#ptau
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apresj20.bsky.social
⏳Chez les personnes symptomatiques depuis plus de 18 mois, l’augmentation de pTau-181 est encore plus marquée, ce qui pourrait présager une détérioration des fonctions cognitives avec l’âge.
January 21, 2026 at 7:18 PM
apresj20.bsky.social
👥 Les 227 patients N-PASC ont été comparés à 227 témoins qui :
- n’avaient pas eu la COVID
- ou n’avaient développé aucun #CovidLong

Aucune augmentation de pTau-181 n’a été observée dans le groupe contrôle.
January 21, 2026 at 7:18 PM
apresj20.bsky.social
📈Résultat central : augmentation moyenne de 59 % de la pTau-181 plasmatique après infection par la #COVID19 chez les personnes atteintes de N-PASC, pendant ou après l’apparition des symptômes neurocognitifs persistants.
January 21, 2026 at 7:18 PM
apresj20.bsky.social
🔬 La protéine mesurée, pTau-181, est une forme anormale de la protéine tau.

Un excès de pTau-181 est classiquement associé à :

- Lésions neuronales durables
- Maladies neurodégénératives, comme #Alzheimer
January 21, 2026 at 7:18 PM
apresj20.bsky.social
🧵🧪Une nouvelle étude publiée dans eBioMedicine montre une augmentation significative de la protéine tau phosphorylée (pTau-181) chez certaines personnes atteintes de #CovidLong avec symptômes neurocognitifs.
January 21, 2026 at 7:18 PM
bhanlon15.bsky.social
Health Day: 'Increased pTau-181 Levels Linked to Neurologic Long COVID'

'Having ≥20 percent increases in pTau-181 associated with increased Aβ40/42 levels and with central neurological symptoms'

www.healthday.com/healthpro-ne...
Increased pTau-181 Levels Linked to Neurologic Long COVID
TUESDAY, Jan. 20, 2026 (HealthDay News) -- Increased phosphorylated Tau-181 (pTau-181) levels are seen in association with neurological manifestations of post-a
www.healthday.com
January 20, 2026 at 5:10 PM
nz-nb.bsky.social
Post-COVID Brain Fog Linked to Elevated pTau-181

https://www.newsbeep.com/nz/241081/

NEW evidence from a prospective cohort study suggests that elevated plasma phosphorylated tau (pTau-181) may be a critical…
Post-COVID Brain Fog Linked to Elevated pTau-181 - New Zealand News Beep
NEW evidence from a prospective cohort study suggests that elevated plasma phosphorylated tau (pTau-181) may be a critical biomarker in patients experiencing
www.newsbeep.com
January 19, 2026 at 5:30 PM
bhanlon15.bsky.social
'Elevated tau in Long COVID patients raises risk for neurodegenerative diseases'

'Overall, the cohort showed a 59 percent increase of tau (pTau-181) in their plasma post COVID-19 infection while or after experiencing neurocognitive symptoms...'

www.news-medical.net/news/2026011...
Elevated tau in Long COVID patients raises risk for neurodegenerative diseases
A study of 227 individuals who experienced neuro cognitive difficulties post COVID-19 infection – such as headaches, vertigo, balance dysregulation, changes in taste/smell, and brain fog – displayed a...
www.news-medical.net
January 19, 2026 at 4:42 PM
virussucks.com
Why do clinicians still think that exercise therapies will help this surge in ataxia cases without a full neurological work up, including pTau-181 and amyloid biomarker signals, as well as testing for SARSCoV2 virus in platelets and subtle changes in brain structure.

Anti-platelet therapy may help.
January 17, 2026 at 12:32 PM
winslowsp.bsky.social
=> tauopathie induite par inflammation/infection, différente de l’Alzheimer « classique »? Processus neurodégénératif déclenché?

