Böke Lab
@bokelab.bsky.social
Oocyte Biology and Cellular Dormancy Lab in CRG, Barcelona, led by Elvan Böke. Joint lab account; Elvan's musings are signed EB.
Pinned
Böke Lab
@bokelab.bsky.social
· Jul 18
Proud to share what we hope will be a reference study on human oocyte proteostasis. Young-donor eggs show globally reduced organelle activity vs. somatic cells, with an even steeper drop as they mature.
👇 for @zaffagg3 's detailed explanation
www.embopress.org/doi/full/10....
👇 for @zaffagg3 's detailed explanation
www.embopress.org/doi/full/10....
Reposted by Böke Lab
Ahead of TSRM 2025, we talk to Dr Baris Ata about his roles as RBMO Female Reproductive Health & Fertility Section Editor and President of the Turkish Society of Reproductive Medicine, and what delegates can expect from the forthcoming conference.
Read it in the latest Insights: bit.ly/AtaTSRM25
Read it in the latest Insights: bit.ly/AtaTSRM25
November 12, 2025 at 5:53 PM
Ahead of TSRM 2025, we talk to Dr Baris Ata about his roles as RBMO Female Reproductive Health & Fertility Section Editor and President of the Turkish Society of Reproductive Medicine, and what delegates can expect from the forthcoming conference.
Read it in the latest Insights: bit.ly/AtaTSRM25
Read it in the latest Insights: bit.ly/AtaTSRM25
Reposted by Böke Lab
Ten days left to apply to be a @crick.ac.uk Early Career Group Leader
Closing date 27th November
www.crick.ac.uk/careers-stud...
Closing date 27th November
www.crick.ac.uk/careers-stud...
November 17, 2025 at 11:55 AM
Ten days left to apply to be a @crick.ac.uk Early Career Group Leader
Closing date 27th November
www.crick.ac.uk/careers-stud...
Closing date 27th November
www.crick.ac.uk/careers-stud...
It was a pleasure to open the ASEBIR (Spanish Society for Reproductive Studies)
annual congress this morning! #XIIICongresoASEBIR - EB
annual congress this morning! #XIIICongresoASEBIR - EB
November 12, 2025 at 1:27 PM
It was a pleasure to open the ASEBIR (Spanish Society for Reproductive Studies)
annual congress this morning! #XIIICongresoASEBIR - EB
annual congress this morning! #XIIICongresoASEBIR - EB
Reposted by Böke Lab
Aquesta setmana, a l'IDIBAPS...
El pròxim dimarts, l’#IDIBAPS organitza el Women Biology & Health Workshop, una jornada científica dedicada a posar en valor la recerca en la biologia i la salut de les dones
👉https://f.mtr.cool/omkrbqxjxo
El pròxim dimarts, l’#IDIBAPS organitza el Women Biology & Health Workshop, una jornada científica dedicada a posar en valor la recerca en la biologia i la salut de les dones
👉https://f.mtr.cool/omkrbqxjxo
November 9, 2025 at 11:01 AM
Aquesta setmana, a l'IDIBAPS...
El pròxim dimarts, l’#IDIBAPS organitza el Women Biology & Health Workshop, una jornada científica dedicada a posar en valor la recerca en la biologia i la salut de les dones
👉https://f.mtr.cool/omkrbqxjxo
El pròxim dimarts, l’#IDIBAPS organitza el Women Biology & Health Workshop, una jornada científica dedicada a posar en valor la recerca en la biologia i la salut de les dones
👉https://f.mtr.cool/omkrbqxjxo
Reposted by Böke Lab
Today we had a great EvoMG Seminar by Dario Valenzano @dvalenzano.bsky.social from FLI, who told us about some of their recent aging work using the fascinating short-lived killifish.
Hosted by @mirimiam.bsky.social
evomedgenomics.com/events/exter...
Hosted by @mirimiam.bsky.social
evomedgenomics.com/events/exter...
