Dane Parker
@daneparkerlab.com
Laboratory of Dane Parker 🇦🇺 Rutgers NJMS USA. Bacterial pathogenesis, host-pathogen interactions and innate immunity. Staphylococcus aureus. Interferons. Trained immunity. Center for Infection and Immunity. #immunology, #microbiology.
www.daneparkerlab.com
www.daneparkerlab.com
Pinned
Dane Parker
@daneparkerlab.com
· Aug 4
Trained immunity in the lung
Several studies have now demonstrated that trained immunity occurs in the airways to several pathogens and products, while its utility is yet to be determined.
elifesciences.org
Latest from the lab! In @elife.bsky.social we reviewed the current status of trained immunity in the lung!
elifesciences.org/articles/104...
elifesciences.org/articles/104...
Reposted by Dane Parker
My nose must be riddled with S. aureus then 🫠
#NewResearch
Nasal colonisation by S. aureus is linked with depression in a human cohort and shown in a mouse model to cause decreased serotonin and dopamine in the brain
#MicroSky #Depression
www.nature.com/articles/s41...
Nasal colonisation by S. aureus is linked with depression in a human cohort and shown in a mouse model to cause decreased serotonin and dopamine in the brain
#MicroSky #Depression
www.nature.com/articles/s41...
Nasal Staphylococcus aureus carriage promotes depressive behaviour in mice via sex hormone degradation - Nature Microbiology
Nasal colonization by Staphylococcus aureus is linked with depression in a human cohort and shown in a mouse model to cause decreased serotonin and dopamine in the brain.
www.nature.com
September 22, 2025 at 5:16 PM
My nose must be riddled with S. aureus then 🫠
Latest from the lab!!! We joined Amali Samarasinge and Charles Dela Cruz and a cast of many on a workshop for best practices for models of bacterial pneumonia @atscommunity.bsky.social
www.atsjournals.org/doi/full/10....
www.atsjournals.org/doi/full/10....
Best Practices in the Development and Use of Experimental Models of Bacterial Pneumonia: An Official American Thoracic Society Workshop Report | American Journal of Respiratory Cell and Molecular Biol...
www.atsjournals.org
August 6, 2025 at 2:31 AM
Latest from the lab!!! We joined Amali Samarasinge and Charles Dela Cruz and a cast of many on a workshop for best practices for models of bacterial pneumonia @atscommunity.bsky.social
www.atsjournals.org/doi/full/10....
www.atsjournals.org/doi/full/10....
Latest from the lab! In @elife.bsky.social we reviewed the current status of trained immunity in the lung!
elifesciences.org/articles/104...
elifesciences.org/articles/104...
Trained immunity in the lung
Several studies have now demonstrated that trained immunity occurs in the airways to several pathogens and products, while its utility is yet to be determined.
elifesciences.org
August 4, 2025 at 12:23 PM
Latest from the lab! In @elife.bsky.social we reviewed the current status of trained immunity in the lung!
elifesciences.org/articles/104...
elifesciences.org/articles/104...
Mice are not always reflective of human studies!
A Rutgers study shows Acinetobacter baumannii hits men harder than women— longer ICU stays, higher severity, and more co-infections. Surprising contrast to mouse data. Sex matters in infectious disease. go.njmicrobe.org/e5DGRy #Microbiology #InfectiousDisease #Rutgers #SexDifferences #Acinetobacter
Unveiling the Hidden Impact: How Biological Sex Influences Acinetobacter baumannii Pneumonia Outcomes
Acinetobacter baumannii is a formidable adversary in healthcare settings, recognized by the World Health Organization as a critical priority pathogen due to its strong association with multidrug-resis...
go.njmicrobe.org
June 22, 2025 at 7:09 PM
Mice are not always reflective of human studies!
Reposted by Dane Parker
1,600 names needed toward the next 12,800 target. Support NIH and research
Stand up for science and sign your name in support of NIH staff and The Bethesda Declaration: A Call for NIH and HHS Leadership to Deliver on Promises of Academic Freedom and Scientific Excellence.
actionnetwork.org/forms/add-na...
actionnetwork.org/forms/add-na...
ADD YOUR NAME: Sign the Open Letter in Support of NIH Staff
Join the courageous and committed National Institutes of Health (NIH) public servants by adding your name now.
actionnetwork.org
June 10, 2025 at 1:20 PM
1,600 names needed toward the next 12,800 target. Support NIH and research
Such an honor to receive the Rutgers New Jersey Medical School Faculty Organization Faculty of the Year Award.
May 27, 2025 at 12:37 PM
Such an honor to receive the Rutgers New Jersey Medical School Faculty Organization Faculty of the Year Award.
Reposted by Dane Parker
An improved humanized mouse model of Staphylococcus aureus infection to study pneumonia from @daneparkerlab.com www.mucosalimmunology.org/article/S193...
