#polymorphisms
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uowenvirofutures.bsky.social
Seminar today at 12.30pm in 6-210 or online!

Join us for Darko D. Cotoras' seminar titled 'Evolution of the color polymorphisms on Theridiidae spiders from the temperate rainforest of southern South America'

buff.ly/ej64EG9
November 17, 2025 at 9:45 PM
slavov-n.bsky.social
Current efforts focus on predicting transcriptional responses to gene silencing.

Even if spectacularly successful, they leave open key questions:
◾️Functions of genetic mutations & polymorphisms
◾️Proteoform functions
◾️Protein abundance regulation

Biology is complex.
November 13, 2025 at 3:39 PM
gcbias.bsky.social
Congratulations to @jeffgroh.bsky.social on the publication of his paper on an ancient balanced polymorphisms controlling heterodichogamy in two genera of wingnuts. The paper shows the putative turnover & reversal of dominance of a mating type polymorphism
www.sciencedirect.com/science/arti...
Distinct haplotypes and reversed dominance at a single-gene balanced polymorphism controlling heterodichogamy in two genera of wingnuts
In the angiosperm mating system of heterodichogamy, two hermaphroditic morphs temporally alternate between male and female flowering phases, promoting…
www.sciencedirect.com
October 16, 2025 at 3:42 PM
biorxivpreprint.bsky.social
Susceptibility to Penicillin G and Ceftriaxone in Three Clinical Treponema pallidum Isolates is not Altered by Amino Acid Polymorphisms in the Tp0705 Penicillin Binding Protein https://www.biorxiv.org/content/10.1101/2025.10.14.682455v1
October 16, 2025 at 12:17 AM
buttbird.bsky.social
Everyone likes different things in apples. There are 69 single nucleotide polymorphisms identified with apple shape, and 16 of those affect other aspects like taste and texture.

Not every toothshaped RD will be mushy, but they are far more likely to be than round ones.
January 7, 2025 at 7:15 AM
phypapers.bsky.social
Ecology and sexual conflict drive the macroevolutionary dynamics of female-limited colour polymorphisms https://www.biorxiv.org/content/10.1101/2025.02.15.637939v1
February 19, 2025 at 12:45 AM
edrybicki.bsky.social
#CANSA Schafer looking at EphA2 variability and polymorphisms to see if this affects KSHV infectivity, incidence and severity.
November 21, 2024 at 12:32 PM
btschirren.bsky.social
Deadline for our #NERC-funded postdoc position in evolutionary ecology @exetercec.bsky.social is fast approaching 👇👇👇Why are balanced genetic polymorphisms in immune function maintained in natural 🐭populations? tinyurl.com/4dkn64x8 Get in touch if you would like to know more. 🌍🧪🐭🦊🦠🧬🔬
btschirren.bsky.social Barbara Tschirren @btschirren.bsky.social · Oct 31
Interested in host-pathogen interactions and how genetic variation in disease susceptibility is maintained over evolutionary times in wild 🐭? Join us at #ExeterCEC for a 3 year #NERC -funded postdoc position. See jobs.exeter.ac.uk/hrpr_webrecr... for more information.
 
#Evobio #evoeco 🧪🌏🦊🐭
November 15, 2023 at 9:52 AM
biorxivpreprint.bsky.social
Identification of transposable element families from pangenome polymorphisms https://www.biorxiv.org/content/10.1101/2024.04.05.588311v1
Identification of transposable element families from pangenome polymorphisms https://www.biorxiv.org/content/10.1101/2024.04.05.588311v1
Background: Transposable Elements (TEs) are fragments of DNA, typically a few hundred base pairs up
www.biorxiv.org
April 6, 2024 at 2:46 AM
biorxivpreprint.bsky.social
The human immunoglobulin heavy chain constant gene locus is enriched for large complex structural variants and coding polymorphisms that vary in frequency among human populations https://www.biorxiv.org/content/10.1101/2025.02.12.634878v1
February 13, 2025 at 7:33 AM
b3anz1e.bsky.social
care to explain what you're doing here? you baselessly & falsely accused Mr. Tribe of being a Zionist. he's never been called that before

