Lightnews — Scholar-powered news

Böke Lab @bokelab.bsky.social · 10h

Massive congrats - no need to say but very well deserved :) :) - EB

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Nick Stroustrup @nstroustrup.bsky.social · 3d

moonbow last night over our neighborhood

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Adriano Bolondi @adrianobolondi.bsky.social · 6d

🚨JOB ALERT🚨

FRIENDS PLEASE SPREAD and RT

We are building a small expert team within the @bokelab.bsky.social at @crg.eu @prbb.org to investigate fundamental questions in oocyte cell biology, focusing on how proteostasis regulation influences dormancy and fertility.

See below 2 calls👇

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IDIBAPS @idibaps.bsky.social · 23d

🟣🟡Call for abstracts!

#IDIBAPS will host the Women, Biology & Health Workshop #WBHW - a meeting point to highlight the role of women in biomedical research

We invite researchers to submit their abstracts and be part of the program👉https://f.mtr.cool/ccejqnjqut

Deadline 30/9

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Böke Lab @bokelab.bsky.social · 23d

I have an educated guess… :) -EB

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Levayer Lab @levayerr.bsky.social · 23d

Epithelial crowding drives membrane depolarisation by ENaC/Na+ entry which triggers rapid volume loss, piezo activation and live cell extrusion. Importantly, low intracellular ATP primes cells for live extrusion by preventing the restoring of mb polarisation.

www.nature.com/articles/s41...

Energy deficiency selects crowded live epithelial cells for extrusion - Nature

Crowded epithelial cells with the least energy and membrane potential are selected for extrusion.

www.nature.com

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Parc de Recerca Biomèdica de Barcelona @prbb.org · 26d

Did you know human oocytes “switch off” to protect themselves?

➡️ A new #CRGenomica study shows that as eggs mature,they partially shut down their cellular clean-up systems.

This pause may help them stay healthy for decades until fertilization

👉Read more:

Human eggs power down to protect themselves - El·lipse

This image, by Gabriele Zaffagnini from the Centre for Genomic Regulation (CRG), showss a human oocyte fixed and immunostained. Mitochondria are shown in orange and the actin cytoskeleton is shown in green. DNA is shown in light blue. The image is part of a recent study by the Elvan Böke lab that showed that human […]

tuit.cat

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Böke Lab @bokelab.bsky.social · 28d

Thanks for highlighting our recent work in human oocytes! :) -EB

Nature Structural & Molecular Biology @natsmb.nature.com · 29d

New online: A snapshot of proteostasis in human oocytes

A snapshot of proteostasis in human oocytes

Nature Structural & Molecular Biology, Published online: 09 September 2025; doi:10.1038/s41594-025-01679-2A snapshot of proteostasis in human oocytes

go.nature.com

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Reposted by Böke Lab

Gabriele Zaffagnini @gzaffagnini.bsky.social · 28d

Great to see our work featured in @natsmb.nature.com!! Thanks editor @dimitristypas.bsky.social for your coverage! @bokelab.bsky.social

Nature Structural & Molecular Biology @natsmb.nature.com · 29d

New online: A snapshot of proteostasis in human oocytes

A snapshot of proteostasis in human oocytes

Nature Structural & Molecular Biology, Published online: 09 September 2025; doi:10.1038/s41594-025-01679-2A snapshot of proteostasis in human oocytes

go.nature.com

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The EMBO Journal @embojournal.org · Aug 25

ISSUE 16
Review on metabolic diversity of plants
Resource: mouse organ-/age-specific proteome profiles
Cardiolipin inhibition of non-canonical inflammasomes
Optochemical profiling of NMDA receptor diversity
Cover: @gzaffagnini.bsky.social et al @bokelab.bsky.social
www.embopress.org/toc/14602075...

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Reposted by Böke Lab

Gabriele Zaffagnini @gzaffagnini.bsky.social · Aug 18

Here we go again! Our paper on #proteostasis in human oocytes appeared on the latest @embojournal.org cover! A great collaboration with Dexeus Mujer @bokelab.bsky.social ! 🥂👏🏻💪🏻

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Böke Lab @bokelab.bsky.social · Aug 7

We’re so happy that our review on “Proteostasis in cellular dormancy” was chosen for the cover of the August issue of @cp-trendsbiochem.bsky.social in the old-school way; we were invited! Many thanks to our editor, Sannie Culbertson, and the reviewers for a great experience - EB

Trends in Biochemical Sciences @cp-trendsbiochem.bsky.social · Aug 7

📢 Our August issue is online!

🎨 The cover highlights a Feature Review from Stephanie Rosswag de Souza, @gzaffagnini.bsky.social, and @bokelab.bsky.social on how proteostasis functions in cellular dormancy across a number of examples, from yeast to adult quiescent stem cells and vertebrate oocytes.

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Aida Rodriguez-Nuevo @aidaronu.bsky.social · Aug 1

It’s been truly wonderful to share these years with you all. Thank you so much for the many great times and all the advice along the way. I will definitely miss you. Look, how could I not?