May 19, 2025 at 1:26 PM
An improved humanized mouse model of Staphylococcus aureus infection to study pneumonia from @daneparkerlab.com www.mucosalimmunology.org/article/S193...
Latest from the lab! We show in @mucosalimmunol.bsky.social
a new humanized mouse model of S. aureus infection using human lung tissue examining the immune and bacterial responses! #OpenAccess
www.mucosalimmunology.org/article/S193...
a new humanized mouse model of S. aureus infection using human lung tissue examining the immune and bacterial responses! #OpenAccess
www.mucosalimmunology.org/article/S193...
Improved humanized mouse model of Staphylococcus aureus infection
Staphylococcus aureus is a significant cause of pulmonary infections, but existing
mouse models fail to recapitulate human-specific responses. In this study, we developed
a novel mouse model of S. aur...
www.mucosalimmunology.org
May 13, 2025 at 9:31 PM
Latest from the lab! We show in @mucosalimmunol.bsky.social
a new humanized mouse model of S. aureus infection using human lung tissue examining the immune and bacterial responses! #OpenAccess
www.mucosalimmunology.org/article/S193...
a new humanized mouse model of S. aureus infection using human lung tissue examining the immune and bacterial responses! #OpenAccess
www.mucosalimmunology.org/article/S193...
The virtual Staphylococcal meeting is happening July 9-10, cheap and easy way to stay up-to-date with the latest research! Over 20 great presentations! #Staphylococcus #Staphylococci
staphsymposia.org
staphsymposia.org
STAPH-SYMPOSIA 2025 – Virtual Symposium on Staphylococcal Infections
staphsymposia.org
May 13, 2025 at 4:16 PM
The virtual Staphylococcal meeting is happening July 9-10, cheap and easy way to stay up-to-date with the latest research! Over 20 great presentations! #Staphylococcus #Staphylococci
staphsymposia.org
staphsymposia.org
Reach out to your representatives to fight the govt cuts to research. ASM has made it easy for you to do so.
The Presidential Budget Request has been released, and it details some serious cuts to scientific funding and research. Please use the link below to automatically send a letter to your Representative and Senators -- you can customize the pre-written message with your personal story.
Action Alerts
ASM is a nonprofit professional society that publishes scientific journals and advances microbiology through advocacy, global health and diversity in STEM programs.
asm.org
May 3, 2025 at 1:16 AM
Reach out to your representatives to fight the govt cuts to research. ASM has made it easy for you to do so.
Reposted by Dane Parker
A huge majority of Americans (77%) oppose the cuts to medical research that the current administration has made.
(Source: Wash. Post/ABC/Ipsos poll)
(Source: Wash. Post/ABC/Ipsos poll)
April 28, 2025 at 8:48 PM
A huge majority of Americans (77%) oppose the cuts to medical research that the current administration has made.
(Source: Wash. Post/ABC/Ipsos poll)
(Source: Wash. Post/ABC/Ipsos poll)
Latest from the lab! We had previously shown sex differences in A. baumannii pulmonary infection. Here, we show that in human males have worse outcomes compared to females. Mice are not people! @asm.org
journals.asm.org/doi/10.1128/...
journals.asm.org/doi/10.1128/...
Biological sex influences severity and outcomes in Acinetobacter baumannii pneumonia | Microbiology Spectrum
Biological sex has been shown to influence the incidence and outcomes of infection.
We had previously documented that in a mouse model of infection, the pathogen Acinetobacter baumannii caused more se...
journals.asm.org
April 17, 2025 at 6:09 PM
Latest from the lab! We had previously shown sex differences in A. baumannii pulmonary infection. Here, we show that in human males have worse outcomes compared to females. Mice are not people! @asm.org
journals.asm.org/doi/10.1128/...
journals.asm.org/doi/10.1128/...
Reposted by Dane Parker
Excited to see this finally out!! We found IL-2 made by CD301b+ DCs critical for the Th2 fate decision of CD4T cells and skewing them away from the Tfh fate. They also seem to use their own CD25 to direct IL-2 to the cognate clone.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
CD301b+ dendritic cell-derived IL-2 dictates CD4+ T helper cell differentiation - Nature Communications
A subset of migratory type 2 conventional dendritic cells marked by CD301b expression (CD301b+DC), are required specifically for the development of Th2 cells. Here authors show that at the mechanistic...
www.nature.com
February 26, 2025 at 10:06 PM
Excited to see this finally out!! We found IL-2 made by CD301b+ DCs critical for the Th2 fate decision of CD4T cells and skewing them away from the Tfh fate. They also seem to use their own CD25 to direct IL-2 to the cognate clone.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Bacteria as food for macrophages!