Quoiqu'il en soit les auteurs montrent que plus le COVID long neurologique dure, plus le pTau-181 augmente.
8/11
January 17, 2026 at 12:28 PM
winslowsp.bsky.social
Dans cette étude, l’augmentation de pTau-181 survient souvent sans amyloïdose franche, ou avec des changements atypiques (amyloïde modérément perturbée, tau disproportionnellement élevée, NfL/GFAP parfois en baisse : très atypique).
7/11
January 17, 2026 at 12:28 PM
winslowsp.bsky.social
👉 La méthodologie est intéressante. Les auteurs disposent de biomarqueurs avant l’infection, biomarqueurs après l’infection, groupes contrôles appariés.
Cela montre que le pTau-181 était normal avant le COVID, qu'il augmente après, spécifiquement chez ceux qui développent un #COVIDlong Neuro :
5/11
January 17, 2026 at 12:28 PM
winslowsp.bsky.social
Or le biomarqueur pTau-181 est habituellement un marqueur précoce et spécifique des maladies neurodégénératives (Alzheimer et apparentées).
Résultats marquants : l’étude montre que 58,6% des patients avec COVID long neurologique présentent une augmentation marquée de pTau-181,
3/11
Graphe avec deux niveaux (jaune : COVID long, gris, covid résolu), covid résolus ou COVID long neuros, et les niveaux de 5 marqueurs : de gauche à droite, p tau181, ab 40-42, NfL, GFAP,IAB. On voit le pTau très élevé en jaune par rapport au COVID résolu
January 17, 2026 at 12:28 PM
winslowsp.bsky.social
#CovidLongNeuro et tauopathie. Dans une étude de cohorte prospective avant/après l'apparition du COVID, 58,6% des patients CL présentant des symptômes neuro présentaient une ↗️ progressive et anormale d’un biomarqueur de tauopathie (pTau-181).

🔗 www.thelancet.com/jo...
1/11
January 17, 2026 at 12:27 PM
plasmapineapple.bsky.social
Increased phosphorylated tau (pTau-181) is associated with neurological post-acute sequelae of coronavirus disease in essential workers: a prospective cohort study before and after COVID-19 onset — Yang et al.

#MECFS

www.sciencedirect.com/science...
January 17, 2026 at 11:15 AM
profesterman.bsky.social
www.sciencedirect.com/science/arti...
Study of essential workers finds neurological Long COVID linked to rises in plasma pTau-181 after infection, especially with long-lasting central symptoms (brain fog etc). pTau-181 increases assoc. with amyloid changes. Early biomarker signal, not diagnosis.
Increased phosphorylated tau (pTau-181) is associated with neurological post-acute sequelae of coronavirus disease in essential workers: a prospective cohort study before and after COVID-19 onset
The COVID-19 pandemic led to a spectrum of post-acute sequelae including several neurological complications including cognitive dysfunction labelled N…
www.sciencedirect.com
January 17, 2026 at 11:06 AM
リン酸化タウ（pTau-181）の増加は、必須労働者におけるCOVID-19発症前後の前向きコホート研究において、COVID-19の神経学的急性後遺症（PASC）と関連している

www.sciencedirect.com/science/arti...

ChatGTP 5.2,素人質問

chatgpt.com/share/696b1e...

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Increased phosphorylated tau (pTau-181) is associated with neurological post-acute sequelae of coronavirus disease in essential workers: a prospective cohort study before and after COVID-19 onset
The COVID-19 pandemic led to a spectrum of post-acute sequelae including several neurological complications including cognitive dysfunction labelled N…
www.sciencedirect.com
January 17, 2026 at 5:33 AM
bhanlon15.bsky.social
Respiratory Therapy: 'Alzheimer’s Protein Detected in Long COVID Patients'

'Individuals with neurological post-acute sequelae of COVID-19 (N-PASC) showed a 59% increase in plasma pTau-181....'

respiratory-therapy.com/disorders-di...
Alzheimer's Protein Detected in Long COVID Patients
Patients with neurocognitive difficulties post COVID-19 infection had elevated levels of a protein found in many Alzheimer’s patients.
respiratory-therapy.com
January 16, 2026 at 2:33 PM
drinfosec.bsky.social
From 👆

"A large UK Biobank longitudinal analysis in Nature Medicine - Duff et al., 2025 -compared plasma Alzheimer’s-related biomarkers before vs after SARS-CoV-2 infection (with matched controls).
They found that SARS-CoV-2 infection was associated with a shift toward..."
Related evidence. A large UK Biobank longitudinal analysis in Nature Medicine - Duff et al., 2025 -compared plasma Alzheimer’s-related biomarkers before vs after SARS-CoV-2 infection (with matched controls). They found that SARS-CoV-2 infection was associated with a shift toward an AD-like biomarker profile - notably a reduced plasma Aβ42:Aβ40 ratio, and in more vulnerable participants lower Aβ42 and higher pTau-181.
January 16, 2026 at 2:19 PM
drinfosec.bsky.social
In a follow up post, Zdenek shares another study that also points to persistent neuro symptoms before & after Covid

"...A true before/after design, a clear tau signal in persistent neurological symptoms, and nearly half exceeding..."

7-tweet 🧵
threadreaderapp.com/thread/20120...

