Catherine Lovegrove
@celovegrove.bsky.social
91 followers 83 following 49 posts
Investigating the genetic and metabolic basis of kidney stone disease and obesity. DPhil. Happiest on a hill by foot or by pedal🏴󠁧󠁢󠁳󠁣󠁴󠁿🚵🏼 🏃🏼‍♀️ ✟
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celovegrove.bsky.social
⏰Maybe, if #DollyParton is anything to go by, working 9-5 is a risk factor to investigate….!

🔮Hopefully her treatments are smooth and her fame raises awareness of a common disease with a high burden on patients and health systems that we need to understand better.
dolly parton is singing into a microphone while holding a guitar ..
ALT: dolly parton is singing into a microphone while holding a guitar ..
media.tenor.com
celovegrove.bsky.social
With colleagues at @uofglasgow.bsky.social & @ndsurgicalsci.bsky.social I aim to understand more about factors affecting the Lithogenic Triad.

💡More information will let us:

🩺Treat people with stones better
🔍Identify which patients are at high risk of more stones
🛑Prevent new stones forming
celovegrove.bsky.social
We know common genetic changes in calcium, phosphate, & vitamin D pathways increase risk of stones doi.org/10.1172/JCI1.... This can change urine composition.

We know obesity causes stones but are not yet sure why doi.org/10.1681/asn..... Obesity might affect any part of the Lithogenic Triad.
JCI - Genetic variants predisposing to an increased risk of kidney stone disease
doi.org
celovegrove.bsky.social
I believe that three kinds of changes can increase the risk of stones forming:

A *Lithogenic Triad* of:

1. Changes in urine composition
2. Changes in urine flow
3. Changes in kidney tubule wall composition
celovegrove.bsky.social
📚This is the topic of my research.
💎Stones affect ~20% people and half will get another within 5-10 years.

🧬Some risk is from common genetic changes.
💦Some risk is lifestyle (hydration, diet, obesity).

🔬If we can understand more about causes of stones, we can make treatments to prevent them.
celovegrove.bsky.social
#KidneyStones in the news!
www.bbc.co.uk/news/article...

❓What are they?
💎 Stones that form in kidneys & can fall into the ureter (drainpipe from kidneys to bladder)

❓So what?
😖 They’re linked to pain, infections, lower quality of life, & can need surgery.

❓What causes them?
🤔 Good question!
Dolly Parton posts 'I ain't dead yet' after sister sparks health concerns - BBC News
The singer's sister had asked fans to pray for her after the star postponed gigs due to health issues.
www.bbc.co.uk
celovegrove.bsky.social
At #ST3bootcamp for urology in Leeds this week. First-class teaching, simulation, and interactions across all new ST3s.
Stones, non technical skills, functional, uroradiology done so far, bladder cancer and recon today.
celovegrove.bsky.social
Really enjoying a late-summer/early autumn read, courtesy of @rcsed.bsky.social. Brilliantly curated and edited @otolaryngolofox.bsky.social
Reposted by Catherine Lovegrove
cyclingscotland.bsky.social
"Six times more people are killed on the roads in the UK each year than through knife crime. If this was any other area of our lives, we would never tolerate this level of harm."

Rebecca Morris’ impassioned speech calls for more immediate action for safer streets. #CyclingScotlandConf
Rebecca Morris, Vision Zero Communications Director and road safety campaigner, addresses the 2025 Cycling Scotland Conference in Dundee.
Reposted by Catherine Lovegrove
cyclinguk.bsky.social
👏 Congrats to Katherine Cory & Phil Noble - joint Cycling Champions of the Year in Scotland 2025!

True champions of cycling for all 💙
cyclingscotland.bsky.social
🚲🏆 Katherine Cory and Phil Noble have been announced as Scotland's 2025 Cycling Champions of the Year, in recognition of their impact in helping more people of all ages to cycle. Congratulations Katherine and Phil! 🎉

cycling.scot/news/2025-cy...
2025 Cycling Champions are announced
Winners of the 2025 Cycling Champion of the Year Awards have been announced, with Katherine Cory and Phil Noble celebrated for their impact in helping to enable more people, of all ages, to cycle in S...
cycling.scot
celovegrove.bsky.social
More and more patients on GLP1RAs so, as surgeons, it’s important to consider the perioperative effects as well as disease/comorbidity- specific effects.
Data to suggest no change in surgical complications, which is reassuring.
Reposted by Catherine Lovegrove
ndm.ox.ac.uk
Behind every door is a discovery...

