We investigated 6 genes in the lab associated with NDD 🧠. Using a luciferase assay, we found the expression of 4/6 genes increased by excluding a uORF-containing exon! 📈 Laying the groundwork for SSO investigations 🔎
December 10, 2025 at 11:11 AM
We investigated 6 genes in the lab associated with NDD 🧠. Using a luciferase assay, we found the expression of 4/6 genes increased by excluding a uORF-containing exon! 📈 Laying the groundwork for SSO investigations 🔎
Congratulations to our Sectional Pitch Master Dr. Whitney Besse for winning 1st place at the 2025 Yale Life Science PitchFest live pitch session for her project PKD1 UORF-Blocking ASOs as Therapy for ADPKD!!
So impressed, so proud!! @yaleventures.bsky.social
So impressed, so proud!! @yaleventures.bsky.social
December 9, 2025 at 11:34 PM
Congratulations to our Sectional Pitch Master Dr. Whitney Besse for winning 1st place at the 2025 Yale Life Science PitchFest live pitch session for her project PKD1 UORF-Blocking ASOs as Therapy for ADPKD!!
So impressed, so proud!! @yaleventures.bsky.social
So impressed, so proud!! @yaleventures.bsky.social
Jim is Gone! - The Office US
YouTube video by The Office
www.youtube.com
September 11, 2025 at 2:59 AM
MotoTec Renegade 40cc Kids Gas ATV | Real Ride or Just a Toy? - YouTube www.youtube.com/watch?v=Uorf...
MotoTec Renegade 40cc Kids Gas ATV | Real Ride or Just a Toy?
YouTube video by Best Buys Reviewed
www.youtube.com
September 5, 2025 at 2:35 AM
MotoTec Renegade 40cc Kids Gas ATV | Real Ride or Just a Toy? - YouTube www.youtube.com/watch?v=Uorf...
Thrilled to share that our paper is finally out in Science Advances!
We uncovered how a uORF-encoded microprotein can control mitochondrial biology and lipid metabolism in brown fat. So proud of this work! www.science.org/doi/10.1126/...
We uncovered how a uORF-encoded microprotein can control mitochondrial biology and lipid metabolism in brown fat. So proud of this work! www.science.org/doi/10.1126/...
Abnormal mitochondrial structure and function in brown adipose tissue of SLC35A4-MP knockout mice
A uORF-encoded microprotein, SLC35A4-MP, modulates mitochondrial morphology and function in brown adipose tissue.
www.science.org
August 29, 2025 at 8:23 PM
Thrilled to share that our paper is finally out in Science Advances!
We uncovered how a uORF-encoded microprotein can control mitochondrial biology and lipid metabolism in brown fat. So proud of this work! www.science.org/doi/10.1126/...
We uncovered how a uORF-encoded microprotein can control mitochondrial biology and lipid metabolism in brown fat. So proud of this work! www.science.org/doi/10.1126/...
Toward a model of uORF-mediated translational control: An integrated bioinformatic and experimental approach [new]
uORFs regulate translation via sequence, position, and interactions; model proposes initiation/recycling/stall.
uORFs regulate translation via sequence, position, and interactions; model proposes initiation/recycling/stall.
August 1, 2025 at 1:08 AM
Toward a model of uORF-mediated translational control: An integrated bioinformatic and experimental approach [new]
uORFs regulate translation via sequence, position, and interactions; model proposes initiation/recycling/stall.
uORFs regulate translation via sequence, position, and interactions; model proposes initiation/recycling/stall.
Toward a model of uORF-mediated translational control: An integrated bioinformatic and experimental approach https://www.biorxiv.org/content/10.1101/2025.07.28.667205v1
August 1, 2025 at 12:45 AM
Toward a model of uORF-mediated translational control: An integrated bioinformatic and experimental approach https://www.biorxiv.org/content/10.1101/2025.07.28.667205v1
Toward a model of uORF-mediated translational control: An integrated bioinformatic and experimental approach https://www.biorxiv.org/content/10.1101/2025.07.28.667205v1
August 1, 2025 at 12:45 AM
Toward a model of uORF-mediated translational control: An integrated bioinformatic and experimental approach https://www.biorxiv.org/content/10.1101/2025.07.28.667205v1
Another set of uORF impact mutations very likely to be causal in this set (uORFs - changes in UTR sequences which make or destroy an upstream ORF - uORF - often key for regulation)
New Publication:
Whole Genome Sequencing of "Mutation-Negative" Individuals With Cornelia de Lange Syndrome
@uoe-igc.bsky.social
doi.org/10.1155/humu...
