Steven Gruber
@stvngrbr.bsky.social
From the Midwest to the West Coast. Fan of biking, learning, and sharing. Scientist at Illumina focused on DNA Methylation.
What a brilliant "State of Gene Editing" write-up by @scienceboss.bsky.social from @endpts.com
Step 1: talk to the scientists who made big claims years ago
Step 2: understand the complexities and where the companies went wrong
Step 3: talk to the same scientists
endpoints.news/as-gene-edit...
Step 1: talk to the scientists who made big claims years ago
Step 2: understand the complexities and where the companies went wrong
Step 3: talk to the same scientists
endpoints.news/as-gene-edit...
Gene editing's search for a 'holy grail' has led to an explosion of tools, but few cures
Former Intellia scientist John Finn reflects on gene editing's evolution and the closure of Tome Biosciences, highlighting the industry's focus on tools over medicines.
endpoints.news
December 29, 2025 at 8:34 PM
What a brilliant "State of Gene Editing" write-up by @scienceboss.bsky.social from @endpts.com
Step 1: talk to the scientists who made big claims years ago
Step 2: understand the complexities and where the companies went wrong
Step 3: talk to the same scientists
endpoints.news/as-gene-edit...
Step 1: talk to the scientists who made big claims years ago
Step 2: understand the complexities and where the companies went wrong
Step 3: talk to the same scientists
endpoints.news/as-gene-edit...
I'm tiptoing back to Twitter (X) 😳🤮🤷♂️
#2026
#2026
December 28, 2025 at 6:30 PM
I'm tiptoing back to Twitter (X) 😳🤮🤷♂️
#2026
#2026
Why do I feel that scientists moved from X (Twitter) to LinkedIn as their preferred communication? Is it the spam of LinkedIn notifications I receive? 🤷♂️
December 27, 2025 at 3:55 AM
Why do I feel that scientists moved from X (Twitter) to LinkedIn as their preferred communication? Is it the spam of LinkedIn notifications I receive? 🤷♂️
I'm either "well read" or a "pop culture junkie". Solid breakdown read of 2025 pop culture!
In a year of pop culture moments, some things were old and some things were very new.
Pop culture in 2025: A ring for Taylor, an ill-timed KissCam ... and whatever ‘6-7’ means
In a year of pop culture moments, some things were old and some things were very new. What does the term “6-7” mean?
bit.ly
December 26, 2025 at 2:32 PM
I'm either "well read" or a "pop culture junkie". Solid breakdown read of 2025 pop culture!
December 18, 2025 at 3:53 AM
This is an awesome, human-generated, essay. I love this comparison to chess and how to belittle AI Large Language Models www.taylorforeman.com/p/semantic-a...
Semantic Apocalypse Now
AI solves language games, not reality.
www.taylorforeman.com
December 17, 2025 at 3:47 AM
This is an awesome, human-generated, essay. I love this comparison to chess and how to belittle AI Large Language Models www.taylorforeman.com/p/semantic-a...
Help me understand why there aren't 100 headlines talking about ACA subsidy extensions. Remember the longest government shutdown ever that just ended...🤷♂️🤦♂️
December 3, 2025 at 11:36 AM
Help me understand why there aren't 100 headlines talking about ACA subsidy extensions. Remember the longest government shutdown ever that just ended...🤷♂️🤦♂️
Reposted by Steven Gruber
The NIH grant cuts in 2025
www.nytimes.com/interactive/...
www.nytimes.com/interactive/...
December 2, 2025 at 3:16 PM
The NIH grant cuts in 2025
www.nytimes.com/interactive/...
www.nytimes.com/interactive/...
I can't agree more with this perspective. It's an investment in the space, which is likely to grow! www.genomeweb.com/cancer/abbot...
Abbott's Exact Sciences Acquisition Signals Maturation of Single-Site Specialty Dx Space
While some industry observers see the deal as a one-off, others suggested similar ones could follow as large medical firms eye fast-growing diagnostic markets.
www.genomeweb.com
November 25, 2025 at 7:41 PM
I can't agree more with this perspective. It's an investment in the space, which is likely to grow! www.genomeweb.com/cancer/abbot...
Reposted by Steven Gruber
“I had hemophilia for nearly five decades. I went to Philadelphia and had a 45-minute infusion, and my hemophilia was gone.”
Genes-> Medicine
nature.com/articles/s41...
Genes-> Medicine
nature.com/articles/s41...
November 21, 2025 at 9:45 PM
“I had hemophilia for nearly five decades. I went to Philadelphia and had a 45-minute infusion, and my hemophilia was gone.”
Genes-> Medicine
nature.com/articles/s41...
Genes-> Medicine
nature.com/articles/s41...
Solid perspective @kyla.bsky.social, thanks!
"America’s problem isn’t that we lack wealth - we have enormous wealth - it’s that we’ve made our wealth invisible while letting everything visible decay in a way. We’ve inverted the formula."
Read: kyla.substack.com/p/30-days-9-...