#SARS-CoV-2
"One of the strongest - and most concerning - studies so far. A true before/after design, a clear tau signal in persistent neurological symptoms, and nearly half exceeding Alzheimer’s research pTau-181 thresholds🧵" The subthread (also by Zdenek) is here: https://bsky.app/profile/drinfosec.bsky.social/post/3mciksdvk7s2g
January 16, 2026 at 2:18 PM
safetyinnumbers.bsky.social
The study that probably prompted reposting above: Jan 2026 study in eBioMedicine showed Long-COVID w/ cognitive/neurological symptoms had biomarker changes (in pTau-181) which often predict cognitive decline, similar to changes seen in Alzheimer's disease.

www.sciencedirect.com/science/arti...
Increased phosphorylated tau (pTau-181) is associated with neurological post-acute sequelae of coronavirus disease in essential workers: a prospective cohort study before and after COVID-19 onset
The COVID-19 pandemic led to a spectrum of post-acute sequelae including several neurological complications including cognitive dysfunction labelled N…
www.sciencedirect.com
January 16, 2026 at 2:30 AM
tomkindlon.bsky.social
Increased phosphorylated tau (pTau-181) is associated with neurological post-acute sequelae of coronavirus disease in essential workers

www.sciencedirect.com/science/arti...

Screenshot from Science for ME update

#LongCovid #COVIDBrain #NeuroPASC #PASC
Increased phosphorylated tau (pTau-181) is associated with neurological post-acute sequelae of coronavirus disease in essential workers: a prospective cohort study before and after COVID-19 onset — Yang et al. "The fact that average elevation in pTau-181 grew over the observational period may, if replicated longitudinally, suggest a temporal lag between COVID-19 onset and increases in circulating levels of tau phosphorylation."
January 15, 2026 at 11:33 PM
virussucks.com
Impact of Multiple #COVID Infections (Re-infection)

The study explicitly identified SARS-CoV-2 re-infection as a recognized risk factor for developing N-PASC.

#LongCOVID
#neuroCOVID
#medsky
The following details the statistical risks (adjusted Relative Risk, or aRR) linking specific symptoms to a \ge20\% increase in pTau-181, as well as the impact of COVID-19 re-infection on the study cohort. Symptom-Specific Risk for Increased pTau-181 The study found that central nervous system symptoms were most strongly associated with significant increases in pTau-181 levels. | Residual Symptom | aRR (95% CI) | P-value | |---|---|---| | Any Central Nervous System | 1.31 (1.09–1.58) | 0.004 | | Muscle Weakness | 1.30 (1.08–1.57) | 0.006 | | Loss of Taste/Smell | 1.30 (1.07–1.59) | 0.010 | | Any Peripheral Nervous System | 1.28 (1.04–1.56) | 0.018 | | Anxiety or Depression | 1.26 (1.05–1.53) | 0.016 | | Brain Fog | 1.22 (1.00–1.48) | 0.047 | Impact of Multiple Infections (Re-infection) The study explicitly identified SARS-CoV-2 re-infection as a recognized risk factor for developing N-PASC. * Increased Risk Factor: Alongside factors like COVID-19 severity and pre-existing medical comorbidities (obesity, diabetes, COPD), re-infection was noted as a contributor to the likelihood of developing persistent neurological symptoms. * Vulnerability Context: The researchers observed that N-PASC was more common in individuals who developed COVID-19 before vaccinations were available. * Long-Term Progression: While the specific statistical aRR for "re-infection vs. single infection" regarding pTau-181 levels was not detailed in the provided table, the study emphasized that those with longer-duration symptoms (>1.5 years) showed the highest increases in pTau-181 (56.5% elevation).
January 15, 2026 at 10:42 PM
drinfosec.bsky.social
Direct link to the research mentioned in the post👆

Increased phosphorylated tau (pTau-181) is associated with neurological post-acute sequelae of coronavirus disease in essential workers: a prospective cohort study before and after COVID-19 onset (Jan 7)
www.thelancet.com/journals/ebi...

[ PDF 🎉]
Increased phosphorylated tau (pTau-181) is associated with neurological post-acute sequelae of coronavirus disease in essential workers: a prospective cohort study before and after COVID-19 onset
N-PASC with symptoms consistent with central damage were associated with increased pTau-181 levels. Increases in pTau-181 were associated with increased risk of changes to amyloid biomarkers consisten...
www.thelancet.com
January 15, 2026 at 9:50 PM
drinfosec.bsky.social
🚨🚨🧵by Zdenek Vrozina on XTwitter:

"In people with neurological long COVID, infection is followed by a significant increase in pTau-181, and in a subset this is accompanied by changes in amyloid markers!
This biomarker pattern is compatible with..."

15-tweet 🧵
threadreaderapp.com/thread/20115...
In people with neurological long COVID, infection is followed by a significant increase in pTau-181, and in a subset this is accompanied by changes in amyloid markers! This biomarker pattern is compatible with tau-related pathology and may point to a worse long-term prognosis🧵
January 15, 2026 at 9:48 PM