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Reposted by Benjamin Weekley, Ph.D.

FragileNucleosome @fnucleosome.bsky.social · May 15

Join us on Wednesday next week for two exciting talks on transcription regulation from @kasitc.bsky.social and @davidsuter.bsky.social!

You can register at: us06web.zoom.us/webinar/regi...

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Reposted by Benjamin Weekley, Ph.D.

European Commission @ec.europa.eu · May 8

Choose Science. Choose Europe.

A new Marie Skłodowska-Curie Actions Postdoctoral Fellowships 2025 call is now open.

With a budget of €404.3 million, it will support around 1,650 researchers from Europe and beyond.

Apply by 10 September → europa.eu/!fBTMgF

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Benjamin Weekley, Ph.D. @benjaminweekley.bsky.social · May 16

Been a great couple of days of fantastic talks at @embl.org in Heidelberg! Presented a poster, and have thoroughly enjoyed learning about all the great epigenetics research going on and making lots of new friends!! #EMBLChromatin

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Reposted by Benjamin Weekley, Ph.D.

Lucas Farnung @lucas.farnunglab.com · Mar 28

🚨New paper🚨Our new study with the lab of Phil Cole uncovers how SIRT6 dynamically adapts structurally and enzymatically to target diverse histone acylations (e.g., H3K27ac) within nucleosomes. @jonmarkert.bsky.social
doi.org/10.1016/j.jb... #Chromatin #SIRT6 #CryoEM

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Benjamin Weekley, Ph.D. @benjaminweekley.bsky.social · Mar 27

www.nature.com/articles/s41...

Reversible histone deacetylase activity catalyzes lysine acylation - Nature Chemical Biology

Tsusaka et al. discover that histone deacetylases, which are well known to remove protein modifications, such as lysine acetylation and β-hydroxybutyrylation, can also reverse their chemical activity ...

www.nature.com

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Reposted by Benjamin Weekley, Ph.D.

Ben Martin @benjaminmartin.bsky.social · Mar 27

Come by my colleague!! Assistant professor position in molecular neurobiology at @mcgill.ca and the Lady Davis Institute! mcgill.wd3.myworkdayjobs.com/McGill_Caree...

Montreal is an amazing city and the Lady Davis is a great institute to work at!

Assistant Professor (Research), Department of Anatomy and Cell Biology (C1-250306)

Please refer to the How to Apply for a Job (for External Candidates) job aid for instructions on how to apply. If you are an active McGill employee (ie: currently in an active contract or position at ...

mcgill.wd3.myworkdayjobs.com

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Benjamin Weekley, Ph.D. @benjaminweekley.bsky.social · Mar 26

Enjoyed writing this review on classic & emerging techniques being used to elucidate neuroepigenetic mechanisms using biochemistry, chemical and molecular biology in both in vitro/vivo models, with a focus on how these can drive therapeutic strategies in the near future.
www.cell.com/iscience/ful...

Elucidating neuroepigenetic mechanisms to inform targeted therapeutics for brain disorders

Therapeutics; Epigenetics; Neuroscience

www.cell.com

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Reposted by Benjamin Weekley, Ph.D.

Jordan Meier @doc-jlmeier.bsky.social · Mar 20

Excited to share this one! We developed an in vivo model for specific manipulation of transfer RNA acetylation and found it serves as a sentinel modification whose loss causes ribosome stalling and stress signaling. Implications for a genetic disorder and cancer.

www.science.org/doi/10.1126/...

Transfer RNA acetylation regulates in vivo mammalian stress signaling

An ancient tRNA modification is used by mammalian cells to coordinate protein translation and adaptive signaling.

www.science.org

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Reposted by Benjamin Weekley, Ph.D.

Sherry Pagoto, PhD @drsherrypagoto.bsky.social · Mar 12

New report shows that NIH grants fueled $95 billion in economic activity and 407,782 jobs in 2024.

That's not to mention the countless lives that biomedical research has saved.

Show me a better investment than that.
www.forbes.com/sites/michae...

NIH Grants Fueled $95 Billion In FY 2024 Economic Activity, Finds New Report

National Institutes of Health grants generated almost $95 billion in economic activity nationwide in FY 2024 according to a new report by United for Medical Research.

www.forbes.com

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Reposted by Benjamin Weekley, Ph.D.

Richard Sever @richardsever.bsky.social · Mar 11

Big news: we are setting up a new non-profit organization to run bioRxiv and medRxiv. It's called openRxiv [no it's not a new preprint server; it's dedicated organization to oversee the servers] openrxiv.org 1/n

Homepage - openRxiv

openRxiv is an independent non-profit, the new organizational home for bioRxiv and medRxiv, enabling researchers to instantly share groundbreaking findings with the global scientific community.

openrxiv.org

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Reposted by Benjamin Weekley, Ph.D.

Fyodor Urnov @urnov.bsky.social · Mar 10

Spectacular news this morning for CRISPR gene editing to treat genetic disease from Beam Therapeutics.
This method was developed by David Liu's lab at the Broad.
= "academic" science produces innovations that enables the biotech sector to build medicines
investors.beamtx.com/news-release...

investors.beamtx.com

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Reposted by Benjamin Weekley, Ph.D.

FragileNucleosome @fnucleosome.bsky.social · Mar 10

🥁We are just 3 days away from our next #FragileNucleosome seminar! We are delighted to host, 2 amazing ECR researchers @rachelhoffman.bsky.social & @jonmarkert.bsky.social this Wed!
PS1: Don't forget that US has switched to PDT
PS2: The recurring registration link:
us06web.zoom.us/webinar/regi...

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Reposted by Benjamin Weekley, Ph.D.

