Ferroptosis and 🩸 stem cell biology have a lot to say to each other... Hoping this work inspires #ferroptosis researchers to explore HSCs and #hematopoiesis researchers to lean into ferroptosis 🤝
Excited to share our new study, led by @dellaVolpe_L, now out in @natcellbio.nature.com! Blocking #ferroptosis enhances human 🩸 stem cell expansion, with implications for transplantation and gene therapy. www.nature.com/articles/s41...
November 19, 2025 at 10:07 PM
Ferroptosis and 🩸 stem cell biology have a lot to say to each other... Hoping this work inspires #ferroptosis researchers to explore HSCs and #hematopoiesis researchers to lean into ferroptosis 🤝
In early fetal development, blood cells are made in the liver & spleen, but by the time of your birth, almost all your blood cells were being made by hematopoietic stem cells (HSCs) in the medulla of your wet bones.
In adults, specific bones do most of the "heavy lift" in blood cell production.
In adults, specific bones do most of the "heavy lift" in blood cell production.
November 3, 2025 at 6:22 PM
In early fetal development, blood cells are made in the liver & spleen, but by the time of your birth, almost all your blood cells were being made by hematopoietic stem cells (HSCs) in the medulla of your wet bones.
In adults, specific bones do most of the "heavy lift" in blood cell production.
In adults, specific bones do most of the "heavy lift" in blood cell production.
5/ There were also similar cells found growing in a new 3D culture system.🤔 A new cell model?💡It activated many marker genes! We would’ve never considered this model because it was designed to expand HSCs from PBMCs, completely unrelated to ILD macrophages! 🙌
November 22, 2024 at 10:16 PM
5/ There were also similar cells found growing in a new 3D culture system.🤔 A new cell model?💡It activated many marker genes! We would’ve never considered this model because it was designed to expand HSCs from PBMCs, completely unrelated to ILD macrophages! 🙌
#Medsky🧪 #Immunosky IEI are monogenic disorders of immune sys that lead to immune deficiency &/or dysregulation in patients.This review the current landscape of somatic genetic errors of #immunity & methods for the detection & validation of somatic variants.
@jem.org
rupress.org/jem/article/...
@jem.org
rupress.org/jem/article/...
April 16, 2025 at 6:20 PM
#Medsky🧪 #Immunosky IEI are monogenic disorders of immune sys that lead to immune deficiency &/or dysregulation in patients.This review the current landscape of somatic genetic errors of #immunity & methods for the detection & validation of somatic variants.
@jem.org
rupress.org/jem/article/...
@jem.org
rupress.org/jem/article/...
The Texas Tech University Health Sciences Center and its El Paso unit (collectively, the HSCs) have announced that they suffered a cyberattack in September.
www.pcmag.com/news/ransomw...
www.pcmag.com/news/ransomw...
December 18, 2024 at 5:05 PM
The Texas Tech University Health Sciences Center and its El Paso unit (collectively, the HSCs) have announced that they suffered a cyberattack in September.
www.pcmag.com/news/ransomw...
www.pcmag.com/news/ransomw...
I volunteered with a coastal wetlands preservation org for a couple of years and we offered people the opportunity to see HSCs up close, with guidance. I LOVED that work.
(And I appreciate the misspelling correction. Thank you SO much.)
(And I appreciate the misspelling correction. Thank you SO much.)
August 20, 2024 at 7:16 PM
I volunteered with a coastal wetlands preservation org for a couple of years and we offered people the opportunity to see HSCs up close, with guidance. I LOVED that work.
(And I appreciate the misspelling correction. Thank you SO much.)
(And I appreciate the misspelling correction. Thank you SO much.)
Stunning hematopoetic stem cell talk by Rob Signer (@signerlab.bsky.social) showing that mouse HSCs depend on a specific family of Arginine tRNAs! 🤯 #ASH24
December 8, 2024 at 1:19 AM
Stunning hematopoetic stem cell talk by Rob Signer (@signerlab.bsky.social) showing that mouse HSCs depend on a specific family of Arginine tRNAs! 🤯 #ASH24
Not quite my area but this is cool. Lentiviral transduction of autologous HSCs to replace genes and cure haemophilia in humans. Potential for long-term responses and early data looks impressive https://buff.ly/3ZnZZcY Found with researchbriefing.com
www.nejm.org
December 12, 2024 at 9:00 AM
Not quite my area but this is cool. Lentiviral transduction of autologous HSCs to replace genes and cure haemophilia in humans. Potential for long-term responses and early data looks impressive https://buff.ly/3ZnZZcY Found with researchbriefing.com
• Inducible deletion of aCDase in HSCs promotes MMP-1-mediated collagen degradation and ECM remodeling, leading to fibrosis regression.
