Well, the weird, spiking, headache has mostly ebbed away. Slept better than anticipated. Took an extra Oxaloacetate which helps, but minor heartburn. Still crashed, but not as poisoned feeling. A little progress. Still very out of it.
January 11, 2026 at 11:04 AM
Well, the weird, spiking, headache has mostly ebbed away. Slept better than anticipated. Took an extra Oxaloacetate which helps, but minor heartburn. Still crashed, but not as poisoned feeling. A little progress. Still very out of it.
Feed: "Oxaloacetate CFS - The Latest In Oxaloacetate Research"
By: Alan Cash on Thursday, January 1, 2026
By: Alan Cash on Thursday, January 1, 2026
Takeaways from the A4M Conference in Las Vegas
Terra Biological recently attended the A4M conference in Las Vegas, where we spent several days speaking directly with physicians about Chronic Fatigue. In total, we connected with more than 400 doctors who are actively looking for better ways to understand, research, and support patients dealing with ongoing fatigue a
oxaloacetatecfs.com
January 2, 2026 at 6:25 PM
Feed: "Oxaloacetate CFS - The Latest In Oxaloacetate Research"
By: Alan Cash on Thursday, January 1, 2026
By: Alan Cash on Thursday, January 1, 2026
Feed: "Oxaloacetate CFS - The Latest In Oxaloacetate Research"
By: Alan Cash on Thursday, December 18, 2025
By: Alan Cash on Thursday, December 18, 2025
Australian Study Maps Linked Vascular, Immune, & Energy Changes in ME/CFS
A newly published, peer-reviewed study from Australia is shedding important light on the biological complexity of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). The research, led by scientists at Macquarie University and published in Cell Reports Medicine, provides compelling evidence that ME/CFS involves
oxaloacetatecfs.com
December 20, 2025 at 5:23 AM
Feed: "Oxaloacetate CFS - The Latest In Oxaloacetate Research"
By: Alan Cash on Thursday, December 18, 2025
By: Alan Cash on Thursday, December 18, 2025
Pumpkin Spice Oxaloacetate
December 12, 2025 at 10:43 PM
Pumpkin Spice Oxaloacetate
Feed: "Oxaloacetate CFS - The Latest In Oxaloacetate Research"
By: Alan Cash on Wednesday, December 10, 2025
By: Alan Cash on Wednesday, December 10, 2025
A New Study explores links between ME/CFS & Long Covid
A groundbreaking research project funded by The ME Association is aiming to uncover the shared biological pathways between ME/CFS and Long COVID. Led by Imperial College London, the three-year initiative—called the Rosetta Stone study—will be the largest investigation of its kind. The study will create a detailed immun
oxaloacetatecfs.com
December 11, 2025 at 2:34 PM
Feed: "Oxaloacetate CFS - The Latest In Oxaloacetate Research"
By: Alan Cash on Wednesday, December 10, 2025
By: Alan Cash on Wednesday, December 10, 2025
Oxaloacetate has been helping me as well, but the imoort duty came to about a third of the cost of the product this time. If I hadn't been bedridden I would have fallen over. It's already very difficult to afford.
Just had to pay £90 import tax on c.£230 (with discount) order of Oxaloacetate.
This pushes it into unaffordability. Yet it really does make a worthwhile difference for me. I hate how expensive ME/CFS vs the pittance of welfare from DWP vs total lack of NHS clinical support.
Cruel Britannia.
This pushes it into unaffordability. Yet it really does make a worthwhile difference for me. I hate how expensive ME/CFS vs the pittance of welfare from DWP vs total lack of NHS clinical support.
Cruel Britannia.
December 11, 2025 at 11:36 AM
Oxaloacetate has been helping me as well, but the imoort duty came to about a third of the cost of the product this time. If I hadn't been bedridden I would have fallen over. It's already very difficult to afford.
Just had to pay £90 import tax on c.£230 (with discount) order of Oxaloacetate.