Whole Genome Sequencing of "Mutation-Negative" Individuals With Cornelia de Lange Syndrome
@uoe-igc.bsky.social
doi.org/10.1155/humu...
Whole Genome Sequencing of “Mutation‐Negative” Individuals With Cornelia de Lange Syndrome
This study was aimed at assessing the diagnostic utility of whole genome sequence analysis in a well-characterised research cohort of individuals referred with a clinical suspicion of Cornelia de Lan....
doi.org
July 29, 2025 at 12:19 PM
Another set of uORF impact mutations very likely to be causal in this set (uORFs - changes in UTR sequences which make or destroy an upstream ORF - uORF - often key for regulation)
For example, the 5′-UTR of the CKS2 RNA populates two conformations, one promoting increased translation of a uORF, and one reducing translation of the main ORF. (7/n)
July 27, 2025 at 5:03 PM
For example, the 5′-UTR of the CKS2 RNA populates two conformations, one promoting increased translation of a uORF, and one reducing translation of the main ORF. (7/n)
“Westland Trojan Barrow | Setup & Breakdown Timelapse! #shorts“ 🎥 Watch here: www.youtube.com/watch?v=uORF... 👍 Like, share & subscribe for more fishing action! #Fishing #Angling #FishingUK #CatchAndRelease #FishingLife
Westland Trojan Barrow | Setup & Breakdown Timelapse! #shorts
Check out this 5x speed timelapse of dismantling and rebuilding the Westland Trojan Barrow — a must-have bit of kit for serious anglers. Whether you’re carp ...
www.youtube.com
July 6, 2025 at 3:28 PM
“Westland Trojan Barrow | Setup & Breakdown Timelapse! #shorts“ 🎥 Watch here: www.youtube.com/watch?v=uORF... 👍 Like, share & subscribe for more fishing action! #Fishing #Angling #FishingUK #CatchAndRelease #FishingLife
Plant Science Research Weekly June 27 2025 plantae.org/plant-scienc... (3/3) Elucidation and recreation of the biosynthetic pathway for taxol; ABA2 uORF regulates germination timing; A phosphorylation switch balances growth and stress response in cotton
June 27, 2025 at 6:53 AM
Plant Science Research Weekly June 27 2025 plantae.org/plant-scienc... (3/3) Elucidation and recreation of the biosynthetic pathway for taxol; ABA2 uORF regulates germination timing; A phosphorylation switch balances growth and stress response in cotton
A bacterial regulatory uORF senses multiple classes of ribosome-targeting antibiotics
elifesciences.org/articles/101...
elifesciences.org/articles/101...
A bacterial regulatory uORF senses multiple classes of ribosome-targeting antibiotics
An upstream open-reading frame in Escherichia coli regulates expression of the downstream genes in response to diverse translation stresses.
elifesciences.org
June 3, 2025 at 7:05 AM
A bacterial regulatory uORF senses multiple classes of ribosome-targeting antibiotics
elifesciences.org/articles/101...
elifesciences.org/articles/101...
Cool new work explaining the dynamics of mRNA translation with the ribosome to inhibit SG localization- by the Moon Lab
#ribosomes #uORF #mRNATranslation #StressResponse
genesdev.cshlp.org/content/earl...
#ribosomes #uORF #mRNATranslation #StressResponse
genesdev.cshlp.org/content/earl...
