Alushin Lab
@alushinlab.bsky.social
Alushin lab at Rockefeller University. Interested in cryo-EM, the cytoskeleton, and mechanosensation at the molecular level.
Reposted by Alushin Lab
Out today, we can now multiplex receptor mapping at synapses thanks to a dimeric gold nanoparticle label optimized by Hoyoung that's distinguishable from monomers!
Dimeric gold nanoparticles enable multiplexed labeling in cryoelectron tomography | PNAS www.pnas.org/doi/10.1073/...
Dimeric gold nanoparticles enable multiplexed labeling in cryoelectron tomography | PNAS www.pnas.org/doi/10.1073/...
PNAS
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...
www.pnas.org
November 24, 2025 at 8:54 PM
Out today, we can now multiplex receptor mapping at synapses thanks to a dimeric gold nanoparticle label optimized by Hoyoung that's distinguishable from monomers!
Dimeric gold nanoparticles enable multiplexed labeling in cryoelectron tomography | PNAS www.pnas.org/doi/10.1073/...
Dimeric gold nanoparticles enable multiplexed labeling in cryoelectron tomography | PNAS www.pnas.org/doi/10.1073/...
Reposted by Alushin Lab
Reposted by Alushin Lab
Reposted by Alushin Lab
FHL2 enhances ITGB1-mediated ECM remodeling and cellular stiffness to promote radioresistance in non-small cell lung cancer
www.nature.com/articles/s41...
www.nature.com/articles/s41...
FHL2 enhances ITGB1-mediated ECM remodeling and cellular stiffness to promote radioresistance in non-small cell lung cancer - Cell Death Discovery
Cell Death Discovery - FHL2 enhances ITGB1-mediated ECM remodeling and cellular stiffness to promote radioresistance in non-small cell lung cancer
www.nature.com
November 9, 2025 at 12:41 PM
FHL2 enhances ITGB1-mediated ECM remodeling and cellular stiffness to promote radioresistance in non-small cell lung cancer
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Alushin Lab
Reposted by Alushin Lab
Greg Alushin (@alushinlab.bsky.social) is decoding how the body’s building blocks sense and respond to force, with implications for everything from cancer to developmental disorders. In this Q&A, he discusses where his work on the cytoskeleton could lead us:
How cells move and change shape--and why it matters for our health - News
Inside each of your cells, there's a microscopic scaffolding that helps determine what the cell looks like, how it moves, and how it responds to its surroundings. This internal structure, called the cytoskeleton, is constantly shifting and adjusting. It...
www.rockefeller.edu
October 24, 2025 at 7:13 PM
Greg Alushin (@alushinlab.bsky.social) is decoding how the body’s building blocks sense and respond to force, with implications for everything from cancer to developmental disorders. In this Q&A, he discusses where his work on the cytoskeleton could lead us:
Reposted by Alushin Lab
Very excited that my final postdoctoral work is now online in Cell @cellpress.bsky.social.
www.sciencedirect.com/science/arti...
Using 16 (!) cryo-EM structures, we uncovered how the three proteins coronin, cofilin and AIP1 work together to rapidly disassemble actin filaments.
www.sciencedirect.com/science/arti...
Using 16 (!) cryo-EM structures, we uncovered how the three proteins coronin, cofilin and AIP1 work together to rapidly disassemble actin filaments.
October 13, 2025 at 9:04 AM
Very excited that my final postdoctoral work is now online in Cell @cellpress.bsky.social.
www.sciencedirect.com/science/arti...
Using 16 (!) cryo-EM structures, we uncovered how the three proteins coronin, cofilin and AIP1 work together to rapidly disassemble actin filaments.
www.sciencedirect.com/science/arti...
Using 16 (!) cryo-EM structures, we uncovered how the three proteins coronin, cofilin and AIP1 work together to rapidly disassemble actin filaments.
Reposted by Alushin Lab
The @crick.ac.uk is recruiting Early Career Group Leaders
- Lab set-up, research costs, salaries for up to 5 researchers
- Support for up to 12 years
- Access to our core facilities
- Competitive salary
- Fantastic colleagues
- All areas of biology
Deadline 27 Nov
www.crick.ac.uk/careers-stud...
- Lab set-up, research costs, salaries for up to 5 researchers
- Support for up to 12 years
- Access to our core facilities
- Competitive salary
- Fantastic colleagues
- All areas of biology
Deadline 27 Nov
www.crick.ac.uk/careers-stud...