November 5, 2025 at 11:18 PM
Today we had a great EvoMG Seminar by Dario Valenzano @dvalenzano.bsky.social from FLI, who told us about some of their recent aging work using the fascinating short-lived killifish.
Hosted by @mirimiam.bsky.social
evomedgenomics.com/events/exter...
Hosted by @mirimiam.bsky.social
evomedgenomics.com/events/exter...
Reposted by Böke Lab
I am honnestly a bit worried by the latest fuss about qed (the IA driven review). While the results are indeed quite impressive (it is very good at listing the claim and finding potential improvement), I don't quite see how this will eventually reduce the reviewing burden or help us
November 7, 2025 at 8:33 AM
I am honnestly a bit worried by the latest fuss about qed (the IA driven review). While the results are indeed quite impressive (it is very good at listing the claim and finding potential improvement), I don't quite see how this will eventually reduce the reviewing burden or help us
Reposted by Böke Lab
Thinking about doing a PhD with us? We're running an online Q&A session just for you! Hear practical advice directly from our experts in the Training and Academic Office and register here: events.teams.microsoft.com/event/26a7dc...
November 4, 2025 at 10:34 AM
Thinking about doing a PhD with us? We're running an online Q&A session just for you! Hear practical advice directly from our experts in the Training and Academic Office and register here: events.teams.microsoft.com/event/26a7dc...
Reposted by Böke Lab
New PhD opportunity studying oocyte biology. Excited about this new direction in the lab.
The ageing nucleus in the mammalian oocyte with Dr Suzanne Madgwick @suzannemadgwick.bsky.social www.findaphd.com/phds/project...
MRC DiMeN Doctoral Training Partnership: The ageing nucleus in the mammalian oocyte at Newcastle University on FindAPhD.com
PhD Project - MRC DiMeN Doctoral Training Partnership: The ageing nucleus in the mammalian oocyte at Newcastle University, listed on FindAPhD.com
www.findaphd.com
November 4, 2025 at 3:48 PM
New PhD opportunity studying oocyte biology. Excited about this new direction in the lab.
Reposted by Böke Lab
Glad to share that the website for the MZT EMBO workshop that I organize together with Ana Boskovic (EMBL, Rome), Antonio Giraldez (Yale U) and Melissa Harrison (U Wisconsin) is out: meetings.embo.org/event/26-awa...
Please spread the word and join us in beautiful Seville next 4-7 May!
Please spread the word and join us in beautiful Seville next 4-7 May!
Awakening the Genome During Developmental Reprogramming: From Embryos to Organoids
This EMBO Workshop explores the gene-regulatory mechanisms that drive developmental reprogramming upon fertilization. It focuses on the interplay of transcriptional, post-transcriptional, and develop…
meetings.embo.org
September 30, 2025 at 4:18 PM
Glad to share that the website for the MZT EMBO workshop that I organize together with Ana Boskovic (EMBL, Rome), Antonio Giraldez (Yale U) and Melissa Harrison (U Wisconsin) is out: meetings.embo.org/event/26-awa...
Please spread the word and join us in beautiful Seville next 4-7 May!
Please spread the word and join us in beautiful Seville next 4-7 May!
Oh wow - pre-made templates :) - EB
I am happy to present our latest research at the ISSCR 2026 Annual Meeting, taking place in Montréal, Canada on 8-11 July 2026. #ISSCR2026 invt.io/1bxb7uh48oo @isscr.org
I am happy to present our latest research at the ISSCR 2026 Annual Meeting, taking place in Montréal, Canada on 8-11 July 2026. #ISSCR2026 invt.io/1bxb7uh48oo @isscr.org
I'm speaking at ISSCR 2026 Annual Meeting, join me
Register now
invt.io
October 27, 2025 at 8:15 PM
Oh wow - pre-made templates :) - EB
I am happy to present our latest research at the ISSCR 2026 Annual Meeting, taking place in Montréal, Canada on 8-11 July 2026. #ISSCR2026 invt.io/1bxb7uh48oo @isscr.org
I am happy to present our latest research at the ISSCR 2026 Annual Meeting, taking place in Montréal, Canada on 8-11 July 2026. #ISSCR2026 invt.io/1bxb7uh48oo @isscr.org
Thank you! I had a great time, and even found my way around the building by late afternoon @biozentrum.unibas.ch :)- EB
Very excited to have Elvan Böke @bokelab.bsky.social today at the @biozentrum.unibas.ch today to talk about eggs, healthy eggs, and everything in-between 🧪
October 26, 2025 at 8:12 AM
Thank you! I had a great time, and even found my way around the building by late afternoon @biozentrum.unibas.ch :)- EB
Reposted by Böke Lab
Is there any data from academia illustrating how short deadlines for things like awards or funding opportunities disadvantage people from groups who tend to take on or are assigned more thankless labor (women), and advantage those who focus more on the work that benefits them (men)?
