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Sean Piantadosi @piantadosisean.bsky.social · 2d

cool new work from @ppiantad.bsky.social and the Holmes laboratory looking at how BLA neurons encode risk using a variety of approaches. check it out!

Patrick Piantadosi @ppiantad.bsky.social · 2d

for anyone interested in the amygdala and risky decision-making, check out our new preprint: biorxiv.org/content/10.1...

amygdala neurons track reward-seeking actions, and punishment risk dramatically alters this function. lots of other (BLA-accumbens!) data included.

Risk reshapes amygdala representation of choice

Modifying behavior in response to changing environmental conditions is a crucial adaptive function. This capacity is exemplified when animals curtail pursuit of a valued outcome that risks being punis...

biorxiv.org

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Reposted by Sean Piantadosi

John Tuthill @tuthill.bsky.social · Apr 7

UW folks, don't miss @ishmailsaboor.bsky.social's seminar tomorrow.

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Reposted by Sean Piantadosi

Tom Kash @superkash.bsky.social · Apr 7

Our work, lead by former graduate student Olivia Hon on the BNST, CRF and regulation of different types of fear is finalized as an elife reviewed preprint.

elifesciences.org/reviewed-pre...

Sex Differences in BNST Signaling and BNST CRF in Fear Processing: Implications for Unpredictable Threat in Sustained Fear

elifesciences.org

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Reposted by Sean Piantadosi

Chris Zimmerman @czimmerman.bsky.social · Apr 3

How do we associate the flavors we experience during a meal 🍽️😋 with postingestive effects like food poisoning 🤢🤮 that arise much later?

Our answer in @nature.com this week: Illness signals from the gut reactivate and strengthen flavor representations in the amygdala.

📄: nature.com/articles/s41...

A neural mechanism for learning from delayed postingestive feedback - Nature

Illness signals from the gut reactivate and strengthen flavour representations in the amygdala to support learning from delayed postingestive feedback.

www.nature.com

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Reposted by Sean Piantadosi

Alex Kwan @alexkwan.bsky.social · Apr 2

Our latest study identifies a specific cell type and receptor essential for psilocybin’s long-lasting neural and behavioral effects 🍄🔬🧠🧪

Led by Ling-Xiao Shao and @ItsClaraLiao

Funded by @NIH @NIMHgov

📄 Read in @nature.com - www.nature.com/articles/s41...

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Psilocybin’s lasting action requires pyramidal cell types and 5-HT2A receptors - Nature

A pyramidal cell type and the 5-HT2A receptor in the medial frontal cortex have essential roles in psilocybin’s long-term drug action.

www.nature.com

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Sean Piantadosi @piantadosisean.bsky.social · Mar 12

congrats Catherine! looking forward to reading this over!

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Kaixin (Catherine) Huang @kxhuang.bsky.social · Mar 12

Thrilled to share our latest work🚀! Interested in corticostriatal circuits and genetics of anorexia nervosa? Check out our preprint on bioRxiv! www.biorxiv.org/content/10.1...

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Reposted by Sean Piantadosi

Susanne Ahmari @ahmarilab.bsky.social · Feb 14

🚨Amidst all the uncertainty at NIH Welcome Leap just launched an important new $50M program in Women’s Health👩🏻‍🔬🧠

CARE focuses on the link between Alzheimer’s and perimenopausal hormonal changes wellcomeleap.org/care/

Note: full indirects!

Please share widely to support women’s health 🙏🏼

CARE Program Details | Wellcome Leap: Unconventional Projects. Funded at Scale.

NEW $50M Program in Women's Health care Cutting Alzheimer's Risk through EndocrinologyWe are pleased to announce the selected performers.Sabine Vollstädt-Klein, Central Institute of Mental Health ...

wellcomeleap.org

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Susanne Ahmari @ahmarilab.bsky.social · Jan 31

Feels odd to post in a normal way about science right now, but I am REALLY proud of this work from the amazing @victoriacorbit.bsky.social from her grad student days in my lab 💪🧠💗 Huge congrats to her, @piantadosisean.bsky.social, & the whole team on this tour-de-force!🎊🎊🎊

Bluetorial on the way...

