David Landeira
@davidlandeira.bsky.social
Learning how cells remember and forget, and how can we restore their memories @GENYO University of Granada, Spain. www.landeiralab.ugr.es
Pinned
David Landeira
@davidlandeira.bsky.social
· Sep 10
https://nature.com/articles/s41467-025-63778-4💥
Thrilled to share our story in its final form! nature.com/articles/s41... 💥 After ~10 years, we show that BMAL1 represses transposons via chromatin regulation in embryonic stem cells—rather than circadian rhythms as in adult tissues.
Reposted by David Landeira
📖 El 24 de noviembre de 1859 se publicó #ElOrigenDeLasEspecies de #Darwin donde se establece su teoría de la #Evolución por #SelecciónNatural
🧬 Una de las obras científicas que más impacto ha tenido en todo el mundo occidental.
#díamundialdelaevolución
🧬 Una de las obras científicas que más impacto ha tenido en todo el mundo occidental.
#díamundialdelaevolución
November 24, 2025 at 6:21 PM
📖 El 24 de noviembre de 1859 se publicó #ElOrigenDeLasEspecies de #Darwin donde se establece su teoría de la #Evolución por #SelecciónNatural
🧬 Una de las obras científicas que más impacto ha tenido en todo el mundo occidental.
#díamundialdelaevolución
🧬 Una de las obras científicas que más impacto ha tenido en todo el mundo occidental.
#díamundialdelaevolución
Reposted by David Landeira
Origins of chromosome instability unveiled by coupled imaging and genomics @nature.com
www.nature.com/articles/s41...
www.nature.com/articles/s41...
October 29, 2025 at 11:37 PM
Origins of chromosome instability unveiled by coupled imaging and genomics @nature.com
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by David Landeira
There is one point of agreement among both enthusiasts and sceptics: the future has already arrived
go.nature.com/48M5Xuu
go.nature.com/48M5Xuu
Universities are embracing AI: will students get smarter or stop thinking?
Nature - Millions of students arriving at campuses are now using artificial intelligence. Worries abound.
go.nature.com
October 26, 2025 at 12:38 PM
There is one point of agreement among both enthusiasts and sceptics: the future has already arrived
go.nature.com/48M5Xuu
go.nature.com/48M5Xuu
Reposted by David Landeira
We are recuiting two new Associate Professors here in Oxford Biochemistry. Come join us! Reach out to me if you have any questions. Please repost! tinyurl.com/mr3m7bd3
October 17, 2025 at 2:56 PM
We are recuiting two new Associate Professors here in Oxford Biochemistry. Come join us! Reach out to me if you have any questions. Please repost! tinyurl.com/mr3m7bd3
Reposted by David Landeira
Y aquí tenéis la noticia en vídeo con entrevista a @davidlandeira.bsky.social en @canalsurradiotv.bsky.social (sí, parece que ha salido en un programa infantil; despertando vocaciones ☺️). labanda.canalsur.es/noticias/and...
El envejecimiento empieza en el embrión, antes de nacer
El programa infantil de Canal Sur. Desde 1994 para todos los niños andaluces. ¡En La Banda Tú Mandas!
labanda.canalsur.es
September 24, 2025 at 1:44 PM
Y aquí tenéis la noticia en vídeo con entrevista a @davidlandeira.bsky.social en @canalsurradiotv.bsky.social (sí, parece que ha salido en un programa infantil; despertando vocaciones ☺️). labanda.canalsur.es/noticias/and...
Our new study supports that aging begins in the early stages of embryo development, and not only in adulthood @canalugr canal.ugr.es/noticia/a-ne...
A new study suggests that aging begins in the early stages of embryo development, and not only in adulthood - Canal UGR
This work by the University of Granada, published in Nature Communications, opens up a new paradigm in biomedicine by examining the role of the BMAL1 protein in aging and the… Seguir Leyendo A new stu...
canal.ugr.es
September 22, 2025 at 7:23 AM
Our new study supports that aging begins in the early stages of embryo development, and not only in adulthood @canalugr canal.ugr.es/noticia/a-ne...