October 24, 2025 at 2:02 PM
Is there any data from academia illustrating how short deadlines for things like awards or funding opportunities disadvantage people from groups who tend to take on or are assigned more thankless labor (women), and advantage those who focus more on the work that benefits them (men)?
Reposted by Böke Lab
The Crick is looking for new junior group leaders! Any postdocs or early career researchers wanting to be our colleagues should apply 👍
We're now recruiting early career group leaders at the Crick to lead ambitious research programmes and explore bold scientific questions.
Hear our Director, Edith Heard, explain why the Crick is a unique place for curiosity-driven research.
Apply now ➡️ www.crick.ac.uk/careers-stud...
Hear our Director, Edith Heard, explain why the Crick is a unique place for curiosity-driven research.
Apply now ➡️ www.crick.ac.uk/careers-stud...
October 9, 2025 at 4:49 PM
The Crick is looking for new junior group leaders! Any postdocs or early career researchers wanting to be our colleagues should apply 👍
Reposted by Böke Lab
moonbow last night over our neighborhood
October 5, 2025 at 8:00 AM
moonbow last night over our neighborhood
Reposted by Böke Lab
🚨JOB ALERT🚨
FRIENDS PLEASE SPREAD and RT
We are building a small expert team within the @bokelab.bsky.social at @crg.eu @prbb.org to investigate fundamental questions in oocyte cell biology, focusing on how proteostasis regulation influences dormancy and fertility.
See below 2 calls👇
FRIENDS PLEASE SPREAD and RT
We are building a small expert team within the @bokelab.bsky.social at @crg.eu @prbb.org to investigate fundamental questions in oocyte cell biology, focusing on how proteostasis regulation influences dormancy and fertility.
See below 2 calls👇
October 2, 2025 at 11:00 AM
🚨JOB ALERT🚨
FRIENDS PLEASE SPREAD and RT
We are building a small expert team within the @bokelab.bsky.social at @crg.eu @prbb.org to investigate fundamental questions in oocyte cell biology, focusing on how proteostasis regulation influences dormancy and fertility.
See below 2 calls👇
FRIENDS PLEASE SPREAD and RT
We are building a small expert team within the @bokelab.bsky.social at @crg.eu @prbb.org to investigate fundamental questions in oocyte cell biology, focusing on how proteostasis regulation influences dormancy and fertility.
See below 2 calls👇
Reposted by Böke Lab
🟣🟡Call for abstracts!
#IDIBAPS will host the Women, Biology & Health Workshop #WBHW - a meeting point to highlight the role of women in biomedical research
We invite researchers to submit their abstracts and be part of the program👉https://f.mtr.cool/ccejqnjqut
Deadline 30/9
#IDIBAPS will host the Women, Biology & Health Workshop #WBHW - a meeting point to highlight the role of women in biomedical research
We invite researchers to submit their abstracts and be part of the program👉https://f.mtr.cool/ccejqnjqut
Deadline 30/9
September 15, 2025 at 9:03 AM
🟣🟡Call for abstracts!
