Yashar Zeighami
@yasharneuro.bsky.social
Neuroscientist-ish, Assistant Professor at the Douglas Research Centre, McGill University. Interested in neuroimaging, genomics, statistics, cats, books, ...
Reposted by Yashar Zeighami
Cortical expansion and genetic risk for PD.
Led by Houman Azizi and Nooshin Abbasi.
With @ptenigma.bsky.social @misicbata.bsky.social @yasharneuro.bsky.social @ndrewvo.bsky.social and many others www.medrxiv.org/content/10.6...
Led by Houman Azizi and Nooshin Abbasi.
With @ptenigma.bsky.social @misicbata.bsky.social @yasharneuro.bsky.social @ndrewvo.bsky.social and many others www.medrxiv.org/content/10.6...
Brain size links neurodevelopment to neurodegeneration in Parkinson's disease
Genetic studies have advanced our understanding of Parkinson's disease (PD) pathogenesis, establishing a role for autophagy and lysosomal dysfunction. However, how genetic risk translates into neurona...
www.medrxiv.org
December 11, 2025 at 10:34 PM
Cortical expansion and genetic risk for PD.
Led by Houman Azizi and Nooshin Abbasi.
With @ptenigma.bsky.social @misicbata.bsky.social @yasharneuro.bsky.social @ndrewvo.bsky.social and many others www.medrxiv.org/content/10.6...
Led by Houman Azizi and Nooshin Abbasi.
With @ptenigma.bsky.social @misicbata.bsky.social @yasharneuro.bsky.social @ndrewvo.bsky.social and many others www.medrxiv.org/content/10.6...
Reposted by Yashar Zeighami
Need more fMRI data (beyond the amazing NSD)? Introducing MOSAIC! Incredible effort led expertly by Ben Lahner, with help from grad student Mayukh Deb. Work in collaboration with the amazing Aude Oliva! @neurosky.bsky.social. More below..
December 4, 2025 at 2:26 PM
Need more fMRI data (beyond the amazing NSD)? Introducing MOSAIC! Incredible effort led expertly by Ben Lahner, with help from grad student Mayukh Deb. Work in collaboration with the amazing Aude Oliva! @neurosky.bsky.social. More below..
Reposted by Yashar Zeighami
November 24, 2025 at 11:49 PM
Reposted by Yashar Zeighami
September 23, 2025 at 12:49 PM
Reposted by Yashar Zeighami
The effect of spherical projections on spin tests for brain maps | doi.org/10.1162/IMAG...
Spin tests are the de facto null model for map-to-map comparisons in brain imaging. Why don't they perfectly control false positives? @vincebaz.bsky.social explores ⤵️
Spin tests are the de facto null model for map-to-map comparisons in brain imaging. Why don't they perfectly control false positives? @vincebaz.bsky.social explores ⤵️
September 10, 2025 at 1:07 PM
The effect of spherical projections on spin tests for brain maps | doi.org/10.1162/IMAG...
Spin tests are the de facto null model for map-to-map comparisons in brain imaging. Why don't they perfectly control false positives? @vincebaz.bsky.social explores ⤵️
Spin tests are the de facto null model for map-to-map comparisons in brain imaging. Why don't they perfectly control false positives? @vincebaz.bsky.social explores ⤵️
Reposted by Yashar Zeighami
Aging. It happens to all of us yet we don’t fully understand how it happens.
Marni and Stephen Boppart from @ahsillinois.bsky.social are developing a new microscopy platform that can illuminate the role of extracellular vesicles in cellular aging. #FrontierScience alleninstitute.org/division/fro...
Marni and Stephen Boppart from @ahsillinois.bsky.social are developing a new microscopy platform that can illuminate the role of extracellular vesicles in cellular aging. #FrontierScience alleninstitute.org/division/fro...
Real-time label-free dynamic imaging of extracellular vesicles in live tissues
Researchers Marni and Stephen Boppart will use next-generation, multimodal, nonlinear optical microscopy techniques to obtain real-time, dynamic images of EVs in living tissues and use this advanced p...
alleninstitute.org
September 2, 2025 at 9:32 PM
Aging. It happens to all of us yet we don’t fully understand how it happens.
