tschwammle.bsky.social
Till Schwämmle
@tschwammle.bsky.social
89 followers 180 following 1 posts
Postdoc Krebs Lab @EMBL Heidelberg Joint with Kundaje Lab @Stanford Previously PhD Schulz Lab @MPI-MG
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Reposted by Till Schwämmle
molgen.mpg.de
Max Planck Institute for Molecular Genetics @molgen.mpg.de · 11h
Using a CRISPR screening approach, first author @tschwammle.bsky.social identified new regulators of Xist, and discovered a two-step process that controls and regulates this important gene behind X-inactivation
Read more: www.molgen.mpg.de/2025-10-06-s...
Publication: doi.org/10.1038/s415...
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A switch and a dial
A study by the Schulz lab describes a novel regulatory principle involved in X-chromosome inactivation during development
www.molgen.mpg.de
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tschwammle.bsky.social
Till Schwämmle @tschwammle.bsky.social · 2d
Happy to share the 2nd part of my PhD @natsmb.nature.com!

Using CRISPR screens, we uncover the TF-RE wiring underlying Xist regulation. Since the preprint, we've added a titration of Xist, showing that XCI is directly dependent on Xist levels.

Check the Bluetorial by @eddaschulz.bsky.social 👇
eddaschulz.bsky.social
Edda Schulz @eddaschulz.bsky.social · 2d
⚠️ Paper alert: Using a novel CRISPR screening approach, we mapped the entire regulatory network controlling Xist—key for X-chromosome inactivation.
👉 We discover how sex and development signals are decoded at a single gene locus.
www.nature.com/articles/s41...
👇 Bluetorial
Reporter CRISPR screens decipher cis-regulatory and trans-regulatory principles at the Xist locus - Nature Structural & Molecular Biology
Here Schwämmle et al. develop CRISPR reporter screens to map transcription-factor-regulatory element interactions at the Xist locus, revealing a two-step mechanism integrating developmental and X-dosage signals to initiate X-chromosome inactivation.
www.nature.com
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Reposted by Till Schwämmle
natsmb.nature.com
Nature Structural & Molecular Biology @natsmb.nature.com · 2d
New online: Reporter CRISPR screens decipher cis-regulatory and trans-regulatory principles at the Xist locus
Reporter CRISPR screens decipher cis-regulatory and trans-regulatory principles at the Xist locus
Nature Structural & Molecular Biology, Published online: 06 October 2025; doi:10.1038/s41594-025-01686-3Here Schwämmle et al. develop CRISPR reporter screens to map transcription-factor-regulatory element interactions at the Xist locus, revealing a two-step mechanism integrating developmental and X-dosage signals to initiate X-chromosome inactivation.
go.nature.com
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Reposted by Till Schwämmle
anshulkundaje.bsky.social
Anshul Kundaje @anshulkundaje.bsky.social · Aug 19
@jengreitz.bsky.social l & my lab want to co-hire a computational biologist/biostatistician with project management expertise to help map the regulatory code of the human genome and discover genetic mechanisms of disease.

Details below
careersearch.stanford.edu/jobs/computa...

Plz RT
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Reposted by Till Schwämmle
arnaudkr.bsky.social
Arnaud Krebs @arnaudkr.bsky.social · Aug 18
This is not a HiC map! Ever wondered if multiple enhancers get activated simultaneously? We measured chromatin accessibility on thousands of molecules by nanopore to create genome-wide co-accessibility maps. Proud of @mathias-boulanger.bsky.social @kasitc.bsky.social Biology in the thread👇
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Reposted by Till Schwämmle
tommytang.bsky.social
Ming Tommy Tang @tommytang.bsky.social · May 31
CRISPR screen decodes SWI/SNF chromatin remodeling complex assembly www.nature.com/articles/s4...
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Reposted by Till Schwämmle
konrad-chudzik.bsky.social
Konrad Chudzik @konrad-chudzik.bsky.social · Apr 14
🚨 Preprint alert 🚨
Excited to share our work on "Ab-trapping," an antibody artifact causing misleading peripheral ("rim") staining in imaging & genomics (IF, CUT&Tag, CUT&RUN). Antibodies fail to penetrate structures, accumulating at the periphery. A 🧵👇
doi.org/10.1101/2025...
Ab-trapping - a peripheral staining artifact in antibody-based microscopy and genomics
Antibodies (Ab) are essential for detecting specific epitopes in microscopy and genomics, but can produce artifacts leading to erroneous interpretations. Here, we characterize a novel artifact, Ab-tra...
doi.org
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Reposted by Till Schwämmle
valentinabaderna.bsky.social
Valentina Baderna @valentinabaderna.bsky.social · Apr 8
Happy to share the latest story from @arnaudkr.bsky.social's lab @embl.org! With @guidobarzaghi.bsky.social, we used Single Molecule Footprinting to quantify how often chromatin is accessible at enhancers after TF and chromatin environment changes! Check our preprint bit.ly/3XQMFxN + thread ⬇️ 1/11
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Reposted by Till Schwämmle
arnaudkr.bsky.social
Arnaud Krebs @arnaudkr.bsky.social · Apr 2
The importance of moving away from bulk! Occupancy of Pol II at promoters is dramatically different between fly and mouse cells! When looking single molecule! Proud of the team! @kasitc.bsky.social @molinalab.bsky.social doi.org/10.1038/s443...
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Reposted by Till Schwämmle
julianeg.bsky.social
Juliane Glaser @julianeg.bsky.social · Jan 16
It’s official 🎉 I am excited to share that I will start my lab this spring at the Max Planck Institute for Immunobiology and Epigenetics @mpi-ie.bsky.social in beautiful Freiburg 🤩🗻☀️ I am looking forward to new collaborations and working with the fantastic community in Freiburg & its surroundings!
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Reposted by Till Schwämmle
events.embl.org
EMBL Events @events.embl.org · Dec 19
A throwback to last month's 'Quantitative biology to molecular mechanisms' conference – time to introduce the poster prize winners! #EMBLOmics

A round of applause for:
🏅 Max Trauernicht
🏅 @ingridpelaez.bsky.social
🏅 Honorine Destain
🏅 Óscar García Blay

Read on 👉🏻 s.embl.org/omx24-01-blog

@embl.org
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Reposted by Till Schwämmle
ingridpelaez.bsky.social
Ingrid Pelaez Conde @ingridpelaez.bsky.social · Nov 27
I attended the ‘Quantitative Biology to Molecular Mechanisms’ conference at EMBL Heidelberg last week and had the incredible honor of winning one of the Poster Prizes! 🏆

A big thanks to the organizers and all the amazing speakers who shared their inspiring research with us. ✨
#EMBLOmics
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