Optimized glycosylation patterns to recapitulate arabidopsis FLS2-flagellin binding in yeast surface display 👏 www.biorxiv.org/content/10.1...
Tuning Yeast Glycosylation Proximal to the FLS2-flg22 Binding Interface enables Functional Yeast Surface Display under Induced ER Stress
Pattern recognition receptors such as FLAGELLIN SENSING 2 (FLS2) are central to plant immunity and attractive targets for engineering broader detection of bacterial phytopathogens. However, evaluating...
www.biorxiv.org
November 27, 2025 at 6:22 PM
Optimized glycosylation patterns to recapitulate arabidopsis FLS2-flagellin binding in yeast surface display 👏 www.biorxiv.org/content/10.1...
Flagellin-mediated TLR5 activation enhances innate immune responses in healthy and diseased human airway epithelium https://www.biorxiv.org/content/10.1101/2025.11.06.686934v1
November 7, 2025 at 10:16 PM
Flagellin-mediated TLR5 activation enhances innate immune responses in healthy and diseased human airway epithelium https://www.biorxiv.org/content/10.1101/2025.11.06.686934v1
Flagellin-mediated TLR5 activation enhances innate immune responses in healthy and diseased human airway epithelium https://www.biorxiv.org/content/10.1101/2025.11.06.686934v1
November 7, 2025 at 10:16 PM
Flagellin-mediated TLR5 activation enhances innate immune responses in healthy and diseased human airway epithelium https://www.biorxiv.org/content/10.1101/2025.11.06.686934v1
First article on the immune responses of poppy from the Department of Experimental Plant Biology and other collaborators. We described the response of four poppy cultivars after treatment with a peptide derived from bacterial flagellin: academic.oup.com/aobpla/artic...
October 31, 2025 at 5:56 PM
First article on the immune responses of poppy from the Department of Experimental Plant Biology and other collaborators. We described the response of four poppy cultivars after treatment with a peptide derived from bacterial flagellin: academic.oup.com/aobpla/artic...
The dual-action approach of immune activation and precise drug delivery highlights the potential of this engineered flagellin-based system for glioblastoma and other TLR5-expressing tumors.
October 23, 2025 at 7:20 AM
The dual-action approach of immune activation and precise drug delivery highlights the potential of this engineered flagellin-based system for glioblastoma and other TLR5-expressing tumors.
The researchers genetically engineered a pH-sensitive flagellin derivative that self-assembles and enables covalent conjugation with the boron-based anticancer drug Ixazomib.
October 23, 2025 at 7:20 AM
The researchers genetically engineered a pH-sensitive flagellin derivative that self-assembles and enables covalent conjugation with the boron-based anticancer drug Ixazomib.
This study investigates flagellin, a bacterial protein that activates the TLR5 receptor, as a platform for immune stimulation and targeted drug delivery against glioblastoma, an aggressive brain tumor.
October 23, 2025 at 7:20 AM
This study investigates flagellin, a bacterial protein that activates the TLR5 receptor, as a platform for immune stimulation and targeted drug delivery against glioblastoma, an aggressive brain tumor.
Engineered flagellin biomaterial activates immune response and delivers targeted cancer drugs, offering a promising approach to tackle glioblastoma's aggressive growth and immunosuppressi...
🧵 Thread below
Full analysis: https://helixbrief.com/article/b89a270b-96f3-4dff-b5ca-4cef9d5f1d51
🧵 Thread below
Full analysis: https://helixbrief.com/article/b89a270b-96f3-4dff-b5ca-4cef9d5f1d51
October 23, 2025 at 7:20 AM
Engineered flagellin biomaterial activates immune response and delivers targeted cancer drugs, offering a promising approach to tackle glioblastoma's aggressive growth and immunosuppressi...
🧵 Thread below
Full analysis: https://helixbrief.com/article/b89a270b-96f3-4dff-b5ca-4cef9d5f1d51
🧵 Thread below
Full analysis: https://helixbrief.com/article/b89a270b-96f3-4dff-b5ca-4cef9d5f1d51
📃Scientific paper: Bronchial epithelial cells release inflammatory markers linked to airway inflammation and remodeling in response to TLR5 ligand flagellin
Ref.: World Allergy Organization, 2023
➡️ Continued on ES/IODE
Ref.: World Allergy Organization, 2023
➡️ Continued on ES/IODE
October 19, 2025 at 5:02 PM
📃Scientific paper: Bronchial epithelial cells release inflammatory markers linked to airway inflammation and remodeling in response to TLR5 ligand flagellin
Ref.: World Allergy Organization, 2023
➡️ Continued on ES/IODE
Ref.: World Allergy Organization, 2023
➡️ Continued on ES/IODE
This is all completely hypothetical. According to Chat-GPT, it is rare to find a bacterial protein in plasma outside of a distinct cause (gut performation). But for the sake of argument it offered up flagellin from e. coli. So, let's say I had a couple peptide Ids from that.
October 13, 2025 at 5:27 PM
This is all completely hypothetical. According to Chat-GPT, it is rare to find a bacterial protein in plasma outside of a distinct cause (gut performation). But for the sake of argument it offered up flagellin from e. coli. So, let's say I had a couple peptide Ids from that.
👏 J. Bigot & V. Balloy @CRSA-paris.bsky.social @sorbonne-universite.fr @hopital-stantoine.bsky.social, R. Legendre & C. Chica @Pasteur.fr + team
🫁 New insights into innate immune memory in lung epithelium #Flagellin 🦠
🙏 @vaincrelamuco.bsky.social & Fondation Air Liquide for support 🔬📄 👉 rdcu.be/eHY
🫁 New insights into innate immune memory in lung epithelium #Flagellin 🦠
🙏 @vaincrelamuco.bsky.social & Fondation Air Liquide for support 🔬📄 👉 rdcu.be/eHY
The epigenomic landscape of bronchial epithelial cells reveals the establishment of trained immunity
Genes & Immunity - The epigenomic landscape of bronchial epithelial cells reveals the establishment of trained immunity
rdcu.be
September 24, 2025 at 2:45 PM
👏 J. Bigot & V. Balloy @CRSA-paris.bsky.social @sorbonne-universite.fr @hopital-stantoine.bsky.social, R. Legendre & C. Chica @Pasteur.fr + team
🫁 New insights into innate immune memory in lung epithelium #Flagellin 🦠
🙏 @vaincrelamuco.bsky.social & Fondation Air Liquide for support 🔬📄 👉 rdcu.be/eHY
🫁 New insights into innate immune memory in lung epithelium #Flagellin 🦠
🙏 @vaincrelamuco.bsky.social & Fondation Air Liquide for support 🔬📄 👉 rdcu.be/eHY
Discovery of the neurobiotic sense, a new gut sense at the interface of the biota and the brain
Flagellin, an ubiquitous microbial pattern, stimulates neuropod cells from the colonic lumen to reduce feeding through a gut–brain sensory neural circuit.
www.nature.com/articles/s41...
Flagellin, an ubiquitous microbial pattern, stimulates neuropod cells from the colonic lumen to reduce feeding through a gut–brain sensory neural circuit.
www.nature.com/articles/s41...
September 18, 2025 at 3:13 PM
Discovery of the neurobiotic sense, a new gut sense at the interface of the biota and the brain
Flagellin, an ubiquitous microbial pattern, stimulates neuropod cells from the colonic lumen to reduce feeding through a gut–brain sensory neural circuit.
www.nature.com/articles/s41...
Flagellin, an ubiquitous microbial pattern, stimulates neuropod cells from the colonic lumen to reduce feeding through a gut–brain sensory neural circuit.
www.nature.com/articles/s41...
On this day in COVID history, September 13, 2021:
Deimmunization of flagellin for repeated administration as a vaccine adjuvant - npj Vaccines
Source: Nature
https://www.nature.com/articles/s41541-021-00379-4
Deimmunization of flagellin for repeated administration as a vaccine adjuvant - npj Vaccines
Source: Nature
https://www.nature.com/articles/s41541-021-00379-4
September 13, 2025 at 4:30 PM
On this day in COVID history, September 13, 2021:
Deimmunization of flagellin for repeated administration as a vaccine adjuvant - npj Vaccines
Source: Nature
https://www.nature.com/articles/s41541-021-00379-4
Deimmunization of flagellin for repeated administration as a vaccine adjuvant - npj Vaccines
Source: Nature
https://www.nature.com/articles/s41541-021-00379-4
By mining genomes and testing gene activation after leaf wounding or bacterial flagellin application, the researchers identified key defense marker genes.
August 29, 2025 at 10:08 PM
By mining genomes and testing gene activation after leaf wounding or bacterial flagellin application, the researchers identified key defense marker genes.
