Certainly not to all patients, but probably just to those with significant cardiovascular risk factors, I would say. If you need to give Lasix and it dips your K to low-normal then add spiro early #NephJC

Even the NEJM editorial comment on RALES argued that spiro reduced sudden cardiac death by arrhythmia by blocking urinary K loss (MRA), this being a superior way to maintain total body stores of an intracellular ion than replacing losses. #NephJC

Keep in mind that there is the argument that blocking urinary K loss (MRA) is a superior way to maintain total body stores of an intracellular ion than replacing losses. Extracellular serum K levels reflect total body stores poorly.

Agreed reduction of sudden cardiac death from spiro use in HF argues for prevention of ventricular arrhythmia

Toshi Akima from Sydney AU. No conflicts of interest. Have been targeting higher K for years, though more >4 than 4.5. #NephJC

Gun control, like infectious disease control, is a matter of public health, and the US is leading the way to its replacement with thoughts and prayers.

Gun control, like infectious disease control, is a matter of public health, and the US is leading the way to its replacement with thoughts and prayers.

particularly in high risk groups to guide personalized therapeutic interventions for mitigating the long term consequences of #COVID or #LongCovid sequelas .

www.sciencedirect.com/science/arti...

Beautiful study coordinated by @resiapretorius.bsky.social
Open Access here:
www.nature.com/articles/s41...

www.parliament.nsw.gov.au/committees/P...