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Antoine Garnier-Crussard

@antoinegc.bsky.social

260 followers 480 following 65 posts

Geriatrician (memory clinic physician, Hospices Civils de Lyon, France) and researcher (associate professor, Université Lyon 1). MD PhD #Alzheimer #LewyBody #WMH #Neuropsychology #Biomarkers #Frailty #IntrinsicCapacity

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Antoine Garnier-Crussard @antoinegc.bsky.social · Dec 9

🚨 Preprint alert
Happy to share this preprint (751,295 participants)
👉social, economic, and environmental well-being of older adults and gender inequality are negatively associated with age-related decline in spatial ability

Led by the fantastic @antoinecoutrot.bsky.social !
👏🙏all the team

🧵👇

Antoine Coutrot @antoinecoutrot.bsky.social · Dec 9

⚠️ New preprint !
« Social determinants of cognitive aging trajectories across 39 countries »
Some people in their 80s have cognitive abilities similar to many 30-year-olds, others are severely diminished.  How comes? 
www.medrxiv.org/content/10.1...
A short 🧵👇 1/7

Older women participating to a race at the Senior Games 2023.

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Reposted by Antoine Garnier-Crussard

Gemma Salvadó @gsalvado.bsky.social · 22d

🚨Postdoc position open at @BarcelonaBeta🚨
We're looking someone to work on a project at the intersection of cardiovascular and neurodegenerative research 🫀🧠
Fully funded position!!!
More details: www.imim.cat/media/upload...
Please share!
#Alzheimer's #ENDALZ

www.imim.cat

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Antoine Garnier-Crussard @antoinegc.bsky.social · 23d

@teddynovais.bsky.social @hcl-recherche.bsky.social

Antoine Garnier-Crussard @antoinegc.bsky.social · 23d

🚨 Happy to share our commentary, on Sacubitril/Valsartan, Heart Failure and Risk of Dementia 🧠💊❤️
link.springer.com/article/10.1...

The original paper link.springer.com/article/10.1...

Our review in 2024 on this topic: alzres.biomedcentral.com/articles/10....

🆘Brain & Heart health are connected 🧠❤️

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Antoine Garnier-Crussard @antoinegc.bsky.social · 24d

🚨VasCog-2🚨

👉 Revised Diagnostic Criteria for Vascular Cognitive Impairment and Dementia—The VasCog-2-WSO Criteria 🧠🩸🧠

jamanetwork.com/journals/jam...

Revised Diagnostic Criteria for Vascular Cognitive Impairment and Dementia

This Delphi study aimed to reach international consensus on the diagnosis of cognitive impairment and dementia via a revision of the International Society for Vascular Behavioural and Cognitive Disord...

jamanetwork.com

Reposted by Antoine Garnier-Crussard

Antoine Garnier-Crussard @antoinegc.bsky.social · Aug 5

🚨 Paper Alert

Happy to share this review on intrinsic capacity (IC) in dementia with Lewy bodies 💪🧠

🔓 www.sciencedirect.com/science/arti...

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Reposted by Antoine Garnier-Crussard

Antoine Garnier-Crussard @antoinegc.bsky.social · Aug 17

🚨 VasCog 2025 🚨 👉 The conference of the International Society of Vascular Behavioural and Cognitive Disorders

🧠 Thrilled to participate in the upcoming #VASCOG2025 conference, where I will be delivering a talk on WMH in AD

💥 program online
lnkd.in/dhhaAytZ

@hcl-recherche.bsky.social

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Antoine Garnier-Crussard @antoinegc.bsky.social · Aug 28

🧠🩺Comorbidities and comorbidity burden in patients with neurocognitive disorders

👉A detailed, in-depth study of comorbidities (individual comorbidities and comorbidity indices) in >3000 real-life patients seen in memory clinics💡

@hcl-recherche.bsky.social

link.springer.com/article/10.1...

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Antoine Garnier-Crussard @antoinegc.bsky.social · Aug 17

⛲💦🚰
👉"In this cluster-randomized, crossover trial, hospital-wide use of lactated Ringer’s solution as compared with normal saline did not alter the incidence of death or hospital readmission within 90 days."