Marni and Stephen Boppart from @ahsillinois.bsky.social are developing a new microscopy platform that can illuminate the role of extracellular vesicles in cellular aging. #FrontierScience alleninstitute.org/division/fro...
Marni and Stephen Boppart from @ahsillinois.bsky.social are developing a new microscopy platform that can illuminate the role of extracellular vesicles in cellular aging. #FrontierScience alleninstitute.org/division/fro...
Reposted by Yashar Zeighami
We are excited to launch The Data Quartet Challenge, recognizing student contributions to projects that integrate data from at least 2 of 4 FRQ supported Quebec Alzheimer’s and Aging cohorts (PREVENT-AD, CIMA-Q, NuAge, TRIAD), with 3 prizes of 5000$ tinyurl.com/3dy899xn
The Data Quartet Challenge.pdf
tinyurl.com
September 2, 2025 at 9:54 PM
We are excited to launch The Data Quartet Challenge, recognizing student contributions to projects that integrate data from at least 2 of 4 FRQ supported Quebec Alzheimer’s and Aging cohorts (PREVENT-AD, CIMA-Q, NuAge, TRIAD), with 3 prizes of 5000$ tinyurl.com/3dy899xn
Reposted by Yashar Zeighami
Still smiling after my keynote abt Community at #useR2025 💜
Huge thanks to the organizing team for the invite, and to everyone who joined, asked questions, and shared their thoughts — you made it truly special!
Slides docs.google.com/presentation...
Video: www.youtube.com/live/CTTvTQ-...
#rstats
Huge thanks to the organizing team for the invite, and to everyone who joined, asked questions, and shared their thoughts — you made it truly special!
Slides docs.google.com/presentation...
Video: www.youtube.com/live/CTTvTQ-...
#rstats
WeRTogether-useR!2025Keynote
We R Together Yanina Bellini Saibene useR! 2025 Duke University How to learn, use and improve a programming language as a community
docs.google.com
August 10, 2025 at 10:28 AM
Still smiling after my keynote abt Community at #useR2025 💜
Huge thanks to the organizing team for the invite, and to everyone who joined, asked questions, and shared their thoughts — you made it truly special!
Slides docs.google.com/presentation...
Video: www.youtube.com/live/CTTvTQ-...
#rstats
Huge thanks to the organizing team for the invite, and to everyone who joined, asked questions, and shared their thoughts — you made it truly special!
Slides docs.google.com/presentation...
Video: www.youtube.com/live/CTTvTQ-...
#rstats
Reposted by Yashar Zeighami
Mapping cerebral blood perfusion and its links to multi-scale brain organization across the human lifespan | doi.org/10.1371/jour...
How does blood perfusion map onto canonical features of brain structure and function? @asafarahani.bsky.social investigates @plosbiology.org ⤵️
How does blood perfusion map onto canonical features of brain structure and function? @asafarahani.bsky.social investigates @plosbiology.org ⤵️
August 8, 2025 at 2:24 PM
Mapping cerebral blood perfusion and its links to multi-scale brain organization across the human lifespan | doi.org/10.1371/jour...
How does blood perfusion map onto canonical features of brain structure and function? @asafarahani.bsky.social investigates @plosbiology.org ⤵️
How does blood perfusion map onto canonical features of brain structure and function? @asafarahani.bsky.social investigates @plosbiology.org ⤵️
Reposted by Yashar Zeighami
Hey #AAIC25 !
Today I'll be sharing our research on the mediating effect of WMH on spontaneous brain activity during aging! 🧠
Join me on poster 430!
@ameliemetz.bsky.social @dadarmahsa.bsky.social @yasharneuro.bsky.social @roqamoqa.bsky.social
Today I'll be sharing our research on the mediating effect of WMH on spontaneous brain activity during aging! 🧠
Join me on poster 430!