This pushes it into unaffordability. Yet it really does make a worthwhile difference for me. I hate how expensive ME/CFS vs the pittance of welfare from DWP vs total lack of NHS clinical support.
Cruel Britannia.
This pushes it into unaffordability. Yet it really does make a worthwhile difference for me. I hate how expensive ME/CFS vs the pittance of welfare from DWP vs total lack of NHS clinical support.
Cruel Britannia.
December 11, 2025 at 11:10 AM
Just had to pay £90 import tax on c.£230 (with discount) order of Oxaloacetate.
This pushes it into unaffordability. Yet it really does make a worthwhile difference for me. I hate how expensive ME/CFS vs the pittance of welfare from DWP vs total lack of NHS clinical support.
Cruel Britannia.
This pushes it into unaffordability. Yet it really does make a worthwhile difference for me. I hate how expensive ME/CFS vs the pittance of welfare from DWP vs total lack of NHS clinical support.
Cruel Britannia.
Pyruvate
Acetyl-CoA
Citrate
Isocitrate
Alpha-ketoglutarate
Succinyl-CoA
Succinate
Fumarate
Malate
Oxaloacetate
(Of course, my education was largely scientific...)
Acetyl-CoA
Citrate
Isocitrate
Alpha-ketoglutarate
Succinyl-CoA
Succinate
Fumarate
Malate
Oxaloacetate
(Of course, my education was largely scientific...)
Which lines of poetry live rent-free in your head?
December 9, 2025 at 9:46 AM
Pyruvate
Acetyl-CoA
Citrate
Isocitrate
Alpha-ketoglutarate
Succinyl-CoA
Succinate
Fumarate
Malate
Oxaloacetate
(Of course, my education was largely scientific...)
Acetyl-CoA
Citrate
Isocitrate
Alpha-ketoglutarate
Succinyl-CoA
Succinate
Fumarate
Malate
Oxaloacetate
(Of course, my education was largely scientific...)
News from View from the Trenches of #MyalgicEncephalomyelitis
- Byron Hyde memorial
- Ivabradine now generic
- Oxaloacetate costs how much?
- Research list
- ME/CFS?
open.substack.com/pub/colleens...
- Byron Hyde memorial
- Ivabradine now generic
- Oxaloacetate costs how much?
- Research list
- ME/CFS?
open.substack.com/pub/colleens...
News: 2025 Dec 3
Byron Hyde memorial, Ivabradine now generic, Oxaloacetate costs how much?, Research list, ME/CFS?
open.substack.com
December 4, 2025 at 3:54 PM
News from View from the Trenches of #MyalgicEncephalomyelitis
- Byron Hyde memorial
- Ivabradine now generic
- Oxaloacetate costs how much?
- Research list
- ME/CFS?
open.substack.com/pub/colleens...
- Byron Hyde memorial
- Ivabradine now generic
- Oxaloacetate costs how much?
- Research list
- ME/CFS?
open.substack.com/pub/colleens...
Feed: "Oxaloacetate CFS - The Latest In Oxaloacetate Research"
By: Alan Cash on Tuesday, December 2, 2025
By: Alan Cash on Tuesday, December 2, 2025
Celebrating 20 Years of Oxaloacetate Research at A4M 2025
In 2025 we celebrate 20 years of oxaloacetate research, a journey that's grown from early biochemical insights to clinical applications like Oxaloacetate CFS...
