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Rupert Beale @bealelab.bsky.social · 6h

Do you want to do a PhD with me and Mike Devine? Of course you do! Or if not, maybe you know someone who does? @devinelab.bsky.social www.crick.ac.uk/careers-stud...

Beale & Devine Lab | Role of the V1H subunit of the V-ATPase in neurons and cell-autonomous immune responses

www.crick.ac.uk

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Rupert Beale @bealelab.bsky.social · 25d

Carbonara.

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Rupert Beale @bealelab.bsky.social · 27d

@southlondongirl.bsky.social right so I don’t recommend swimming with your iPhone in your pocket. Long story, also boring. But Sicily, excellent, @flossieteacake.bsky.social said I should share this pasta alla Norma with you. It’s got Ricotta Salata and everything. Aces. Shall we do dinner sometime?

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Rupert Beale @bealelab.bsky.social · 27d

No it's normal.

Rupert Beale @bealelab.bsky.social · 29d

Congrats, very interesting work!

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Reposted by Rupert Beale

Kristian G. Andersen @kgandersen.bsky.social · Aug 15

The main thing - is it not already clear - RFKr Jr is uniquely unqualified to lead the HHS.

All main agencies under his watch - NIH, FDA, CMS - are also headed by incompetent contrarian peddlers of disinformation, conspiracy theories, and pseudoscience.

This will, and already does, cost lives.

Brandy Zadrozny @brandyzadrozny.bsky.social · Aug 15

New: I spent the week looking into the cancelled mRNA contracts. Interviews with HHS officials and MAGA and MAHA influencers reveal an HHS agency plagued by dysfunction as Kennedy chips away at the nation’s public health.

www.msnbc.com/news/news-an...

How RFK Jr. alienated MAGA, MAHA and the White House in a single week

The botched announcement about mRNA vaccines reveals a health department full of dysfunction and infighting.

www.msnbc.com

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Reposted by Rupert Beale

Simon Fisher @profsimonfisher.bsky.social · Aug 7

If someone you know buys into claims about "genetic optimization" of embryos using polygenic scores of cognition, just send them our 2024 paper on Beethoven & musicality. We wrote it to help communicate limits of individual-level genetic predictions & complexity of links between DNA & behaviour. 🧪👇

Notes from Beethoven’s genome

Wesseldijk et al. compare the genomic information collected from Ludwig van Beethoven with population-based datasets used to quantify musical achievement.

www.cell.com

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Reposted by Rupert Beale

Damnèd Screamvens @thehighsign.bsky.social · Aug 13

I know we're supposed to reflexively dismiss the loss of any niche subject in the humanities, but this is a big part of why the university exists: so a student who wants to learn Basque can learn Basque. & the reason a school can offer that class is because THEY HAVE A ROMANCE LANGUAGES DEPARTMENT.

ginganinja2507.bsky.social @ginganinja2507.bsky.social · Aug 13

I learned beginner Basque at UChicago, an experience that i still cherish. This is fucking appalling to hear

Damnèd Screamvens @thehighsign.bsky.social · Aug 13

Wow. The University of Chicago, a world-class institution whose humanities faculty in the past has included Homi Bhabha & Lauren Berlant & Ralph Ellison & Hannah freaking Arendt, is getting rid of basically every graduate department involving the acknowledgment that other cultures & languages exist.

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Rupert Beale @bealelab.bsky.social · Aug 14

Surely you meant to write ‘formerly a world class institution’?

Damnèd Screamvens @thehighsign.bsky.social · Aug 13

Wow. The University of Chicago, a world-class institution whose humanities faculty in the past has included Homi Bhabha & Lauren Berlant & Ralph Ellison & Hannah freaking Arendt, is getting rid of basically every graduate department involving the acknowledgment that other cultures & languages exist.

Quote from a story on changes at the U of Chicago that notes they are "pausing" doctoral eduction in Classics, Comp Lit, Germanic studies, Middle Eastern Studies, Romance languages and literatures, and South Asian Studies.