Early career group leaders
We appoint researchers from across biology and biomedicine to set up their first groups at the Crick.
www.crick.ac.uk
October 10, 2025 at 8:20 AM
The @crick.ac.uk is recruiting Early Career Group Leaders
- Lab set-up, research costs, salaries for up to 5 researchers
- Support for up to 12 years
- Access to our core facilities
- Competitive salary
- Fantastic colleagues
- All areas of biology
Deadline 27 Nov
www.crick.ac.uk/careers-stud...
- Lab set-up, research costs, salaries for up to 5 researchers
- Support for up to 12 years
- Access to our core facilities
- Competitive salary
- Fantastic colleagues
- All areas of biology
Deadline 27 Nov
www.crick.ac.uk/careers-stud...
Reposted by Alushin Lab
How do cells move, divide, & sense their surroundings? The answer lies in the cytoskeleton--and when it malfunctions, cancer & birth defects follow. @alushinlab.bsky.social at @rockefeller.edu is developing new tools to probe this tiny, dynamic cell scaffolding.
www.rockefeller.edu/news/38446-h...
www.rockefeller.edu/news/38446-h...
How cells move and change shape—and why it matters for our health - News
Inside each of your cells, there’s a microscopic scaffolding that helps determine what the cell looks like, how it moves, and how it responds to its surroundings. This internal structure, called the c...
www.rockefeller.edu
October 9, 2025 at 11:54 AM
How do cells move, divide, & sense their surroundings? The answer lies in the cytoskeleton--and when it malfunctions, cancer & birth defects follow. @alushinlab.bsky.social at @rockefeller.edu is developing new tools to probe this tiny, dynamic cell scaffolding.
www.rockefeller.edu/news/38446-h...
www.rockefeller.edu/news/38446-h...
Reposted by Alushin Lab
Learn all things #cytoskeleton #research in an interdisciplinary environment at EMBO Workshop "Structure and Function of the Cytoskeleton" in Paris, FR, 7–10 April 2026.
Deadline: 20 December 2025
https://meetings.embo.org/event/26-cytoskeleton
#EMBOCytoskeletalFunction #EMBOevents #conference 🧪
Deadline: 20 December 2025
https://meetings.embo.org/event/26-cytoskeleton
#EMBOCytoskeletalFunction #EMBOevents #conference 🧪
Structure and Function of the Cytoskeleton
The cytoskeleton, a dynamic and intricate network of protein filaments, is found within the cytoplasm of all cells, from bacteria and archaea to complex eukaryotes. This essential cellular component …
meetings.embo.org
October 7, 2025 at 3:35 PM
Learn all things #cytoskeleton #research in an interdisciplinary environment at EMBO Workshop "Structure and Function of the Cytoskeleton" in Paris, FR, 7–10 April 2026.
Deadline: 20 December 2025
https://meetings.embo.org/event/26-cytoskeleton
#EMBOCytoskeletalFunction #EMBOevents #conference 🧪
Deadline: 20 December 2025
https://meetings.embo.org/event/26-cytoskeleton
#EMBOCytoskeletalFunction #EMBOevents #conference 🧪
Reposted by Alushin Lab
Garcia Lab did it again! Such a fantastic read if you are interested in FAs mechanics and biology. Congratulations to @garcialabgt.bsky.social
Mechanochemical waves in focal adhesions during cell migration
Traction force and FAK signaling exhibit oscillatory temporal coupling in adhesive structures.
www.science.org
October 6, 2025 at 3:13 PM
Garcia Lab did it again! Such a fantastic read if you are interested in FAs mechanics and biology. Congratulations to @garcialabgt.bsky.social
Reposted by Alushin Lab
Molecular features of Myosin F adapted for driving actin flows in Toxoplasma gondii
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Molecular features of Myosin F adapted for driving actin flows in Toxoplasma gondii
Toxoplasma gondii ( T. gondii ) is a single-celled Apicomplexan parasite that relies on a highly polarized endomembrane system for its invasion into and survival within host cells. Recent advancements...
www.biorxiv.org
October 4, 2025 at 12:19 PM
Molecular features of Myosin F adapted for driving actin flows in Toxoplasma gondii
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Alushin Lab
Molecular features of Myosin F adapted for driving actin flows in Toxoplasma gondii https://www.biorxiv.org/content/10.1101/2025.10.02.679852v1
October 4, 2025 at 5:47 AM
Molecular features of Myosin F adapted for driving actin flows in Toxoplasma gondii https://www.biorxiv.org/content/10.1101/2025.10.02.679852v1
Reposted by Alushin Lab
How do #stemcells integrate information to coordinate fate decisions? Delighted to finally see our work showing how growth factors regulate the mechano-osmotic state of the #nucleus and #chromatin to control #pluripotency exit out! www.nature.com/articles/s41... see 🧵 👇
Mechano-osmotic signals control chromatin state and fate transitions in pluripotent stem cells - Nature Cell Biology
McCreery, Stubb et al. show that mechano-osmotic changes in the nucleus induce general transcriptional repression and prime chromatin for cell fate transitions by relieving repression of specific differentiation genes.