oxaloacetatecfs.com
December 4, 2025 at 2:27 AM
Feed: "Oxaloacetate CFS - The Latest In Oxaloacetate Research"
By: Alan Cash on Tuesday, December 2, 2025
By: Alan Cash on Tuesday, December 2, 2025
Also, there has been a lot of criticism of Terra Biological LLC and its push to use oxaloacetate for the treatment of a number of poorly understood disorders, including PMS. Often a red flag. (Kaufman did move to Seattle, not sure why this article makes such a fuss about it.) psblab.org?p=759
Cashing in on Oxaloacetate | PSBLAB
psblab.org
December 3, 2025 at 8:02 PM
Also, there has been a lot of criticism of Terra Biological LLC and its push to use oxaloacetate for the treatment of a number of poorly understood disorders, including PMS. Often a red flag. (Kaufman did move to Seattle, not sure why this article makes such a fuss about it.) psblab.org?p=759
I've been seeing a lot of fuss over oxaloacetate for ME/CFS recently, a supplement that didn't work for me and caused severe heartburn, and honestly I think Fig. 4 about sums it up www.frontiersin.org/journals/neu...
December 3, 2025 at 6:55 PM
I've been seeing a lot of fuss over oxaloacetate for ME/CFS recently, a supplement that didn't work for me and caused severe heartburn, and honestly I think Fig. 4 about sums it up www.frontiersin.org/journals/neu...
Oxaloacetate, long COVID and ME/CFS: what the new trial shows — and a pragmatic (non-prescriptive) scheme for clinicians
danilobuonsenso.substack.com/p/oxaloaceta...
danilobuonsenso.substack.com/p/oxaloaceta...
Oxaloacetate, long COVID and ME/CFS: what the new trial shows — and a pragmatic (non-prescriptive) scheme for clinicians
Fatigue and cognitive fog remain among the most disabling complaints for people with long COVID and with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS).
danilobuonsenso.substack.com
November 30, 2025 at 5:16 PM
Oxaloacetate, long COVID and ME/CFS: what the new trial shows — and a pragmatic (non-prescriptive) scheme for clinicians
danilobuonsenso.substack.com/p/oxaloaceta...
danilobuonsenso.substack.com/p/oxaloaceta...
Feed: "Oxaloacetate CFS - The Latest In Oxaloacetate Research"
By: Alice Cash on Wednesday, November 26, 2025
By: Alice Cash on Wednesday, November 26, 2025
NDNR Highlights Oxaloacetate as a Breakthrough for CFS & Long Covid
We’re excited to share that oxaloacetate and our ongoing work in ME/CFS and Long COVID research were recently featured in NDNR (Naturopathic Doctor News & Review) in an article authored by Dr. Chris D. Meletis, N.D. The piece, “Oxaloacetate: A Missing Link in CFS, Long-Haul COVID, and Mitochondrial Performance,” hi
oxaloacetatecfs.com
November 27, 2025 at 1:13 AM
Feed: "Oxaloacetate CFS - The Latest In Oxaloacetate Research"
By: Alice Cash on Wednesday, November 26, 2025
By: Alice Cash on Wednesday, November 26, 2025
Feed: "Oxaloacetate CFS - The Latest In Oxaloacetate Research"
By: RICHARD BROWN on Wednesday, November 19, 2025
By: RICHARD BROWN on Wednesday, November 19, 2025
Oxaloacetate CFS Earning Widespread Attention From ME/CFS Research Community
After its launch in 2023, Oxaloacetate CFS immediately gained the attention of the ME/CFS research community. Research collaborations with Stanford University, Mount Sinai Health System, The Bateman Horne Center, University of California Los Angeles, University of Melbourne Australia, University of Michigan and many mo
oxaloacetatecfs.com
November 21, 2025 at 12:18 AM
Feed: "Oxaloacetate CFS - The Latest In Oxaloacetate Research"
By: RICHARD BROWN on Wednesday, November 19, 2025
By: RICHARD BROWN on Wednesday, November 19, 2025
Crossing the capacity threshold, in ME/CFS;
If I do too much, I crash AND sleep bad.
If have coffee I perk up, but sleep even worse.
If I double my Oxaloacetate I get some energy, but heartburn.
If I crash I get air hunger, sleep worse, sound sensitivity, plus all other symptoms much worse.
Yay.
If I do too much, I crash AND sleep bad.
If have coffee I perk up, but sleep even worse.
