**Abstract:** This research details a novel framework for personalized zinc chelation therapy targeting neurodegenerative disease prevention. By employing a multi-modal data ingestion pipeline and a reinforcement learning (RL) model, we demonstrate the feasibility of dynamically optimizing chelation agent dosage and formulation based on real-time metabolite profiling. This system, termed "NeuroShield", builds on established chelation methodologies but introduces a high level of adaptation and precision not previously achievable, offering a pathway to increased therapeutic efficacy while minimizing potential adverse effects.

Explore the genetic, environmental, and immunological drivers of multiple sclerosis, and how they inform diagnosis and therapeutic strategies targeting both autoimmunity and neuroprotection.

Sterile alpha and TIR motif-containing protein 1 (SARM1),is a central enzyme that drives programmed axon degeneration and has gathered significant interest as a therapeutic target. Despite preclinical...

Sterile alpha and TIR motif-containing protein 1 (SARM1),is a central enzyme that drives programmed axon degeneration and has gathered significant interest as a therapeutic target. Despite preclinical development of inhibitory therapeutic approaches, clear evidence of the role of SARM1 in human neurodegeneration had been missing until recently. New discoveries demonstrate SARM1 involvement in widespread human neurodegenerative processes. Advances in understanding the mechanism of action of SARM1 have revealed key properties for developing the next generation of SARM1 inhibitors for neuroprotection. Unexpectedly, recent discoveries of pyridine-derived specific SARM1 activators have expanded the therapeutic possibilities for SARM1 beyond neuroprotection to include neuroablation. In this review, we discuss evidence linking SARM1 to human disease and the current challenges to developing safe and effective inhibitors. We also review the emerging field of SARM1 activators and their potential for the development of highly selective neuroablative therapeutics.

Neuronal proteasomal dysfunction is a hallmark of neuroinflammatory and neurodegenerative diseases. This study reveals that the interferon-induced immunoproteasome drastically decreases proteasomal ac...

Gene therapy is emerging as a transformative approach for treating amyotrophic lateral sclerosis (ALS), a progressive and fatal neurodegenerative disease. While gene replacement has shown a groundbrea...

Elamipretide TFA (CAS 1606994-55-1), a mitochondria-targeting peptide, is widely studied for cardioprotection, renal improvement, and neuroprotection against oxidative stress. Supplied by a GMP-certified manufacturer, purity ≥99%. Available for wholesale and retail. For laboratory research only.（If you need to place an order or inquire about wholesale product prices, specifications and uses, please contact our staff）

YouTube video by Protocol Labs

RAD-140, also known as Testolone, is a selective androgen receptor modulator (SARM) widely studied for its potential impact on muscle tissue selectivity and neuroprotective pathways. This bottle conta...

YouTube video by Greenhouse for Mental Health Development

A promising drug protects the brain’s blood-brain barrier and halts neurodegeneration in Alzheimer’s models—without targeting amyloid. Could this be the breakthrough medicine has been waiting for?