"Moreover, flagellin reduces feeding independent of immune responses, metabolic changes or the presence of gut microbiota. This sense enables the host to adjust its behaviour in response to a molecular pattern from its resident microorganisms. We call this sense at the interface of the biota and […]
Original post on mastodon.social
mastodon.social
August 13, 2025 at 3:03 AM
"Moreover, flagellin reduces feeding independent of immune responses, metabolic changes or the presence of gut microbiota. This sense enables the host to adjust its behaviour in response to a molecular pattern from its resident microorganisms. We call this sense at the interface of the biota and […]
The surprising ingredients found in vaccines
https://www.diningandcooking.com/2216725/the-surprising-ingredients-found-in-vaccines/
Flagellin isn’t yet licensed for use in any human vaccine, but it’s shown promising results in trials. During a natural infection with bacteria, the protein binds …
https://www.diningandcooking.com/2216725/the-surprising-ingredients-found-in-vaccines/
Flagellin isn’t yet licensed for use in any human vaccine, but it’s shown promising results in trials. During a natural infection with bacteria, the protein binds …
The surprising ingredients found in vaccines - Dining and Cooking
Flagellin isn’t yet licensed for use in any human vaccine, but it’s shown promising results in trials.
www.diningandcooking.com
August 5, 2025 at 2:35 PM
The surprising ingredients found in vaccines
https://www.diningandcooking.com/2216725/the-surprising-ingredients-found-in-vaccines/
Flagellin isn’t yet licensed for use in any human vaccine, but it’s shown promising results in trials. During a natural infection with bacteria, the protein binds …
https://www.diningandcooking.com/2216725/the-surprising-ingredients-found-in-vaccines/
Flagellin isn’t yet licensed for use in any human vaccine, but it’s shown promising results in trials. During a natural infection with bacteria, the protein binds …
Your Stomach Might Just Be Smarter Than You Think, It Could Be Your ‘Sixth Sense’
Last Updated:August 02, 2025, 16:20 IST Researchers discovered that our gut contains specialised cells that can detect the protein flagellin and instantly send a signal to the brain, indicating the stomach is full…
Last Updated:August 02, 2025, 16:20 IST Researchers discovered that our gut contains specialised cells that can detect the protein flagellin and instantly send a signal to the brain, indicating the stomach is full…
Your Stomach Might Just Be Smarter Than You Think, It Could Be Your ‘Sixth Sense’
Last Updated:August 02, 2025, 16:20 IST Researchers discovered that our gut contains specialised cells that can detect the protein flagellin and instantly send a signal to the brain, indicating the stomach is full Thanks to tiny microbial proteins, your stomach could be playing a role in how happy or anxious you feel. (AI Generated) We often think the stomach’s sole function is to digest food, but a new study suggests it does much more. Scientists at Duke University in the US have discovered that our stomach can “talk" to our brain and signal when to stop eating.
10bmnews.com
August 2, 2025 at 9:01 PM
Your Stomach Might Just Be Smarter Than You Think, It Could Be Your ‘Sixth Sense’
Last Updated:August 02, 2025, 16:20 IST Researchers discovered that our gut contains specialised cells that can detect the protein flagellin and instantly send a signal to the brain, indicating the stomach is full…
Last Updated:August 02, 2025, 16:20 IST Researchers discovered that our gut contains specialised cells that can detect the protein flagellin and instantly send a signal to the brain, indicating the stomach is full…
Unlocking expanded flagellin perception through rational receptor engineering
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Unlocking expanded flagellin perception through rational receptor engineering - Nature Plants
Receptor kinase FLS2 detects the flg22 epitope of bacterial flagellin. Here the authors identify key residues on FLS2’s concave surface that enable expanded perception of flg22 variants, allowing the ...
www.nature.com
July 29, 2025 at 7:55 PM
Unlocking expanded flagellin perception through rational receptor engineering
www.nature.com/articles/s41...
www.nature.com/articles/s41...
🌱 From Nature Plants: By modifying key surface residues, researchers expanded FLS2 receptor recognition of polymorphic flagellin. AlphaFold guided the engineering. (Tianrun Li, Esteban Jarquin Bolaños, Danielle M. Stevens, Hanxu Sha, Gitta Coaker)
▶️ www.nature.com/articles/s41...
#PlantBiology
▶️ www.nature.com/articles/s41...
#PlantBiology
Unlocking expanded flagellin perception through rational receptor engineering - Nature Plants
Receptor kinase FLS2 detects the flg22 epitope of bacterial flagellin. Here the authors identify key residues on FLS2’s concave surface that enable expanded perception of flg22 variants, allowing the ...
www.nature.com
July 29, 2025 at 5:03 PM
🌱 From Nature Plants: By modifying key surface residues, researchers expanded FLS2 receptor recognition of polymorphic flagellin. AlphaFold guided the engineering. (Tianrun Li, Esteban Jarquin Bolaños, Danielle M. Stevens, Hanxu Sha, Gitta Coaker)
▶️ www.nature.com/articles/s41...
