Lightnews — Scholar-powered news

Reposted by Damián García-García

EMBO Lab Leadership @embolableadership.bsky.social · Sep 5

Places available in our online courses this autumn: @embo.org Project Management (17-19.09), Negotiation for Scientists (18-19.09), Lab Leadership for Postdocs (07-09.10) and for Group Leaders (04-06.11) + Self-Leadership (14-16.10). Register now: www.embolableadership.org/our-courses/ #EMBOLabLead

People discussing projects at a pin board with text promoting upcoming online courses this autumn.

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Reposted by Damián García-García

MDI Biological Laboratory @mdibiolab.bsky.social · Jun 30

A preprint co-authored by MDI Bio Lab Ph.D. student @damgargar.bsky.social (@murawalalab.bsky.social) is already turning heads!

The study was recently highlighted by @prelights.bsky.social, a journal featuring noteworthy preprints of particular interest to the biological community. 🧪 🤝

The essential role of connective-tissue cells during axolotl limb regeneration - preLights

Axolotl limb regeneration decoded! Connective-tissue cells aren’t just participants – they are essential architects of new limbs. Remove them, and regeneration stalls!

prelights.biologists.com

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Damián García-García @damgargar.bsky.social · Jun 30

We're grateful to have our #preprint featured in @prelights.bsky.social. Thank you @dhanuush.bsky.social for selecting it!

Check it out! 🤩

@mdibiolab.bsky.social @murawalalab.bsky.social

preLights @prelights.bsky.social · Jun 30

Axolotl limb regeneration decoded! Connective-tissue cells aren’t just participants – they are essential architects of new limbs. Remove them, and regeneration stalls!

First #preLight post from @dhanuush.bsky.social, highlighting #preprint from @murawalalab.bsky.social and team:

The essential role of connective-tissue cells during axolotl limb regeneration - preLights

Axolotl limb regeneration decoded! Connective-tissue cells aren’t just participants – they are essential architects of new limbs. Remove them, and regeneration stalls!

prelights.biologists.com

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Reposted by Damián García-García

Leo Otsuki @leootsuki.bsky.social · May 21

Delighted that our work on positional memory is now published. We asked how axolotl cells 'know' which part of the limb to regenerate after injury.
www.nature.com/articles/s41...
A joy to work with super team Sarah Plattner, Yuka Sugiura, Francisco Falcon and Elly Tanaka.
🧵1/14

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Karen Echeverri @karenecheverri.bsky.social · May 8

Delighted to see this work from my lab published today, where we identify a population of ETV-1 positive glutamatergic neurons that are activated in the brain in response to a distant injury.

www.nature.com/articles/s41...

Neuronal activation in the axolotl brain promotes tail regeneration - npj Regenerative Medicine

npj Regenerative Medicine - Neuronal activation in the axolotl brain promotes tail regeneration

www.nature.com

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Crystal Rogers, PhD @rogerslabucd.bsky.social · Apr 20

Happy Easter to all who celebrate from Chonk and the axolotls!

Two pink axolotls and one (Chonk) has bunny ears

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paveltomancak.bsky.social @paveltomancak.bsky.social · Apr 15

The @embo.org practical course on #lightsheet #microscopy is back!

Join us in #Dresden for 2 weeks with #your #samples, try the complete line-up of #lightsheet microscopes, tackle big data image analysis, sample prep, OA hardware & much more

Apply now!

Repost 🙏

meetings.embo.org/event/25-lsm

Light sheet microscopy

Light sheet microscopy is a technology that enables near-isotropic imaging of large biological specimens over time. It opens new avenues to study biological processes with unprecedented imaging speed…

meetings.embo.org

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Reposted by Damián García-García

Tatiana Sandoval Guzmán @tatianasg.bsky.social · Apr 14

It has been known for a long time that if the starting point of limb regeneration is at the hand level or close to the shoulder, it would take about the same time to regenerate. Puzzling right?
Check out this preprint from our lab to know more about it:
www.biorxiv.org/content/10.1...

Mechanical control of tissue growth during limb regeneration

The axolotl is a highly regenerative species, capable of restoring full limbs, regardless of the amputation site. However, the regeneration rate is adjusted with the plane of amputation along the prox...

www.biorxiv.org

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Matyas Bubna-Litic @matyasbl.bsky.social · Apr 11

Embryonic induction of fate is a core concept in developmental biology. But, cells can also modify the physical state of surrounding tissues a process we call 'actuation'.

I reviewed with
@mayorlab.bsky.social 3 excellent papers that show how actuation and feedback can drive changes in the embryo.

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Esteban Miglietta @emiglietta.bsky.social · Apr 10

🚨Latin American Workshop Series🚨

The team from @bethcimini.bsky.social‘s lab at @broadinstitute.org and the Center for Open Bioimage Analysis will host three free online image analysis workshops for LATAM ... in SPANISH🇪🇸 and PORTUGUESE🇧🇷!!!🎉🎊

broad.io/latam_worksh...