@ameliemetz.bsky.social @dadarmahsa.bsky.social @yasharneuro.bsky.social @roqamoqa.bsky.social
July 28, 2025 at 2:11 PM
Hey #AAIC25 !
Today I'll be sharing our research on the mediating effect of WMH on spontaneous brain activity during aging! 🧠
Join me on poster 430!
@ameliemetz.bsky.social @dadarmahsa.bsky.social @yasharneuro.bsky.social @roqamoqa.bsky.social
Today I'll be sharing our research on the mediating effect of WMH on spontaneous brain activity during aging! 🧠
Join me on poster 430!
@ameliemetz.bsky.social @dadarmahsa.bsky.social @yasharneuro.bsky.social @roqamoqa.bsky.social
Reposted by Yashar Zeighami
A healthy lifestyle in intervention clinical trials for weight loss, even without long term weight loss (only achieved in ~33%), led to improvement of key cardiometabolic factors
academic.oup.com/eurjpc/advan...
academic.oup.com/eurjpc/advan...
Individual response to lifestyle interventions: a pooled analysis of three long-term weight loss trials
AbstractAims. We explored the manifestations of individual weight loss (WL) response to long-term lifestyle interventions on cardiometabolic risk.Methods a
academic.oup.com
June 5, 2025 at 9:32 PM
A healthy lifestyle in intervention clinical trials for weight loss, even without long term weight loss (only achieved in ~33%), led to improvement of key cardiometabolic factors
academic.oup.com/eurjpc/advan...
academic.oup.com/eurjpc/advan...
Reposted by Yashar Zeighami
Vascular risk factors mediate the relationship between education and white matter hyperintensities https://www.medrxiv.org/content/10.1101/2025.06.03.25328899v1
June 5, 2025 at 1:26 AM
Vascular risk factors mediate the relationship between education and white matter hyperintensities https://www.medrxiv.org/content/10.1101/2025.06.03.25328899v1
Reposted by Yashar Zeighami
Gray matter microstructure from in-vivo diffusion MRI reflects post-mortem neuropathology severity and clinical progression of Alzheimer's disease https://www.medrxiv.org/content/10.1101/2025.05.30.25328630v1
June 4, 2025 at 9:11 PM
Gray matter microstructure from in-vivo diffusion MRI reflects post-mortem neuropathology severity and clinical progression of Alzheimer's disease https://www.medrxiv.org/content/10.1101/2025.05.30.25328630v1
Reposted by Yashar Zeighami
Sex Differences in Vulnerability to Tau Pathology: Impact on Cognitive Decline https://www.medrxiv.org/content/10.1101/2025.05.25.25328324v1
May 27, 2025 at 2:26 AM
Sex Differences in Vulnerability to Tau Pathology: Impact on Cognitive Decline https://www.medrxiv.org/content/10.1101/2025.05.25.25328324v1
Reposted by Yashar Zeighami
Congrats to HBHL-funded researcher & 2022 HBHL New Faculty Recruit @dadarmahsa.bsky.social on being awarded the President’s Prize for Outstanding Emerging Researchers at the 2025 @mcgill.ca @healthsciences.mcgill.ca Convocation Ceremony! Well deserved. 👏
🔗 reporter.mcgill.ca/mcgills-pres...
🔗 reporter.mcgill.ca/mcgills-pres...
May 29, 2025 at 7:10 PM
Congrats to HBHL-funded researcher & 2022 HBHL New Faculty Recruit @dadarmahsa.bsky.social on being awarded the President’s Prize for Outstanding Emerging Researchers at the 2025 @mcgill.ca @healthsciences.mcgill.ca Convocation Ceremony! Well deserved. 👏
🔗 reporter.mcgill.ca/mcgills-pres...
🔗 reporter.mcgill.ca/mcgills-pres...
Reposted by Yashar Zeighami
#SpatialTranscriptomics #BatchCorrelation
SpaBatch
Align multi-slice sequencing-based spatial data
Visium ST Stereo-seq
#VariationalGraphAutoEncoder
Masked data augmentation
vs STG3Net STAligner SEDR DeepST SpaGIC STitch3D
bioRxiv 2025
www.biorxiv.org/content/10.1...