www.nature.com
September 29, 2025 at 4:45 PM
How do #stemcells integrate information to coordinate fate decisions? Delighted to finally see our work showing how growth factors regulate the mechano-osmotic state of the #nucleus and #chromatin to control #pluripotency exit out! www.nature.com/articles/s41... see 🧵 👇
Reposted by Alushin Lab
We are hiring an Assistant Professor of Biochemistry and Biophysics at Weill Cornell Medicine. Come join our collaborative research environment with state-of-the-art facilities in NYC! Application review starts Oct 22.
biochem.weill.cornell.edu/join-our-fac...
biochem.weill.cornell.edu/join-our-fac...
Join our Faculty | Department of Biochemistry & Biophysics
Call for applications:We invite applications for a tenure-track Assistant Professor position in the newly established Department of Biochemistry and Biophysics. We are conducting an open search for ou...
biochem.weill.cornell.edu
September 29, 2025 at 7:58 PM
We are hiring an Assistant Professor of Biochemistry and Biophysics at Weill Cornell Medicine. Come join our collaborative research environment with state-of-the-art facilities in NYC! Application review starts Oct 22.
biochem.weill.cornell.edu/join-our-fac...
biochem.weill.cornell.edu/join-our-fac...
Reposted by Alushin Lab
And from other labs’ work this is really cool:
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Mechanosensitive genomic enhancers potentiate the cellular response to matrix stiffness
Epigenetic control of gene expression and cellular phenotype is influenced by changes in the local microenvironment, yet how mechanical cues precisely influence epigenetic state to regulate transcript...
www.science.org
September 28, 2025 at 2:56 PM
And from other labs’ work this is really cool:
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by Alushin Lab
Using cryo-ET, CRN Team Reck-Peterson showed that full-length LRRK2 can oligomerize on microtubules in its autoinhibited state. Both WT-LRRK2 and PD-linked LRRK2 mutants formed filaments on microtubules.
🔗 Read the full #preprint to learn more about their recent research: bit.ly/3VrVNaB
🔗 Read the full #preprint to learn more about their recent research: bit.ly/3VrVNaB
September 26, 2025 at 3:29 PM
Using cryo-ET, CRN Team Reck-Peterson showed that full-length LRRK2 can oligomerize on microtubules in its autoinhibited state. Both WT-LRRK2 and PD-linked LRRK2 mutants formed filaments on microtubules.
🔗 Read the full #preprint to learn more about their recent research: bit.ly/3VrVNaB
🔗 Read the full #preprint to learn more about their recent research: bit.ly/3VrVNaB
Reposted by Alushin Lab
Huntingtin binds and bundles F-actin!
Thrilled to team up with the Humbert (Sorbonne Université) and Song (KAIST) labs on this discovery.
We had a blast doing cryo-ET on this unexpected complex — and now so many new questions lie ahead!
#TeamTomo #CryoET #HTT #actin
doi.org/10.1126/scia...
Thrilled to team up with the Humbert (Sorbonne Université) and Song (KAIST) labs on this discovery.
We had a blast doing cryo-ET on this unexpected complex — and now so many new questions lie ahead!
#TeamTomo #CryoET #HTT #actin
doi.org/10.1126/scia...
September 25, 2025 at 3:01 PM
Huntingtin binds and bundles F-actin!
Thrilled to team up with the Humbert (Sorbonne Université) and Song (KAIST) labs on this discovery.
We had a blast doing cryo-ET on this unexpected complex — and now so many new questions lie ahead!
#TeamTomo #CryoET #HTT #actin
doi.org/10.1126/scia...
Thrilled to team up with the Humbert (Sorbonne Université) and Song (KAIST) labs on this discovery.
We had a blast doing cryo-ET on this unexpected complex — and now so many new questions lie ahead!
#TeamTomo #CryoET #HTT #actin
doi.org/10.1126/scia...