• Developed a novel small-molecule aCDase inhibitor, compound 5A, demonstrated efficacy in enhancing ECM degradation and resolving fibrosis in two mouse models.
• Developed a novel small-molecule aCDase inhibitor, compound 5A, demonstrated efficacy in enhancing ECM degradation and resolving fibrosis in two mouse models.
August 28, 2025 at 8:07 PM
• Inducible deletion of aCDase in HSCs promotes MMP-1-mediated collagen degradation and ECM remodeling, leading to fibrosis regression.
• Developed a novel small-molecule aCDase inhibitor, compound 5A, demonstrated efficacy in enhancing ECM degradation and resolving fibrosis in two mouse models.
• Developed a novel small-molecule aCDase inhibitor, compound 5A, demonstrated efficacy in enhancing ECM degradation and resolving fibrosis in two mouse models.
There is no clear agreement on the effects of aging on HSCs, and how different types of HSCs play into this. So we pulled seven datasets together and re-analyzed them using new bioinformatic methods, revealing a clearer picture 💻 3/5
September 6, 2025 at 1:33 AM
There is no clear agreement on the effects of aging on HSCs, and how different types of HSCs play into this. So we pulled seven datasets together and re-analyzed them using new bioinformatic methods, revealing a clearer picture 💻 3/5
The January issue of #Science #Immunology is now live! This week: new insights into #NLRP3 #inflammasome activation; key distinctions btw rodent & human #PD1 orthologs uncovered; & targeting thrombospondin-1 (Thbs1) to suppress #HSC #inflammaging!
www.science.org/toc/sciimmun...
www.science.org/toc/sciimmun...
January 3, 2025 at 8:06 PM
The January issue of #Science #Immunology is now live! This week: new insights into #NLRP3 #inflammasome activation; key distinctions btw rodent & human #PD1 orthologs uncovered; & targeting thrombospondin-1 (Thbs1) to suppress #HSC #inflammaging!
www.science.org/toc/sciimmun...
www.science.org/toc/sciimmun...
Excited to share our latest work on blood aging! To find out why the blood system changes as people age, we started at the source: hematopoietic stem cells (HSCs) #hemesky 🩸🧬 doi.org/10.1101/2025... 🧵 1/5
September 6, 2025 at 1:33 AM
Excited to share our latest work on blood aging! To find out why the blood system changes as people age, we started at the source: hematopoietic stem cells (HSCs) #hemesky 🩸🧬 doi.org/10.1101/2025... 🧵 1/5
... and here's the #talk!
✅ web1-web2-web3 and read-write-own
✅ 1st, 2nd, & 3rd gen blockchains
✅ hashgraph consensus
✅ HCS, HTS, & HSCS - the #hedera services
✅ hedera governance
👀 Missed it? Here's a recording: www.youtube.com/watch?v=ag-Y...
✅ web1-web2-web3 and read-write-own
✅ 1st, 2nd, & 3rd gen blockchains
✅ hashgraph consensus
✅ HCS, HTS, & HSCS - the #hedera services
✅ hedera governance
👀 Missed it? Here's a recording: www.youtube.com/watch?v=ag-Y...
Hedera TLDR
YouTube video by Hands-on DevRel
www.youtube.com
January 22, 2025 at 2:16 AM
... and here's the #talk!
✅ web1-web2-web3 and read-write-own
✅ 1st, 2nd, & 3rd gen blockchains
✅ hashgraph consensus
✅ HCS, HTS, & HSCS - the #hedera services
✅ hedera governance
👀 Missed it? Here's a recording: www.youtube.com/watch?v=ag-Y...
✅ web1-web2-web3 and read-write-own
✅ 1st, 2nd, & 3rd gen blockchains
✅ hashgraph consensus
✅ HCS, HTS, & HSCS - the #hedera services
✅ hedera governance
👀 Missed it? Here's a recording: www.youtube.com/watch?v=ag-Y...
Our preprint using EGFL7 to expand HSCs is finally out 🥳 www.biorxiv.org/content/10.1...
Regulation of hematopoietic stem cell (HSC) proliferation by Epithelial Growth Factor Like-7 (EGFL7)
Understanding the pathways regulating normal and malignant hematopoietic stem cell (HSC) biology is important for improving outcomes for patients with hematologic disorders. Epithelial Growth Factor L...
www.biorxiv.org
January 23, 2025 at 3:48 PM
Our preprint using EGFL7 to expand HSCs is finally out 🥳 www.biorxiv.org/content/10.1...
Exploiting elevated mitochondrial membrane potential, we used long-chain alkyl-TPP molecules (ex. MitoQ) that selectively accumulate in the mitochondria. These caused reduced mitochondrial respiration, apoptosis, and ablated the competitive advantage of Dnmt3a-mutant HSCs.
