Lightnews — Scholar-powered news

Reposted

Aaron Rupar @atrupar.com · 8d

MADELEINE DEAN: The president is unhinged. He's unwell

JOHNSON: A lot of folks on your side are too

D: Oh my god, please. That performance in front of the generals?

J: I didn't see it

D: It's so dangerous! Our allies are looking elsewhere. Our enemies are laughing. You have a POTUS who's unwell.

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Reposted

Alexei Maklakov @alexeimaklakov.bsky.social · 14d

www.science.org/doi/10.1126/...

Lysosomes signal through the epigenome to regulate longevity across generations

The epigenome is sensitive to metabolic inputs and is crucial for aging. Lysosomes act as a signaling hub to sense metabolic cues and regulate longevity. We found that lysosomal metabolic pathways sig...

www.science.org

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Reposted

Chris Kluwe @chriswarcraft.bsky.social · 22d

Just talked with my wife, we are cancelling our Disney+ subscription. If you have one, I encourage you to do the same.

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ericgreerlab.bsky.social @ericgreerlab.bsky.social · 23d

A lynching of a black man in Mississippi. www.wapt.com/article/delt...

Student found hanging from tree at Delta State University

Delta State University has identified the person found dead on campus as Demontre "Tre" Reed, 21, a student from Grenada.

www.wapt.com

Reposted

NPR @npr.org · Sep 4

A federal judge in Boston said she found it "difficult to conclude anything other than that [the Trump administration] used antisemitism as a smokescreen for a targeted, ideologically-motivated assault on this country's premier universities, and did so in a way that runs afoul of [federal law]."

Trump administration illegally froze billions in Harvard funds, judge rules

The ruling is a legal victory for Harvard but the White House says it will appeal the decision.

n.pr

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Reposted

Liz Krueger @lizkrueger.bsky.social · Aug 28

Donna Lieberman of @nyclu.org is absolutely right. It's vital that @governor.ny.gov sign these critical bills to protect New Yorkers' reproductive freedom, including the NY Health Information Privacy Act that I carry w/@lindabrosenthal.bsky.social.
www.timesunion.com/opinion/arti...

Commentary: Hochul must sign bills that protect access to reproductive care

As threats mount nationwide, New York must do all it can to ensure everyone can get the care they need.

www.timesunion.com

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Reposted

Aaron Rupar @atrupar.com · Aug 25

Trump: "A lot of people are saying maybe we'd like a dictator."

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Reposted

Kristian G. Andersen @kgandersen.bsky.social · Aug 7

This is literally some of the craziest shit I have ever read.

And that's saying a lot.

www.whitehouse.gov/presidential...

Improving Oversight of Federal Grantmaking

By the authority vested in me as President by the Constitution and the laws of the United States of America, and to improve the process of Federal

www.whitehouse.gov

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ericgreerlab.bsky.social @ericgreerlab.bsky.social · Jul 31

Some good news. NIH budget to get $400M bump not the 40% cut requested. Hopefully not just ignored ... www.appropriations.senate.gov/news/minorit...

Senator Murray Opening Remarks at Full Committee Mark Up of Defense and Labor, Health and Human Services, and Education Bills | United States Senate Committee on Appropriations

United States Senate Committee on Appropriations

www.appropriations.senate.gov

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Reposted

Megan Ranney MD MPH @meganranney.bsky.social · Jul 29

A little known - but hugely consequential - part of the government’s changes to science funding:

open.substack.com/pub/sciencea...

A Quiet Policy Shift That Could Devastate American Science

Why NIH’s sudden move to multi-year grant funding should alarm every principal investigator and university

open.substack.com

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ericgreerlab.bsky.social @ericgreerlab.bsky.social · Jul 29

Thank you! It's been a fun project for sure. Have enjoyed your work on ribosome heterogeneity and aging as well! pubmed.ncbi.nlm.nih.gov/25635753/, pubmed.ncbi.nlm.nih.gov/33289480/

Methylation of ribosomal RNA by NSUN5 is a conserved mechanism modulating organismal lifespan - PubMed

Several pathways modulating longevity and stress resistance converge on translation by targeting ribosomal proteins or initiation factors, but whether this involves modifications of ribosomal RNA is u...

pubmed.ncbi.nlm.nih.gov

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ericgreerlab.bsky.social @ericgreerlab.bsky.social · Jul 29

This work was spearheaded by M. Hafiz Rothi, Gautam Sarkar and Joseph Alhaddad who were helped by Wayne Mitchell, @kejunying.bsky.social, Nancy Pohl, Roberto Mena, Julia Natale, Scarlett Dellacono, and @gladyshev.bsky.social. Thanks to all the authors! 8/8

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ericgreerlab.bsky.social @ericgreerlab.bsky.social · Jul 29