Victoria Corbit, PhD @victoriacorbit.bsky.social · Jan 30

It's a little surreal that this paper is finally out. My last paper from my PhD and likely my last mouse neuro publication ever!
Ft. @ahmarilab.bsky.social @piantadosisean.bsky.social

If you're into mouse behavior, optogenetics, and calcium imaging, here's this 🐀🔦🔬
www.cell.com/cell-reports...

Dissociable roles of central striatum and anterior lateral motor area in initiating and sustaining naturalistic behavior

Corbit et al. studied patterns of activity in corticostriatal circuits during naturally occurring complex behavior in mice. In contrast to models in which cortex leads striatum, these findings suggest...

www.cell.com

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Reposted by Sean Piantadosi

bioRxiv Neuroscience @biorxiv-neursci.bsky.social · Feb 1

The NIH BRAIN Initiatives Impacts in Systems and Computational Neuroscience, 2014-2023 https://www.biorxiv.org/content/10.1101/2025.01.30.635684v1

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Reposted by Sean Piantadosi

Victoria Corbit, PhD @victoriacorbit.bsky.social · Jan 31

FYI @ahmarilab.bsky.social is still following up on this work if any trainees are interested 👀

Great opportunity to study behavior relevant for OCD🐀🧠 use cutting edge techniques🔬🧬 and have a supportive and encouraging mentor 🫶
Not to mention, Pittsburgh is the best 💛🖤

Victoria Corbit, PhD @victoriacorbit.bsky.social · Jan 30

It's a little surreal that this paper is finally out. My last paper from my PhD and likely my last mouse neuro publication ever!
Ft. @ahmarilab.bsky.social @piantadosisean.bsky.social

If you're into mouse behavior, optogenetics, and calcium imaging, here's this 🐀🔦🔬
www.cell.com/cell-reports...

Dissociable roles of central striatum and anterior lateral motor area in initiating and sustaining naturalistic behavior

Corbit et al. studied patterns of activity in corticostriatal circuits during naturally occurring complex behavior in mice. In contrast to models in which cortex leads striatum, these findings suggest...

www.cell.com

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Sean Piantadosi @piantadosisean.bsky.social · Jan 31

So happy to see this paper out! Congrats @victoriacorbit.bsky.social and @ahmarilab.bsky.social! Lots of fond memories from running these experiments. The similarity in the behavioral and striatal neural response time course produced by driving M2 inputs was really striking.

Victoria Corbit, PhD @victoriacorbit.bsky.social · Jan 30

It's a little surreal that this paper is finally out. My last paper from my PhD and likely my last mouse neuro publication ever!
Ft. @ahmarilab.bsky.social @piantadosisean.bsky.social

If you're into mouse behavior, optogenetics, and calcium imaging, here's this 🐀🔦🔬
www.cell.com/cell-reports...

Dissociable roles of central striatum and anterior lateral motor area in initiating and sustaining naturalistic behavior

Corbit et al. studied patterns of activity in corticostriatal circuits during naturally occurring complex behavior in mice. In contrast to models in which cortex leads striatum, these findings suggest...

www.cell.com

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Reposted by Sean Piantadosi

Mel Sharpe @melissajsharpe.bsky.social · Jan 29

Folks at #wcbr- Come check out our symposium on lateral hypothalamus and addiction tomorrow (Wed), 4:30pm in Alpine B. Organised by @marcusweera.bsky.social! I’ll be presenting on #dopamine in lateral hypothalamus and how this changes after methamphetamine self-admin! 🧠 🧪 🧬

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Susanne Ahmari @ahmarilab.bsky.social · Jan 28

NIH memo addresses ‘confusion’ about restrictions imposed by Trump, easing some concerns | Science | AAAS www.science.org/content/arti...