April 16, 2025 at 9:02 PM
Exploiting elevated mitochondrial membrane potential, we used long-chain alkyl-TPP molecules (ex. MitoQ) that selectively accumulate in the mitochondria. These caused reduced mitochondrial respiration, apoptosis, and ablated the competitive advantage of Dnmt3a-mutant HSCs.
Led by Gunnar Thompson. We're developing a model of the hypoxic bone marrow that supports hematopoiesis. We show hypoxia & angiocrine signals produced by the marrow vasculature shape HSCs. Strikingly, we must mitigate oxygen shock during isolation using cyclosporin A (a first for in vitro culture)!
June 23, 2025 at 3:26 PM
Led by Gunnar Thompson. We're developing a model of the hypoxic bone marrow that supports hematopoiesis. We show hypoxia & angiocrine signals produced by the marrow vasculature shape HSCs. Strikingly, we must mitigate oxygen shock during isolation using cyclosporin A (a first for in vitro culture)!
Nargis Khan and Maz Divangahi show that β-glucan reprograms HSCs in the bone marrow to generate ‘regulatory’ neutrophils (IL-10hi) which are required for promoting #diseasetolerance and lung tissue integrity against IAV challenge. [1/n]
www.nature.com/articles/s41...
#TrainedImmunity #RegNeuts
www.nature.com/articles/s41...
#TrainedImmunity #RegNeuts
β-Glucan reprograms neutrophils to promote disease tolerance against influenza A virus - Nature Immunology
Divangahi and colleagues report that β-glucan pretreatment before influenza A virus challenge can increase survival by inducing long-term reprogramming of neutrophils, promoting disease tolerance irre...
www.nature.com
February 21, 2025 at 3:39 AM
Nargis Khan and Maz Divangahi show that β-glucan reprograms HSCs in the bone marrow to generate ‘regulatory’ neutrophils (IL-10hi) which are required for promoting #diseasetolerance and lung tissue integrity against IAV challenge. [1/n]
www.nature.com/articles/s41...
#TrainedImmunity #RegNeuts
www.nature.com/articles/s41...
#TrainedImmunity #RegNeuts
#MedSky🧪#Hematopoiesis #Clinicalresearch
#Macrophages and #hematopoieticstemcells teach us that sharing is caring @natureportfolio.bsky.social
rdcu.be/dTV5E
www.science.org/doi/10.1126/...
#Macrophages and #hematopoieticstemcells teach us that sharing is caring @natureportfolio.bsky.social
rdcu.be/dTV5E
www.science.org/doi/10.1126/...
September 14, 2024 at 7:19 AM
#MedSky🧪#Hematopoiesis #Clinicalresearch
#Macrophages and #hematopoieticstemcells teach us that sharing is caring @natureportfolio.bsky.social
rdcu.be/dTV5E
www.science.org/doi/10.1126/...
#Macrophages and #hematopoieticstemcells teach us that sharing is caring @natureportfolio.bsky.social
rdcu.be/dTV5E
www.science.org/doi/10.1126/...
Weekend recommended #stemcell & regenerative reads: chemical reprogramming, fat precursors, HSCs, more ipscell.com/2025/08/week... #stemcells #stemcell
Weekend reads: chemical reprogramming, fat precursors, HSCs - The Niche
Professor discusses recent news on stem cells including chemical reprogramming, which is a way of making stem cells without genetic changes.
ipscell.com
August 31, 2025 at 3:40 PM
Weekend recommended #stemcell & regenerative reads: chemical reprogramming, fat precursors, HSCs, more ipscell.com/2025/08/week... #stemcells #stemcell
so are the types of cis man called what like autoandrophile vs heterosexual cissexual? aap and hscs?
if youre a cis man and dont like looking at your own dick im sorry sweetie but that's called bottom dysphoria there are treatments for it but theyre expensive dont worry there are support groups
if youre a cis man and dont like looking at your own dick im sorry sweetie but that's called bottom dysphoria there are treatments for it but theyre expensive dont worry there are support groups
September 5, 2025 at 7:54 PM
so are the types of cis man called what like autoandrophile vs heterosexual cissexual? aap and hscs?