DAF-9 was previously shown by @antebilab.bsky.social to produce the signaling lipid dafachronic acid to signal from the germline to the soma to regulate lifespan. pubmed.ncbi.nlm.nih.gov/11740945/ pubmed.ncbi.nlm.nih.gov/17360327/ . dimt-1 induced lifespan extension was dependent on this pathway 7/8

A hormonal signaling pathway influencing C. elegans metabolism, reproductive development, and life span - PubMed

During C. elegans development, animals must choose between reproductive growth or dauer diapause in response to sensory cues. Insulin/IGF-I and TGF-beta signaling converge on the orphan nuclear recept...

pubmed.ncbi.nlm.nih.gov

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ericgreerlab.bsky.social @ericgreerlab.bsky.social · Jul 29

We also found that DIMT-1 regulates selective translation of stress resistance and lifespan regulating transcripts in the worm's germline but not in the muscle. One transcript which we identified as displaying differential ribosome occupancy was the cytochrome P450 enzyme DAF-9. 6/8

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ericgreerlab.bsky.social @ericgreerlab.bsky.social · Jul 29

We found that dimt-1 deficiency requires the TOR signaling pathway and an intact germline to extend lifespan. Using auxin-inducible degron tagged dimt-1 and tissue specific RNAi we found DIMT-1 functions in the worms' germline after mid-life to regulate organismal lifespan 5/8

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ericgreerlab.bsky.social @ericgreerlab.bsky.social · Jul 29

An RNAi screen identified that dimt-1 KD caused lifespan extension. We had previously shown that DIMT-1 is an 18S rRNA m62A methylase and that methylated rRNAs are transmitted to subsequent generations to drive intergenerational response to starvation pubmed.ncbi.nlm.nih.gov/37689068/ 4/8

18S rRNA methyltransferases DIMT1 and BUD23 drive intergenerational hormesis - PubMed

Heritable non-genetic information can regulate a variety of complex phenotypes. However, what specific non-genetic cues are transmitted from parents to their descendants are poorly understood. Here, w...

pubmed.ncbi.nlm.nih.gov

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ericgreerlab.bsky.social @ericgreerlab.bsky.social · Jul 29

We found that DIMT-1 functions in the germline and works after mid-life to extend lifespan. This reveals a new layer of regulation of lifespan, which transcripts are selectively translated, and found that ribosome heterogeneity is critical later in life to promote healthy aging. 3/8

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ericgreerlab.bsky.social @ericgreerlab.bsky.social · Jul 29

As we age there is a dysregulation of which proteins are degraded and which proteins are produced. We showed that DIMT-1 methylation of the ribosome selectively regulates the production of stress resistance and longevity regulating proteins and regulates aging. 2/8

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ericgreerlab.bsky.social @ericgreerlab.bsky.social · Jul 29

Excited to see our manuscript out @natcomms.nature.com pubmed.ncbi.nlm.nih.gov/40721431/. We identified that the 18S rRNA methylase DIMT-1 regulates lifespan by functioning in the germline after midlife. 1/8

The 18S rRNA methyltransferase DIMT-1 regulates lifespan in the germline later in life - PubMed

Specialized ribosomes help determine which proteins are synthesized, however, the influence of age on ribosome heterogeneity and whether dysregulation of this process drives organismal aging is unknow...

pubmed.ncbi.nlm.nih.gov

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ericgreerlab.bsky.social @ericgreerlab.bsky.social · May 9

My lab name is EZE. Was nicknamed easy-E cause I like rap and am relatively easy going.

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Reposted

Donna Lieberman @dlnyclu.bsky.social · May 1

I was born in the McCarthy era, but this is McCarthyism on steroids.

Our democracy is under dire threat. But we have a government of laws, not men. And NO ONE is above the law.

NYCLU @nyclu.org · May 1

Across the country, the ACLU has already filed more than 50 lawsuits to defend free speech, due process, equal rights, and the rule of law.

We’ve got the assignment. And we’re not slowing down.

@dlnyclu.bsky.social
📍Foley Square

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ericgreerlab.bsky.social @ericgreerlab.bsky.social · Apr 23

Congratulations! Looking forward to reading it.

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ericgreerlab.bsky.social @ericgreerlab.bsky.social · Apr 23

Congratulations to Anne @brunetlab.bsky.social for being elected to the AAAS www.amacad.org/new-members-...! And congratulations to all the other new members

New Academy Members

Elected in 2025

www.amacad.org

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ericgreerlab.bsky.social @ericgreerlab.bsky.social · Apr 17

Congratulations. Looking forward to reading it!

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Reposted

Surojit Sural @surojitsural.bsky.social · Apr 11

New WormBook Chapter: Chromatin and epigenetics in aging biology

academic.oup.com/genetics/adv...

Chromatin and epigenetics in aging biology

Abstract. This book chapter will focus on modifications to chromatin itself, how chromatin modifications are regulated, and how these modifications are dec

academic.oup.com

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