If I double my Oxaloacetate I get some energy, but heartburn.
If I crash I get air hunger, sleep worse, sound sensitivity, plus all other symptoms much worse.
Yay.
November 20, 2025 at 10:25 AM
Crossing the capacity threshold, in ME/CFS;
If I do too much, I crash AND sleep bad.
If have coffee I perk up, but sleep even worse.
If I double my Oxaloacetate I get some energy, but heartburn.
If I crash I get air hunger, sleep worse, sound sensitivity, plus all other symptoms much worse.
Yay.
If I do too much, I crash AND sleep bad.
If have coffee I perk up, but sleep even worse.
If I double my Oxaloacetate I get some energy, but heartburn.
If I crash I get air hunger, sleep worse, sound sensitivity, plus all other symptoms much worse.
Yay.
Pharma's pockets and supplement providers' pockets ready to bulge. See Oxaloacetate for Me/cfs. $500 for 90 pills.
November 18, 2025 at 3:42 PM
Pharma's pockets and supplement providers' pockets ready to bulge. See Oxaloacetate for Me/cfs. $500 for 90 pills.
Dr Suzanne Vernon explains how oxaloacetate may strengthen the fatigue-cognition axis by restoring efficient cellular metabolism in ME/CFS and Long COVID [8 mins] +Transcript www.youtube.com/watch?v=McZn...
IACFSME 2025 Conference Suzanne D. Vernon, PhD
YouTube video by Bateman Horne Center
www.youtube.com
November 15, 2025 at 11:46 AM
Dr Suzanne Vernon explains how oxaloacetate may strengthen the fatigue-cognition axis by restoring efficient cellular metabolism in ME/CFS and Long COVID [8 mins] +Transcript www.youtube.com/watch?v=McZn...
Fatigue & cognition are linked in #MECFS & #LongCOVID.
At #IACFSME2025, Dr. Suzanne Vernon (BHC Research Director) shared how oxaloacetate may restore energy metabolism & cognitive clarity by strengthening the fatigue-cognition axis.
Watch:
At #IACFSME2025, Dr. Suzanne Vernon (BHC Research Director) shared how oxaloacetate may restore energy metabolism & cognitive clarity by strengthening the fatigue-cognition axis.
Watch:
IACFSME 2025 Conference Susan Vernon, PhD
In this IACFSME 2025 conference highlight, Suzanne D. Vernon, PhD, Research Director at Bateman Horne Center, explains how oxaloacetate may strengthen the fa...
youtu.be
November 13, 2025 at 7:36 PM
Fatigue & cognition are linked in #MECFS & #LongCOVID.
At #IACFSME2025, Dr. Suzanne Vernon (BHC Research Director) shared how oxaloacetate may restore energy metabolism & cognitive clarity by strengthening the fatigue-cognition axis.
Watch:
At #IACFSME2025, Dr. Suzanne Vernon (BHC Research Director) shared how oxaloacetate may restore energy metabolism & cognitive clarity by strengthening the fatigue-cognition axis.
Watch:
Can anecdotally say breath holds are as helpful/beneficial for me as LDN, my supplement regime, Oxaloacetate.
November 10, 2025 at 2:37 PM
Can anecdotally say breath holds are as helpful/beneficial for me as LDN, my supplement regime, Oxaloacetate.
Yes LDN (4mg, 8 drops) is working well thanks, no grumbles. I dream more, but sleep seems unaffected. It seems to play nicely with Oxaloacetate (I do get heartburn at three capsules daily, so I take two), the combo of which I now wouldn't want to be without :) Along with a dozen other supplements...
November 8, 2025 at 5:50 PM
Yes LDN (4mg, 8 drops) is working well thanks, no grumbles. I dream more, but sleep seems unaffected. It seems to play nicely with Oxaloacetate (I do get heartburn at three capsules daily, so I take two), the combo of which I now wouldn't want to be without :) Along with a dozen other supplements...
