Pak, Saurty-Seerunghen et al. present a method, GoT-Multi, that co-detects single-cell multiplexed somatic genotyping and whole transcriptomes in high throughput from fresh or FFPE samples, overcoming...

Phylogenetic mining and protein language models uncover improved PiggyBac transposase sequences.

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Nature, Published online: 01 October 2025; doi:10.1038/s41586-025-09570-2Heat recharges enzyme-free DNA circuits, enabling complex logic operations and neural networks to perform multiple computations, offering a universal energy source for molecular machines and advancing autonomous behaviours in artificial chemical systems.

The transition from benign to malignant growth is a pivotal yet poorly understood step in cancer progression that marks the shift from a pathologically inert condition to a clinically lethal disease. ...

Using mouse pancreatic cancer models, Tsanov et al. show that reactivation of SMAD4 at metastatic sites promotes tumor growth in the lung through RUNX1 but restrains metastatic growth through KLF4 in the liver, influenced by organ-specific epigenetic states.

Obtaining novel antibodies against specific protein targets is a widely important yet experimentally laborious process. Meanwhile, computational methods for antibody design have been limited by low su...

To enable meaningful model comparison in the Virtual Cell Challenge, we needed more than just a new Perturb-seq dataset; we needed a high-quality and high-fidelity benchmark. This required us to make ...