Lightnews — Scholar-powered news

Reposted by Eyal Rozenfeld

Andrew Lin @andrewclin.bsky.social · Sep 1

Excited to share our latest work - expressing the bacterial sodium channel in fly Kenyon cells surprisingly *decreases* their excitability, thanks partly to decreased endogenous sodium channels. This prevents learning and decreases odor-evoked calcium influx doi.org/10.1113/JP28...

Ectopic sodium channel expression decreases excitability of Drosophila Kenyon cells

Abstract figure legend: We tested the effects of expressing the bacterial voltage-gated sodium channel NaChBac in the Kenyon cells of the Drosophila memory centre, the mushroom body. NaChBac expressi...

doi.org

1 16 46

Reposted by Eyal Rozenfeld

Dayu Lin @moccalin.bsky.social · May 9

Congrats, Eyal! A great way to start.

NYU Grossman School of Medicine Postdoctoral Affairs @nyumedpostdocs.bsky.social · May 8

✨😀Congratulations to postdocs Eyal Rozenfeld and Francesco Limone on being named 2025 Leon Levy Scholars by The New York Academy of Sciences!

@sciencelemon92.bsky.social
@eyalrozenfeld.bsky.social
@moccalin.bsky.social
@liddelowsa.bsky.social

www.nyas.org/press-releas...

The New York Academy of Sciences and the Leon Levy Foundation Announce the 2025 Leon Levy Scholars in Neuroscience - NYAS

The New York Academy of Sciences and the Leon Levy Foundation have announced the 2025 class of Leon Levy Scholars in Neuroscience.

www.nyas.org

1 3

Reposted by Eyal Rozenfeld

NYU Grossman School of Medicine Postdoctoral Affairs @nyumedpostdocs.bsky.social · May 8

✨😀Congratulations to postdocs Eyal Rozenfeld and Francesco Limone on being named 2025 Leon Levy Scholars by The New York Academy of Sciences!

@sciencelemon92.bsky.social
@eyalrozenfeld.bsky.social
@moccalin.bsky.social
@liddelowsa.bsky.social

www.nyas.org/press-releas...

The New York Academy of Sciences and the Leon Levy Foundation Announce the 2025 Leon Levy Scholars in Neuroscience - NYAS

The New York Academy of Sciences and the Leon Levy Foundation have announced the 2025 class of Leon Levy Scholars in Neuroscience.

www.nyas.org

3 6

Reposted by Eyal Rozenfeld

mosheparnas.bsky.social @mosheparnas.bsky.social · Mar 20

1/ Check out our Juila Manoim, Tal Camchy, @eyalrozenfeld.bsky.social, Hadas Lerner, Hao-Hsin Chang, Ran Darshan, and Ya-Hui Chou new study in @currentbiology.bsky.social. www.sciencedirect.com/science/arti...

Nonlinear high-activity neuronal excitation enhances odor discrimination

Discrimination between different signals is crucial for animals’ survival. Inhibition that suppresses weak neural activity is crucial for pattern deco…

www.sciencedirect.com

2 4 12

Reposted by Eyal Rozenfeld

Tal Laviv @lavivtal.bsky.social · Feb 20

I started my lab more then 4 years ago, and we have endured some very challenging times ever since.…I am very excited to share the first paper from my lab, published now in @naturemethods.bsky.social
www.nature.com/articles/s41...

Genetically encoded biosensor for fluorescence lifetime imaging of PTEN dynamics in the intact brain - Nature Methods

A first-in-class fluorescence lifetime-based FRET sensor for phosphatase and tensin homolog (PTEN) enables the dynamic monitoring of PTEN activity in cultured cells and in vivo with high spatiotempora...

www.nature.com

10 31 140

Reposted by Eyal Rozenfeld

Wolf Huetteroth @wolfhuette.bsky.social · Feb 10

Our story about flies on carousels is out in @currentbiology.bsky.social! After formally engaging the fantastic @clarahowcroft.bsky.social and integrating helpful reviewer feedback, we present a more concise story with detailed behavioural quantification and cooler videos! doi.org/10.1016/j.cu...

a dog sits on a merry go round while a boy sits on a scooter

ALT: a dog sits on a merry go round while a boy sits on a scooter

media.tenor.com

2 15 28

Reposted by Eyal Rozenfeld

Sean Piantadosi @piantadosisean.bsky.social · Jan 31

So happy to see this paper out! Congrats @victoriacorbit.bsky.social and @ahmarilab.bsky.social! Lots of fond memories from running these experiments. The similarity in the behavioral and striatal neural response time course produced by driving M2 inputs was really striking.

Victoria Corbit, PhD @victoriacorbit.bsky.social · Jan 30

It's a little surreal that this paper is finally out. My last paper from my PhD and likely my last mouse neuro publication ever!
Ft. @ahmarilab.bsky.social @piantadosisean.bsky.social

If you're into mouse behavior, optogenetics, and calcium imaging, here's this 🐀🔦🔬
www.cell.com/cell-reports...