When and how do we start aging? Our recent work, led by Amador Gallardo, suggests that aberrant expression of ancient viral remnants in our genome—already during embryonic development—may induce aging in adults. 😮https://www.nature.com/articles/s41467-025-63778-4.pdf
September 12, 2025 at 1:30 PM
When and how do we start aging? Our recent work, led by Amador Gallardo, suggests that aberrant expression of ancient viral remnants in our genome—already during embryonic development—may induce aging in adults. 😮https://www.nature.com/articles/s41467-025-63778-4.pdf
Reposted by David Landeira
🔴 ¡Acaba de publicarse en Nature Communications (@natcomms.nature.com)! 🎉 Feliz de haber contribuido a este increíble trabajo del grupo de David Landeira (@davidlandeira.bsky.social), con Amador Gallardo como primer autor. (1/2)
September 10, 2025 at 9:35 AM
🔴 ¡Acaba de publicarse en Nature Communications (@natcomms.nature.com)! 🎉 Feliz de haber contribuido a este increíble trabajo del grupo de David Landeira (@davidlandeira.bsky.social), con Amador Gallardo como primer autor. (1/2)
Ahi va la nota redactada por nuestro equipo de divulgación sobre nuestro ultimo trabajo! canal.ugr.es/noticia/enve...
Un nuevo estudio sugiere que el envejecimiento empieza en las primeras fases del desarrollo del embrión, y no solo en la vida adulta - Canal UGR
Este trabajo de la UGR, publicado en Nature Communications, abre un paradigma en biomedicina al examinar el papel de la proteína BMAL1 en la vejez y el desarrollo de enfermedades
canal.ugr.es
September 10, 2025 at 2:42 PM
Ahi va la nota redactada por nuestro equipo de divulgación sobre nuestro ultimo trabajo! canal.ugr.es/noticia/enve...
Thrilled to share our story in its final form! nature.com/articles/s41... 💥 After ~10 years, we show that BMAL1 represses transposons via chromatin regulation in embryonic stem cells—rather than circadian rhythms as in adult tissues.
https://nature.com/articles/s41467-025-63778-4💥
September 10, 2025 at 2:26 PM
Thrilled to share our story in its final form! nature.com/articles/s41... 💥 After ~10 years, we show that BMAL1 represses transposons via chromatin regulation in embryonic stem cells—rather than circadian rhythms as in adult tissues.
Reposted by David Landeira
Thomas Mann describiendo con un asombroso realismo las redes sociales (como esta) en «La montaña mágica», escrito hace más de 100 años.
September 6, 2025 at 9:03 AM
Thomas Mann describiendo con un asombroso realismo las redes sociales (como esta) en «La montaña mágica», escrito hace más de 100 años.
Reposted by David Landeira
💬 “Science is the mother of industry”
In the latest ERC Magazine, Jean-François van Boxmeer of the European Round Table for Industry argues Europe must do more to turn scientific discovery into economic value; and that research is central to future strength and sovereignty.
🔗 europa.eu/!m3hK7c
In the latest ERC Magazine, Jean-François van Boxmeer of the European Round Table for Industry argues Europe must do more to turn scientific discovery into economic value; and that research is central to future strength and sovereignty.
🔗 europa.eu/!m3hK7c
July 1, 2025 at 7:01 AM
💬 “Science is the mother of industry”
In the latest ERC Magazine, Jean-François van Boxmeer of the European Round Table for Industry argues Europe must do more to turn scientific discovery into economic value; and that research is central to future strength and sovereignty.
🔗 europa.eu/!m3hK7c
In the latest ERC Magazine, Jean-François van Boxmeer of the European Round Table for Industry argues Europe must do more to turn scientific discovery into economic value; and that research is central to future strength and sovereignty.
🔗 europa.eu/!m3hK7c
Reposted by David Landeira
From the archives: Transposable elements shape the evolution of mammalian development go.nature.com/4mfy7lI #Review by Anna D. Senft & Todd S. Macfarlan
Transposable elements shape the evolution of mammalian development - Nature Reviews Genetics
In this Review, Senft and Macfarlan discuss the diverse ways by which transposable elements (TEs) contribute to mammalian development and evolution, including direct contributions through TE-derived r...
go.nature.com
May 13, 2025 at 3:38 PM
From the archives: Transposable elements shape the evolution of mammalian development go.nature.com/4mfy7lI #Review by Anna D. Senft & Todd S. Macfarlan
Reposted by David Landeira
A strain of bacterium that often causes infections in hospital can break down plastic
https://go.nature.com/3SvsiTC
https://go.nature.com/3SvsiTC
Microbe that infests hospitals can digest medical-grade plastic ― a first
Nature - The bacterium Pseudomonas aeruginosa produces an enzyme that breaks down biodegradable plastics.
go.nature.com
May 10, 2025 at 10:47 AM
A strain of bacterium that often causes infections in hospital can break down plastic
https://go.nature.com/3SvsiTC
https://go.nature.com/3SvsiTC
Reposted by David Landeira
Beautiful work 🤩
💥🥳 At long last, our latest paper is out!
Gag proteins of endogenous retroviruses are required for zebrafish development
www.pnas.org/doi/10.1073/...
