The authors uncovered channeled pyrimidine de novo biosynthesis and the preferential utilization of mitochondrially generated aspartic acid for pyrimidinosome and the purinosome mediated channeled pyrimidine and purine synthesis, respectively.

Programming stimulus responsiveness into living systems enables advanced biocomputation. Here, the authors autonomously compile proteins with defined topology that can be site-specifically tethered to and conditionally released from biomaterials and cells following user-specified Boolean logic.

Mitochondrial synthesis of adenosine triphosphate is essential for eukaryotic life but is dependent on the cooperation of two genomes: nuclear and mitochondrial DNA (mtDNA). mtDNA mutates ~15 times as...

A hydrogel platform with latent ionic cross-linking enables spatiotemporal control over stiffness and toughness for diverse uses.

Resilient bacterial cellulose–based living materials store dormant spores, awakening to deliver programmable functions.

Programming stimulus responsiveness into living systems enables advanced biocomputation. Here, the authors autonomously compile proteins with defined topology that can be site-specifically tethered to and conditionally released from biomaterials and cells following user-specified Boolean logic.

Extracellular ATP acts as a signal regulating physiology and immunity in eukaryotes and is elevated during intestinal infection or damage. Tronnet et al. show that extracellular ATP reprograms the tra...

Researchers show that embryonic skin stem cells rely on a specialized mechanism to resist injury. The findings could lead to new strategies for repairing wounds

Sica et al. show that the circadian clock in the brain controls daily rhythms in muscle stem cells. These rhythms affect stem cell metabolism and repair capacity, even in the absence of a local clock. The findings reveal how central signals shape tissue-specific stem cell functions through systemic cues like feeding.

mRNA-DNA hybrid origami offers a powerful route to combine the structural programmability of DNA origami with the biological functionality of messenger RNA, but generalizable design and assembly rules...

Skeletal muscle is the main consumer of glucose after a mixed meal, and resistance exercise further increases muscle glucose uptake. Emerging evidence suggests that glucose uptake in muscles is not on...