Dissociable roles of central striatum and anterior lateral motor area in initiating and sustaining naturalistic behavior

Corbit et al. studied patterns of activity in corticostriatal circuits during naturally occurring complex behavior in mice. In contrast to models in which cortex leads striatum, these findings suggest...

www.cell.com

1 2 15

Reposted by Eyal Rozenfeld

Jonas Wietek @jwietek.bsky.social · Jan 30

An early surge of norepinephrine along brainstem pathways drives sensory-evoked awakening

www.biorxiv.org/content/10.1...

Happy to see this great work (and some PdCO application) out in the wild.

The locus coeruleus norepinephrine (LC-NE) system regulates arousal and awakening; however, it remains unclear whether the LC does this in a global or circuit specific manner. We hypothesized that sensory-evoked awakenings are predominantly regulated by specific LC-NE efferent pathways. Anatomical, physiological, and functional modularities of LC-NE pathways involving the mouse basal forebrain (BF) and pontine reticular nucleus (PRN) were tested. We found partial anatomical segregation between the LC->PRN and LC->BF circuits. Extracellular NE dynamics in BF and PRN exhibited distinct sound-evoked activation during sleep, including a fast sound-evoked NE peak specific to PRN. Causal optogenetic interrogation of LC efferent pathways, by retro-ChR2 activation or PdCO silencing of synapses in target regions, revealed a pivotal role for early LC->PRN activity in driving arousal and sound-evoked awakenings. Together, our results uncover a prominent role for early LC-NE PRN activity in connecting sensory and arousal pathways and establish LC heterogeneity in regulating arousal.

1 2 20

Reposted by Eyal Rozenfeld

Bianca Jones Marlin, PhD @bjmarlin.bsky.social · Jan 29

Marlin Lab’s 1st Thesis Defense ✨
Hear the science @2:30pm EST
bit.ly/MarlinLab
Have the cheers @5:00 pm EST JLG✨

Columbia Biology student Beka Stecky will share her discoveries on “What the Nose, Knows” after learning an odor predicts a stressful experience.👃🏽🧬🧪

3 6 24

Reposted by Eyal Rozenfeld

Ya'el Courtney, PhD @scienceyael.bsky.social · Jan 25

1/ The choroid plexus (ChP) isn’t just a CSF producer. It’s a dynamic interface between the brain and body, playing key roles in immune regulation, maintaining the blood-CSF barrier, and secreting signaling molecules critical for CNS health.

Illustration of the choroid plexus (ChP) showing its anatomical location in the brain and detailed cellular components. The ChP is highlighted within the lateral ventricle of the brain, shown in red. A zoomed-in view depicts the epithelial barrier of the ChP, which interfaces between cerebrospinal fluid (CSF) and blood vessels in the stromal space. Epithelial cells have cilia and microvilli on their apical surfaces, facilitating secretion and transport. Various secreted molecules into the CSF are labeled, including metabolites, steroid hormones, nutrients, DNA, catalytic enzymes, growth factors, lipoproteins, RNA, peptide hormones, and morphogens. The stromal space includes immune cells like basophils, dendritic cells, mast cells, lymphocytes, macrophages, and neutrophils, as well as fibroblasts and endothelial cells lining blood vessels. Tight junction proteins (claudins and occludins) maintain the epithelial barrier, while junctional adhesion molecules are shown regulating cell interactions. The figure emphasizes the ChP's dual role in barrier function and secretion.

1 2 3

Reposted by Eyal Rozenfeld

Rachel Gatlin, PhD (she/her) @rachelgatlin5.bsky.social · Jan 23

My thesis defense date is official! And yes I put my cat and Tac2 neurons on my poster 🥰

1 4

Reposted by Eyal Rozenfeld

Dayu Lin @moccalin.bsky.social · Jan 22

Antipsychotics is often used to suppress hyper-aggression. Does it really suppress aggression or just cause sedation? Antipsychotics targets dopamine receptors. Our new study revealed that dopamine modulates aggression based on animals' fighting experience.

www.nature.com/articles/s41...

Experience-dependent dopamine modulation of male aggression - Nature

Dopaminergic neurons in the ventral tegmental area have a role in modulating aggression in adult male mice, and this effect of dopamine depends strongly on fighting experience.

www.nature.com

7 13 40

Eyal Rozenfeld @eyalrozenfeld.bsky.social · Jan 19

www.biorxiv.org/content/10.1...

An improved FLARE system for recording and manipulating neuronal activity

Recording and manipulating neuronal ensembles that underlie cognition and behavior in vivo is challenging. FLARE is a light- and calcium-gated transcriptional reporting system for labeling activated n...

www.biorxiv.org

1 3

Reposted by Eyal Rozenfeld

Richard Benton @bentonlab.bsky.social · Jan 15

Fly neuro people: has anyone tried the Ting lab’s scFLARE (or variants) for labelling active neurons in Drosophila? Thanks.

1 5 3

Reposted by Eyal Rozenfeld

Julieta Lis @julietalis.bsky.social · Jan 16

🚨Postdoc and Postbac positions available in my group at the NIEHS/NIH!