Cynthia Wolberger @cwolberger.bsky.social · Mar 9

I was that woman! I have frequently told the story of how Jeremy responded after my second NIH rejection. He said, “Whatever you do, don’t stop spending. If you run out of startup, we’ll find more money for you.” I didn’t need it in the end, but knowing he had my back was huge. Thank you!

Jeremy Berg @jeremymberg.bsky.social · Mar 9

Our first recruit struggled initially to succeed in obtaining NIH funding. But her science was/is terrific and we bridged her along. She subsequent received an HHMI appointment, and then substantial NIH funding. She is now a member of the National Academy and is the current department director

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Reposted by Benjamin Weekley, Ph.D.

Jackie Flynn Mogensen @jackiefmogensen.bsky.social · Mar 7

At the #StandUpforScience protest in NYC—several hundred people turned out to Washington Square Park today to protest Trump’s cuts to public research

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Reposted by Benjamin Weekley, Ph.D.

Jennifer Chan @chanjenerational.bsky.social · Mar 7

Maze lab at #standupforscience NYC! cut gels not funding!! 🧬

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Benjamin Weekley, Ph.D. @benjaminweekley.bsky.social · Mar 7

Maze lab representing!!

Benjamin Weekley, Ph.D. @benjaminweekley.bsky.social · Mar 7

#StandUpForScience2025

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Reposted by Benjamin Weekley, Ph.D.

Stand Up for Science! @standupforscience.bsky.social · Mar 6

SO MANY STAND UP FOR SCIENCE EVENTS TO CHOOSE FROM—153 and COUNTING!

To get more information on our local events and to register your own, head to www.standupforscience2025.org/local-event-information/ ☀️⬇️🌎

List of Stand Up for Science events—official events in red, solidarity events in blue.

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Reposted by Benjamin Weekley, Ph.D.

Hank Green @hankgreen.bsky.social · Mar 3

Yall better be both sharing the Stand up for Science posts /and/ figuring out how to get your butt to one of them!

@standupforscience.bsky.social

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Benjamin Weekley, Ph.D. @benjaminweekley.bsky.social · Mar 4

I will be at the Stand Up for Science NYC event on Friday! Calling all NYC and New York area based scientists to join!!

Stand Up for Science! @standupforscience.bsky.social · Mar 1

NYC! 📣🗽☀️

We’re Standing Up for Science in Washington Square Park on March 7th from 12-3 PM!

Share with someone in NYC who should show up & support Science! ⬇️

#standupforscience2025

flyer for stand up for science with a blue statue of liberty drawing, and event details of the NYC stand up for science march at washington square park from 12-3 PM. More information is available at standupforscience2025.org!

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Reposted by Benjamin Weekley, Ph.D.

Waggoner Lab @labwaggoner.bsky.social · Feb 19

Mechanism for local attenuation of DNA replication at double-strand breaks @nature.com
www.nature.com/articles/s41...

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Reposted by Benjamin Weekley, Ph.D.

Leonie Kollenstart @lleonie.bsky.social · Feb 20

Excited to share my main postdoctoral work and our new insights into epigenome inheritance! Huge thanks to an amazing team—especially Alva Biran (@biranalva.bsky.social) & Anja Groth (@groth-anja.bsky.social). 🧵👇

The Groth lab @grothlab.bsky.social · Feb 19

𝐇𝐨𝐰 𝐝𝐨 𝐜𝐞𝐥𝐥𝐬 𝐫𝐞𝐦𝐞𝐦𝐛𝐞𝐫 𝐰𝐡𝐨 𝐭𝐡𝐞𝐲 𝐚𝐫𝐞 𝐚𝐟𝐭𝐞𝐫 𝐃𝐍𝐀 𝐫𝐞𝐩𝐥𝐢𝐜𝐚𝐭𝐢𝐨𝐧? Our new study “Disabling leading and lagging strand histone transmission results in parental histones loss and reduced cell plasticity and viability” is out in 𝘚𝘤𝘪𝘦𝘯𝘤𝘦 𝘈𝘥𝘷𝘢𝘯𝘤𝘦𝘴. Led by @lleonie.bsky.social @biranalva.bsky.social 🧵 More below👇

Disabling leading and lagging strand histone transmission results in parental histones loss and reduced cell plasticity and viability

Losing parental histones during DNA replication fork passage challenges differentiation competence and cell viability.

tinyurl.com

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Benjamin Weekley, Ph.D. @benjaminweekley.bsky.social · Feb 20

www.biorxiv.org/content/10.1...

Histone Lysine Crotonylation Regulates Long-Term Memory Storage

Histone post-translational modifications (PTMs), particularly lysine acetylation (Kac), are critical epigenetic regulators of gene transcription underlying long-term memory consolidation. Beyond Kac, ...

www.biorxiv.org

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Reposted by Benjamin Weekley, Ph.D.

Science Magazine @science.org · Feb 18

New research in Science represents a notable step forward in designing enzymes from scratch.

With a new approach, researchers designed an enzyme that uses a covalent intermediate to catalyze a two-step reaction, analogous to what many proteases do when breaking apart proteins. scim.ag/41kZBOI

Computational design of serine hydrolases

The design of enzymes with complex active sites that mediate multistep reactions remains an outstanding challenge. With serine hydrolases as a model system, we combined the generative capabilities of ...

scim.ag

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Reposted by Benjamin Weekley, Ph.D.

Di Jiang @dijiang319.bsky.social · Feb 16

@science.org RNA polymerase II at histone genes predicts outcome in human cancer 🧬💊 @fredhutch.bsky.social @hhmi.bsky.social www.science.org/doi/10.1126/...

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