"America’s problem isn’t that we lack wealth - we have enormous wealth - it’s that we’ve made our wealth invisible while letting everything visible decay in a way. We’ve inverted the formula."
Read: kyla.substack.com/p/30-days-9-...
30 Days, 8 Cities, 1 Question: Where Did American Prosperity Go?
Traveling the country to understand it
kyla.substack.com
November 19, 2025 at 2:51 PM
Solid perspective @kyla.bsky.social, thanks!
"America’s problem isn’t that we lack wealth - we have enormous wealth - it’s that we’ve made our wealth invisible while letting everything visible decay in a way. We’ve inverted the formula."
Read: kyla.substack.com/p/30-days-9-...
"America’s problem isn’t that we lack wealth - we have enormous wealth - it’s that we’ve made our wealth invisible while letting everything visible decay in a way. We’ve inverted the formula."
Read: kyla.substack.com/p/30-days-9-...
Reposted by Steven Gruber
Also, here’s an accessible video intro:
November 15, 2025 at 5:33 PM
Also, here’s an accessible video intro:
THIS!
I always click the button to "share" for this exact reason! Your data is so much bigger than you! Be selfless!
youtu.be/MOu8sYPV_EY?...
I always click the button to "share" for this exact reason! Your data is so much bigger than you! Be selfless!
youtu.be/MOu8sYPV_EY?...
What if your health data could save a life? | Ashley Van Zeeland | TEDxSanDiegoWomen
YouTube video by TEDx Talks
youtu.be
October 29, 2025 at 7:34 PM
THIS!
I always click the button to "share" for this exact reason! Your data is so much bigger than you! Be selfless!
youtu.be/MOu8sYPV_EY?...
I always click the button to "share" for this exact reason! Your data is so much bigger than you! Be selfless!
youtu.be/MOu8sYPV_EY?...
Dear Bluesky Career Network,
Should I draft an email using CoPilot explaining to a coworker how excessive use of CoPilot makes emails feel disingenuous?
Best regards,
Me
P.S. "Best regards" is a clear sign that CoPilot wrote the email.
Should I draft an email using CoPilot explaining to a coworker how excessive use of CoPilot makes emails feel disingenuous?
Best regards,
Me
P.S. "Best regards" is a clear sign that CoPilot wrote the email.
October 15, 2025 at 4:45 AM
Dear Bluesky Career Network,
Should I draft an email using CoPilot explaining to a coworker how excessive use of CoPilot makes emails feel disingenuous?
Best regards,
Me
P.S. "Best regards" is a clear sign that CoPilot wrote the email.
Should I draft an email using CoPilot explaining to a coworker how excessive use of CoPilot makes emails feel disingenuous?
Best regards,
Me
P.S. "Best regards" is a clear sign that CoPilot wrote the email.
I am continually impressed by these studies and findings! They keep developing and growing, it's getting difficult to keep up!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Rapid epigenomic classification of acute leukemia - Nature Genetics
The authors present a molecular classification of acute leukemia using 5-methylcytosine signatures, together with a neural network-based classifier for clinical use.
www.nature.com
September 29, 2025 at 3:36 PM
I am continually impressed by these studies and findings! They keep developing and growing, it's getting difficult to keep up!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Steven Gruber
In the early years of my PhD I remember being asked if we'd ever treat or cure diseases like HIV or Huntington's. I remember saying maybe, but not knowing if I believed. Seeing research pay off as real impact on human lives is - incredible.
www.bbc.com/news/article...
www.bbc.com/news/article...
www.bbc.com/news/article...
www.bbc.com/news/article...
Huntington's disease successfully treated for first time
One of the most devastating diseases finally has a treatment that can slow its progression and transform lives, tearful doctors tell BBC.
www.bbc.com
September 24, 2025 at 12:41 PM
In the early years of my PhD I remember being asked if we'd ever treat or cure diseases like HIV or Huntington's. I remember saying maybe, but not knowing if I believed. Seeing research pay off as real impact on human lives is - incredible.
www.bbc.com/news/article...
www.bbc.com/news/article...
www.bbc.com/news/article...
www.bbc.com/news/article...
Reposted by Steven Gruber
Epigenetics goes applied - The Methylation Screening Array
www.cell.com/cell-genomic...
www.cell.com/cell-genomic...
Scalable screening of ternary-code DNA methylation dynamics associated with human traits
Goldberg et al. develop the methylation screening array for profiling large human
populations for trait associations. They generate and analyze a 5mC-5hmC methylation
atlas across human tissue, reveal...
www.cell.com
July 18, 2025 at 8:04 PM
Epigenetics goes applied - The Methylation Screening Array
www.cell.com/cell-genomic...
www.cell.com/cell-genomic...
Bravo!! Need more states to follow in these footprints!
news.fsu.edu/news/health-...
news.fsu.edu/news/health-...
Florida surges to forefront of rare disease research with boost from Sunshine Genetics Act
news.fsu.edu
July 15, 2025 at 4:49 PM
Bravo!! Need more states to follow in these footprints!
news.fsu.edu/news/health-...
news.fsu.edu/news/health-...