you also say "they're from the Kingdom of Khazaria". I know we're sort of back to square one, but you're saying this in response to the origins of Ashkenazi Jews
Muffin @montrealmuffin.bsky.social she/her "No, they don't. That's fake. Palestinians are from Palestine. European Jews are Europeans who converted to Judaism. Hitler was the one who thought Jews were an alien race in Europe." A Tribe Called Kvetch, PhD @atribecalledkvetch.bsky.social he/him "This is not true, but it's also irrelevant to the broader point - Ashkenazim would not suddenly be allowed to do ethnic cleansing of Palestinians if they had maintained enough endogamy throughout their diasporic existence in Europe." Muffin @montrealmuffin.bsky.social she/her "No, it's true. They're from the Kingdom of Khazaria and were driven West by the Mongols. The idea of a 1st century exile of Jews was a Christian myth where they imagined a holy punishment from God for the death of Jesus. There's no historical evidence to support it." A Tribe Called Kvetch, PhD @atribecalledkvetch.bsky.social he/him "No, it isn't. The Khazar hypothesis is not supported by genetic studies." Muffin @montrealmuffin.bsky.social she/her "Yes it is. Your theory is not supported by any historical evidence." A Tribe Called Kvetch, PhD @atribecalledkvetch.bsky.social he/him "Yeah, I know about Shlomo Sand's historiography. You really don't know what you're talking about. Ashkenazim Y-haplotypes are overwhelmingly middle eastern, with ~12% European admixture. pmc.ncbi.nlm.nih.gov/articles/PMC... " [link to PubMed article. excerpt says: "Jewish and Middle Eastern non-Jewish populations share a common pool of Y-chromosome biallelic haplotypes Haplotypes constructed from Y-chromosome markers were used to trace the paternal origins of the Jewish Diaspora. A set of 18 biallelic polymorphisms ..."] Muffin @montrealmuffin.bsky.social she/her "His book debunks this exact claim" A Tribe Called Kvetch, PhD @atribecalledkvetch.bsky.social he/him "It doesn't, though, because it's not a genetic analysis of any kind." Muffin @montrealmuffin.bsky.social she/her "It's bad science done by people trying to prove the existence of a 'Jewish Race' in a way that would make Hitler proud. He also looked for a 'Jewish Gene'." Muffin @montrealmuffin.bsky.social she her "You have your hasbara, Zionist. I am sure nothing will slow you" A Tribe Called Kvetch, PhD @atribecalledkvetch.bsky.social he/him "This is incredibly embarassing for you." Muffin @montrealmuffin.bsky.social she/her "I'm not embarrassed by Zionists refusing to educate themselves or their attachment to Nazi race science." A Tribe Called Kvetch, PhD @atribecalledkvetch.bsky.social he/him "I started this off by saying Ashkenazic DNA origin would not be an excuse for the ethnic cleansing (genocide) of the Palestinians. I have never posted in favor of the apartheid state. You are so stuck on promoting pseudoscience that you can't help but call me a Zionist anyway." Muffin@montrealmuffin.bsky.social she/her "You are still pushing Zionist mythistory that is based on Nazi race science and is used to justify Zionism. And oppose anything that disagrees. Maybe you should be a bit embarrassed."
June 28, 2025 at 10:55 AM
taltondrumbo.bsky.social
>>

IT AIN'T THE VACCINES...

Neanderthal polymorphisms in autistic probands and siblings

TRANSLATION: NEANDERTHAL DNA LINKED TO AUTISM

These results strongly suggest Neanderthal-derived DNA is playing a significant role in autism susceptibility across major populations in the U.S.

/1 of 3/
Enrichment of a subset of Neanderthal polymorphisms in autistic probands and siblings - Molecular Psychiatry
Molecular Psychiatry - Enrichment of a subset of Neanderthal polymorphisms in autistic probands and siblings
doi.org
July 12, 2025 at 5:28 PM
drelsje.bsky.social
🧬 Language & reading show moderate to high heritability—differences among children are partly inherited.

A polygenic score sums thousands of tiny DNA effects to estimate genetic propensity, but it’s not destiny: environment & chance still matter.

🖼️ many small variants → one polygenic score
A polygenic score (PGS) estimates an individual’s genetic propensity for a trait. Genome-wide association studies (GWAS) identify small effects (β) of many single-nucleotide polymorphisms (SNPs). Each person’s PGS is the sum of their trait-associated alleles weighted by these effects, forming a normal distribution. Figure design by Neil Usher, adapted from Hart, Little & van Bergen (2021, https://www.nature.com/articles/s41539-020-00079-z). Figure from this review paper: https://doi.org/10.31234/osf.io/w23yz_v1
October 6, 2025 at 10:03 AM
biorxiv-evobio.bsky.social
Evolution of novel mimicry polymorphisms through Haldanes sieve and rare recombination https://www.biorxiv.org/content/10.1101/2024.07.24.605018v1
Evolution of novel mimicry polymorphisms through Haldanes sieve and rare recombination https://www.biorxiv.org/content/10.1101/2024.07.24.605018v1
Origins of phenotypic novelty represent a paradox. Maintenance of distinct, canalized morphs usually
www.biorxiv.org
July 25, 2024 at 9:31 AM
psyarxivbot.bsky.social
Emotional modulation of visceral pain is associated with fear of pain and serotonergic polymorphisms: http://osf.io/svneu/
December 1, 2023 at 1:00 PM
kinetoplastpapers.bsky.social
Polymorphisms Influence the Expression of the Fas and FasL Genes in COVID-19 pubmed.ncbi.nlm.nih.gov/39859379/
January 27, 2025 at 5:18 AM
tabulanongrata.bsky.social
I mean, if we're capable of editing these single-gene polymorphisms to give people enhanced capabilities....how about we try curing all the diseases that result from single-gene polymorphisms first? Like, I know you techbros want to be the X-Men, but if you noticed, the X-Men try to *help people*.
December 11, 2024 at 6:07 PM
pharmacopsychiatry.bsky.social
📢 A great weekend read:

The article looks into the relationship between #antidepressant efficacy and seven single nucleotide polymorphisms of ABCB1 and ABCB6 genes, which encode ATP-dependent transport proteins to facilitate the transport of #psychotropic drugs.

