Richard M. Carpiano

Some say that the incident is yet another glimpse of the tense climate experienced on local and national campuses by people who support Palestine.

Rush will head out on a reunion tour in 2026, with Geddy Lee and Alex Lifeson joined by a new drummer. The tour will pay homage to the late Neil Peart.

Background Weight gain after starting antihypertensive medications is a frequent concern for patients, but there is limited data on expected weight change after initiation of these medications. A comparative effectiveness trial to evaluate this outcome would not be feasible. Objective To estimate and compare average weight change under initiating and adhering to commonly prescribed, first-line antihypertensive medications as monotherapy by emulating a target trial. Design Retrospective observational cohort study over 24 months of follow-up using electronic health records (EHR). Participants 141,260 patients prescribed one of seven antihypertensives between 2010 and 2019 across 8 US health systems. Main Outcome and Measures We examined mean weight change associated with initiation of and adherence to amlodipine, atenolol, hydrochlorothiazide, losartan, metoprolol, or propranolol, relative to lisinopril, at 6, 12, and 24 months after initiation. To adjust for baseline confounding and informative outcome measurement, we used inverse probability weighting with repeated outcome marginal structural models. Key Results After baseline and time-varying covariate adjustment, initiation of and adherence to lisinopril were associated with mean weight loss at 6 months (− 0.69 kg, 95% CI − 0.92, − 0.47), 12 months (− 0.58 kg, 95% CI − 1.05, − 0.30), and 24 months (− 1.121 kg, 95% CI − 2.013, − 0.46). Compared to lisinopril, the estimated 6-month weight change was higher for patients prescribed hydrochlorothiazide (0.68 kg, 95% CI 0.31, 1.04), losartan (0.54 kg, 95% CI 0.17, 0.93), metoprolol (1.38 kg, 95% CI 0.95, 1.76), and propranolol (1.03 kg, 95% CI 0.346, 1.62). At 12 months, metoprolol (1.74 kg, 95% CI 1.03, 2.41) and propranolol (1.72 kg, 95% CI 0.06, 3.235) continued to show higher weight change compared to lisinopril. Conclusion We observed small differences in weight change across antihypertensive medications, with lisinopril leading to weight loss and metoprolol and propranolol to modest weight gain. Clinicians should consider potential weight gain when selecting antihypertensive medications.

As part of a multi-pronged deal with Pfizer, President Trump announced a new government website called “TrumpRx,” where he says Americans can buy discounted drugs directly from manufacturers. Co-Founder of The Contrarian, Norm Eisen, tells Ali Velshi that Americans are “already getting lower prices” because of the Affordable Care Act, and TrumpRx is “another example of President Trump deceiving and distracting” for political gain.

Campaigning in Pennsylvania last September, JD Vance seemed to strike at an unlikely political foe: the besieged president of Ukraine, Volodymyr Zelensky, who’d spent most of the previous two years be...

YouTube video by Led Zeppelin - Topic

The U.S. measles outbreak has reached 1,514 confirmed cases, the highest number of cases in over 30 years since the disease was declared eliminated. Texas health officials declared the large outbreak ...

Gossip about Kristi Noem and Corey Lewandowski has persisted for several years now.

Recipient diagnosed with brain death received a type-O organ, which is compatible with all blood types.