Led heroically by Sylvia Chang & @jonowells.bsky.social
A study which has changed the way I think of #transposons! No less! 🧵 1/n
Gag proteins of endogenous retroviruses are required for zebrafish development
www.pnas.org/doi/10.1073/...
Led heroically by Sylvia Chang & @jonowells.bsky.social
A study which has changed the way I think of #transposons! No less! 🧵 1/n
Gag proteins encoded by endogenous retroviruses are required for zebrafish development | PNAS
Transposable elements (TEs) make up the bulk of eukaryotic genomes and examples abound
of TE-derived sequences repurposed for organismal function. ...
www.pnas.org
May 7, 2025 at 1:39 PM
Beautiful work 🤩
Reposted by David Landeira
📢 Register! us02web.zoom.us/webinar/regi...
@akispapantonis.bsky.social presents "Senescent cells co-opt CTCF on nuclear speckles to sustain their splicing program" on May 8, 4PM UK, moderated by @stefanschoenfelder.bsky.social
#GenomeArchitecture #Senescence
@akispapantonis.bsky.social presents "Senescent cells co-opt CTCF on nuclear speckles to sustain their splicing program" on May 8, 4PM UK, moderated by @stefanschoenfelder.bsky.social
#GenomeArchitecture #Senescence
May 1, 2025 at 1:36 PM
📢 Register! us02web.zoom.us/webinar/regi...
@akispapantonis.bsky.social presents "Senescent cells co-opt CTCF on nuclear speckles to sustain their splicing program" on May 8, 4PM UK, moderated by @stefanschoenfelder.bsky.social
#GenomeArchitecture #Senescence
@akispapantonis.bsky.social presents "Senescent cells co-opt CTCF on nuclear speckles to sustain their splicing program" on May 8, 4PM UK, moderated by @stefanschoenfelder.bsky.social
#GenomeArchitecture #Senescence
Reposted by David Landeira
Want to learn more about chromatin and its dynamics? Read this review by Charlotte and Jolijn in our lab, aimed at giving an overview on this and the ways this is dealt with during transcription, replication and damage repair. Thanks to Biochemistry for inviting us! doi.org/10.1021/acs....
Always on the Move: Overview on Chromatin Dynamics within Nuclear Processes
Our genome is organized into chromatin, a dynamic and modular structure made of nucleosomes. Chromatin organization controls access to the DNA sequence, playing a fundamental role in cell identity and...
doi.org
May 4, 2025 at 7:39 AM
Want to learn more about chromatin and its dynamics? Read this review by Charlotte and Jolijn in our lab, aimed at giving an overview on this and the ways this is dealt with during transcription, replication and damage repair. Thanks to Biochemistry for inviting us! doi.org/10.1021/acs....
Reposted by David Landeira
US President Donald Trump’s proposed budget for fiscal year 2026 calls for unprecedented cuts to scientific agencies that, if enacted, would deal a devastating blow to US science, policy specialists say.
https://go.nature.com/4jYv3IP
https://go.nature.com/4jYv3IP
Trump proposes unprecedented budget cuts to US science
Huge reductions, if enacted, could have ‘catastrophic’ effects on US competitiveness and the scientific pipeline, critics say.
go.nature.com
May 2, 2025 at 10:25 PM
US President Donald Trump’s proposed budget for fiscal year 2026 calls for unprecedented cuts to scientific agencies that, if enacted, would deal a devastating blow to US science, policy specialists say.
https://go.nature.com/4jYv3IP
https://go.nature.com/4jYv3IP
Very interesting reflection. I would include in primary and secondary school curriculas a yearly dedicated class to teach ways to identify truth in the post-truth era.
May 2, 2025 at 6:40 AM
Very interesting reflection. I would include in primary and secondary school curriculas a yearly dedicated class to teach ways to identify truth in the post-truth era.
Reposted by David Landeira
We are excited to have Emmanuel Boakye (African Reproducibility Network), Henk Kummeling (Utrecht University, CoARA), and Andiswa Mfengu (PhD) (University of Cape Town) sharing perspectives for the Africa&Europe launch, hosted by DORA Vice-Chair @rnls.bsky.social. Register at bit.ly/Africa-Europ...
May 1, 2025 at 10:08 PM
We are excited to have Emmanuel Boakye (African Reproducibility Network), Henk Kummeling (Utrecht University, CoARA), and Andiswa Mfengu (PhD) (University of Cape Town) sharing perspectives for the Africa&Europe launch, hosted by DORA Vice-Chair @rnls.bsky.social. Register at bit.ly/Africa-Europ...