Ribosome association inhibits stress-induced gene mRNA localization to stress granules
A biweekly scientific journal publishing high-quality research in molecular biology and genetics, cancer biology, biochemistry, and related fields
genesdev.cshlp.org
May 15, 2025 at 2:00 PM
Cool new work explaining the dynamics of mRNA translation with the ribosome to inhibit SG localization- by the Moon Lab
#ribosomes #uORF #mRNATranslation #StressResponse
genesdev.cshlp.org/content/earl...
#ribosomes #uORF #mRNATranslation #StressResponse
genesdev.cshlp.org/content/earl...
Inhibitors of eIF1A-ribosome interaction unveil uORF-dependent regulation of translation initiation and antitumor and antiviral effects
Rivka Dikstein and colleagues
www.embopress.org/doi/full/10....
Rivka Dikstein and colleagues
www.embopress.org/doi/full/10....
May 14, 2025 at 10:46 AM
Inhibitors of eIF1A-ribosome interaction unveil uORF-dependent regulation of translation initiation and antitumor and antiviral effects
Rivka Dikstein and colleagues
www.embopress.org/doi/full/10....
Rivka Dikstein and colleagues
www.embopress.org/doi/full/10....
A paper using RRID:Addgene_123230 was just published in Scientific Reports see "A novel uORF regulates folliculin to promote cell growth and lysosomal biogenesis during cardiac stress". Thank you for making your methods matter! #reproducibility #STMpublishing
doi.org
April 2, 2025 at 7:00 AM
A paper using RRID:Addgene_123230 was just published in Scientific Reports see "A novel uORF regulates folliculin to promote cell growth and lysosomal biogenesis during cardiac stress". Thank you for making your methods matter! #reproducibility #STMpublishing
RRID:Addgene_12259, was just reported to be used in "Non-AUG HIV-1 uORF translation elicits specific T cell immune response and regulates viral transcript expression". RRIDs like this improve reproducibility in scientific research. #RRID #methodsmatter
doi.org
March 27, 2025 at 10:12 PM
RRID:Addgene_12259, was just reported to be used in "Non-AUG HIV-1 uORF translation elicits specific T cell immune response and regulates viral transcript expression". RRIDs like this improve reproducibility in scientific research. #RRID #methodsmatter
ME: Anyway, what I'm proposing here is a slight orthographic reform to make spelled-out numbers follow alphabetical order, like this: One, Two, Twree, Uorf, Vive, Ziks, Ziven, Zöight, Zyne, Zzen.
WOMAN NAMED MIRIAM WEBSTER ON OUR FIRST DATE: Is this why you swept right
WOMAN NAMED MIRIAM WEBSTER ON OUR FIRST DATE: Is this why you swept right
March 21, 2025 at 8:23 PM
ME: Anyway, what I'm proposing here is a slight orthographic reform to make spelled-out numbers follow alphabetical order, like this: One, Two, Twree, Uorf, Vive, Ziks, Ziven, Zöight, Zyne, Zzen.
WOMAN NAMED MIRIAM WEBSTER ON OUR FIRST DATE: Is this why you swept right
WOMAN NAMED MIRIAM WEBSTER ON OUR FIRST DATE: Is this why you swept right
HIV-1 uses a non-AUG uORF for protein translation, activating a specific T cell response and modulating transcript expression. Fascinating insights into viral strategy! #HIVResearch PMID:39966383, Nat Commun 2025, @NatureComms https://doi.org/10.1038/s41467-025-56772-3 #Medsky #Pharmsky #RNA 🧪
Non-AUG HIV-1 uORF translation elicits specific T cell immune response and regulates viral transcript expression | Nature Communications
Human immunodeficiency virus type-1 (HIV-1) is a complex retrovirus that relies on alternative splicing, translational, and post-translational mechanisms to produce over 15 functional proteins from its single ~10 kb transcriptional unit. Using ribosome profiling, nascent protein labeling, RNA sequencing, and whole-proteomics of infected CD4 + T lymphocytes, we characterized the transcriptional, translational, and post-translational landscape during infection. While viral infection exerts a significant impact on host transcript abundance, global translation rates are only modestly affected. Proteomics data reveal extensive transcriptional and post-translational regulation, with many genes showing opposing trends between transcript/ribosome profiling and protein abundance. These findings highlight a complex regulatory network orchestrating gene expression at multiple levels. Viral ribosome profiling further uncovered extensive non-AUG translation of small peptides from upstream open read
doi.org
March 17, 2025 at 12:10 AM
HIV-1 uses a non-AUG uORF for protein translation, activating a specific T cell response and modulating transcript expression. Fascinating insights into viral strategy! #HIVResearch PMID:39966383, Nat Commun 2025, @NatureComms https://doi.org/10.1038/s41467-025-56772-3 #Medsky #Pharmsky #RNA 🧪
A paper using RRID:Addgene_12260 was just published in The EMBO Journal see "MCTS2 and distinct eIF2D roles in uORF-dependent translation regulation revealed by in vitro re-initiation assays". Thank you for making your methods matter! #accelerateopenscience #RRID
doi.org
March 6, 2025 at 8:01 AM
A paper using RRID:Addgene_12260 was just published in The EMBO Journal see "MCTS2 and distinct eIF2D roles in uORF-dependent translation regulation revealed by in vitro re-initiation assays". Thank you for making your methods matter! #accelerateopenscience #RRID
Whorfian social butterfly.
