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Tim Julian @trj2.bsky.social · Mar 6

According to this paper, 8+ hours is adequate: "severe inadequate ...4.7 to 4.1 hours per night... moderate inadequate... (6.0 to 5.5 hours per night... , mild inadequate... 7.2 to 6.8 hours per night... and adequate... 8.4 to 8.0 hours per night."

Eric Topol @erictopol.bsky.social · Mar 5

Sleep duration/timing and glucose regulation in over 1,100 people with 14-day continuous glucose sensor tracking
jamanetwork.com/journals/jam...

Tim Julian @trj2.bsky.social · Feb 27

Check out the website here: genspectrum.org/swiss-wastew.... And follow our work tracking virus loads in #RSV here: wise.ethz.ch. We're still in the middle of an #RSV wave now, but it looks like the peak may be behind us.

Swiss wastewater - RSV

GenSpectrum is an interactive dashboard to query and analyze pathogen sequences, currently available for Influenza H5N1, RSV, SARS-CoV-2 and the West Nile virus.

genspectrum.org

Tim Julian @trj2.bsky.social · Feb 27

So now back to our work sequencing #RSV, available from #Genspectrum website: We can track genomic changes in virus regions targeted by #Nirsevimab and the vaccines, to detect, within the population, whether or not the virus mutates in ways that may confer resistance to our available treatments.

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Tim Julian @trj2.bsky.social · Feb 27

But the good news is, in #Switzerland, we have monoclonal antibody Nirsevimab for infants to reduce risks of severe disease, or as a prophylaxis to prevent infections in at-risk infants. We also have two vaccines against #RSV approved for the elderly: www.bag.admin.ch/bag/en/home/...

Respiratory syncytial virus (RSV)

RS viruses cause colds and bronchiolitis during the winter half-year. They often lead to hospitalisation. Now there are possibilities for prevention, including the antibody Nirsevimab for newborns and...

www.bag.admin.ch

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Tim Julian @trj2.bsky.social · Feb 27

«Wir haben momentan keine Reserve mehr an freien Betten mit pflegerischer Betreuung.» Christoph Berger said at the time, as reported in @20min.ch www.20min.ch/story/wegen-...

RSV: Wegen diesem Virus sind die Kinderspitäler überfüllt

Wegen des sogenannten Respiratorischen Synzytial-Virus (RSV) müssen immer mehr Kleinkinder und Säuglinge in der Schweiz im Spital behandelt werden.

www.20min.ch

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Tim Julian @trj2.bsky.social · Feb 27

Another number that's important is #hospitalizations. #CDC estimates 130-260k hospitalizations in the #US. These are infections severe enough to require a hospital bed, which means that bed is not available for other illnesses. In 2022-23, #Switzerland, a huge RSV wave impacted hospitals...

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Tim Julian @trj2.bsky.social · Feb 27

#RSV is a common #respiratory virus. We've probably all had it at some point in our life. For most of us, its a nuisance* But for some people, including #children and the elderly, its deadly. #CDC reports an estimated 7k-16k deaths due to RSV this season alone. www.cdc.gov/rsv/php/surv...

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Tim Julian @trj2.bsky.social · Feb 27

We are tracking mutations of #RSV in #wastewater: genspectrum.org/swiss-wastew.... Why this matters and why you should re-tweet for visibility (a 🧵).

Swiss wastewater - RSV

GenSpectrum is an interactive dashboard to query and analyze pathogen sequences, currently available for Influenza H5N1, RSV, SARS-CoV-2 and the West Nile virus.

genspectrum.org

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Tim Julian @trj2.bsky.social · Feb 17

The highest incidence rates of upper #Respiratory diseases is in children under 2 years old, again from The Lancet. www.thelancet.com/journals/lan...

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Tim Julian @trj2.bsky.social · Feb 17

As #Respiratory #Disease peaks in #Switzerland, a few notes. More than 12.8 billion upper respiratory infections are estimated globally every year, that's >1 per person per year! See www.thelancet.com/journals/lan...

Global, regional, and national burden of upper respiratory infections and otitis media, 1990–2021: a systematic analysis from the Global Burden of Disease Study 2021

The findings of this study highlight the widespread burden posed by URIs and otitis media across all age groups and both sexes. There is a continued need for surveillance, prevention, and management t...

www.thelancet.com

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Tim Julian @trj2.bsky.social · Feb 17

#Wastewater in #Switzerland showing high levels of circulating #RSV, #InfluenzaA, and #InfluenzaB. A lot going around at the moment. See our dashboard at wise.ethz.ch, or the FOPH Infectious Disease Dashboard for integrated surveillance at idd.bag.admin.ch

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Reposted by Tim Julian

Amy Pickering @seqh2o.bsky.social · Feb 9

Postdoctoral scholar Dr. Kendra Dahmer discusses how the new administration's policies could affect her global health research apnews.com/article/trum...

Trump's DEI order leaves academic researchers fearful of political influence over grants

President Donald Trump’s order declaring diversity, equity and inclusion policies illegal has thrown into doubt the future of research Kendra Dahmer has been doing on intestinal parasites in India and...

apnews.com

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Tim Julian @trj2.bsky.social · Feb 4

"New infections in children were associated with preceding household detection of the same pathogen in soil (Odds ratio: 8.8, 95% confidence interval: 3.3, 23) and on child hands (Odds ratio: 5.0, 95% confidence interval 1.1, 17)."

Amy Pickering @seqh2o.bsky.social · Feb 3

New pre-print on infant first infections with enteric pathogens! 85% of pathogens detected in infants are also in animals living nearby, using longitudinal sampling we find child hand contact with soil contaminated with animal feces is a primary transmission pathway! www.medrxiv.org/content/10.1...