NEJM.org @nejm.org · Aug 16

Whether lactated Ringer’s solution is clinically superior to normal saline for routine intravenous administration of fluids to hospitalized patients is unclear. Research findings from the FLUID trial are summarized in a new Quick Take video. nej.md/4oCRgQ4

#MedSky #CriticalCare

Visual representation of the FLUID trial, which evaluated lactated Ringer’s solution vs. normal saline for routine intravenous administration of fluids to hospitalized patients.

Reposted by Antoine Garnier-Crussard

Shibley @drshibley.bsky.social · Aug 17

My Substack. open.substack.com/pub/shibley/...

Crossroads in diagnosis of dementia in England: a perilous position

The recent Care England exposed further tensions in English dementia policy as regards dementia diagnosis.

open.substack.com

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Antoine Garnier-Crussard @antoinegc.bsky.social · Aug 17

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Antoine Garnier-Crussard @antoinegc.bsky.social · Aug 15

🧠🩸Blood phosphorylated tau for the diagnosis of Alzheimer's disease: a systematic review and meta-analysis

www.sciencedirect.com/science/arti...

Blood phosphorylated tau for the diagnosis of Alzheimer's disease: a systematic review and meta-analysis

Plasma phosphorylated tau (p-tau) biomarkers show promise to transform the clinical management of Alzheimer's disease by providing more accessible and…

www.sciencedirect.com

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Antoine Garnier-Crussard @antoinegc.bsky.social · Aug 5

🚨 Paper Alert

Happy to share this review on intrinsic capacity (IC) in dementia with Lewy bodies 💪🧠

🔓 www.sciencedirect.com/science/arti...

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Reposted by Antoine Garnier-Crussard

Seb Walsh @sebwalsh.bsky.social · Jul 28

What evidence do we have on the Social Determinants of Dementia (SDOD)?

Delighted that this scoping review, a year or so in the making, is now published in @alzdemjournals.bsky.social. Expertly led by Anouk Geraets, we identified...

doi.org/10.1002/alz....

1/

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Reposted by Antoine Garnier-Crussard

Eric Topol @erictopol.bsky.social · Jul 28

A randomized trial (N>2,100 participants, multi-center) of structured vs self-guided lifestyle interventions in older adults shows the former improved cognitive function jamanetwork.com/journals/jam...

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Antoine Garnier-Crussard @antoinegc.bsky.social · Jul 28

🧠🎈Structured vs Self-Guided Multidomain Lifestyle Interventions for Global Cognitive Function
The US POINTER RCT

👉The structured higher-intensity intervention had a greater benefit on global cognition than the self-guided low-intensity intervention.

jamanetwork.com/journals/jam...

Structured vs Self-Guided Multidomain Lifestyle Interventions for Global Cognitive Function

This randomized clinical trial assesses the effect of structured vs self-guided multidomain lifestyle interventions on changes in global cognitive function over 2 years among older adults at risk of c...

jamanetwork.com

Antoine Garnier-Crussard @antoinegc.bsky.social · Jul 25

Donanemab receives positive opinion from the Committee for Medicinal Products for Human Use (CHMP) in early symptomatic Alzheimer's disease

investor.lilly.com/news-release...

Donanemab receives positive opinion from the Committee for Medicinal Products for Human Use (CHMP) in early symptomatic Alzheimer's disease | Eli Lilly and Company

The Investor Relations website contains information about Eli Lilly and Company's business for stockholders, potential investors, and financial analysts.

investor.lilly.com

Antoine Garnier-Crussard @antoinegc.bsky.social · Jul 20

🚀 Étude publiée sur les facteurs associés à la prescription d'une prise en soins en orthophonie 🗣️💬 en consultation mémoire 🧠 à partir des données de 574 patient-es !
www.jle.com/fr/revues/gp...

Reposted by Antoine Garnier-Crussard

Claire André, PhD @claireandre.bsky.social · Apr 18

📢 Preprint alert!
Check out the results of our international consensus effort which established research recommendations and identified high-priority future directions in the field of sleep, aging and dementia. Huge thank you to ISTAART and all collaborators for this tremendous team work ✨👇

medRxivpreprint @medrxivpreprint.bsky.social · Apr 8

International recommendations for sleep and circadian research in aging and Alzheimers disease: a Delphi consensus study. https://www.medrxiv.org/content/10.1101/2025.04.06.25325352v1

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Reposted by Antoine Garnier-Crussard

Claire André, PhD @claireandre.bsky.social · Apr 30

Very happy to share our preprint on the associations between sleep disturbances and cholinergic PET imaging in older adults! 🧠 💤

👉 We found that higher REM sleep EEG slowing was associated with cholinergic denervation in older participants with and without MCI.