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Böke Lab @bokelab.bsky.social · Jul 31

A bittersweet and slightly late! post: we celebrated
@aidaronu.bsky.social
as she heads off to start her own lab in the Department of Physiological Sciences at the University of Barcelona! 🥂 From postdoc to PI, we’re so proud and can’t wait to see all she accomplishes! Go shine, Aida! 🌟🥂

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Manuel Ansede @manuelansede.bsky.social · Jul 31

Sorpresa en la familia vegetal: la patata es hija del tomate
elpais.com/ciencia/2025...

Sorpresa en la familia vegetal: la patata es hija del tomate

Un equipo liderado por científicos chinos descubre que hubo un cruce natural hace nueve millones de años, en una investigación con implicaciones geopolíticas: quien controla las papas, domina el mundo

elpais.com

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Ian Sample @iansample.bsky.social · Jul 26

We’re hiring for a major role in the US, an investigative journalist to cover what’s happening with science in the US and beyond. This is extremely important territory for us. 🧪

workforus.theguardian.com/jobs/795 The Guardian :: Senior Science Investigative Reporter

The Guardian :: Senior Science Investigative Reporter

workforus.theguardian.com

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Reposted by Böke Lab

Manuel Irimia @mirimiam.bsky.social · Jul 23

🚨🚨🚨

Please RT!

We're looking for a postdoc to join an exciting joint project between our lab @upf.edu & @crg.eu (Barcelona) and the Sander lab @mdc-berlin.bsky.social (Berlin) investigating how alternative splicing and microexons influences the maturation of pancreatic islets.

Deadline: 30/09/25👇

www.upf.edu

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Reposted by Böke Lab

Luca Jovine @jovinelab.org · Jul 22

Excited that the Gordon Research Conference on Fertilization and Activation of Development 2025 (and associated GRS) is just a few days away!

www.grc.org/fertilizatio...

www.grc.org/fertilizatio...

#GRC #GRS #fertilization #development #egg #sperm

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Reposted by Böke Lab

Christopher Thomas @ovarylab.bsky.social · Jul 18

Pleased to share my new review:

Ovulation: A cellular symphony in three movements 💥🥚

Ovulation is more than egg release—it's a tightly regulated, tissue-scale process. Here, I present a temporal framework structured as a symphony performed by the cells of the follicle.

🔗 doi.org/10.1016/j.se...

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Böke Lab @bokelab.bsky.social · Jul 18

Proud to share what we hope will be a reference study on human oocyte proteostasis. Young-donor eggs show globally reduced organelle activity vs. somatic cells, with an even steeper drop as they mature.
👇 for @zaffagg3 's detailed explanation

www.embopress.org/doi/full/10....

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Reposted by Böke Lab

The EMBO Journal @embojournal.org · Jul 16

The proteostatic landscape of healthy human oocytes
Elvan Böke and colleagues @bokelab.bsky.social find that mature human oocytes show reduced activity of lysosomes, proteasomes and mitochondria, highlighting reproductive differences between humans and mouse
www.embopress.org/doi/full/10....

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Gabriele Zaffagnini @gzaffagnini.bsky.social · Jul 16

📣 Paper alert!! Excited to share the 2nd research paper from my time in the @bokelab.bsky.social at @crg.eu, out today in the @embojournal.org!

We asked: "how do human oocytes regulate proteostatic organelles under physiological conditions?"

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Adriano Bolondi @adrianobolondi.bsky.social · Jul 8

Excited to share that this July I will be starting my #marie-skłosowska-curie #MSCA fellowship @ec.europa.eu to continue working on ovarian proteostasis and oocyte dormancy in the @bokelab.bsky.social at @crg.eu @prbb.org!

marie-sklodowska-curie-actions.ec.europa.eu/news/msca-aw...

MSCA awards €417 million to postdoctoral researchers

1696 outstanding postdoctoral researchers were selected for funding among 10,360 applicants.

marie-sklodowska-curie-actions.ec.europa.eu

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Reproseminars @reproseminars.bsky.social · Jul 2

🧬 We're thrilled to close this semester of Reproseminars with Dr. Elvan Böke (@crg.eu‬, Barcelona)!
🗣 Talk (in English): "Evading ageing: metabolic and proteostatic adaptations in oocytes"
🗓 Monday 07/07, Special time!
🕐 1 PM ARG🇦🇷 | 12 PM 🇺🇸 East | 6 PM 🇪🇺 Europe
Join us!

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Bardin Lab @bardinlab.bsky.social · Jul 1

Book your calendars for the 2026 ISSCR meeting in Montreal in 1 year! An exciting speaker line up!

@isscr.org

www.isscr2026.org/overview

Program Overview — ISSCR 2026

Explore an overview of the scientific program, organizing committee, and event details for ISSCR 2026!

www.isscr2026.org

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