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Sandhya Koushika @wormlockholmes.bsky.social · 12d

Super interesting-dig in

Pre- and postantibiotic epoch: The historical spread of antimicrobial resistance | Science www.science.org/doi/10.1126/...

Pre- and postantibiotic epoch: The historical spread of antimicrobial resistance

Plasmids are now the primary vectors of antimicrobial resistance, but our understanding of how human industrialisation of antibiotics influenced their evolution is limited by a paucity of data predati...

www.science.org

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Sandhya Koushika @wormlockholmes.bsky.social · 23d

A 19-page article in the National Geographic that covers the work of @uramakri.bsky.social @ncbsbangalore.bsky.social @tifr.res.in on black tigers, mutation load and corridors for tiger migration.

Important story and impactful work.
👏🏾

www.nationalgeographic.com/animals/arti...

The curious case of the tigers who changed their stripes

A century ago, India’s tigers were on the brink of extinction. Slowly, their numbers have rebounded. But that ecological success has prompted a dire problem—and a race to save many of them from geneti...

www.nationalgeographic.com

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Sandhya Koushika @wormlockholmes.bsky.social · Sep 1

What a feast....

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Sandhya Koushika @wormlockholmes.bsky.social · Aug 21

This award aims to highlight outstanding research by active neuroscientists working in countries underrepresented in neuroscience publications and conferences. @network-alba.bsky.social @sfn.org @ibroorg.bsky.social @fens.org

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Sandhya Koushika @wormlockholmes.bsky.social · Aug 21

Our worm lab is recovering from a mite attack. Trainees devoted hours to cleanup

A mite or two or an army
They are hateful and smarmy
Our helpless little ones
Crushed by their whirling carny

Hello give up not
Gather all the stock
Pick, bleach, clean
Burn to death a game well fought

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Reposted by Sandhya Koushika

Society for Developmental Biology @socdevbio.bsky.social · Aug 12

🚨Only 4 days to apply!!!🚨Join the SDB SciComm Internship! Gain hands-on experience writing stories on the latest developmental biology discoveries🔬Connect with top mentors & earn $500 to attend the SDB Annual Meeting 🎉! 👉 www.sdbonline.org/science_comm... #SciComm #DevBio

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Sandhya Koushika @wormlockholmes.bsky.social · Aug 12

Thank you--this is cool

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Sandhya Koushika @wormlockholmes.bsky.social · Aug 12

How widespread is heat-dependent sterility. Is this only in C. elegans? Does it happen in other nematodes or other cold-blooded animals?

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Sandhya Koushika @wormlockholmes.bsky.social · Aug 12

😮 Just WOW!!

Spray GFP mRNAs on plant leaves and the leaves translate this and you get glowing leaves.

www.biorxiv.org/content/10.1...

Foliar mRNA spray induces protein synthesis in monocot crop and dicot model plant species

In planta gene expression via exogenous mRNAs has a wide range of potential biotechnological applications from genome editing to plant protection and to circumventing tissue culture. Yet, regarding mR...

www.biorxiv.org

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Sandhya Koushika @wormlockholmes.bsky.social · Aug 12

Really interesting preprint on how the nervous-system modulates heat-dependent fertility. Work from @ethanewe.bsky.social from @odedrechavi.bsky.social lab. May well be relevant in a planet that is heating up.

bioRxivpreprint @biorxivpreprint.bsky.social · Aug 11

Neuronal oversight of germline small RNAs prevents heat-induced sterility in lab-domesticated Caenorhabditis elegans https://www.biorxiv.org/content/10.1101/2025.08.07.669182v1

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Sandhya Koushika @wormlockholmes.bsky.social · Aug 11

Loved this @heiman.bsky.social

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Sandhya Koushika @wormlockholmes.bsky.social · Aug 9

Read today

"Comparison is the thief of Joy"

True that

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Sandhya Koushika @wormlockholmes.bsky.social · Jul 30

Our dept @tifr.res.in ‬ran an MSc by research for ~25yrs. Our last batch graduated this month. Several headed to excellent PhD programs, some to jobs.

Congratulations and good luck for many fun adventures.

👏🏾Sohan Seal from my lab headed for a PhD to @mpi-cbg.de. 2nd from L, row 2

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Sandhya Koushika @wormlockholmes.bsky.social · Jul 10

😔 Doing science has taken on elements of a corporation w/ writing=one "vertical". Output of research as patents and IP seems to be another. Metrics is a temple at which we worship at.

Sometimes overlooked is serendipity, small groups that meander & in this context the idea that writing is thinking.

Christophe 🔬 L @christlet.bsky.social · Jul 9

This is so upsetting. Outsourcing writing does not "free up time to do more science" it's just a step further toward becoming the CSO at the top of a managerial pyramid rather than being a scientist

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Sandhya Koushika @wormlockholmes.bsky.social · Jul 8

Important.......

Richard Sever @richardsever.bsky.social · Jul 8

"Our observations should prompt an essential re-evaluation of the literature concerning astrocyte-neuron mitochondrial transfer" www.biorxiv.org/content/10.1...

MitoTracker transfers from astrocytes to neurons independently of mitochondria

The neuroprotective transfer of mitochondria from astrocytes to neurons has been primarily investigated by labelling astrocytic mitochondria with the dye MitoTracker. Here we report that MitoTracker transfers to neurons from both astrocytes and astrocyte-conditioned media, independently of mitochondrial transfer. Our observations should prompt an essential re-evaluation of the literature concerning astrocyte-neuron mitochondrial transfer and in other systems in which contact-independent transfer has been observed using mitochondrial dyes. ### Competing Interest Statement The authors have declared no competing interest. MSD (United Kingdom), https://ror.org/004nn4n27, PRJ_20446 DEVINE MSD MRC The Francis Crick Institute, https://ror.org/04tnbqb63, CC2206

www.biorxiv.org

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Sandhya Koushika @wormlockholmes.bsky.social · Jul 8

⭐ 🌟 image

Journal of Cell Biology @jcb.org · Jul 7

Our July issue is here! rupress.org/jcb/issue/22...
The cover shows a confocal timelapse imaging of #Celegans one-cell embryo expressing fluorescently labeled plasma membrane, microtubules, chromosomes, and ZEN-4, a plus-end directed kinesin motor protein. By Adhikary et al. doi.org/10.1083/jcb....

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Reposted by Sandhya Koushika

Eric Topol @erictopol.bsky.social · Jul 5

New organ clock data support the anti-aging benefits of estrogen for postmenopausal women. Reviewed here in context with previous and other recent reports.
erictopol.substack.com/p/new-anti-a...

Organ clocks for post-menopausal women taking estrogen or not taking estrogen

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Reposted by Sandhya Koushika

W. Brent Derry @wbderry.bsky.social · Jul 5

Bummed I missed the worm meeting this year but happy Worm Show was posted on YouTube. Bravo Morris and Curtis! www.youtube.com/watch?v=HXgU...

Worm Show 2025

YouTube video by Morris Maduro

www.youtube.com

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Reposted by Sandhya Koushika

Baris Tursun @baristursun.bsky.social · Jul 2

We are looking forward to the Worm Meeting 2027 and thank
Suhong Xu(Zhejiang University School of Medicine, Hangzhou, China),
Kavita Babu (Indian Institute of Science, Bangalore, India), and
Erik Andersen (Johns Hopkins
University Baltimore, USA)
for organising. #worm25

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Sandhya Koushika @wormlockholmes.bsky.social · Jul 2

Worms with neurons, a bracelet? Promise to buy. Missing #Worm25

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Reposted by Sandhya Koushika

Samal Tazhibayeva @samal-tjb.bsky.social · Jun 27

As it’s my first time joining Worm Meeting, I was excited to participate in Worm Art show as well.
This year’s topic is resilience. In times of scarcity, worms gather holding one another to reach new grounds. Alone - they are fragile, together - they rise. Even the sky yields in unity. #worm25

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Sandhya Koushika @wormlockholmes.bsky.social · Jul 2

Role of clathrin adaptor complex AP3 in secretion of dense core vesicles from the Sahu lab, NBRC.

Badal from my lab has added an experiment testing the role of AP3 in secretion of neuropeptides in C. elegans.

bioRxiv Cell Biology @biorxiv-cellbio.bsky.social · Jul 2

AP-3 complex sorts preferential cargo to govern dense core vesicle function in neuroendocrine cells https://www.biorxiv.org/content/10.1101/2025.06.27.661901v1