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Maximilian Friedrich, vertigologist

@vertigologist.bsky.social

780 followers 270 following 41 posts

Neurologist and Neuroscientist studying movement, balance and perception through the lens of computer vision, connectomic neuroimaging, neuromodulation. @University Hospital Ulm by way of @braincircuits.bsky.social

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Maximilian Friedrich, vertigologist @vertigologist.bsky.social · Nov 18

Have you ever felt like you're in a surreal world where sizes and scales are all warped? No, it's not a fantasy—it's a real medical condition! Come dive with me into this mind-bending phenomenon called Alice in Wonderland Syndrome (AIWS):
onlinelibrary.wiley.com/doi/abs/10.1...

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Reposted by Maximilian Friedrich, vertigologist

Hadas Weiss @hadas.bsky.social · May 24

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Reposted by Maximilian Friedrich, vertigologist

Frederic Schaper @fredschaper.bsky.social · Mar 24

Is generalized epilepsy a seizure of the whole brain or a specific brain network?

In our new paper out now in @naturecomms.bsky.social, we investigate this by combining brain abnormalities and DBS with the human connectome.

Paper: nature.com/articles/s41...

A 🧵 below:

A generalized epilepsy network derived from brain abnormalities and deep brain stimulation - Nature Communications

Ji et al. identify an idiopathic generalised epilepsy network that links heterogeneously distributed brain abnormalities to a common brain network and deep brain stimulation sites which reduce general...

nature.com

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Maximilian Friedrich, vertigologist @vertigologist.bsky.social · Mar 24

Best of luck- we’re cheering for ya!

Reposted by Maximilian Friedrich, vertigologist

Michael Okun @michaelokun.bsky.social · Mar 7

About 12,000 people globally have signed up and the United States and Canada are lagging behind. It is mostly video content and enjoyable. The course closes for feedback analysis and development at the end of March so I challenge you to jump on board.
mooc.utas.edu.au/course/20278...

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Maximilian Friedrich, vertigologist @vertigologist.bsky.social · Feb 21

Neurologists use videos to augment the clinical examination, and new AI methods promise to transform these videos into granular biomarkers. Here, we review the fascinating past, present and future of AI-powered video analyses in clinical neurology. Enjoy!

jamanetwork.com/journals/jam...

Computer Vision in Clinical Neurology and AI Augmentation of the Neurological Examination

This narrative review outlines recent advances and challenges in technologies arising from computer vision, a branch of artificial intelligence (AI), which has the potential to improve clinical neurol...

jamanetwork.com

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Maximilian Friedrich, vertigologist @vertigologist.bsky.social · Feb 17

Pretty sure I don‘t have to introduce Andy, so to make it very short: interested in DBS and brain networks? Check out this super exciting new institute in Cologne!

Andreas Horn @andreashorn.org · Feb 17

I am excited to announce that I will be founding an institute for network stimulation at the University Hospital Cologne – already this coming May!

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Reposted by Maximilian Friedrich, vertigologist

Andrew Pines @andrewpines.bsky.social · Feb 12

What brain regions are involved in causing psychotic symptoms?

Take a moment away from the existential dread about the future of science, and join me in this summary of some incredibly cool stuff that could help patients!
1/n🧵

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Reposted by Maximilian Friedrich, vertigologist

Andreas Horn @andreashorn.org · Feb 12

Do lesions that cause psychosis fall into a common brain network?

Exciting new work by @andrewpines.bsky.social, @shansiddiqi.bsky.social and colleagues – tweetorial below by the first author, paper here:
jamanetwork.com/journals/jam...

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Reposted by Maximilian Friedrich, vertigologist

Center for Brain Circuit Therapeutics @braincircuits.bsky.social · Feb 12

New Center paper out at JAMA psychiatry: jamanetwork.com/journals/jam...

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Reposted by Maximilian Friedrich, vertigologist

Michael Fox @foxmdphd.bsky.social · Jan 10

Awesome thread by @andreashorn.org on his recent paper on STN DBS for dystonia. Details a great collaboration and his thought process as the study evolved. @braincircuits.bsky.social

Andreas Horn @andreashorn.org · Jan 8

🚨Interested in Dystonia?🚨
@braincircuits.bsky.social

GPi DBS for dystonia is effective.

More recently, STN DBS has been investigated, as an alternative.

In what enfolded like a stunning thriller to me, Konstantin Butenko tells a tale of two networks…

www.pnas.org/doi/10.1073/...

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Maximilian Friedrich, vertigologist @vertigologist.bsky.social · Jan 10

Great thread and interesting work which further supports the idea that axial dystonic symptoms map closer to cerebellar networks. Nicely aligns with old (and some new) lesion and experimental midbrain stim studies

Maximilian Friedrich, vertigologist @vertigologist.bsky.social · Jan 2

What an impressive list of achievements! Congrats Doug!

Reposted by Maximilian Friedrich, vertigologist

Michael Fox @foxmdphd.bsky.social · Dec 24

Cool to see our work from @braincircuits.bsky.social featured in @sciam.bsky.social today. Great read on an interesting and bizarre neurological condition.
www.scientificamerican.com/article/how-...

How Rare ‘Alice in Wonderland Syndrome’ Warps Reality

Researchers are learning what causes Alice in Wonderland syndrome, a rare neurological condition that can appear to warp bodies, time and reality itself

www.scientificamerican.com

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Maximilian Friedrich, vertigologist @vertigologist.bsky.social · Dec 24

Wonderful christmas read featuring our network mapping work on Alice in Wonderland syndrome- a bizarre and fascinating perceptual disorder. Kudos @sciam.bsky.social @foxmdphd.bsky.social @braincircuits.bsky.social
www.scientificamerican.com/article/how-...

How Rare ‘Alice in Wonderland Syndrome’ Warps Reality

Researchers are learning what causes Alice in Wonderland syndrome, a rare neurological condition that can appear to warp bodies, time and reality itself

www.scientificamerican.com

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Reposted by Maximilian Friedrich, vertigologist

bioRxiv Neuroscience @biorxiv-neursci.bsky.social · Dec 22

Spanning spatial scales with functional imaging in the human brain; initial experiences at 10.5 Tesla https://www.biorxiv.org/content/10.1101/2024.12.20.629800v1

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Maximilian Friedrich, vertigologist @vertigologist.bsky.social · Dec 20

I have one of these and can confirm they induce a cathartic experience. Great for grants and life!

Maximilian Friedrich, vertigologist @vertigologist.bsky.social · Dec 15

Great take. It‘s sometimes bewildering to me just how advanced imaging pipelines are, while at the same time, behavioral assessments are very rudimentary and crude.

Reposted by Maximilian Friedrich, vertigologist

Emily Moin @emilymoin.com · Dec 11

I think a fun teaching exercise for medical students would be to each take a common clinical pearl and trace the citations until you find the primary data it's based on.

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Reposted by Maximilian Friedrich, vertigologist

Andreas Horn @andreashorn.org · Dec 5

Showed a glimpse of a new atlas that we're building in Paris yesterday. Pretty excited about it and implications for network modeling.

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Maximilian Friedrich, vertigologist @vertigologist.bsky.social · Dec 5

It‘s a wrap! Do you have a video database you‘d like to analyze? Feel free to reach out, or DIY as our code is #opensource. Enjoy the read!

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Maximilian Friedrich, vertigologist @vertigologist.bsky.social · Dec 5

This machine learning framework uncovers latent, but relevant pathosignatures of dystonia. We envision its integration into the modern canon of neuromodulation, neurotechnology and neuroimaging (did I hear dysfunctome?), powering translational & precision Neurology

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Maximilian Friedrich, vertigologist @vertigologist.bsky.social · Dec 5

Finally, data driven analyses of head/neck movements converge on an almost identical feature set across different types of dystonia, supporting the idea that dystonia subtype and severity map onto a "kinematic continuum"

Maximilian Friedrich, vertigologist @vertigologist.bsky.social · Dec 5

We also find that phasic (tremulous) and tonic (fixed deviations) dystonia components may map to different circuits. Movement disorders aficionados had this gut feeling for quite a while

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Maximilian Friedrich, vertigologist @vertigologist.bsky.social · Dec 5

We identified a set of clinically-inspired features from full video assessments that provide additional insights into disease severity, subtype & brain stim effects. We found: tremor matters! (but hasn't even been quantified in scores for a long time...)

Maximilian Friedrich, vertigologist @vertigologist.bsky.social · Dec 5

We develop a visual computer vision framework which extracts a rich, yet intuitively interpretable set of kinematic features of head movement dynamics- from videos taken several years (or decades) ago in 7 different academic centers!