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Dada Pisconti @dadapisconti.bsky.social · 1d

too bad there isn't a "like to to the power of 100" button. I would so use it for this post!
Alas, let alone stupid RFK Jr, way too many times I hear colleagues saying this in talks. It always makes me so sad.

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Dada Pisconti @dadapisconti.bsky.social · 3d

same, but terrified for my son

derek guy @dieworkwear.bsky.social · 3d

glad to be born at a time when i got to see what life was like before the internet and will be dead before AI completely destroys humanity

Dada Pisconti @dadapisconti.bsky.social · 4d

And I challenge you to find a good pair of ethical shoes anyway

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Dada Pisconti @dadapisconti.bsky.social · 4d

We call this "the scientific method" 🙂

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Dada Pisconti @dadapisconti.bsky.social · 4d

Ideally, one should get biopsies from each tissue and study them separately, but heart and brain are obviously a no go. Liver can be biopsied but it's very invasive. Maybe muscle and fat? Also invasive but less than liver, and at least it would be a start!

Dada Pisconti @dadapisconti.bsky.social · 4d

Typically we say that the most metabolically active organs/tissues are the heart, liver, muscle and brain. But I would say that we shouldn't forget about fat either. All if them are dumping their metabolic products into the blood so it's hard to know who is doing exactly what.

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Dada Pisconti @dadapisconti.bsky.social · 4d

These are the typical findings of ME/CFS plasma metabolomics that I was referring to earlier. One of the problems with this type of assays is that we don't actually know which tissues/organs could be contributing the differences.

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Dada Pisconti @dadapisconti.bsky.social · 4d

You're incredibly smart and have drawn the right conclusion from your observations. I can assure you, only about 5% of my biochemistry college students could have mustered such amazing scientific thinking. You have a talent, I wish you were my student, I am sure you would do great!

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Dada Pisconti @dadapisconti.bsky.social · 4d

How do you know yours are broken?

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Dada Pisconti @dadapisconti.bsky.social · 4d

And I suppose Apple juice works great for you because is very sugary but also hydrating at the same time. It makes sense.

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Dada Pisconti @dadapisconti.bsky.social · 4d

What do you mean by "feed the crash", exactly?

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Dada Pisconti @dadapisconti.bsky.social · 4d

This is so interesting and I didn't know it is so common amongst ppl with lived experience. Is this something well known amongst physicians too?

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Dada Pisconti @dadapisconti.bsky.social · 4d

Me to my 3.5-year old son: Look Nico, it's full moon tonight, isn't it beautiful?

Nico: no, I am scared

Me: why are you scared?

Nico: because it has red eyes

Me: 🙄🤦🏻‍♀️

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Dada Pisconti @dadapisconti.bsky.social · 4d

I am not sure there is a clear shift to Warburg effect in ME/CFS, at least not clear for the cell types/tissues that would matter the most (muscle and brain). But it would make a lot of sense, it and it would be consistent with some of the plasma metabolomics findings too.

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Dada Pisconti @dadapisconti.bsky.social · 4d

Do you remember anyone finding mitochondrial uncoupling (amongst the many types of mitochondrial dysfunction people have found) in ME/CFS? That could explain both the fatigue and the fever upon "usage"

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Dada Pisconti @dadapisconti.bsky.social · 7d

Oh, say, can you see? 🥰

Me by the federal courthouse seal holding my US citizenship certificate

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It's ME(Jaime) @exceedhergrasp1.bsky.social · 9d

Hey, #MedSky & #SciSky! New text from Elsevier out today, "The Scientific Basis of Fatigue", with multiple chapters on different diseases, including #MECFS, COVID, Parkinson's, stroke and MS.

Proud to be the co-author of the #MECFS chapter with authors from Mayo and Bateman-Horne! More info:🧪

#MEAction Network @meactnet.bsky.social · 9d

Stellar new work from @grachstephanie.bsky.social, @exceedhergrasp1.bsky.social, @batemanhornecenter.bsky.social's Bell and Yellman & @raviganeshmd.bsky.social in the Elsevier text 'The Scientific Basis of Fatigue'! The book has chapters on #MECFS, COVID, Parkinson’s, stroke, and multiple sclerosis.