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Phil Corlett @philcorlett.bsky.social · Jan 27

Early start (7:30am symposium) in Grand Ballroom C, for WinterBrain

❄️🧠

I’ll be talking about translational approaches to paranoia, and consilience across rodents, primates, and humans

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Daniela Duarte Domingues @neurodaniela.bsky.social · Jan 20

Registrations are open for the 2nd "Beginners training school on the use of home-cage technologies to monitor rodents".

If you are working or interested in working in animal behaviour using home-cage systems, you need to sign up! All costs covered!

17-20 June Bratislava
https://buff.ly/3E7MiaW

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Reposted by Sean Piantadosi

Phil Corlett @philcorlett.bsky.social · Jan 14

@kurtfraser.bsky.social and I just had our paper on dopamine, salience, and psychosis accepted @ Am J Psychiatry. We review the history of aberrant salience and the data gathered since: osf.io/preprints/ps...

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Sean Piantadosi @piantadosisean.bsky.social · Jan 14

Be sure to check out new Bruchas lab work from @davidjmarcus.bsky.social and co-authors! An exciting and nuanced story unraveling how endocannabinoid signaling influences behavioral engagement. Make sure to dive into the Supplemental Figures which describes the circuit's role in aversive behavior.

davidjmarcus.bsky.social @davidjmarcus.bsky.social · Jan 10

I’m excited to share the most recent study from the Bruchas
lab, which represents the culmination of my postdoctoral work, and serves as the platform for my future research programs investigating the in vivo role of the endocannabinoid signaling system!

www.biorxiv.org/content/10.1...

Endocannabinoids facilitate transitory reward engagement through retrograde gain-control

Neuromodulatory signaling is poised to serve as a neural mechanism for gain control, acting as a crucial tuning factor to influence neuronal activity by dynamically shaping excitatory and inhibitory f...

www.biorxiv.org

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Paul Frankland @franklandlab.bsky.social · Jan 10

A reminder about our position at SickKids/U of T. Accepting applications until February 15th. Please share widely.
can-acn.org/scientist-se...

Scientist/Senior Scientist – Research Institute, Hospital for Sick Children, University of Toronto – Canadian Association for Neuroscience

can-acn.org

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Sean Piantadosi @piantadosisean.bsky.social · Dec 19

Very excited for this! Abstract submission is open now and the due date is Februrary 14th, 2025!

Tomás Ryan @tjryan.bsky.social · Dec 19

Announcing the 2025 "Engram and Ensembles in Learning and Memory" meeting, at @tcddublin.bsky.social

Half of speakers will be selected from abstracts submitted by trainees. Registration is open below, with discounted rates available until January 31st.

event.fourwaves.com/engramsensem...

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Sean Piantadosi @piantadosisean.bsky.social · Dec 18

congrats olivia and all! great work!

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Masseck Lab @massecklab.bsky.social · Dec 18

🎄PinkyCaMP- our christmas gift to you! 🎁: We are excited to present PinkyCaMP, the first mScarlet based calcium sensor with:
✨exceptional, brightness
✨phototability
✨and optogenetic compatability.
Check out our new preprint:
www.biorxiv.org/content/10.1...

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davidweinshenker.bsky.social @davidweinshenker.bsky.social · Dec 11

Saving the best for last! If you are still at #ACNP2024 stop by grad student Abby Galvez's poster (W48) describing mesolimbic dopamine dysfunction in a selectively bred rat model of bipolar disorder.

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Sean Piantadosi @piantadosisean.bsky.social · Dec 11

If you are still at #ACNP2024 and are interested in the locus coeruleus and/or the amygdala, please stop by my poster from the @mbruchas lab examining how both nodes of this circuit mediate stress-induced anxiety-like behavior tonight (W169)!

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Paul Frankland @franklandlab.bsky.social · Dec 11

Coming soon: We have a Scientist position in the Neuroscience & Mental Health Program at SickKids. Should post details later this week. Stay tuned.

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