Arek Kendirli
@arekken.bsky.social
Crispring in #MultipleSclerosis (MS) research at BMC, Munich.
https://www.linkedin.com/in/arek-kendirli-68268732?trk=contact-info
https://www.linkedin.com/in/arek-kendirli-68268732?trk=contact-info
Reposted by Arek Kendirli
How does Epstein- Barr virus induce multiple sclerosis?
The infection leads to B cells that get into the brain, attracting pro-inflammatory T cells (mouse model)
www.nature.com/articles/s41...
The infection leads to B cells that get into the brain, attracting pro-inflammatory T cells (mouse model)
www.nature.com/articles/s41...
EBV induces CNS homing of B cells attracting inflammatory T cells - Nature
Epstein–Barr virus infection generates a neuroinvasive B cell subset, which recruits activated T cells to the central nervous system, promoting multiple sclerosis.
www.nature.com
August 6, 2025 at 3:24 PM
How does Epstein- Barr virus induce multiple sclerosis?
The infection leads to B cells that get into the brain, attracting pro-inflammatory T cells (mouse model)
www.nature.com/articles/s41...
The infection leads to B cells that get into the brain, attracting pro-inflammatory T cells (mouse model)
www.nature.com/articles/s41...
Reposted by Arek Kendirli
#EpigeneticPower! 💥 #NewPaperAlert! We show @cp-immunity.bsky.social that endogenous oxidized lipids decide whether host survives or dies during #sepsis, #ARDS, or Staph infection! Ox lipids bind & inhibit #AKT, boosting inhibitory H3K27 methylation via EZH2 & blocking #IL10!
Epigenetic silencing of interleukin-10 by host-derived oxidized phospholipids supports a lethal inflammatory response to infections
Upon pathogen detection, phagocytes trigger immunity. This process induces tissue
stress and the formation of host-derived molecules that further tune immune responses.
We show that host-derived oxidi...
dlvr.it
July 17, 2025 at 3:35 PM
#EpigeneticPower! 💥 #NewPaperAlert! We show @cp-immunity.bsky.social that endogenous oxidized lipids decide whether host survives or dies during #sepsis, #ARDS, or Staph infection! Ox lipids bind & inhibit #AKT, boosting inhibitory H3K27 methylation via EZH2 & blocking #IL10!
Reposted by Arek Kendirli
CINTER-seq enables in situ capture and multimodal profiling of interacting cells in living mice, uncovering specific LAG3-MHC II-mediated CD4+ T cell-cancer cell interactions & tumor-reprogrammed neutrophils
www.cell.com/immunity/ful... @cp-immunity.bsky.social
www.cell.com/immunity/ful... @cp-immunity.bsky.social
July 17, 2025 at 4:50 PM
CINTER-seq enables in situ capture and multimodal profiling of interacting cells in living mice, uncovering specific LAG3-MHC II-mediated CD4+ T cell-cancer cell interactions & tumor-reprogrammed neutrophils
www.cell.com/immunity/ful... @cp-immunity.bsky.social
www.cell.com/immunity/ful... @cp-immunity.bsky.social
Doktora tezimin giriş bölümü.. #AhmedArif
June 2, 2025 at 8:46 AM
Doktora tezimin giriş bölümü.. #AhmedArif
Reposted by Arek Kendirli
Shout out to all the amazing scientists who worked on these 8 studies - your work will accelerate neuroscience research globally!
We're grateful to play a part in helping these tools reach labs worldwide.
www.addgene.org/collections/...
We're grateful to play a part in helping these tools reach labs worldwide.
www.addgene.org/collections/...
May 21, 2025 at 5:19 PM
Shout out to all the amazing scientists who worked on these 8 studies - your work will accelerate neuroscience research globally!
We're grateful to play a part in helping these tools reach labs worldwide.
www.addgene.org/collections/...
We're grateful to play a part in helping these tools reach labs worldwide.
www.addgene.org/collections/...
Reposted by Arek Kendirli
This collection describes a range of methods allowing access to neuronal and non-neuronal cell types, opening the door to targeting the nervous system in ways that were previously unimaginable 🧠
Check out our BRAIN Armamentarium Consortium🧵
www.cell.com/consortium/b...
Check out our BRAIN Armamentarium Consortium🧵
www.cell.com/consortium/b...
May 22, 2025 at 4:41 PM
This collection describes a range of methods allowing access to neuronal and non-neuronal cell types, opening the door to targeting the nervous system in ways that were previously unimaginable 🧠
Check out our BRAIN Armamentarium Consortium🧵
www.cell.com/consortium/b...
Check out our BRAIN Armamentarium Consortium🧵
www.cell.com/consortium/b...
Reposted by Arek Kendirli
🧬 How #immune #cells protect their #centrosome under stress. To fight infection, immune cells must divide rapidly and squeeze through tight tissue spaces. @renkawitzteam.bsky.social shows that two proteins help protect the centrosome from damage during this process.
📄 www.med.lmu.de/bmc/en/news/...