SpaBatch
Align multi-slice sequencing-based spatial data
Visium ST Stereo-seq
#VariationalGraphAutoEncoder
Masked data augmentation
vs STG3Net STAligner SEDR DeepST SpaGIC STitch3D
bioRxiv 2025
www.biorxiv.org/content/10.1...
May 22, 2025 at 12:22 PM
#SpatialTranscriptomics #BatchCorrelation
SpaBatch
Align multi-slice sequencing-based spatial data
Visium ST Stereo-seq
#VariationalGraphAutoEncoder
Masked data augmentation
vs STG3Net STAligner SEDR DeepST SpaGIC STitch3D
bioRxiv 2025
www.biorxiv.org/content/10.1...
SpaBatch
Align multi-slice sequencing-based spatial data
Visium ST Stereo-seq
#VariationalGraphAutoEncoder
Masked data augmentation
vs STG3Net STAligner SEDR DeepST SpaGIC STitch3D
bioRxiv 2025
www.biorxiv.org/content/10.1...
Reposted by Yashar Zeighami
(1/6) Thrilled to share our triple-N dataset (Non-human Primate Neural Responses to Natural Scenes)! It captures thousands of high-level visual neuron responses in macaques to natural scenes using #Neuropixels.
May 11, 2025 at 1:33 PM
(1/6) Thrilled to share our triple-N dataset (Non-human Primate Neural Responses to Natural Scenes)! It captures thousands of high-level visual neuron responses in macaques to natural scenes using #Neuropixels.
Reposted by Yashar Zeighami
New paper in Imaging Neuroscience by Gustavo Chau Loo Kung, Jennifer A. McNab, et al:
Non-parametric prediction of brain MRI microstructure using transfer learning
doi.org/10.1162/imag...
Non-parametric prediction of brain MRI microstructure using transfer learning
doi.org/10.1162/imag...
May 6, 2025 at 5:24 AM
New paper in Imaging Neuroscience by Gustavo Chau Loo Kung, Jennifer A. McNab, et al:
Non-parametric prediction of brain MRI microstructure using transfer learning
doi.org/10.1162/imag...
Non-parametric prediction of brain MRI microstructure using transfer learning
doi.org/10.1162/imag...
Reposted by Yashar Zeighami
Sneak peek from first poster session at #HBHLSymposium2025 📸
With over 100 trainees presenting their innovative research on brain health, it's a great opportunity to explore new perspectives and pioneering work from the next generation of researchers! 🖼️🎓 @healthsciences.mcgill.ca
With over 100 trainees presenting their innovative research on brain health, it's a great opportunity to explore new perspectives and pioneering work from the next generation of researchers! 🖼️🎓 @healthsciences.mcgill.ca
May 6, 2025 at 5:13 PM
Sneak peek from first poster session at #HBHLSymposium2025 📸
With over 100 trainees presenting their innovative research on brain health, it's a great opportunity to explore new perspectives and pioneering work from the next generation of researchers! 🖼️🎓 @healthsciences.mcgill.ca
With over 100 trainees presenting their innovative research on brain health, it's a great opportunity to explore new perspectives and pioneering work from the next generation of researchers! 🖼️🎓 @healthsciences.mcgill.ca
Reposted by Yashar Zeighami
A Multi-Scale Neuron Morphometry Dataset from Peta-voxel Mouse Whole-Brain Images | Scientific Data www.nature.com/articles/s41...
A Multi-Scale Neuron Morphometry Dataset from Peta-voxel Mouse Whole-Brain Images - Scientific Data
Scientific Data - A Multi-Scale Neuron Morphometry Dataset from Peta-voxel Mouse Whole-Brain Images
www.nature.com
May 6, 2025 at 10:21 PM
A Multi-Scale Neuron Morphometry Dataset from Peta-voxel Mouse Whole-Brain Images | Scientific Data www.nature.com/articles/s41...