#PlantBiology
▶️ www.nature.com/articles/s41...
#PlantBiology
Excited this paper is finally published! We focused on the inner concave surface of LRR RKs to expand bacterial flagellin perception in plants. Selection indicates expanded perception is more common than previously thought. Experiments led by @jerrytli.bsky.social www.nature.com/articles/s41...
Unlocking expanded flagellin perception through rational receptor engineering - Nature Plants
Receptor kinase FLS2 detects the flg22 epitope of bacterial flagellin. Here the authors identify key residues on FLS2’s concave surface that enable expanded perception of flg22 variants, allowing the ...
www.nature.com
July 29, 2025 at 1:18 AM
Excited this paper is finally published! We focused on the inner concave surface of LRR RKs to expand bacterial flagellin perception in plants. Selection indicates expanded perception is more common than previously thought. Experiments led by @jerrytli.bsky.social www.nature.com/articles/s41...
Engineering Receptors to Enhance Flagellin Detection
In the ever-evolving battlefield of plant-pathogen interactions, the intricate dance between plant immune receptors and microbial invaders continues to captivate scientists worldwide. A groundbreaking study recently published in Nature Plants by…
In the ever-evolving battlefield of plant-pathogen interactions, the intricate dance between plant immune receptors and microbial invaders continues to captivate scientists worldwide. A groundbreaking study recently published in Nature Plants by…
Engineering Receptors to Enhance Flagellin Detection
In the ever-evolving battlefield of plant-pathogen interactions, the intricate dance between plant immune receptors and microbial invaders continues to captivate scientists worldwide. A groundbreaking study recently published in Nature Plants by Li, T., Jarquin Bolaños, E., Stevens, D.M., and colleagues, unveils a transformative approach to amplifying plant immune responses by rationally engineering receptors to broaden their ability to perceive microbial flagellin.
scienmag.com
July 28, 2025 at 5:41 PM
Engineering Receptors to Enhance Flagellin Detection
In the ever-evolving battlefield of plant-pathogen interactions, the intricate dance between plant immune receptors and microbial invaders continues to captivate scientists worldwide. A groundbreaking study recently published in Nature Plants by…
In the ever-evolving battlefield of plant-pathogen interactions, the intricate dance between plant immune receptors and microbial invaders continues to captivate scientists worldwide. A groundbreaking study recently published in Nature Plants by…
Species specific marker genes for systemic defence and stress responses to leaf wounding and flagellin stimuli in hybrid aspen and silver birch https://www.biorxiv.org/content/10.1101/2025.07.23.666137v1
July 27, 2025 at 2:52 PM
Species specific marker genes for systemic defence and stress responses to leaf wounding and flagellin stimuli in hybrid aspen and silver birch https://www.biorxiv.org/content/10.1101/2025.07.23.666137v1
Species specific marker genes for systemic defence and stress responses to leaf wounding and flagellin stimuli in hybrid aspen and silver birch https://www.biorxiv.org/content/10.1101/2025.07.23.666137v1
July 26, 2025 at 6:02 PM
Species specific marker genes for systemic defence and stress responses to leaf wounding and flagellin stimuli in hybrid aspen and silver birch https://www.biorxiv.org/content/10.1101/2025.07.23.666137v1
Species specific marker genes for systemic defence and stress responses to leaf wounding and flagellin stimuli in hybrid aspen and silver birch https://www.biorxiv.org/content/10.1101/2025.07.23.666137v1
July 26, 2025 at 6:02 PM
Species specific marker genes for systemic defence and stress responses to leaf wounding and flagellin stimuli in hybrid aspen and silver birch https://www.biorxiv.org/content/10.1101/2025.07.23.666137v1
#WeekendRead! #EveryCellIsAnImmuneCell! #TollPower! Kaelberer Bohorquez &co show @nature.com that #TLR5 signaling in response to flagellin drives neuropeptide PYY release by gut colonic neuropod cells, activating vagal neurons that signal to #brain, reducing feeding via a “neurobiotic sense”!
A gut sense for a microbial pattern regulates feeding - Nature
A study reveals a gut–brain sensory pathway through which the microbial component flagellin activates neuropod cells in the colon to signal the brain and reduce feeding in mice.
www.nature.com
July 26, 2025 at 3:59 PM
#WeekendRead! #EveryCellIsAnImmuneCell! #TollPower! Kaelberer Bohorquez &co show @nature.com that #TLR5 signaling in response to flagellin drives neuropeptide PYY release by gut colonic neuropod cells, activating vagal neurons that signal to #brain, reducing feeding via a “neurobiotic sense”!