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Sudipta Mondal

@sudipta-cryoet.bsky.social

82 followers 290 following 4 posts

In situ structural biology enthusiast | chasing molecular machines in their native habitat #cryoET Postdoc @ParkLab Scripps

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Reposted by Sudipta Mondal

Oli Clarke @olibclarke.bsky.social · 26d

This one is a bit of a departure from the usual and definitely a work in progress!

We found that by using ab initio reconstruction at very high res, in very small steps, we could crack some small structures that had eluded us - e.g. 39kDa iPKAc (EMPIAR-10252), below.

Read on for details... 1/x

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Sudipta Mondal @sudipta-cryoet.bsky.social · Jul 8

This composition is a tribute to the legendary Bill Jacobs, who isolated the Bxb1 phage-aka the 'Bronx Bomber'-from the dirt in his backyard in the Bronx, NY. 🦠🏠🗽
A true classic in #phage lore! #tuberculosis

Sudipta Mondal @sudipta-cryoet.bsky.social · Jul 8

#NotTheCover @cellpress.bsky.social ...but, we’re still pretty proud of it! 😄 Had an awesome time putting this together with the amazing @kfreeman.bsky.social and @raphaelpark.bsky.social What a ride! 🚀
#SciArt #CryoET #CryoEM

Paper👉 www.cell.com/cell/fulltex...

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Reposted by Sudipta Mondal

RCSB Protein Data Bank @rcsbpdb.bsky.social · May 18

The very first structural images of a tuberculosis-fighting virus
New insights could advance phage therapies for the world’s deadliest bacteria—including drug-resistant strains.
www.scripps.edu/news...

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Reposted by Sudipta Mondal

Di Jiang @dijiang319.bsky.social · May 15

@science.org 🧫🧬❄️🔬 Molecular basis of influenza ribonucleoprotein complex assembly and processive RNA synthesis | Science www.science.org/doi/10.1126/...
@yiweichang.bsky.social www.yiweichanglab.org @jiwasa.bsky.social #virology #Influenza #Cryo-EM #StructuralBiology #RNA #polymerase

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Reposted by Sudipta Mondal

Scripps Research @scripps.edu · Apr 23

Scripps Research and @pittofficial.bsky.social capture the first cryo-EM & cryo-ET images of a virus infecting TB-causing Mycobacteria, revealing an unexpected infection mechanism that could inform phage therapies for drug-resistant TB, per @cellpress.bsky.social.

The very first structural images of a tuberculosis-fighting virus

www.scripps.edu

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Reposted by Sudipta Mondal

Ben Engel @cellarchlab.com · Apr 18

Some eye-catching #TeamTomo work here. Congrats to @kfreeman.bsky.social and all the authors! 🧪🧶🧬🔬

ᐯIᑕTOᖇ ᑎIᘔET, ᗰᗪ @nizet.bsky.social · Apr 18

Krista Freeman et al 𝘊𝘌𝘓𝘓

stunning atomic-level imaging (Cryo-EM, cryo-ET) reveals how 𝐛𝐚𝐜𝐭𝐞𝐫𝐢𝐨𝐩𝐡𝐚𝐠𝐞 Bxb1 reshapes its tail tip to breach the mycobacterial cell wall and deliver DNA to the cytoplasm

can inform precise targeted phage therapies for TB and NTM infections

www.cell.com/cell/fulltex...

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Sudipta Mondal @sudipta-cryoet.bsky.social · Apr 17

Host invasion by a mycobacteriophage—visualized in action! 🦠✨
Thrilled to have contributed to this exciting work! Great collaboration with the amazing Krista @kfreeman.bsky.social & Graham Hatfull lab. Huge thanks to the Park lab for this fantastic opportunity 🙌 #CryoEM #CryoET #phage #mycobacteria

Krista Freeman @kfreeman.bsky.social · Apr 16

Hurray, it is finally out! Meet bacteriophage Bxb1 - the subject of my first full-phage cryo-EM study. My structures are beautifully complemented by the Park Lab’s cryo-ET analysis, shedding light on mycobacteriophage structural changes during infection.

www.sciencedirect.com/science/arti...

Structure and infection dynamics of mycobacteriophage Bxb1

Mycobacteriophage Bxb1 is a well-characterized virus of Mycobacterium smegmatis with double-stranded DNA and a long, flexible tail. Mycobacteriophages…

www.sciencedirect.com

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Sudipta Mondal @sudipta-cryoet.bsky.social · Apr 11

Had an amazing week at the Gordon Research Conference on Biology of Mycobacteria! Great chats, exciting posters and the chance to meet both legends in the field and awesome new peers…
#mycobacteria