#IDIBAPS will host the Women, Biology & Health Workshop #WBHW - a meeting point to highlight the role of women in biomedical research
We invite researchers to submit their abstracts and be part of the program👉https://f.mtr.cool/ccejqnjqut
Deadline 30/9
#IDIBAPS will host the Women, Biology & Health Workshop #WBHW - a meeting point to highlight the role of women in biomedical research
We invite researchers to submit their abstracts and be part of the program👉https://f.mtr.cool/ccejqnjqut
Deadline 30/9
Reposted by Böke Lab
Epithelial crowding drives membrane depolarisation by ENaC/Na+ entry which triggers rapid volume loss, piezo activation and live cell extrusion. Importantly, low intracellular ATP primes cells for live extrusion by preventing the restoring of mb polarisation.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Energy deficiency selects crowded live epithelial cells for extrusion - Nature
Crowded epithelial cells with the least energy and membrane potential are selected for extrusion.
www.nature.com
September 15, 2025 at 1:52 PM
Epithelial crowding drives membrane depolarisation by ENaC/Na+ entry which triggers rapid volume loss, piezo activation and live cell extrusion. Importantly, low intracellular ATP primes cells for live extrusion by preventing the restoring of mb polarisation.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Böke Lab
Did you know human oocytes “switch off” to protect themselves?
➡️ A new #CRGenomica study shows that as eggs mature,they partially shut down their cellular clean-up systems.
This pause may help them stay healthy for decades until fertilization
👉Read more:
➡️ A new #CRGenomica study shows that as eggs mature,they partially shut down their cellular clean-up systems.
This pause may help them stay healthy for decades until fertilization
👉Read more:
Human eggs power down to protect themselves - El·lipse
This image, by Gabriele Zaffagnini from the Centre for Genomic Regulation (CRG), showss a human oocyte fixed and immunostained. Mitochondria are shown in orange and the actin cytoskeleton is shown in green. DNA is shown in light blue. The image is part of a recent study by the Elvan Böke lab that showed that human […]
tuit.cat
September 12, 2025 at 6:43 PM
Did you know human oocytes “switch off” to protect themselves?
➡️ A new #CRGenomica study shows that as eggs mature,they partially shut down their cellular clean-up systems.
This pause may help them stay healthy for decades until fertilization
👉Read more:
➡️ A new #CRGenomica study shows that as eggs mature,they partially shut down their cellular clean-up systems.
This pause may help them stay healthy for decades until fertilization
👉Read more:
Thanks for highlighting our recent work in human oocytes! :) -EB
New online: A snapshot of proteostasis in human oocytes
A snapshot of proteostasis in human oocytes
Nature Structural & Molecular Biology, Published online: 09 September 2025; doi:10.1038/s41594-025-01679-2A snapshot of proteostasis in human oocytes
go.nature.com
September 10, 2025 at 4:53 PM
Thanks for highlighting our recent work in human oocytes! :) -EB
Reposted by Böke Lab
Great to see our work featured in @natsmb.nature.com!! Thanks editor @dimitristypas.bsky.social for your coverage! @bokelab.bsky.social
New online: A snapshot of proteostasis in human oocytes
A snapshot of proteostasis in human oocytes
Nature Structural & Molecular Biology, Published online: 09 September 2025; doi:10.1038/s41594-025-01679-2A snapshot of proteostasis in human oocytes
go.nature.com
September 10, 2025 at 10:14 AM
Great to see our work featured in @natsmb.nature.com!! Thanks editor @dimitristypas.bsky.social for your coverage! @bokelab.bsky.social
Reposted by Böke Lab
ISSUE 16
Review on metabolic diversity of plants
Resource: mouse organ-/age-specific proteome profiles
Cardiolipin inhibition of non-canonical inflammasomes
Optochemical profiling of NMDA receptor diversity
Cover: @gzaffagnini.bsky.social et al @bokelab.bsky.social
www.embopress.org/toc/14602075...
Review on metabolic diversity of plants
Resource: mouse organ-/age-specific proteome profiles
Cardiolipin inhibition of non-canonical inflammasomes
Optochemical profiling of NMDA receptor diversity
Cover: @gzaffagnini.bsky.social et al @bokelab.bsky.social
www.embopress.org/toc/14602075...
