Nucleotide triphosphate (NTP)-dependent molecular switches regulate essential cellular processes by cycling between active and inactive states through nucleotide binding and hydrolysis. These mechanis...

Nucleotide triphosphate (NTP)-dependent molecular switches regulate essential cellular processes by cycling between active and inactive states through nucleotide binding and hydrolysis. These mechanis...

There are over 100 chapters at institutions worldwide. Washington, D.C. January 4–7, 2026 Capitol Hill Day January 8 Collaborative networks in

Patterns of evolutionary change in the fin and body shapes of fishes are strongly related to dietary ecology and locomotor mechanisms, and associations between shapes affects ecomorphological relation...

The lectin-like oxidized low-density lipoprotein (LDL) receptor-1 (LOX-1) is a key scavenger receptor for oxidized low-density lipoprotein cholesterol (oxLDL), which promotes inflammation and atherosclerosis. Here we evaluated MEDI6570, an antibody that acts as a LOX-1 antagonist, in a randomized, double-blind, dose-finding study in patients with myocardial infarction (MI) and residual inflammation (high-sensitivity C-reactive protein ≥ 1 mg l−1). At 30–365 days after MI, 423 patients (75 women, 348 men) were randomly allocated to 50 mg, 150 mg or 400 mg MEDI6570 or placebo treatment subcutaneously every 4 weeks for 32 weeks. The primary endpoint, the change in the noncalcified plaque volume in the most diseased coronary segment (NCPVMD) by computed tomography angiography, was not significantly different between placebo and MEDI6570 at any dose. The secondary endpoints, global NCPV and low-attenuation plaque volume, were also not different between placebo and MEDI6570 at any dose (all

Running a simulation model on a GPU can be a daunting task for somebody not acquainted with programming. However, there is a solution, and it is called WebGL. WebGL is a Java-based system that allo…

Cortical function, including sensory processing, is surprisingly resilient to neuron loss during aging and neurodegeneration. In this Article, we used the mouse auditory cortex to investigate how homeostatic mechanisms protect the representational map of sounds after neuron loss. We combined two-photon calcium imaging with targeted microablation of 30–40 sound-responsive neurons in layer 2/3. Microablation led to a temporary disturbance of the representational map, but it recovered in the following days. Recovery was primarily driven by neurons that were initially unresponsive to sounds but gained responsiveness and strengthened the network’s correlation structure. By contrast, selective microablation of inhibitory neurons caused prolonged disturbance, characterized by destabilized sound responses. Our results link individual neuron tuning and plasticity to the stability of the population-level representational map, highlighting homeostatic mechanisms that safeguard sensory processing

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view and explore 2D, 3D, and higher-dimensional arrays on a canvas;, overlay derived data such as points, polygons, segmentations, and more;, annotate and edit derived datasets, using standard data st...

Isotopic analysis as a method of assessing diet or geographical origin is now ubiquitous in archaeology, to the point where seemingly no project is co…

IntroductionSleep plays a crucial role in memory consolidation, not only stabilizing newly encoded information but also potentially supporting forgetting. Ye...