Interested in investigating the neural mechanisms for social behaviors across development in a supportive environment? Make sure to apply!

Job ads in🧵Feel free to DM/email w/ questions, please RT

1 4 8

Reposted by Eyal Rozenfeld

Björn Brembs @brembs.mastodon.social.ap.brid.gy · Jan 7

We are hiring!

We are looking for two PhD students interested in the regulation of habit formation. Habits are useful to decrease cognitive load, but carry the risk of becoming stereotyped and hard to control - it’s hard to shake a bad habit. The fruit fly Drosophila also forms habits and we […]

Original post on mastodon.social

mastodon.social

13 6

Reposted by Eyal Rozenfeld

Annegret Falkner @neurrriot.bsky.social · Jan 2

New year new work from the lab! We explore whether aggression experience and observation lead to similar changes in future aggression strategy. (They do!) We perform 2-color imaging across the whole social behavior network across time and track changes www.biorxiv.org/content/10.1...

Aggression experience and observation promote shared behavioral and neural changes

The ability to observe the social behavior of others and use observed information to bias future action is a fundamental building block of social cognition. A foundational question is whether social o...

www.biorxiv.org

2 27 49

Reposted by Eyal Rozenfeld

Yulong Li Lab @yulonglilab.bsky.social · Dec 28

(1/6) Excited to introduce our first generation red acetylcholine sensors! #acetylcholine #GRAB #RedSensors
www.biorxiv.org/content/10.1...

Red-shifted GRAB acetylcholine sensors for multiplex imaging in vivo

The neurotransmitter acetylcholine (ACh) is essential in both the central and peripheral nervous systems. Recent studies highlight the significance of interactions between ACh and various neuromodulat...

www.biorxiv.org

1 11 37

Reposted by Eyal Rozenfeld

Masseck Lab @massecklab.bsky.social · Dec 18

🎄PinkyCaMP- our christmas gift to you! 🎁: We are excited to present PinkyCaMP, the first mScarlet based calcium sensor with:
✨exceptional, brightness
✨phototability
✨and optogenetic compatability.
Check out our new preprint:
www.biorxiv.org/content/10.1...

5 33 100

Reposted by Eyal Rozenfeld

Timothy O'Leary @timothyoleary.bsky.social · Dec 17

Apropos of never ending discussions about whether ANNs are "good" models of the nervous system, here is a slide I present to masters students showing a network that is found in motor control circuits *across phyla* (that's pretty ubiquitous!) I ask them to guess what it does...

6 64 170

Reposted by Eyal Rozenfeld

Johannes Felsenberg @felsenberg.bsky.social · Dec 16

Why not joining us?

FMI science @fmiscience.bsky.social · Dec 16

📣 Please share: We’re hiring a tenure-track Group Leader in Multicellular Systems to explore the molecular and cellular mechanisms driving the formation, maintenance, or destabilization of tissues, organs and organisms. Apply at: www.fmi.ch/education-ca...

2 3

Reposted by Eyal Rozenfeld

Jonas Wietek @jwietek.bsky.social · Dec 16

Wanna switch on/off synaptic transmission but not the ideal vector for your🧠🧪🔬, we are happy to help!

Requested recently & available to you:

ChrimsonR(no soma targeting)+PdCO (Cre & non-Cre)
DoxOn/OFF PdCO-EGFP (TREtight)

-> docs.google.com/spreadsheets...

Probably soon @addgene.bsky.social too.

1 2 12

Reposted by Eyal Rozenfeld

Carolina Rezaval @crezaval.bsky.social · Nov 15

Sex or survival—what’s more important? Excited to share our
@Nature paper on how flies resolve this conflict.

We found a dopamine-based filter that reduces threat perception, helping flies focus on courtship when close to mating.

www.nature.com/articles/s41...

Mating proximity blinds threat perception - Nature

A state-dependent dopamine filter system in the male Drosophila brain balances threat perception against the drive to mate.

www.nature.com

12 30

Reposted by Eyal Rozenfeld

Daniela Duarte Domingues @neurodaniela.bsky.social · Dec 15

Hi everyone!

I am Daniela, a pre-clinical psychedelic researcher doing a PhD at the Paris Brain Institute under the supervision of Eric Burguière. I am working with the SAPAP3-KO mice and LSD.

I am a great advocate for open science, diversity and science communication!

Nice to meet you all 🥰

1 2 16

Reposted by Eyal Rozenfeld

Luke Sjulson @lukesjulson.bsky.social · Dec 13

Neuroscience students asked us to teach a PRACTICAL course on experimental methods, and it is now on YouTube!

Please like and repost to help us get the word out!

www.youtube.com/playlist?lis...

Lecture 1: Signals and data acquisition
Focusing on hardware, digital/analog I/O, synchronization
🧵

Neuroscience methods - YouTube

Nanocourse: Approaches to Study Neural Circuits This course was taught by Anita Autry, Tiago Gonçalves, and Luke Sjulson at Albert Einstein College of Medici...

www.youtube.com

19 200 420