Nature research paper: Macrophages recycle phagocytosed bacteria to fuel immunometabolic responses
https://go.nature.com/3XmyOPD
https://go.nature.com/3XmyOPD
Macrophages recycle phagocytosed bacteria to fuel immunometabolic responses - Nature
Phagocytosed bacteria can serve as an alternative nutrient source for macrophages, influencing their metabolic and immune responses through the recycling of microbial components, with the process regulated by nutrient-sensing mechanisms and bacterial viability.
go.nature.com
February 27, 2025 at 4:13 PM
Bacteria as food for macrophages!
RIPK3 can promote neuronal survival during viral infection by @briandaniels.bsky.social at @rutgersuniversity.bsky.social !
www.cell.com/immunity/ful...
www.cell.com/immunity/ful...
The kinase RIPK3 promotes neuronal survival by suppressing excitatory neurotransmission during central nervous system viral infection
How innate immune signaling within neurons influences neurotransmission remains poorly
understood. Estevez et al. show that the necroptotic kinase RIPK3 promotes neuronal
survival during viral infecti...
www.cell.com
February 25, 2025 at 3:45 PM
RIPK3 can promote neuronal survival during viral infection by @briandaniels.bsky.social at @rutgersuniversity.bsky.social !
www.cell.com/immunity/ful...
www.cell.com/immunity/ful...
Living with cats and dogs showed an association with MRSA infection!
pubmed.ncbi.nlm.nih.gov/39995309/
pubmed.ncbi.nlm.nih.gov/39995309/
Living with dogs and cats: Is it a risk factor for community acquired methicillin-resistant Staphylococcus aureus skin and soft tissue infections in humans? - PubMed
We conclude that there is an association between human MRSA SSTIs and living with CF.
pubmed.ncbi.nlm.nih.gov
February 25, 2025 at 1:42 PM
Living with cats and dogs showed an association with MRSA infection!
pubmed.ncbi.nlm.nih.gov/39995309/
pubmed.ncbi.nlm.nih.gov/39995309/
Check out my old @columbiauniversity.bsky.social colleague @adamratnermd.bsky.social on his book tour, #vaccines! Or check out his book, "Booster shots". Link here, www.amazon.com/Booster-Shot....
It's time for another Health Storytelling LIVE Author Q&A w/ @marynmck.bsky.social. Next up @adamratnermd.bsky.social with his vital & incredibly timely #NewBook BOOSTER SHOTS: The Urgent Lessons of #Measles and the Uncertain Future of #ChildrensHealth
➡️ 2/26 7pm ET www.youtube.com/watch?v=leKj...
➡️ 2/26 7pm ET www.youtube.com/watch?v=leKj...
February 21, 2025 at 1:41 PM
Check out my old @columbiauniversity.bsky.social colleague @adamratnermd.bsky.social on his book tour, #vaccines! Or check out his book, "Booster shots". Link here, www.amazon.com/Booster-Shot....
Come find us and others here! #immunology #innateimmunity #inflammation. Join the fam!
go.bsky.app/QqJ9AgB
go.bsky.app/QqJ9AgB
February 20, 2025 at 1:44 PM
Come find us and others here! #immunology #innateimmunity #inflammation. Join the fam!
go.bsky.app/QqJ9AgB
go.bsky.app/QqJ9AgB
Are you a bioinformatician and want to work in Australia. @torstenseemann.bsky.social is fabulous!! Check it out!
Want to help build capacity public health pathogen bioinformatics in the Asia Pacific region?
🦘 Based in Melbourne Australia with me
✈️ Travel to and work internationally
🧠 Lead strategy, training & infrastructure
Applications close soon!
jobs.unimelb.edu.au/caw/en/job/9...
🦘 Based in Melbourne Australia with me
✈️ Travel to and work internationally
🧠 Lead strategy, training & infrastructure
Applications close soon!
jobs.unimelb.edu.au/caw/en/job/9...
Details : Bioinformatician, International Training & Research : The University of Melbourne
Careers at The University of Melbourne
jobs.unimelb.edu.au
February 5, 2025 at 5:03 PM
Are you a bioinformatician and want to work in Australia. @torstenseemann.bsky.social is fabulous!! Check it out!
February 4, 2025 at 5:46 PM
Reposted by Dane Parker
See that gap between the United States of America and those other countries?
That gap… that gulf…
That’s profit.
Profit at the expense of health.
That gap… that gulf…
That’s profit.
Profit at the expense of health.
An update with latest data available for graph of life expectancy vs health care expenditures per capita for 20 countries and one outlier.
February 3, 2025 at 4:28 PM
See that gap between the United States of America and those other countries?
That gap… that gulf…
That’s profit.
Profit at the expense of health.
That gap… that gulf…
That’s profit.
Profit at the expense of health.
February 3, 2025 at 1:54 PM
Hello all. Finally made my way to 🦋. Looking for my people in host defense, innate immunology, bacterial pathogenesis and lung biology! Please help me find you!
January 31, 2025 at 3:01 PM
Hello all. Finally made my way to 🦋. Looking for my people in host defense, innate immunology, bacterial pathogenesis and lung biology! Please help me find you!