Zoonotic and environmental sources of infant enteric pathogen infections identified with longitudinal sampling

Enteric pathogen infections in young children can result in diarrhea, malnutrition, and developmental impairments. Many enteric pathogens that infect young children can be zoonotic, yet the exposure r...

www.medrxiv.org

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Tim Julian @trj2.bsky.social · Jan 31

📯 #Swiss wastewater dashboard through our #wise project is now updated with historic data within which you can overlay the seasons. #Influenza B is now high, after skipping a year. Check it out here: wise.ethz.ch

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Tim Julian @trj2.bsky.social · Jan 31

#Wastewater-based monitoring for #PublicHealth holds a lot of promise, but an outstanding challenge is to understand what public health relevant metrics can be derived, and how we translate data into impact. See our Viewpoint on #AMR #AntimicrobialResistance in #EST 👇

Uli Klümper @ulikluemper.bsky.social · Jan 29

Our new Viewpoint article led by Sheena Conforti & Amy Pruden originating from the #EDAR7 conference is now out in Environmental Science & Technology (@acs.org)

"Strengthening Policy Relevance of Wastewater-Based Surveillance for Antimicrobial Resistance"

pubs.acs.org/doi/10.1021/...
#AMR

Integration of data across One Health sectors to inform AMR policy and the potential role of WBS. Clinical settings, environmental studies, and agricultural surveillance can provide indicators used for antimicrobial stewardship and antimicrobial resistance (AMR) management. Indicators include prevalence of AMR and prescription patterns in clinical settings, geographic distribution and emerging threats in the environment to identify horizontal gene transfer (HGT) hot spots, and antibiotic/biocide residues and zoonotic pathways in agriculture. Wastewater-based surveillance (WBS) programs can be designed to integrate within and across all sectors.

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Tim Julian @trj2.bsky.social · Jan 31

If you're measuring #Legionella in a water system using qPCR, how do you relate your value to culture? We suggest a conservative 1:1 assumption! Unless you know more about your system, this seems accurate based on a systematic review. Led by Emile Sylvestre: journals.plos.org/water/articl...

Quantification of Legionella pneumophila in building potable water systems: A meta-analysis comparing qPCR and culture-based detection methods

Quantitative polymerase chain reaction (qPCR) offers a rapid, automated, and potentially on-site method for quantifying L. pneumophila in building potable water systems, complementing and potentially ...

journals.plos.org

Tim Julian @trj2.bsky.social · Jan 17

The mutation impacts the digital PCR efficiency, resulting in an underestimate of the concentration (for N1). As a consequence, we now monitor the ratio as part of our weekly QA/QC. We observe some fluctuation from week to week, but the ratio has returned back to 1.

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Tim Julian @trj2.bsky.social · Jan 17

We observed a decoupling in the ratio consistent with a mutation in the forward primer region, which increased and then decreased throughout 2023: cov-spectrum.org/explore/Swit...

covSPECTRUM

covSPECTRUM is an interactive platform aiming to help scientists investigate and identify variants of SARS-CoV-2.

cov-spectrum.org

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Tim Julian @trj2.bsky.social · Jan 17

Yes, we have data from mid-2022; we're working on updating our database to include older data, it should be up in a week or two.

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Tim Julian @trj2.bsky.social · Jan 13

From the #Swiss #Wastewater, signs of #SARS-CoV-2 receding, while both #influenza A and B continue an upward rise. #RSV looks to be staying stable, could be evidence that it has peaked. From: wise.ethz.ch

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Tim Julian @trj2.bsky.social · Jan 9

Everything is everywhere all at once: #Influenza A, Influenza B, and #RSV are all increasing in #Zurich wastewater, while #SARS-CoV-2 still circulates. From wise.ethz.ch.

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Reposted by Tim Julian

Vera Vollenweider @veraeva.bsky.social · Jan 9

Thanks for the digest, @elife.bsky.social 💥
How to combat pathogenic bacteria through iron starvation:
Read more ⬇️
#AMR #Siderophore

eLife @elife.bsky.social · Jan 3

Researchers are hoping to fight antibiotic-resistant bacteria by harnessing other microbes that are experts at stealing iron.
https://buff.ly/4grpj97

Starving microbes of iron

Pyoverdines, iron-trapping molecules found in certain microbes, can help in the fight against antibiotic-resistant bacteria that can cause incurable infections.

buff.ly

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Reposted by Tim Julian

Kai Kupferschmidt @kakape.bsky.social · Dec 14

Sadly, it’s a good time to once again share this amazing infographic that we ran at @science.org more than 7 years ago
🧪 #IDsky
www.science.org/content/arti...

Here's the visual proof of why vaccines do more good than harm

See year by year how vaccines beat back nine dangerous infectious diseases

www.science.org

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Tim Julian @trj2.bsky.social · Dec 23

we've been working on multiplex #dPCR assays the last few years, and here are a few things we've figured out along the way. Lead by Jolinda de Korne-Elenbaas: academic.oup.com/lambio/advan...

Design, validation and implementation of multiplex digital PCR assays for simultaneous quantification of multiple targets

Abstract. Quantitative PCR (qPCR) and digital PCR (dPCR) are applied for quantifying molecular targets in disease diagnostics, pathogen detection and ecolo

academic.oup.com

Tim Julian @trj2.bsky.social · Dec 22

interesting article about making teaching about climate change personal to students at @cornelluniversity.bsky.social, from @npr.org. www.npr.org/2024/12/22/n...

College students get emotional about climate change. Some are finding help in class

A recent survey finds that more than half of young people aged 16-25 are highly worried about climate change. Some universities are now trying to help them navigate those emotions in class.

www.npr.org