This study show us that physiology supports a rise from 4.0 to 4.3 mmol/L which leads to:
⚡Fewer hypokalemia episodes
🫀Stabilized resting potential
🔋Fewer ICD shocks & arrhythmias #NephJC
This study show us that physiology supports a rise from 4.0 to 4.3 mmol/L which leads to:
⚡Fewer hypokalemia episodes
🫀Stabilized resting potential
🔋Fewer ICD shocks & arrhythmias #NephJC
From discussions to blog posts warning us about hypokalemia…
We’ve learned that low K⁺ is not benign, especially in cardiac patients
What if high-normal potassium is protective?
From discussions to blog posts warning us about hypokalemia…
We’ve learned that low K⁺ is not benign, especially in cardiac patients
What if high-normal potassium is protective?
To read more: doi.org/10.1007/s115...
To read more: doi.org/10.1007/s115...
go visit and/or play this sick @piss.beauty track and i'll post the updated share link details later. if you're not logged in, your visit/listen will be counted as anonymous
plyr.fm/track/56?ref...
Severe hypomagnesemia can independently cause both hypokalemia (by affecting the ROMK channel in the kidneys) and hypocalcemia (by inducing PTH resistance).
Long-term PPI use can lead to profound hypomagnesemia.
Source: CPS - Episode 431: The Clinical Unknown Series
Severe hypomagnesemia can independently cause both hypokalemia (by affecting the ROMK channel in the kidneys) and hypocalcemia (by inducing PTH resistance).
Long-term PPI use can lead to profound hypomagnesemia.
Source: CPS - Episode 431: The Clinical Unknown Series
Read more: www.cureus.com/articles/448...
#Cureus #MedSky #Endocrinology #Oncology
Read more: www.cureus.com/articles/448...
#Cureus #MedSky #Endocrinology #Oncology
Hi, I'm acute pancreatitis with hypokalemia, hyperlipidemia so bad there's a visible fat layer on my blood samples (triglycerides at 1997 mg/dL), and an A1C of 11.2.
All of this has been reversed now! Great changes are possible!
Hi, I'm Rhabdomyolysis in the middle of Yosemite with the nearest trailhead 22 miles away.
HI, I'm 360s across 4 lanes of busy but not slow I-95 traffic
Hi, I'm acute pancreatitis with hypokalemia, hyperlipidemia so bad there's a visible fat layer on my blood samples (triglycerides at 1997 mg/dL), and an A1C of 11.2.
All of this has been reversed now! Great changes are possible!
KEY LESSONS 🎯:
1. Consider autoimmune diseases (especially Sjögren's) in refractory hypokalemia + distal RTA
2. Sicca symptoms may be subtle - ask specifically about them!
3. HCV can mimic Sjögren's - check viral load
4. Early diagnosis + electrolyte correction = rapid recovery
KEY LESSONS 🎯:
1. Consider autoimmune diseases (especially Sjögren's) in refractory hypokalemia + distal RTA
2. Sicca symptoms may be subtle - ask specifically about them!
3. HCV can mimic Sjögren's - check viral load
4. Early diagnosis + electrolyte correction = rapid recovery
PATHOPHYSIOLOGY of distal RTA in Sjögren's:
Autoimmune attack → absence of H+-ATPase pumps in intercalated cells → can't excrete H+ into urine → H+ retention → metabolic acidosis with normal anion gap.
Increased urinary K+ loss → severe hypokalemia → quadriparesis 💪
PATHOPHYSIOLOGY of distal RTA in Sjögren's:
Autoimmune attack → absence of H+-ATPase pumps in intercalated cells → can't excrete H+ into urine → H+ retention → metabolic acidosis with normal anion gap.
Increased urinary K+ loss → severe hypokalemia → quadriparesis 💪
Muscle enzymes were dramatically elevated:
CK 36,614 IU/L ↑↑↑
AST 348 U/L ↑↑
LDH 404 U/L ↑↑
Initially suggested inflammatory myopathy, BUT:
❌ Acute onset (not gradual)
❌ No rash
❌ Enzymes normalized WITHOUT immunosuppression
Diagnosis: hypokalemia-induced rhabdomyolysis!
Muscle enzymes were dramatically elevated:
CK 36,614 IU/L ↑↑↑
AST 348 U/L ↑↑
LDH 404 U/L ↑↑
Initially suggested inflammatory myopathy, BUT:
❌ Acute onset (not gradual)
❌ No rash
❌ Enzymes normalized WITHOUT immunosuppression
Diagnosis: hypokalemia-induced rhabdomyolysis!
Despite adequate K+ and fluid replacement AND no more vomiting after antiemetics, potassium levels REMAINED critically low! 🚨
This refractory hypokalemia suggested something more than just GI losses.
ABG was ordered and revealed:
pH 7.296 ↓
HCO3- 14.4 mmol/L ↓
Normal anion gap: 11
Despite adequate K+ and fluid replacement AND no more vomiting after antiemetics, potassium levels REMAINED critically low! 🚨
This refractory hypokalemia suggested something more than just GI losses.
ABG was ordered and revealed:
pH 7.296 ↓
HCO3- 14.4 mmol/L ↓
Normal anion gap: 11
Initial labs showed SEVERE electrolyte disturbances:
K+ 1.7 mmol/L ↓↓ (critical!)
Na+ 130.1 mmol/L ↓
Mg2+ 1.05 mg/dL ↓
Working diagnosis: quadriparesis secondary to hypokalemia.
Treatment started: IV fluids, potassium supplementation, antiemetics.
But there was a problem...
Initial labs showed SEVERE electrolyte disturbances:
K+ 1.7 mmol/L ↓↓ (critical!)
Na+ 130.1 mmol/L ↓
Mg2+ 1.05 mg/dL ↓
Working diagnosis: quadriparesis secondary to hypokalemia.
Treatment started: IV fluids, potassium supplementation, antiemetics.
But there was a problem...
#Nephpearls #NephSky
On a mg per mg diuretic potency basis, loop diuretics cause greater K⁺ loss.
However, chlorthalidone is asso. w/ notably frequent hypokalemia in HTN treatment, partly because it is long-acting.
#Nephpearls #NephSky
On a mg per mg diuretic potency basis, loop diuretics cause greater K⁺ loss.
However, chlorthalidone is asso. w/ notably frequent hypokalemia in HTN treatment, partly because it is long-acting.
#ElectrolyteImbalance #PotassiumLevels #Hypokalemia #Hyperkalemia #iPrkashMisgra #MedicalEducation #NursingStudents #MedNotes
#ElectrolyteImbalance #PotassiumLevels #Hypokalemia #Hyperkalemia #iPrkashMisgra #MedicalEducation #NursingStudents #MedNotes