Reposted by Alushin Lab
And now for something completely different @tianyang22.bsky.social & #YanCao uncover of how SPIN90 dimers activate Arp2/3 to nucleate bidirectional linear actin filaments. Great collaboration with @romet-jegou-lab.bsky.social & @carolynmoores1.bsky.social #Cryo-EM #Arp2/3 rdcu.be/eGoH4
Arp2/3-mediated bidirectional actin assembly by SPIN90 dimers
Nature Structural & Molecular Biology - Liu et al. show that SPIN90 dimerizes and binds two Arp2/3 complexes to nucleate two bidirectional actin filaments and the dimerization domain is...
rdcu.be
September 16, 2025 at 6:09 AM
And now for something completely different @tianyang22.bsky.social & #YanCao uncover of how SPIN90 dimers activate Arp2/3 to nucleate bidirectional linear actin filaments. Great collaboration with @romet-jegou-lab.bsky.social & @carolynmoores1.bsky.social #Cryo-EM #Arp2/3 rdcu.be/eGoH4
Reposted by Alushin Lab
Some good news: the NIH has now reinstated my R35 since the termination was found unconstitutional (still waiting on NSF), though the government continues to withhold the contractually obligated funds
September 13, 2025 at 1:02 AM
Some good news: the NIH has now reinstated my R35 since the termination was found unconstitutional (still waiting on NSF), though the government continues to withhold the contractually obligated funds
Reposted by Alushin Lab
A. James Hudspeth, Who Unlocked Mysteries Behind Hearing, Dies at 79 www.nytimes.com/2025/09/05/s...
A. James Hudspeth, Who Unlocked Mysteries Behind Hearing, Dies at 79
www.nytimes.com
September 7, 2025 at 4:39 PM
A. James Hudspeth, Who Unlocked Mysteries Behind Hearing, Dies at 79 www.nytimes.com/2025/09/05/s...
Reposted by Alushin Lab
My recent postdoctoral work is out today in @nature.com! We found that physical confinement makes melanoma cells more invasive and drug tolerant. Thanks to all who made this work possible @whitefishlab.bsky.social @mskcancercenter.bsky.social #NIH #NCI www.nature.com/articles/s41...
Mechanical confinement governs phenotypic plasticity in melanoma - Nature
Mechanical confinement of cancer cells at the tumour–microenvironment interface induces phenotype switching through chromatin remodelling by HMGB2, leading to a more invasive and drug-resistant state ...
www.nature.com
August 27, 2025 at 5:18 PM
My recent postdoctoral work is out today in @nature.com! We found that physical confinement makes melanoma cells more invasive and drug tolerant. Thanks to all who made this work possible @whitefishlab.bsky.social @mskcancercenter.bsky.social #NIH #NCI www.nature.com/articles/s41...
Rockefeller is conducting a faculty search; apply to become our colleague!
Applications for faculty positions at Rockefeller are now open! We are seeking exceptional, creative scientists to join our faculty.
Learn more below:
Learn more below:
Faculty recruitment - Our Scientists
Applications for faculty positions are currently being accepted. Application deadline is October 6, 2025.
www.rockefeller.edu
August 20, 2025 at 3:22 PM
Rockefeller is conducting a faculty search; apply to become our colleague!
Reposted by Alushin Lab
Interested in #mechanobiology of the cell nucleus? The submission deadline for the first ever FASEB Science Research Conference on the Mechanobiology of the Nucleus is August 31, 2025. Submit your abstract to be considered for a platform presentation.
#MBNSRC
events.faseb.org/event/Mechan...
#MBNSRC
events.faseb.org/event/Mechan...
August 19, 2025 at 7:43 PM
Interested in #mechanobiology of the cell nucleus? The submission deadline for the first ever FASEB Science Research Conference on the Mechanobiology of the Nucleus is August 31, 2025. Submit your abstract to be considered for a platform presentation.
#MBNSRC
events.faseb.org/event/Mechan...
#MBNSRC
events.faseb.org/event/Mechan...
Reposted by Alushin Lab
We are deeply saddened to share that our friend and colleague Jim Hudspeth passed away on Saturday. We will remember and continue to be inspired by Jim’s integrity, his humility, and his unwavering commitment to discovery.
A. James Hudspeth, neuroscientist who unlocked secrets of hearing, has died - News
A. James Hudspeth, a Rockefeller neuroscientist who discovered how sound waves are converted into electrical signals in the ear's cochlea, died Saturday at his home in Manhattan. A pioneering scientist and dedicated mentor, he was the university's F.M. ...
www.rockefeller.edu
August 18, 2025 at 7:59 PM
We are deeply saddened to share that our friend and colleague Jim Hudspeth passed away on Saturday. We will remember and continue to be inspired by Jim’s integrity, his humility, and his unwavering commitment to discovery.