.le selsa'a toldi pe la .uorf. bangu jinvi
The cultural symbol of Wolf's language expresses a view.
.le selsa'a toldi pe la .uorf. bangu jinvi
The cultural symbol of Wolf's language expresses a view.
February 22, 2025 at 4:36 PM
Whorfian social butterfly.
.le selsa'a toldi pe la .uorf. bangu jinvi
The cultural symbol of Wolf's language expresses a view.
.le selsa'a toldi pe la .uorf. bangu jinvi
The cultural symbol of Wolf's language expresses a view.
Non-AUG #HIV-1 uORF translation elicits specific T cell immune response and regulates viral transcript expression www.nature.com/articles/s41... (open access) @naturecomms.bsky.social
Non-AUG HIV-1 uORF translation elicits specific T cell immune response and regulates viral transcript expression - Nature Communications
Here, integrating ribosome profiling, RNA-seq and proteomics to reveal transcriptional and post-translational regulation in HIV-infected T cells, the authors show that non-AUG translation of viral ups...
www.nature.com
February 18, 2025 at 10:31 PM
Non-AUG #HIV-1 uORF translation elicits specific T cell immune response and regulates viral transcript expression www.nature.com/articles/s41... (open access) @naturecomms.bsky.social
Are you interested in plant development? Looking for new opportunities? We are hiring!
2-year Postdoc position at the SignalFlow Lab at the University
of Valencia in the uORF-LEGADAPT project. The
project will be in collaboration with the group of
Johannes Hanson at Umea Plant Science Center.
2-year Postdoc position at the SignalFlow Lab at the University
of Valencia in the uORF-LEGADAPT project. The
project will be in collaboration with the group of
Johannes Hanson at Umea Plant Science Center.
February 14, 2025 at 11:04 AM
Are you interested in plant development? Looking for new opportunities? We are hiring!
2-year Postdoc position at the SignalFlow Lab at the University
of Valencia in the uORF-LEGADAPT project. The
project will be in collaboration with the group of
Johannes Hanson at Umea Plant Science Center.
2-year Postdoc position at the SignalFlow Lab at the University
of Valencia in the uORF-LEGADAPT project. The
project will be in collaboration with the group of
Johannes Hanson at Umea Plant Science Center.
Worf would nod at the warp and weft.
la .uorf ka'e toldi fi le kliti e le vliku
Wolf can become a butterfly from/out of the cliff and the wolf.
la .uorf ka'e toldi fi le kliti e le vliku
Wolf can become a butterfly from/out of the cliff and the wolf.
January 30, 2025 at 7:07 PM
Worf would nod at the warp and weft.
la .uorf ka'e toldi fi le kliti e le vliku
Wolf can become a butterfly from/out of the cliff and the wolf.
la .uorf ka'e toldi fi le kliti e le vliku
Wolf can become a butterfly from/out of the cliff and the wolf.