly @stevereilly.bsky.social · Apr 25

To add insult to injury, the termination letter reads like the free version of chatGPT imitating a nut job, not a piece of official US correspondence:

Steve Reilly @stevereilly.bsky.social · Apr 25

This student went against the odds to make it where he is, leaning on his brilliance and tenacity. He moved to WI and attended UW-Madison.
Would love to hear from #repgusbilirakis @baldwin.senate.gov #ronjohnson about how defunding the brightest young scientists from rural America makes us great?

Steve Reilly @stevereilly.bsky.social · Apr 25

The work was going to better understand how evolutionary pressures in people's ancestry altered their risk for disease. It was helping to make the promise of precision genetic medicine a reality. It was at the forefront of global biomedical research, now quickly being ceded to Europe and China.

Steve Reilly @stevereilly.bsky.social · Apr 25

Incredibly frustrated today that we had a PhD trainee's NIH grant TERMINATED. He EARNED it by scoring in the top %.

Would love to hear from #murkowski @sendansullivan.bsky.social
@nickbegich.bsky.social think about a bright AK native son's prospects getting cut short due to DOGE lunacy.

a man holding a cup of coffee with the words it 's horrible written on his face

ALT: a man holding a cup of coffee with the words it 's horrible written on his face

media.tenor.com

Reposted by Steve Reilly

Arya Rao @aryarao.bsky.social · Apr 24

Thanks #MITS2025 for inviting me to speak about our deep learning-based search for variants under positive selection in the human genome; more to come! @pardissabeti.bsky.social @stevereilly.bsky.social

Craig Anderson @craigandersn.bsky.social · Apr 23

Arya Rao in the search for adaptive traits #MITS25

Reposted by Steve Reilly

Jeremy Berg @jeremymberg.bsky.social · Apr 23

ACTION ITEM-----ACTION ITEM

Implementation of Schedule F

This is what a lot of us have been worried about.

This allows for many civil service positions to replaced with political appointees. This could include NIH institute directors and even POs.

BUT THERE IS A COMMENT PERIOD...

1/n

the word alert is in a purple circle

ALT: the word alert is in a purple circle

media.tenor.com

Steve Reilly @stevereilly.bsky.social · Apr 23

Read through to see our new collaborative work predicting the effects of regulatory variation, for complex traits, rare disease, cancer, and evolution by making ML models of MPRA and scaling to the entire genome.

John Butts @j-c-butts.bsky.social · Apr 23

Excited to share our MPAC preprint, a scalable ensemble of ML models for genome-wide non-coding variant effect prediction and our findings from 575M predictions across databases including @ukbiobank.bsky.social, GTEx, ClinVar, COSMIC, and @gnomad-project.bsky.social
www.biorxiv.org/content/10.1...

bioRxiv - the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution

https://www.biorxiv.org/content/10.1101/2025.04.16.648420v1\

Steve Reilly @stevereilly.bsky.social · Apr 22

Hello Bluesky. The Reilly lab fully made the jump from twitter. Thought it was time to say hello, so: hello!

Excited to join a great community of scientists here!