Deadline: April 23rd, 2025

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bioRxiv Developmental Biology @biorxiv-devbio.bsky.social · Apr 2

The essential role of connective-tissue cells during axolotl limb regeneration https://www.biorxiv.org/content/10.1101/2025.03.30.645595v1

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Damián García-García @damgargar.bsky.social · Apr 3

I want to thank my Ph.D. mentor, @murawalalab.bsky.social, and all the co-authors in the manuscript. Without their work, this project wouldn’t be a reality! 🫶

Let us know what you think 😀

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Damián García-García @damgargar.bsky.social · Apr 3

With this
•⁠ We conclude that CT cells are the majority of blastema cells and are necessary for axolotl limb regeneration
•⁠ ⁠Establish a cell ablation system in the axolotl that can be combined with any Cre-specific line
•⁠ ⁠⁠Provide a new database of the dynamics in CT cells expression over time

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Damián García-García @damgargar.bsky.social · Apr 3

Given their importance, we characterized the molecular dynamics of CT cells over time and deposited this database into an interactive web platform 💻(microarrayct-murawalalab.mdibl.org)

Murawala Agilent Axo Gene Expression

microarrayct-murawalalab.mdibl.org

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Damián García-García @damgargar.bsky.social · Apr 3

We then eliminated CT cells by using the NTR/MTZ #ablation system. After the specific elimination of CT cells, limb regeneration was delayed or truncated, underscoring the necessity of these cells for #regeneration 🤯

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Damián García-García @damgargar.bsky.social · Apr 3

We defined the dynamic changes of cellular identities within the blastema over time by using 10X #Xenium spatial transcriptomics. Immune cells predominate in the first stages, whereas CT cells gradually increment and become the predominant cell type (~73%) at the late-bud blastema stage 🤔.

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Damián García-García @damgargar.bsky.social · Apr 3

Pre-print alert:
This is our latest work on limb regeneration. We found that connective-tissue (CT) cells are necessary for this process by using a combinatorial approach of #spatial transcriptomics and an #ablation system for the first time in the #axolotl!
👇🧵1/6
www.biorxiv.org/content/10.1...

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International Society for Regenerative Biology @isrbio.bsky.social · Mar 26

Registration for the ISRB Madison Conference is now open. Early bird registration ends June 15th so don't delay. We also have a pre-meeting workshop for trainees. Hope to see you all in Madison!

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Marina B. Cuenca @cuencam15.bsky.social · Mar 26

Registrations are open for the EMBO Practical course on light sheet microscopy! Great opportunity to learn all kinds of light-sheet, as well as image postprocessing from the experts themselves.

meetings.embo.org/event/25-lsm

Light sheet microscopy

Light sheet microscopy is a technology that enables near-isotropic imaging of large biological specimens over time. It opens new avenues to study biological processes with unprecedented imaging speed…

meetings.embo.org

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Reposted by Damián García-García

James Briscoe @jamesbriscoe.bsky.social · Mar 25

Peer review completed within 7 days!
Paying peer reviewers!
Yes, it's possible.

Fast & Fair peer review by @biologyopen.bsky.social

More innovation from @biologists.bsky.social

Details here: www.biorxiv.org/content/10.1...

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MDI Biological Laboratory @mdibiolab.bsky.social · Mar 24

This is a cross section of an axolotl's zeugopod by @damgargar.bsky.social, shows the #nuclei (blue), muscles (yellow), and connective tissue (red). A #zeugopod is the middle segment of a vertebrate limb, allowing movements like flexion, rotation & extension.

#microscopymonday #standwithscience 🧪 🤝

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MDI Biological Laboratory @mdibiolab.bsky.social · Mar 17

This #microscopymonday image by Katelyn White is an HCR-ISH on an axolotl neural tube — a technique that amplifies the signal of #RNAtranscripts in cells and tissues (blue nuclei & magenta Shh gene). The Shh gene plays a crucial role in embryonic development. 🧪🤝 👩‍🔬

#standwithscience

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Daniel Ríos @yosoyden.bsky.social · Mar 17

The first original research paper from my lab is now out in @biorxivpreprint.bsky.social! www.biorxiv.org/content/10.1...
Tracheal development is an amazing model to study morphogenesis. There are great works out there that show how this tissue elongates, interconnects, and forms branches (1/n)

Adhesion to a common ECM mediates interdependence in tissue morphogenesis in Drosophila

For organs to be functional, the cells and tissues that constitute them must effectively interact with each other and coordinate their behaviours. Halfway during Drosophila embryogenesis, two lateral ...

www.biorxiv.org

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MDI Biological Laboratory @mdibiolab.bsky.social · Mar 7

Science thrives because of our dedicated researchers, students, supporters, and community members. At MDI Bio Lab, we believe in the power of discovery, education, and collaboration. Thank you for #standupforscience2025, believing in science, and being part of our community!

#standwithscience 🧪 🤝

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Eric Topol @erictopol.bsky.social · Feb 20

At @science.org today, an important new way we can make major headway into immunologic and infectious diseases. Sequencing the lymphocyte B and T cell receptors and A.I. to accurately make the diagnosis!
www.science.org/doi/10.1126/science.adp2407
A seminal study by @anshulkundaje.bsky.social et al

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