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Alessandro Gozzi

@gozziale.bsky.social

1K followers 710 following 110 posts

Senior scientist at Istituto Italiano di Tecnologia (Rovereto, Italy) 🧠 🐁 Functional Neuroimaging, Brain (dys)connectivity and Autism ERC Grantee https://www.iit.it/it/people-details/-/people/alessandro-gozzi

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Neuroscience 77%

Biology 18%

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Alessandro Gozzi @gozziale.bsky.social · Mar 6

Can we use brain scans to identify biologically distinct "autisms"? And If so, how?

In our latest cross-species study 🐭👨 with @iitalk.bsky.social we dive into these questions!

Find out more here 👇👇
www.biorxiv.org/content/10.1...

Thread below 🧵 1/n

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Alessandro Gozzi @gozziale.bsky.social · 7d

Anytime!! (And thanks!!)

Alessandro Gozzi @gozziale.bsky.social · 7d

Congrats!!!

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Reposted by Alessandro Gozzi

Mallar Chakravarty @mallarchak.bsky.social · 7d

Check out this great summary of our recent paper on the impact of exposure to #THC during gestation.

Thanks @douglasresearch.bsky.social !!

Orig paper here:

www.nature.com/articles/s41...

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Reposted by Alessandro Gozzi

Department of Psychiatry, University of Oxford @oxfordpsychiatry.bsky.social · 8d

🔊We are delighted to announce the appointment of Armin Raznahan as the new WA Handley Professor of Psychiatry.

Professor Raznahan is a child & adolescent psychiatrist, joining us from the US National Institute of Mental Health Intramural Research Program.

More: www.psych.ox.ac.uk/news/armin-r...

An image of Professor Armin Raznahan, Incoming WA Handley Professor of Psychiatry, with a quote from him saying: "Returning to the UK to work and learn with the remarkable community at Oxford is a real privilege. There is such a unique landscape of opportunity across the university and local NHS Trusts to both advance our understanding of the developing human brain and make a difference in the way we care for youth experiencing mental health difficulties."

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Varun Warrier @vw1234.bsky.social · 8d

It is now clear that more people are being diagnosed as autistic in their teens and as adults than in childhood. A prevailing theory is that those diagnosed later have "milder" form of autism, and later diagnosis entirely due to social factors.

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Benjamin Kay @benjaminkay.bsky.social · 9d

Ever wondered if your interesting brain-behavior correlation was over- or under-estimated due to head motion, but were afraid to ask? We’ve created a motion impact score for detecting spurious brain-behavior associations, now available in Nature Communications!
doi.org/10.1038/s414...

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Reposted by Alessandro Gozzi

Jingnan Du @jingnandu.bsky.social · 13d

Our new paper is out now in Neuron! 🎉 With @vaibhavtripathi.bsky.social @maxwellelliott.bsky.social Joanna Ladopoulou, Wendy Sun, Mark Eldaief, and Randy Buckner

Paper link: www.sciencedirect.com/science/arti...

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Reposted by Alessandro Gozzi

Mac Shine @macshine.bsky.social · 14d

random neuroimaging question: does anyone in bluesky-land have access to the loadings for neurosynth topics in schaefer 400 (yeo7) space? #neuroskyence @misicbata.bsky.social @richardfbetzel.bsky.social @borismontreal.bsky.social @sofievalk.bsky.social

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Reposted by Alessandro Gozzi

Mark Histed @markhisted.org · 14d

The brain is incredibly densely connected. Human cerebral cortex may have as many as *one trillion* connections.

Most of those cortical connections are recurrent, inside each area. What do they do?

New paper from me in Annual Reviews: 🧪 🧠📈 1/

www.annualreviews.org/content/jour...

Active Filtering: A Predictive Function of Recurrent Circuits of Sensory Cortex | Annual Reviews

Our brains encode many features of the sensory world into memories: We can sing along with songs we have heard before, interpret spoken and written language composed of words we have learned, and reco...

www.annualreviews.org

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Reposted by Dorothy Bishop, Alessandro Gozzi

Ravi Menon, Ph.D. @northernthrux.bsky.social · 14d

Science is self correcting. Finally!

Authors retract Science paper on controversial fMRI method

Several MRI artifacts contribute to the neuronal activity signal picked up by the method, according to a preprint the authors posted this month.

www.thetransmitter.org

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Reposted by Alessandro Gozzi

Biological Psychiatry @biologicalpsych.bsky.social · 15d

The Biological Psychiatry family of journals is now officially on Bluesky!

Follow us for the latest research in psychiatric neuroscience, cognitive neuroimaging, and global open science from our three leading journals.

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Alessandro Gozzi @gozziale.bsky.social · 15d

Global brain activity (indexed by Ca2+ in the cortex) can be described by a latent arousal manifold — reliably tracked by pupil dynamics 🤯🤯
▶️ www.nature.com/articles/s41...

Arousal as a universal embedding for spatiotemporal brain dynamics - Nature

Reframing of arousal as a latent dynamical system can reconstruct multidimensional measurements of large-scale spatiotemporal brain dynamics on the timescale of seconds in mice.

www.nature.com

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Reposted by Alessandro Gozzi

Julia Belluz @juliabelluz.bsky.social · 17d

Well, well, well. After a long wait, the big day is here!