📅 On 13 Sept, we’re opening ours at the Old Road Campus Research Building for #OxfordOpenDoors. @cmd.ox.ac.uk, @idrm.ox.ac.uk, @ludwigcancer.bsky.social, @oncology.ox.ac.uk and more will be there, will you?

Find out more 👉 buff.ly/WV8TAXt
Reposted by Catherine Lovegrove
nephmoor.bsky.social
Looking for a PhD/Md-PhD candidate for a fully funded project at University Hospital Bern Switzerland to work at the intersection of kidney and bone biology. Please share, DM or comment. #NephSky #AskRenal
Reposted by Catherine Lovegrove
thisismyglasgow.bsky.social
Even this late in the summer, the ornamental flower beds in Victoria Park in Glasgow are still looking very colourful.

#glasgow #victoriapark #flowers #glasgowparks
Reposted by Catherine Lovegrove
anshulkundaje.bsky.social
@jengreitz.bsky.social l & my lab want to co-hire a computational biologist/biostatistician with project management expertise to help map the regulatory code of the human genome and discover genetic mechanisms of disease.

Details below
careersearch.stanford.edu/jobs/computa...

Plz RT
Reposted by Catherine Lovegrove
ox.ac.uk
'If we want more people to cycle, we need to build for the bikes - and riders - we have now and want in the future.'

@tsuoxford.bsky.social's Dr Zakiyya Adam outlines recommendations for the implementation of cycling-promoting initiatives in mid-sized European cities 🚲

#CycleToWorkDay
Cities for cycling: what is needed beyond good will and cycle paths?
www.ox.ac.uk
Reposted by Catherine Lovegrove
sarahhowles.bsky.social
Our latest with editorial. Genetic susceptibility to kidney stone disease: unveiling pathogenesis and potential therapeutic targets @jclinicalinvest @drsarahhowles
jci.org/articles/view/…
jci.org/articles/view/�
�� @celovegrove.bsky.social @ndsurgicalsci.bsky.social
https://jci.org/articles/view/…
Reposted by Catherine Lovegrove
jci.org
No stone goes unturned in the search for risk-associated variants in kidney stone disease—

@celovegrove.bsky.social @sarahhowles.bsky.social & team identify three biologic pathways that underlie ~11-19% of common causes of stone formation: buff.ly/INjAjLy
celovegrove.bsky.social
Likely not helped by initiatives such as paper mills which reward for churning out publications, targeting the people seeking authorship for job applications. The consequences of these targets are not insignificant and their purpose/relevance needs to be considered.

www.science.org/content/arti...
Questionable firms tempt young doctors with ‘easy’ publications
Foreign trainees seeking U.S. medical residencies pay hefty sums to build research resumes
www.science.org
celovegrove.bsky.social
Scientific fraud is an issue that needs to be tackled for stakeholders’ (including medical patients’) benefit.

“Unless publishers, funders, and people in charge of hiring and promotion pay attention and penalize this behaviour…it will continue. It’s growing fast.”

www.science.org/content/arti...
Scientific fraud has become an ‘industry,’ alarming analysis finds
Sophisticated global networks are infiltrating journals to publish fake papers
www.science.org
celovegrove.bsky.social
I agree.
Was also taught not to “apologise for this busy slide”- pitch it at an appropriate level so that the audience are on board with the info rather than feeling they’re barely hanging on to the message by a thread.
Reposted by Catherine Lovegrove
nickywhiffin.bsky.social
📣 We are recruiting! Please share!!

Are you a bioinformatician / computational scientist who wants to apply your skills to understanding regulatory biology and improving rare disease diagnosis and treatment? 🧠 💻 🧬 🩺

We have two roles available 👇

🧵 1/4
Image of an old building in Oxford with the heading 'postdoc opportunities' and the text 'computational approaches to improve rare disease diagnosis and treatment' and 'Big Data Institute, University of Oxford'