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Reposted by Rupert Beale

Keystone Symposia @keystonesymposia.bsky.social · Jul 17

🎥 The Keystone Symposium on Autophagosomes & Endolysosomes is now on demand!

Watch talks on lysosome‑mediated quality control, nutrient regulation & cell signaling—insights from leaders in the field
.
👉 keysym.us/KSAutophagy2...
#KSAutophagy25 #autophagosome #endolysosomes @bealelab.bsky.social

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Rupert Beale @bealelab.bsky.social · Jul 18

Not necessarily anything very much to do with heart function.

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Reposted by Rupert Beale

Keystone Symposia @keystonesymposia.bsky.social · Jun 28

The Autophagosomes & Endolysosomes meeting wraps today in Whistler, capping days of deep insight into lysosomal biology & autophagy.

👏 Congrats to our Keystone scholarship awardees—your future in science is bright!
🔗 keysym.us/scholarships...
#KSAutophagy25 @bealelab.bsky.social

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Rupert Beale @bealelab.bsky.social · Jun 20

Cheering myself up by reminding myself this is happening next week.

Rupert Beale @bealelab.bsky.social · Jan 27

How many Bluesky people can you spot as speakers? @kraftlabfr.bsky.social @martenslab.bsky.social @maxgg.bsky.social @jimhurley.bsky.social for starters. Exciting #autophagy talks guaranteed! #KSAutophagy25

Rupert Beale @bealelab.bsky.social · Jan 27

If you are wondering if you should come to the Keystone #autophagy meeting this year, the answer is – yes! Of course you should! www.keystonesymposia.org/conferences/...

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Rupert Beale @bealelab.bsky.social · Jun 20

Congrats, very interesting paper.

Reposted by Rupert Beale

Harvard Med Cell Biology @harvardcellbio.bsky.social · Jun 17

Chan Lee @harperlabhms.bsky.social reports CASM-driven V-ATPase recruitment to lysosomes for acidification upon TRPML1 activation via DMXL1-RAVE loader. With Magdalene Moran(Caraway), Sophie Helaine lab, Joao Paulo, & HarperLab teams(HMS). Funds: Warren Alpert FND/NIH www.nature.com/articles/s41...

DMXL1 promotes recruitment of V1-ATPase to lysosomes upon TRPML1 activation - Nature Structural & Molecular Biology

Lee et al. show that DMXL1, a regulator of V-ATPase assembly, is recruited to lysosomes upon TRPML1 activation in a manner dependent on conjugation of ATG8 proteins on lysosomal membranes (CASM) and p...

www.nature.com

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Reposted by Rupert Beale

Dr Rachel Clarke @drrachelclarke.com · Jun 19

Sharing this on the eve of tomorrow's vote.

I am a palliative care doctor who is not opposed to AD. But enshrining in law a state-funded right to die, while not enshrine a similar right to the palliative care that might make life worth living, is so very wrong.

www.theguardian.com/commentisfre...

MPs have personal beliefs, but also solemn duties: that’s why they must reject the assisted dying bill this week | Gordon Brown

Our obligations to each other are ill served if laws focus unduly on those who want assisted dying. The priority should be the best palliative care, says former prime minister Gordon Brown

www.theguardian.com

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Reposted by Rupert Beale

Stefan Marciniak @profmarciniak.bsky.social · Jun 10

Robert F Kennedy Jr said he is “retiring” all 17 members of a crucial government panel of vaccine advisors

He is removing all members of the Advisory Committee on Immunization Practices, which advises the CDC and Prevention

This could serious damage US health
www.cnbc.com/2025/06/09/r...

RFK Jr. removes all members of CDC panel advising U.S. on vaccines

It's the latest move by Kennedy – a prominent vaccine skeptic – to change and potentially undermine vaccinations in the U.S. since he took the helm at HHS.

www.cnbc.com

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Reposted by Rupert Beale

Royal College of Physicians @rcphysicians.bsky.social · Jun 9

We have raised concerns about existing deficiencies in the Terminally Ill Adults (End of Life) Bill.

We believe the bill in its current form lacks adequate protections for patients and professionals.

Full statement: ow.ly/EOhP50W692q