#REMsleep #cholinergicsystem

medRxivpreprint @medrxivpreprint.bsky.social · Apr 29

REM sleep EEG slowing reflects brain cholinergic denervation in aging and Mild Cognitive Impairment https://www.medrxiv.org/content/10.1101/2025.04.28.25326545v1

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Reposted by Antoine Garnier-Crussard

Olivier Rouaud @orouaud1.bsky.social · May 24

www.linkedin.com/posts/centre...

#rfmasa2025 #lausanne #alzheimer #diagnostic #avancées #démences… | Leenaards Memory Center | CHUV

🚀 Annonce Spéciale ! 𝗥𝗙𝗠𝗔𝗦𝗔𝟮𝟬𝟮𝟱 𝗘𝗽𝗶𝘀𝗼𝗱𝗲 𝟭 Nous sommes ravis de vous annoncer que Nicolas Villain sera l'un des orateurs vedettes du congrès #RFMASA2025 à #Lausanne ! 🗣️ Il traitera du grand déb...

www.linkedin.com

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Reposted by Antoine Garnier-Crussard

Olivier Rouaud @orouaud1.bsky.social · May 24

www.linkedin.com/posts/centre...

#rfmasa2025 #lausanne #interventions #non #médicamenteuses #prévention… | Leenaards Memory Center | CHUV

🚀 Annonce Spéciale ! 𝗥𝗙𝗠𝗔𝗦𝗔𝟮𝟬𝟮𝟱 𝗘𝗽𝗶𝘀𝗼𝗱𝗲 𝟮 Nous sommes heureux de vous annoncer que Laura Stankeviciute, PhD nous fera l’honneur de sa venue et sera l'une des oratrices renommées du congrès #RFMAS...

www.linkedin.com

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Antoine Garnier-Crussard @antoinegc.bsky.social · May 12

LATE-NC and cerebrovascular disease associated with hippocampal sclerosis, not AD pathology (in models ajdusted for LATE)

👉Common neuropathologic change drivers of hippocampal sclerosis of ageing
shorturl.at/Coxcb

Common neuropathologic change drivers of hippocampal sclerosis of ageing

Woodworth et al. investigate associations between common neuropathologic changes (NCs) and hippocampal sclerosis of aging (HS-A). While limbic-predominant

shorturl.at

Antoine Garnier-Crussard @antoinegc.bsky.social · May 9

Research Participant Interest in Learning Results of Biomarker Tests for AD

👉in this cohort study of 274 individuals with available biomarker data, 40% of participants declined the option to learn their AD research results

shorturl.at/9Rbgv

Research Participant Interest in Results of Biomarker Tests for Alzheimer Disease

This cohort study quantitatively and qualitatively assesses research participants’ decision to learn individual Alzheimer disease biomarker research results and what factors are associated with this d...

shorturl.at

Reposted by Antoine Garnier-Crussard

biofinder.bsky.social @biofinder.bsky.social · Apr 25

🧠Exciting new findings from a great collaboration between the BioFINDER study and the talented
@xiaoyucaly.bsky.social from @jwvogel.bsky.social group!! In their preprint, they show that tau presence and tau load are guided by unique brain mechanisms. Dive into the details here 👇

Yu Xiao (肖燏) @xiaoyucaly.bsky.social · Apr 24

🧠New preprint! What drives tau, the pathological protein in AD, to spread?
We found that WHERE tau appears and HOW MUCH accumulates are governed by different mechanisms. Check it out: www.biorxiv.org/content/10.1... 

#MedSky #neuroskyence #neurosky #alzsky #compneuro #MRI #neuroimaging #neurology

www.biorxiv.org

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Antoine Garnier-Crussard @antoinegc.bsky.social · Apr 28

Neurodegeneration and the immune system: lessons from autoimmune encephalitis
link.springer.com/article/10.1...

Neurodegeneration and the immune system: lessons from autoimmune encephalitis - Journal of Neurology

The spectrum of autoimmune encephalitis (AE) is expanding to atypical clinical presentations that can mimic neurodegenerative disorders. Among the autoantibodies most frequently associated with manife...

link.springer.com