Reposted by Steven Gruber
The FY26 budget will devastate our innovation driven economy. A summary in 3 parts...
Part 1 - The White House vision for dismantling science, as described in one simple plot, means slashing budgets of NIH, NASA, NSF & going back 25 years (or more).
joshuasweitz.substack.com/p/the-white-...
Part 1 - The White House vision for dismantling science, as described in one simple plot, means slashing budgets of NIH, NASA, NSF & going back 25 years (or more).
joshuasweitz.substack.com/p/the-white-...
June 30, 2025 at 1:46 PM
The FY26 budget will devastate our innovation driven economy. A summary in 3 parts...
Part 1 - The White House vision for dismantling science, as described in one simple plot, means slashing budgets of NIH, NASA, NSF & going back 25 years (or more).
joshuasweitz.substack.com/p/the-white-...
Part 1 - The White House vision for dismantling science, as described in one simple plot, means slashing budgets of NIH, NASA, NSF & going back 25 years (or more).
joshuasweitz.substack.com/p/the-white-...
Reposted by Steven Gruber
Summary Table of the massive defunding of biomedical research in the United States
www.nytimes.com/interactive/...
www.nytimes.com/interactive/...
July 6, 2025 at 3:13 PM
Summary Table of the massive defunding of biomedical research in the United States
www.nytimes.com/interactive/...
www.nytimes.com/interactive/...
So sad and disappointing. I just can't imagine having a productive science conversation with RFK Jr. The quotes in the article are face-melting. 😱🤦♂️
This is a travesty & a nightmare. The US was a founder of @gavi.org. It lowers global vaccine costs, has vaccinated 1B children, & averted 19M deaths. This pull out will cost 100s of thousands of children's lives a year - and RFK Jr will be personally responsible.
www.politico.com/news/2025/06...
www.politico.com/news/2025/06...
RFK Jr. says US won’t donate to global vaccine effort
Kennedy ripped into Gavi, the Vaccine Alliance, in a video address at its pledging summit.
www.politico.com
June 25, 2025 at 7:52 PM
So sad and disappointing. I just can't imagine having a productive science conversation with RFK Jr. The quotes in the article are face-melting. 😱🤦♂️
Reposted by Steven Gruber
Unlock the power of the epigenome with the latest Infinium technology
Submit your epigenetics research proposal (only 400 words!) by Aug 24th for a chance to win 1008 samples of the Infinium Methylation Screening Array-48 Kit more than $100,000 🔬
www.illumina.com/techniques/m...
Submit your epigenetics research proposal (only 400 words!) by Aug 24th for a chance to win 1008 samples of the Infinium Methylation Screening Array-48 Kit more than $100,000 🔬
www.illumina.com/techniques/m...
June 25, 2025 at 6:34 PM
Unlock the power of the epigenome with the latest Infinium technology
Submit your epigenetics research proposal (only 400 words!) by Aug 24th for a chance to win 1008 samples of the Infinium Methylation Screening Array-48 Kit more than $100,000 🔬
www.illumina.com/techniques/m...
Submit your epigenetics research proposal (only 400 words!) by Aug 24th for a chance to win 1008 samples of the Infinium Methylation Screening Array-48 Kit more than $100,000 🔬
www.illumina.com/techniques/m...
Very neat paper, comparing reference "healthy" Methylation atlas with that of liver-transplant patients!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Circulating cell-free DNA methylation patterns indicate cellular sources of allograft injury after liver transplant - Nature Communications
Current approaches to detect allograft damages non-invasively are limited and do not differentiate between cellular mechanisms. Here, the authors show that the composition of cell-free DNA in blood sa...
www.nature.com
June 20, 2025 at 4:35 PM
Very neat paper, comparing reference "healthy" Methylation atlas with that of liver-transplant patients!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
@katiecouric.bsky.social 🤝 @erictopol.bsky.social
This was such a refreshing discussion filled with a healthy dose of "we don't know" statements. Can't wait to pick up the Superagers book! My favorite part of the conversation: 👇
podcasts.apple.com/us/podcast/g...
This was such a refreshing discussion filled with a healthy dose of "we don't know" statements. Can't wait to pick up the Superagers book! My favorite part of the conversation: 👇
podcasts.apple.com/us/podcast/g...
Katie Couric and Eric Topol: On the State of US Life Science and Extending Healthspan
Podcast Episode · Ground Truths · 06/12/2025 · 55m
podcasts.apple.com
June 13, 2025 at 2:44 PM
@katiecouric.bsky.social 🤝 @erictopol.bsky.social
This was such a refreshing discussion filled with a healthy dose of "we don't know" statements. Can't wait to pick up the Superagers book! My favorite part of the conversation: 👇
podcasts.apple.com/us/podcast/g...
This was such a refreshing discussion filled with a healthy dose of "we don't know" statements. Can't wait to pick up the Superagers book! My favorite part of the conversation: 👇
podcasts.apple.com/us/podcast/g...