📄 www.med.lmu.de/bmc/en/news/...
Cell biology: how cells protect their centrosome against mechanical forces
When motile immune cells move through tissue, they are exposed to strong forces. Researchers at LMU have discovered how these cells protect a sensitive organelle, the centrosome, from being destroyed.
www.med.lmu.de
April 29, 2025 at 8:25 AM
🧬 How #immune #cells protect their #centrosome under stress. To fight infection, immune cells must divide rapidly and squeeze through tight tissue spaces. @renkawitzteam.bsky.social shows that two proteins help protect the centrosome from damage during this process.
📄 www.med.lmu.de/bmc/en/news/...
📄 www.med.lmu.de/bmc/en/news/...
Reposted by Arek Kendirli
New study from Anneli Peters’ team shows how B and T cells interact in #multiple #sclerosis (MS), fuelling chronic #inflammation. Their cooperation may be key to a potential target for future #treatments.
www.med.lmu.de/bmc/en/news/...
#Autoimmunity #Neuroimmunology @lmumuenchen.bsky.social
www.med.lmu.de/bmc/en/news/...
#Autoimmunity #Neuroimmunology @lmumuenchen.bsky.social
How B and T cells fuel the pathological process in MS
Anneli Peters and her team have deciphered immunological mechanisms in so-called ectopic lymphoid follicle-like structures in multiple sclerosis (MS).
www.med.lmu.de
April 30, 2025 at 9:00 AM
New study from Anneli Peters’ team shows how B and T cells interact in #multiple #sclerosis (MS), fuelling chronic #inflammation. Their cooperation may be key to a potential target for future #treatments.
www.med.lmu.de/bmc/en/news/...
#Autoimmunity #Neuroimmunology @lmumuenchen.bsky.social
www.med.lmu.de/bmc/en/news/...
#Autoimmunity #Neuroimmunology @lmumuenchen.bsky.social
Reposted by Arek Kendirli
T–B cell cooperation in ectopic lymphoid follicles propagates CNS autoimmunity
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
T–B cell cooperation in ectopic lymphoid follicles propagates CNS autoimmunity
T and B cells cooperate in meningeal eLFs to promote differentiation and clonal expansion of B cells and reactivation of CNS T cells.
www.science.org
April 25, 2025 at 8:09 PM
T–B cell cooperation in ectopic lymphoid follicles propagates CNS autoimmunity
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
A few months ago, I had the opportunity to receive the #MultipleSclerosis Prize of the Eva and Helmer Lehmann Foundation, awarded by the German Neurological Society @dgn-ev.bsky.social and the Disease-Related Competence Network Multiple Sclerosis (Geschäftsstelle KKNMS e.V.)
March 16, 2025 at 1:00 AM
A few months ago, I had the opportunity to receive the #MultipleSclerosis Prize of the Eva and Helmer Lehmann Foundation, awarded by the German Neurological Society @dgn-ev.bsky.social and the Disease-Related Competence Network Multiple Sclerosis (Geschäftsstelle KKNMS e.V.)
Reposted by Arek Kendirli
How do myelin-specific T cells migrate to the central nervous system during the initial phase of neuroinflammation? Check out our genome-wide in vivo #CRISPR screen in #Tcells @natureneuro.bsky.social #MultipleSclerosis #MS www.nature.com/articles/s41...
A genome-wide in vivo CRISPR screen identifies essential regulators of T cell migration to the CNS in a multiple sclerosis model - Nature Neuroscience
Multiple sclerosis (MS) lesions are initiated by the infiltration of T cells to the CNS. Here, Kendirli et al. use a genome-wide CRISPR screen in an MS model to define the molecules that regulate T ce...
www.nature.com
March 10, 2025 at 10:39 PM
How do myelin-specific T cells migrate to the central nervous system during the initial phase of neuroinflammation? Check out our genome-wide in vivo #CRISPR screen in #Tcells @natureneuro.bsky.social #MultipleSclerosis #MS www.nature.com/articles/s41...
Reposted by Arek Kendirli
💭 Our PhD & Postdoc reps initiated visits to our Technology Hubs for our researchers and kicked off with a visit to our Single-Cell and Spatial Transcriptome Hubs last week.
👋 Thanks Arek Kendirli, Janos Groh, Clara de la Rosa del Val, and Simon Frerich for hosting the first event of the series!
👋 Thanks Arek Kendirli, Janos Groh, Clara de la Rosa del Val, and Simon Frerich for hosting the first event of the series!
March 6, 2025 at 12:50 PM
💭 Our PhD & Postdoc reps initiated visits to our Technology Hubs for our researchers and kicked off with a visit to our Single-Cell and Spatial Transcriptome Hubs last week.
👋 Thanks Arek Kendirli, Janos Groh, Clara de la Rosa del Val, and Simon Frerich for hosting the first event of the series!
👋 Thanks Arek Kendirli, Janos Groh, Clara de la Rosa del Val, and Simon Frerich for hosting the first event of the series!