💻 lnkd.in/d3cGyDgy
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January 31, 2025 at 3:19 PM
acr-journals.bsky.social
Review summarizes major findings from GWAS studies in Takayasu arteritis, identifies candidate causal genes, and presents a cumulative genetic risk score

In ACR Open Rheumatology
acr.tw/3UI4Y6z
#Medsky #Rheumsky
Gene ontologies (Biological Process) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways main clusters enriched in Takayasu arteritis-related loci. Genes annotated from Takayasu arteritis-associated single-nucleotide polymorphisms in large-scale genetic studies, variants in high linkage disequilibrium with them (r2 > 0.8), and overlapping genes among eQTL and physical interaction annotations were used as input. Metascape web-based portal was used to perform this analysis. Only terms with a P <1 × 10−3 and at least three genes in the term were reported. eQTL, expression quantitative trait loci Cumulative GRS for Takayasu arteritis–associated loci across the major populations of the 1000 Genomes Project phase 3 release. The red histogram represents the GRS including all the genetic susceptibility loci (P < 5 × 10−8), and the blue line depicts the genetic risk in loci annotated to HLA genes. One-way analysis of variance P was < 1 × 10−4 for both the total GRS and the GRS for HLA genes
November 13, 2024 at 1:44 PM
biorxiv-bioinfo.bsky.social
Identification of transposable element families from pangenome polymorphisms https://www.biorxiv.org/content/10.1101/2024.04.05.588311v1
Identification of transposable element families from pangenome polymorphisms https://www.biorxiv.org/content/10.1101/2024.04.05.588311v1
Background: Transposable Elements (TEs) are fragments of DNA, typically a few hundred base pairs up
www.biorxiv.org
April 6, 2024 at 2:46 AM
bedhom.bsky.social
Led by Lauriane Cacheux, our new article about shared chromosomal polymorphisms and hybrids in guenons (Cercopithecus)

@recherche.mnhn.fr #ISYEB

link.springer.com/article/10.1...
Chromosomal Polymorphism in Cercopithecini: Cytogenomics Provides Evidence for Reticulate Evolution and Incomplete Reproductive Isolation - International Journal of Primatology
Reticulate evolution is considered a widespread phenomenon in primates, as hybridization shaped evolutionary histories in all primate radiations, including Catarrhini. While genomic data suggest exten...
link.springer.com
March 20, 2025 at 9:58 AM
isogg.bsky.social
“Genetic studies have identified single nucleotide polymorphisms associated with ancestry as key contributors to lung cancer risk and outcomes, emphasizing the importance of genomic insights for early detection and personalized treatments.” #ISOGG #epigenetics

www.sciencedirect.com/science/arti...
Genetic Ancestry and Lung Cancer in Latin American Patients: A Crucial Step for Understanding a Diverse Population
Lung cancer is the second leading cause of cancer-related deaths in Latin America. While incidence and mortality rates are higher in other populations…
www.sciencedirect.com
May 25, 2025 at 6:39 PM
natcellbio.nature.com
💫NEW: Bi, Mo, Liu et al. carry out high-throughput screening and analysis to profile genome-wide pro-tumor enhancers and uncover enhancer connectomes in #glioma. In particular, they identify specific single-nucleotide polymorphisms associated with glioma risk and progression.
bit.ly/41Snwom
Systematic decoding of functional enhancer connectomes and risk variants in human glioma - Nature Cell Biology
Bi, Mo, Liu et al. carry out high-throughput screening and analysis to profile genome-wide pro-tumour enhancers and uncover enhancer connectomes in glioma. In particular, they identify specific single...
bit.ly
August 25, 2025 at 2:42 PM
ped-neph.bsky.social
Aquaporins (AQPs) are proteins that transport water molecules across membranes. Read this Original Article on the correlation between polymorphisms of the AQP-1 gene & peritoneal function in children on chronic peritoneal dialysis.
link.springer.com/article/10.1...
Correlation between polymorphisms of the aquaporin-1 gene and peritoneal function in children on chronic peritoneal dialysis
October 1, 2025 at 6:43 PM
helixbrief.bsky.social
It highlights the divergent roles of TNF receptor 1 and 2, and how non-selective TNF neutralization disrupts the balance between apoptotic and regenerative pathways. Key signaling cascades and genetic polymorphisms that influence therapeutic response are discussed.
October 12, 2025 at 8:34 AM