3) The article also mentions oxaloacetate, but trials of this treatment did not really show an effect and had a conflict of interest.
For more info, see:
x.com/mecfsskeptic/s...
For more info, see:
x.com/mecfsskeptic/s...
November 8, 2025 at 8:36 AM
3) The article also mentions oxaloacetate, but trials of this treatment did not really show an effect and had a conflict of interest.
For more info, see:
x.com/mecfsskeptic/s...
For more info, see:
x.com/mecfsskeptic/s...
Microclots in ME/CFS; which symptoms are indicative of this?
Am mulling revisiting Nattokinase a go again for the hope/lols. Tried it briefly five years ago, but that was before I was on LDN and Oxaloacetate, so may/not have been representative.
Ta, as ever.
#MECFS #MicroClots #Nattokinase
Am mulling revisiting Nattokinase a go again for the hope/lols. Tried it briefly five years ago, but that was before I was on LDN and Oxaloacetate, so may/not have been representative.
Ta, as ever.
#MECFS #MicroClots #Nattokinase
November 6, 2025 at 11:29 AM
Microclots in ME/CFS; which symptoms are indicative of this?
Am mulling revisiting Nattokinase a go again for the hope/lols. Tried it briefly five years ago, but that was before I was on LDN and Oxaloacetate, so may/not have been representative.
Ta, as ever.
#MECFS #MicroClots #Nattokinase
Am mulling revisiting Nattokinase a go again for the hope/lols. Tried it briefly five years ago, but that was before I was on LDN and Oxaloacetate, so may/not have been representative.
Ta, as ever.
#MECFS #MicroClots #Nattokinase
doi.org/10.1038/s415...
"Optimal growth was achieved on 0.1–0.5 µM pyruvate and oxaloacetate and 0.5–1 µM of sulfur-containing amino acids. Cell densities of both strains were significantly lower at 5 µM concentrations of any carbon or sulfur source, ~~."
"Optimal growth was achieved on 0.1–0.5 µM pyruvate and oxaloacetate and 0.5–1 µM of sulfur-containing amino acids. Cell densities of both strains were significantly lower at 5 µM concentrations of any carbon or sulfur source, ~~."
Ecophysiology and global dispersal of the freshwater SAR11-IIIb genus Fontibacterium - Nature Microbiology
Isolates and metagenome-assembled genomes from a global survey show quasi-endemic and cosmopolitan lineages of SAR11-IIIb, with patterns driven by temperature and latitude.
doi.org
November 4, 2025 at 7:52 AM
doi.org/10.1038/s415...
"Optimal growth was achieved on 0.1–0.5 µM pyruvate and oxaloacetate and 0.5–1 µM of sulfur-containing amino acids. Cell densities of both strains were significantly lower at 5 µM concentrations of any carbon or sulfur source, ~~."
"Optimal growth was achieved on 0.1–0.5 µM pyruvate and oxaloacetate and 0.5–1 µM of sulfur-containing amino acids. Cell densities of both strains were significantly lower at 5 µM concentrations of any carbon or sulfur source, ~~."
The BHC explores in detail the recent clinical trial which found that targeting metabolism with Oxaloacetate could help improve both brain function & daily activity in people with ME/CFS. Larger trials & more research is needed to pinpoint the biological mechanisms.
tinyurl.com/mrxbxv8x
tinyurl.com/mrxbxv8x
Deep Dive: Oxaloacetate for Fatigue Reduction
A new clinical trial led by researchers at the Bateman Horne Center (BHC) offers encouraging evidence that targeting metabolism may help improve both brain function and daily activity in people with…
tinyurl.com
October 30, 2025 at 10:10 AM
The BHC explores in detail the recent clinical trial which found that targeting metabolism with Oxaloacetate could help improve both brain function & daily activity in people with ME/CFS. Larger trials & more research is needed to pinpoint the biological mechanisms.
tinyurl.com/mrxbxv8x
tinyurl.com/mrxbxv8x