Reposted by Yashar Zeighami
@maximoprado.bsky.social and @mallarchak.bsky.social present their @westernubrainscan.bsky.social supported work on early biomarkers for development and monitoring of effective disease-modifying therapies at the #hbhlsymposium2025. @hbhlmcgill.bsky.social @westernu.bsky.social
May 6, 2025 at 6:21 PM
@maximoprado.bsky.social and @mallarchak.bsky.social present their @westernubrainscan.bsky.social supported work on early biomarkers for development and monitoring of effective disease-modifying therapies at the #hbhlsymposium2025. @hbhlmcgill.bsky.social @westernu.bsky.social
Reposted by Yashar Zeighami
Up next at #HBHLSymposium2025, @maximoprado.bsky.social & @mallarchak.bsky.social discussed their Initiative for Translational Neuroscience (ITN) collaboration & unpacked how early biomarkers help develop & monitor better treatments for neurodegenerative diseases. 🧪
@westernuresearch.bsky.social
@westernuresearch.bsky.social
May 6, 2025 at 6:15 PM
Up next at #HBHLSymposium2025, @maximoprado.bsky.social & @mallarchak.bsky.social discussed their Initiative for Translational Neuroscience (ITN) collaboration & unpacked how early biomarkers help develop & monitor better treatments for neurodegenerative diseases. 🧪
@westernuresearch.bsky.social
@westernuresearch.bsky.social
Reposted by Yashar Zeighami
For #TidyTuesday this week, we're looking at data on terminations of NSF grants 📊
🎨 Using colour to highlight one category
📈 Transparency to highlight the important data
✍️ Annotations instead of a legend for transparency
#RStats #ggplot2 #DataViz
🎨 Using colour to highlight one category
📈 Transparency to highlight the important data
✍️ Annotations instead of a legend for transparency
#RStats #ggplot2 #DataViz
May 6, 2025 at 10:03 AM
For #TidyTuesday this week, we're looking at data on terminations of NSF grants 📊
🎨 Using colour to highlight one category
📈 Transparency to highlight the important data
✍️ Annotations instead of a legend for transparency
#RStats #ggplot2 #DataViz
🎨 Using colour to highlight one category
📈 Transparency to highlight the important data
✍️ Annotations instead of a legend for transparency
#RStats #ggplot2 #DataViz
Reposted by Yashar Zeighami
This Thursday I will give a talk on (causal) mediation analysis -- happy to have finally worked out what I want to tell people.
And happy to pilot a new mode of slide sharing: just putting them on my website (juliarohrer.com/resources/)
And happy to pilot a new mode of slide sharing: just putting them on my website (juliarohrer.com/resources/)
May 5, 2025 at 10:42 AM
This Thursday I will give a talk on (causal) mediation analysis -- happy to have finally worked out what I want to tell people.
And happy to pilot a new mode of slide sharing: just putting them on my website (juliarohrer.com/resources/)
And happy to pilot a new mode of slide sharing: just putting them on my website (juliarohrer.com/resources/)
Reposted by Yashar Zeighami
You've heard of the many analysts projects, right?
Scholars give the same dataset/question to a bunch of researchers & they still get different answers.
Why is that?
Data cleaning!
This is consistent with Gelman's "garden of forking paths." Small coding decisions often drive results.
Scholars give the same dataset/question to a bunch of researchers & they still get different answers.
Why is that?
Data cleaning!
This is consistent with Gelman's "garden of forking paths." Small coding decisions often drive results.
May 5, 2025 at 2:13 PM
You've heard of the many analysts projects, right?
Scholars give the same dataset/question to a bunch of researchers & they still get different answers.
Why is that?
Data cleaning!
This is consistent with Gelman's "garden of forking paths." Small coding decisions often drive results.
Scholars give the same dataset/question to a bunch of researchers & they still get different answers.
Why is that?
Data cleaning!
This is consistent with Gelman's "garden of forking paths." Small coding decisions often drive results.