@kevinh-phd.bsky.social and I finally get to share with you the book we've worked so long and hard on

I wrote a little substack about the question that powered every chapter of Food Intelligence

juliabelluz.substack.com/p/the-big-da...

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Alessandro Gozzi @gozziale.bsky.social · 21d

Congrats!!!

Reposted by Alessandro Gozzi

Bratislav Misic @misicbata.bsky.social · 22d

Neuromorphic hierarchical modular reservoirs | doi.org/10.1101/2025...

How does hierarchical modularity shape computational function? ⤵️

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Reposted by Alessandro Gozzi

Adeel Razi @adeelrazi.bsky.social · 23d

We are hiring for our psilocybin clinical trial.

1. Research Officer (testing and screening), 2 positions
careers.pageuppeople.com/513/cw/en/jo...

2. Research Officer (Peer Navigator)
careers.pageuppeople.com/513/cw/en/jo...

DM if you have questions.

@wellcomeleap.bsky.social

This link will take you to a page that’s not on LinkedIn

lnkd.in

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Reposted by Alessandro Gozzi

Mattia Chini @mattiachini.bsky.social · 23d

🚨 2 Postdoc openings in Neuroscience – Liège, Belgium 🚨

We are recruiting for a project on brain development & autism that includes:

⚡ Neuropixels recordings
⚡ Opto/chemo
⚡ Behavior
⚡ Neural network modeling

If you know someone, tag them or RT for visibility! 🙏
www.fens.org/careers/job-...

2 Postdoc Positions in Systems Neuroscience - Federation of European Neuroscience Societies

www.fens.org

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Alessandro Gozzi @gozziale.bsky.social · 23d

Congrats!!!!

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Imaging Neuroscience @imagingneurosci.bsky.social · 23d

New paper in Imaging Neuroscience by Matthew R. Lowerison, Pengfei Song, et al:

Comparison of high-frequency ultrasound transducers for microvascular localization microscopy in the mouse brain

doi.org/10.1162/IMAG...

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Reposted by Alessandro Gozzi

Bratislav Misic @misicbata.bsky.social · 23d

Network spreading and local biological vulnerability in amyotrophic lateral sclerosis |
doi.org/10.1038/s420...

How do brain network structure and local biological features shape the spatial patterning of atrophy in ALS? @asafarahani.bsky.social investigates ⤵️

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Reposted by Alessandro Gozzi

Russ Poldrack @russpoldrack.org · 23d

Strategies for effective coding agent usage - the latest in my Better Code, Better Science series russpoldrack.substack.com/p/strategies...

Strategies for effective coding agent usage

Better Code, Better Science: Chapter 5, Part 4

russpoldrack.substack.com

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Reposted by Alessandro Gozzi, Taku Ito

Michael W. Cole @mwcole.bsky.social · 25d

Lab’s latest is out in Imaging Neuroscience, led by Kirsten Peterson: “Regularized partial correlation provides reliable functional connectivity estimates while correcting for widespread confounding”, where we demonstrate a major improvement to standard fMRI functional connectivity (correlation) 1/n

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Alessandro Gozzi @gozziale.bsky.social · 25d

Ahah thanks @valeriejsydnor.bsky.social
if you say so...😅🙌

Reposted by Alessandro Gozzi

DrBreaky @drbreaky.bsky.social · 26d

Interested in hippocampal dynamics and their interactions with cortical rhythms?

Our physically constrained model of cortico-hippocampal interactions - complete with fast geometrically informed numerical simulation (available at embedded github repo)

www.biorxiv.org/content/10.1...

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Alessandro Gozzi @gozziale.bsky.social · 27d

Outstanding work!!!! Bravo Ofer and team!!!!

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Ofer Yizhar @oyiz.bsky.social · 27d

Excited to share our latest paper - now out in @science.org - we showed how oxytocin modulates maternally-directed behavior in young mice (P15).

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Alessandro Gozzi @gozziale.bsky.social · 29d

Working link to the preprint 👇
www.biorxiv.org/content/10.1...
See thread below for a looong explainer

Alessandro Gozzi @gozziale.bsky.social · 29d

🚨 Excited to share the latest preprint form the lab ➡️https://tinyurl.com/32d3be9f

Here we tackle a long-standing chicken-or-egg 🐣🥚question in #autism and developmental neuroscience

➡️ Is excitation–inhibition (E:I) imbalance a "cause" or a "consequence" of #autism?

Check out what we found!
🧵1/n

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Alessandro Gozzi @gozziale.bsky.social · 29d

Thank you!!!

Alessandro Gozzi @gozziale.bsky.social · 29d

Huge congrats to Dr. #Alexia_Stuefer for steadily leading this tour-de-force 🥳, and to all the collaborators who generously contributed to this study. Special thanks also to @simonsfoundation.org @erc.europa.eu @iitalk.bsky.social (brain & machine flagship) for funding this effort!

Alessandro Gozzi @gozziale.bsky.social · 29d

So what does this all mean?
➡️ A brief developmental E:I imbalance causes lasting autism-relevant phenotypes
➡️ Mechanism: transcriptional reprogramming of social brain circuits
➡️ Answer to the chicken-egg question? *Developmental* imbalance *is sufficient* to cause autism-relevant phenotypes!

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