August 25, 2025 at 8:04 AM
ISSUE 16
Review on metabolic diversity of plants
Resource: mouse organ-/age-specific proteome profiles
Cardiolipin inhibition of non-canonical inflammasomes
Optochemical profiling of NMDA receptor diversity
Cover: @gzaffagnini.bsky.social et al @bokelab.bsky.social
www.embopress.org/toc/14602075...
Review on metabolic diversity of plants
Resource: mouse organ-/age-specific proteome profiles
Cardiolipin inhibition of non-canonical inflammasomes
Optochemical profiling of NMDA receptor diversity
Cover: @gzaffagnini.bsky.social et al @bokelab.bsky.social
www.embopress.org/toc/14602075...
Reposted by Böke Lab
Here we go again! Our paper on #proteostasis in human oocytes appeared on the latest @embojournal.org cover! A great collaboration with Dexeus Mujer @bokelab.bsky.social ! 🥂👏🏻💪🏻
August 18, 2025 at 12:35 PM
Here we go again! Our paper on #proteostasis in human oocytes appeared on the latest @embojournal.org cover! A great collaboration with Dexeus Mujer @bokelab.bsky.social ! 🥂👏🏻💪🏻
We’re so happy that our review on “Proteostasis in cellular dormancy” was chosen for the cover of the August issue of @cp-trendsbiochem.bsky.social in the old-school way; we were invited! Many thanks to our editor, Sannie Culbertson, and the reviewers for a great experience - EB
📢 Our August issue is online!
🎨 The cover highlights a Feature Review from Stephanie Rosswag de Souza, @gzaffagnini.bsky.social, and @bokelab.bsky.social on how proteostasis functions in cellular dormancy across a number of examples, from yeast to adult quiescent stem cells and vertebrate oocytes.
🎨 The cover highlights a Feature Review from Stephanie Rosswag de Souza, @gzaffagnini.bsky.social, and @bokelab.bsky.social on how proteostasis functions in cellular dormancy across a number of examples, from yeast to adult quiescent stem cells and vertebrate oocytes.
August 7, 2025 at 3:07 PM
We’re so happy that our review on “Proteostasis in cellular dormancy” was chosen for the cover of the August issue of @cp-trendsbiochem.bsky.social in the old-school way; we were invited! Many thanks to our editor, Sannie Culbertson, and the reviewers for a great experience - EB
Reposted by Böke Lab
It’s been truly wonderful to share these years with you all. Thank you so much for the many great times and all the advice along the way. I will definitely miss you. Look, how could I not?
August 1, 2025 at 8:56 AM
It’s been truly wonderful to share these years with you all. Thank you so much for the many great times and all the advice along the way. I will definitely miss you. Look, how could I not?
A bittersweet and slightly late! post: we celebrated
@aidaronu.bsky.social
as she heads off to start her own lab in the Department of Physiological Sciences at the University of Barcelona! 🥂 From postdoc to PI, we’re so proud and can’t wait to see all she accomplishes! Go shine, Aida! 🌟🥂
@aidaronu.bsky.social
as she heads off to start her own lab in the Department of Physiological Sciences at the University of Barcelona! 🥂 From postdoc to PI, we’re so proud and can’t wait to see all she accomplishes! Go shine, Aida! 🌟🥂
July 31, 2025 at 7:12 PM
A bittersweet and slightly late! post: we celebrated
@aidaronu.bsky.social
as she heads off to start her own lab in the Department of Physiological Sciences at the University of Barcelona! 🥂 From postdoc to PI, we’re so proud and can’t wait to see all she accomplishes! Go shine, Aida! 🌟🥂
@aidaronu.bsky.social
as she heads off to start her own lab in the Department of Physiological Sciences at the University of Barcelona! 🥂 From postdoc to PI, we’re so proud and can’t wait to see all she accomplishes! Go shine, Aida! 🌟🥂