if youre a cis man and dont like looking at your own dick im sorry sweetie but that's called bottom dysphoria there are treatments for it but theyre expensive dont worry there are support groups
if youre a cis man and dont like looking at your own dick im sorry sweetie but that's called bottom dysphoria there are treatments for it but theyre expensive dont worry there are support groups
Link 👉 amzn.to/4lpxTZ5 ➤ Hyperx HX-HSCS-BK/NA Cloud Stinger Fone de Ouvido
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#ofertas #OfertasEspeciais #OfertaExclusiva #OfertasDaSemana #ofertasdodia #promo #BBB #PRIMEDAY #valetudo
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April 10, 2025 at 2:07 PM
Link 👉 amzn.to/4lpxTZ5 ➤ Hyperx HX-HSCS-BK/NA Cloud Stinger Fone de Ouvido
💳 Em até 6x R$ 58,34
Cartão Mercado Pago:
mpago.li/1hQYCzT
GRUPOS E REDES SOCIAIS:
bio.site/ofertas.dehoje
#ofertas #OfertasEspeciais #OfertaExclusiva #OfertasDaSemana #ofertasdodia #promo #BBB #PRIMEDAY #valetudo
💳 Em até 6x R$ 58,34
Cartão Mercado Pago:
mpago.li/1hQYCzT
GRUPOS E REDES SOCIAIS:
bio.site/ofertas.dehoje
#ofertas #OfertasEspeciais #OfertaExclusiva #OfertasDaSemana #ofertasdodia #promo #BBB #PRIMEDAY #valetudo
Including >500 serial single HSC transplants where direct pair-wise performance of a parent HSCs with multiple daughter HSCs could be assessed in a transplantation setting. 3/7
February 5, 2025 at 10:57 AM
Including >500 serial single HSC transplants where direct pair-wise performance of a parent HSCs with multiple daughter HSCs could be assessed in a transplantation setting. 3/7
🌟#IMMERGE 2025 PI spotlight!
@dimiccolab.bsky.social at OSR reveals how CRISPR-Cas9 in HSCs can trigger senescence-like responses, & provides optimized protocols to preserve edited cells long-term!
1️⃣ pubmed.ncbi.nlm.nih.gov/40466639/
2️⃣ pubmed.ncbi.nlm.nih.gov/40173037/
More highlights coming soon🚀
@dimiccolab.bsky.social at OSR reveals how CRISPR-Cas9 in HSCs can trigger senescence-like responses, & provides optimized protocols to preserve edited cells long-term!
1️⃣ pubmed.ncbi.nlm.nih.gov/40466639/
2️⃣ pubmed.ncbi.nlm.nih.gov/40173037/
More highlights coming soon🚀
September 5, 2025 at 8:40 AM
🌟#IMMERGE 2025 PI spotlight!
@dimiccolab.bsky.social at OSR reveals how CRISPR-Cas9 in HSCs can trigger senescence-like responses, & provides optimized protocols to preserve edited cells long-term!
1️⃣ pubmed.ncbi.nlm.nih.gov/40466639/
2️⃣ pubmed.ncbi.nlm.nih.gov/40173037/
More highlights coming soon🚀
@dimiccolab.bsky.social at OSR reveals how CRISPR-Cas9 in HSCs can trigger senescence-like responses, & provides optimized protocols to preserve edited cells long-term!
1️⃣ pubmed.ncbi.nlm.nih.gov/40466639/
2️⃣ pubmed.ncbi.nlm.nih.gov/40173037/
More highlights coming soon🚀
Recommended reads: gov scientists fear Trump 2nd term, MYCT1 in HSCs, in vivo editing ipscell.com/2024/06/reco...
Recommended reads: gov scientists fear Trump 2nd term, MYCT1 in HSCs, in vivo editing - The Niche
Stem cell biologist discusses recent news in the field including concerns over a possible second Trump term and possible impacts on science.
ipscell.com
June 16, 2024 at 2:38 PM
Recommended reads: gov scientists fear Trump 2nd term, MYCT1 in HSCs, in vivo editing ipscell.com/2024/06/reco...
#HSCS #HSCSW HeartSciences Signs First MyoVista Insights™ Platform Customer, Marking Major Commercial Milestone
https://www.stocktitan.net/news/HSCS/heart-sciences-signs-first-myo-vista-insights-tm-platform-customer-kmz0ahtuv7j6.html
https://www.stocktitan.net/news/HSCS/heart-sciences-signs-first-myo-vista-insights-tm-platform-customer-kmz0ahtuv7j6.html
HeartSciences AI-Powered ECG Platform Lands Major NHS Partnership: UK Healthcare Provider Signs First Commercial Deal
HeartSciences partners with major UK healthcare provider to deploy AI-powered ECG platform. First commercial deal targets NHS patient care improvement. See rollout details.
www.stocktitan.net
May 29, 2025 at 1:00 PM
#HSCS #HSCSW HeartSciences Signs First MyoVista Insights™ Platform Customer, Marking Major Commercial Milestone
https://www.stocktitan.net/news/HSCS/heart-sciences-signs-first-myo-vista-insights-tm-platform-customer-kmz0ahtuv7j6.html
https://www.stocktitan.net/news/HSCS/heart-sciences-signs-first-myo-vista-insights-tm-platform-customer-kmz0ahtuv7j6.html