Text-based graphic with one photo. Text: New publication. Managing myalgic encephalomyelitis/chronic fatigue syndrome: a new narrative. a chapter in a new Elsevier textbook written by coauthors from #MEAction, Mayo Clinic Rochester and the Bateman-Horne Center. “I was honored to co-author this chapter with colleagues from Mayo Clinic and the Bateman-Horne Center to give clinicians and researchers the tools they need to better recognize, study and treat ME/CFS.”
Jaime Seltzer,
Scientific Director, #MEAction
Photo: Jaime Seltzer (white woman with long, dark hair) wearing glasses and cream blazer and red top slightly smiling.

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BWJones @bwjones.bsky.social · 9d

This is what's it's about.

Representing, and being accessible through service.

Thank you AOC for doing the right thing by those students.

Alexandria Ocasio-Cortez @aoc.bsky.social · 9d

A bus of Bronx middle schoolers pulled up to the Capitol this morning for a long-planned field trip just a few hours after the government shut down.

All Capitol tours were cancelled as the guides can’t work in shutdown.

So I escorted them in myself and gave them a personal tour. They were great!

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Chris Murphy @chrismurphyct.bsky.social · 11d

Every major Democrat has millions in their campaign account. The threat to democracy is big enough that we need to be funding mobilization and messaging right now - not just banking money for the next election.

If we don't build right now, there might not be another election.

Julie Tsirkin @newsjul.bsky.social · 12d

scoop: Sen Chris Murphy is donating 100k from his political fund to Indivisible — the latest in a series of donations he says total ~1m to progressive organizing groups taking on the Trump admin

Murphy said fellow Dems should take notes to “meet the moment”

www.nbcnews.com/politics/202...

Sen. Chris Murphy sends funds to anti-Trump organizing groups

The Connecticut Democrat has distributed nearly $1 million this year to groups organizing against the Trump administration.

www.nbcnews.com

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Jeremy Berg @jeremymberg.bsky.social · 12d

When I was at NIH and shutdowns loomed, it was discovered that the administration was planning to shut down PubMed. The head of NCBI called the powers that be and pointed out that this would threaten patient safety

Who knows what will happen now

Just in case, remember Euruope-PMC
(europepmc.org )

a cartoon of donald trump with the words be prepared above him

ALT: a cartoon of donald trump with the words be prepared above him

media.tenor.com

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Dada Pisconti @dadapisconti.bsky.social · 13d

Oh, aren't those adjusted p-values (as in, corrected for multiple comparisons)?

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Dada Pisconti @dadapisconti.bsky.social · 13d

Holy-smolly, did you notice how exceptionally high the -Log(p) of HTT is? I honestly don't know what to make of that! Maybe I could start by reading the whole paper... thanks for sharing!

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Dada Pisconti @dadapisconti.bsky.social · 15d

😱
And here I thought my experience of not finding a good croissant at CDG was the most annoying 😰

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Julien Ochala @droch.bsky.social · 15d

Postdoc opportunity in muscle cell biology! You would not only be involved in an ambitious project but would also help develop cutting edge methods! Highly recommended! @robertseaborne.bsky.social

Postdoctoral Research Associate in Muscle Biology and Genomics | King's College London

www.kcl.ac.uk

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Dada Pisconti @dadapisconti.bsky.social · 15d

excellent news! Although, perhaps providing expectant women with REALLY OUTSTANDING FREE HEALTHCARE woukld have already been a good starting point.

Jessica Lussenhop @jlussenhop.bsky.social · 15d

This is EXTRAORDINARY impact, driven by the Pulitzer Prize-finalist journalism of @deldeib.bsky.social. At a time when so much is being dismantled, it is incredible to see something like this launching to improve health outcomes for moms and babies: www.propublica.org/article/nih-...

NIH Launches New Multimillion-Dollar Initiative to Reduce U.S. Stillbirth Rate

Clinical teams across the country are forming a five-year, $37 million consortium to research stillbirth, a long-neglected public health concern. “There’s no question that the ProPublica reporting was...

www.propublica.org