Reposted by David Landeira
A new policy from the US National Institutes of Health (NIH) will end billions of dollars of funding to laboratories and hospitals outside the United States, imperiling thousands of projects on topics such as emerging infectious diseases and cancer.
https://go.nature.com/4jEDppr
https://go.nature.com/4jEDppr
Exclusive: NIH to suspend funds for research abroad as it overhauls policy
Move by US biomedical agency threatens thousands of projects on infectious diseases, cancer and more.
go.nature.com
May 2, 2025 at 1:07 AM
A new policy from the US National Institutes of Health (NIH) will end billions of dollars of funding to laboratories and hospitals outside the United States, imperiling thousands of projects on topics such as emerging infectious diseases and cancer.
https://go.nature.com/4jEDppr
https://go.nature.com/4jEDppr
Reposted by David Landeira
Nature research paper: Cold memories control whole-body thermoregulatory responses
https://go.nature.com/4iAvCHU
https://go.nature.com/4iAvCHU
Cold memories control whole-body thermoregulatory responses - Nature
Cold-sensitive engrams contribute to learned thermoregulation in mice that are returned to an environment in which they previously experienced a cold challenge, through a network formed between the hippocampus and hypothalamus that enables the recall of cold-related memories.
go.nature.com
April 26, 2025 at 11:29 AM
Nature research paper: Cold memories control whole-body thermoregulatory responses
https://go.nature.com/4iAvCHU
https://go.nature.com/4iAvCHU
Reposted by David Landeira
NEW: Entire scientific fields have been wiped out by the nearly 800 grants cancelled at NIH, finds a @nature.com analysis of the unprecedented cuts.
About half of all 2024 NIH projects related to LGBT+ health or vaccine hesitancy — gone.
See the other topics and US states hardest hit here:
About half of all 2024 NIH projects related to LGBT+ health or vaccine hesitancy — gone.
See the other topics and US states hardest hit here:
How Trump 2.0 is slashing NIH-backed research — in charts
Nature analyses which fields of science and US states are being hit hardest by grant terminations.
www.nature.com
April 10, 2025 at 8:36 PM
NEW: Entire scientific fields have been wiped out by the nearly 800 grants cancelled at NIH, finds a @nature.com analysis of the unprecedented cuts.
About half of all 2024 NIH projects related to LGBT+ health or vaccine hesitancy — gone.
See the other topics and US states hardest hit here:
About half of all 2024 NIH projects related to LGBT+ health or vaccine hesitancy — gone.
See the other topics and US states hardest hit here:
Congras sergi! That is a start!
Extremely happy to share that the first paper from our lab is now published! Driven by the very talented PhD student Maria Cadefau, we studied how CEBPA mutations shape transcriptional programs in AML. A thread 🧵👇
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Mutant CEBPA promotes tolerance to inflammatory stress through deficient AP-1 activation - Nature Communications
CEBPA is frequently mutated in acute myeloid leukemia (AML), but the transcriptional impact of the AML-associated isoform remains unclear. Here, the authors show that CEBPA-mutant cells have reduced i...
www.nature.com
April 14, 2025 at 2:12 PM
Congras sergi! That is a start!
Reposted by David Landeira
Excited to share our latest work on how cells fold their genomes, and build mitotic chromosomes! Out in Science today!
Lots of interesting results and proposals for those interested in loop extrusion, and chromosomes!
With @golobor.bsky.social, Leonid Mirny, Bill Earnshaw labs.
See thread below:
Lots of interesting results and proposals for those interested in loop extrusion, and chromosomes!
With @golobor.bsky.social, Leonid Mirny, Bill Earnshaw labs.
See thread below:
Earnshaw, Goloborodko, Dekker & Mirny labs are excited to present our latest work, "Rules of engagement for condensins and cohesins guide mitotic chromosome formation" - now accepted!!
www.science.org/doi/10.1126/...
A short clip describing the key results:
www.youtube.com/watch?v=pmvO...
www.science.org/doi/10.1126/...
A short clip describing the key results:
www.youtube.com/watch?v=pmvO...
Rules of Engagement
YouTube video by Johan Gibcus
www.youtube.com
April 11, 2025 at 4:06 PM
Excited to share our latest work on how cells fold their genomes, and build mitotic chromosomes! Out in Science today!
Lots of interesting results and proposals for those interested in loop extrusion, and chromosomes!
With @golobor.bsky.social, Leonid Mirny, Bill Earnshaw labs.
See thread below:
Lots of interesting results and proposals for those interested in loop extrusion, and chromosomes!
With @golobor.bsky.social, Leonid Mirny, Bill Earnshaw labs.
See thread below: