Frank Harrell
@f2harrell.bsky.social
Professor of Biostatistics
Vanderbilt University School of Medicine
Expert Biostatistics Advisor
FDA Center for Drug Evaluation and Research
https://hbiostat.org https://fharrell.com
Vanderbilt University School of Medicine
Expert Biostatistics Advisor
FDA Center for Drug Evaluation and Research
https://hbiostat.org https://fharrell.com
The FDA Commissioner advocating for Bayesian design and analysis is a thrill to see. www.fda.gov/news-events/... #StatsSky #Statistics #bayes #clinicaltrial #pharma #rct @fda.gov
January 15, 2026 at 1:58 PM
The FDA Commissioner advocating for Bayesian design and analysis is a thrill to see. www.fda.gov/news-events/... #StatsSky #Statistics #bayes #clinicaltrial #pharma #rct @fda.gov
FDA drugs and biologics guidance for Bayesian clinical trials is something I've been dreaming of for decades. I am thrilled that this draft has been released!! #Statistics #StatsSky #fda #clinicaltrial #bayes
This is a big deal for speeding up clinical trials, and for pediatric use after adult trials have proved successful. The @USFDA goes Bayesian.
A win for #IBD patients, and especially for kids with #IBD. @crohnsandcolitisau.bsky.social @f2harrell.bsky.social
www.fda.gov/news-events/...
A win for #IBD patients, and especially for kids with #IBD. @crohnsandcolitisau.bsky.social @f2harrell.bsky.social
www.fda.gov/news-events/...
FDA Issues Guidance on Modernizing Statistical Methods for Clinical Trials
The U.S. Food and Drug Administration today published draft guidance designed to facilitate the use of Bayesian methodologies in clinical trials of drugs and biologics, helping drug developers make be...
www.fda.gov
January 13, 2026 at 4:07 PM
FDA drugs and biologics guidance for Bayesian clinical trials is something I've been dreaming of for decades. I am thrilled that this draft has been released!! #Statistics #StatsSky #fda #clinicaltrial #bayes
I can hear Noem saying "These look like domestic terrorists."
11 January 1939 | Czech Jewish girl Věra Vohryzková was born (right).
She was deported to #Auschwitz from #Theresienstadt ghetto on 18 December 1943 with her mother Štěpánka and brother Jiří. None of them survived.
She was deported to #Auschwitz from #Theresienstadt ghetto on 18 December 1943 with her mother Štěpánka and brother Jiří. None of them survived.
January 11, 2026 at 1:49 PM
I can hear Noem saying "These look like domestic terrorists."
Reposted by Frank Harrell
A stunning, and damning, video analysis by @nytimes.com
After rewatching the video a few more times and seeing the NYT breakdown there are a few things that stand out.
First, it looks like there’s an onlooker standing *very* close to, if not directly in, the line of fire behind the vehicle. This seems exceptionally reckless.
First, it looks like there’s an onlooker standing *very* close to, if not directly in, the line of fire behind the vehicle. This seems exceptionally reckless.
Video: Videos Contradict Trump Administration Account of ICE Shooting in Minneapolis
An analysis of footage from three camera angles show that the vehicle appears to be turning away from a federal officer as he opened fire.
www.nytimes.com
January 8, 2026 at 6:11 PM
A stunning, and damning, video analysis by @nytimes.com
WTF?
"I’m going to pause here just to review: an institution that purports to be a university has told a philosophy professor he is forbidden from teaching Plato."
surreal times
dailynous.com/2026/01/06/t...
surreal times
dailynous.com/2026/01/06/t...
Texas A&M Bans Plato - Daily Nous
Drop the race and gender material from your course and the Plato readings, or teach a different course. You have a day to decide. That's a paraphrase of what Martin Peterson, professor of philosophy a...
dailynous.com
January 7, 2026 at 12:43 PM
WTF?
Highly, highly recommended for persons interested in Bayesian methods and for persons not interested in Bayesian methods who should be.
And we're live, Lecture A1 is online. Introduction to Bayesian workflow, generative models, estimands, estimators, estimates, error checking, beginnings of probability theory and Bayesian updating. www.youtube.com/watch?v=ztbY...
January 6, 2026 at 12:21 PM
Highly, highly recommended for persons interested in Bayesian methods and for persons not interested in Bayesian methods who should be.
Reposted by Frank Harrell
The website of the foundation Jalil founded, which publishes several journals, hosts conferences and offers editorial services, also referred to him as Al-Attabi until recently. But after we contacted him, the name of the foundation’s CEO and owner changed to “Mustafa Tareq Shanshool" on the site.
Dogged by retractions, Iraqi researcher and publisher uses a different name
Abduladheem Turki Jalil Researchers change the name they publish under for many reasons, most of which aren’t fodder for a Retraction Watch story. Trying to skirt a publishing ban is one that is. A…
retractionwatch.com
January 6, 2026 at 11:58 AM
The website of the foundation Jalil founded, which publishes several journals, hosts conferences and offers editorial services, also referred to him as Al-Attabi until recently. But after we contacted him, the name of the foundation’s CEO and owner changed to “Mustafa Tareq Shanshool" on the site.
Reposted by Frank Harrell
Timezones are so weird. Australia is in 2026, Canada is in 2025, and the United States is in 1939.
December 31, 2025 at 6:12 PM
Timezones are so weird. Australia is in 2026, Canada is in 2025, and the United States is in 1939.
Computing tool of the day: I use Visual Studio Code Editor as my general purpose editor. But it's an overkill for almost everything I do. Enter CotEditor for Mac which so far is my dream editor (except for printing syntax-highlighted code). coteditor.com
CotEditor
Text Editor for macOS
coteditor.com
December 31, 2025 at 3:01 PM
Computing tool of the day: I use Visual Studio Code Editor as my general purpose editor. But it's an overkill for almost everything I do. Enter CotEditor for Mac which so far is my dream editor (except for printing syntax-highlighted code). coteditor.com
This makes pharma giant GSK look silly for paying $720M for a previous hoax anti-aging compound from the same @harvard.edu prof.
Great to see this guy on bsky. Things must be going well for the grifters to start appearing. 😜
www.dailymail.co.uk/health/artic...
www.dailymail.co.uk/health/artic...
Top Harvard prof 'forced out' of presidency at prestigious academy
One of America's most influential health gurus, and founding father of longevity research, has been accused of 'selling snake oil' and 'deceiving' the public due to fatal flaws in his studies.
www.dailymail.co.uk
December 29, 2025 at 3:02 PM
This makes pharma giant GSK look silly for paying $720M for a previous hoax anti-aging compound from the same @harvard.edu prof.
Reposted by Frank Harrell
I’m receiving an increasing number of messages from some of you who are concerned about me. Please don’t be. I’m not going to stop speaking out. Some thoughts... https://robertreich.substack.com/p/please-dont-worry-about-me
Please don’t worry about me
Friends,
robertreich.substack.com
December 28, 2025 at 3:01 AM
I’m receiving an increasing number of messages from some of you who are concerned about me. Please don’t be. I’m not going to stop speaking out. Some thoughts... https://robertreich.substack.com/p/please-dont-worry-about-me
How much biomedical research and how much money billed to patients are based on measurements that were never fully validated? Too many.
Don't build your discipline on the sandy land.
"40 percent of MRI signals do not correspond to actual brain activity"; "Since tens of thousands of fMRI studies worldwide are based on this assumption, our results could lead to opposite interpretations in many of them.”
www.tum.de/en/news-and-...
www.tum.de/en/news-and-...
December 28, 2025 at 2:14 PM
How much biomedical research and how much money billed to patients are based on measurements that were never fully validated? Too many.
Americans are not supposed to see this, and @cbsnews.com is now an embarrassment.
December 23, 2025 at 11:17 PM
Americans are not supposed to see this, and @cbsnews.com is now an embarrassment.
Reposted by Frank Harrell
It’s the run up to the holidays so there can only be one #MethodologyMonday topic - the scientific way to cut your Christmas cake. Published c1906 in Nature by the statistician Francis Galton 🎂🎄🔪😊 Enjoy!
galton.org/essays/1900-...
galton.org/essays/1900-...
December 22, 2025 at 7:57 AM
It’s the run up to the holidays so there can only be one #MethodologyMonday topic - the scientific way to cut your Christmas cake. Published c1906 in Nature by the statistician Francis Galton 🎂🎄🔪😊 Enjoy!
galton.org/essays/1900-...
galton.org/essays/1900-...
Reposted by Frank Harrell
In case people need a refresher:
The Trump administration is fighting contempt proceedings y in federal court over what happened “inside CECOT” to human beings unlawfully renditioned there.
Bari Weiss’s CBS News is now part of the coverup.
The Trump administration is fighting contempt proceedings y in federal court over what happened “inside CECOT” to human beings unlawfully renditioned there.
Bari Weiss’s CBS News is now part of the coverup.
December 21, 2025 at 10:13 PM
In case people need a refresher:
The Trump administration is fighting contempt proceedings y in federal court over what happened “inside CECOT” to human beings unlawfully renditioned there.
Bari Weiss’s CBS News is now part of the coverup.
The Trump administration is fighting contempt proceedings y in federal court over what happened “inside CECOT” to human beings unlawfully renditioned there.
Bari Weiss’s CBS News is now part of the coverup.
#Statistics thought of the day: For longitudinal studies, don't treat the baseline measurement as the first follow-up measurement. Baseline cannot be considered a response to treatment. You'd be surprised how often this in done in #pharma. hbiostat.org/rmsc/long#mo... #StatsSky
7 Modeling Longitudinal Responses using Generalized Least Squares – Regression Modeling Strategies
hbiostat.org
December 22, 2025 at 1:45 PM
#Statistics thought of the day: For longitudinal studies, don't treat the baseline measurement as the first follow-up measurement. Baseline cannot be considered a response to treatment. You'd be surprised how often this in done in #pharma. hbiostat.org/rmsc/long#mo... #StatsSky
Reposted by Frank Harrell
I did a whole post about stat software warranties a few years back notstatschat.rbind.io/2019/02/18/a...
Absolutely no warranty? - Biased and Inefficient
notstatschat.rbind.io
December 19, 2025 at 11:29 PM
I did a whole post about stat software warranties a few years back notstatschat.rbind.io/2019/02/18/a...
Doug Altman - an eternal inspiration for all medical statisticians and non-statistician medical researchers. #StatsSky #Statistics
Doug Altman was an internationally renowned statistician who served as The BMJ’s chief statistical adviser.
Read about life and work that made this statistician a "citation millionaire"
#BMJChristmas
www.bmj.com/content/391/...
Read about life and work that made this statistician a "citation millionaire"
#BMJChristmas
www.bmj.com/content/391/...
December 19, 2025 at 2:52 PM
Doug Altman - an eternal inspiration for all medical statisticians and non-statistician medical researchers. #StatsSky #Statistics
Reposted by Frank Harrell
This is actually the trippiest thing I've ever seen that was not deliberately created by M C Fucking Escher. It straight up took me over a minute to make sense of and now I can't go back.
This is the white-and-gold dress on a gram a week of trenbolone.
This is the white-and-gold dress on a gram a week of trenbolone.
Ok, this is nuts. Once you see it you cannot unsee it. Do you see it?
(OP @drgbuckingham.bsky.social )
(OP @drgbuckingham.bsky.social )
December 17, 2025 at 6:52 AM
This is actually the trippiest thing I've ever seen that was not deliberately created by M C Fucking Escher. It straight up took me over a minute to make sense of and now I can't go back.
This is the white-and-gold dress on a gram a week of trenbolone.
This is the white-and-gold dress on a gram a week of trenbolone.
Reposted by Frank Harrell
Sounds about right.
December 15, 2025 at 12:38 PM
Sounds about right.
Reposted by Frank Harrell
I knew his response to this was going to be one of the worst things he ever posted and somehow, it was even worse than I imagined it could be.
December 15, 2025 at 3:03 PM
I knew his response to this was going to be one of the worst things he ever posted and somehow, it was even worse than I imagined it could be.
Reposted by Frank Harrell
Use of {tinyplot} is very nice.
But, I'd love to see examples that don't use variables like
c("e16sex", "c172code", "e42dep")
But, I'd love to see examples that don't use variables like
c("e16sex", "c172code", "e42dep")
🎉 Great news for #rstats users! If you love the native R graphics feel of #tinyplot AND you're a fan of the powerful #easystats #modelbased package, this is for you!
Thanks to @gmcd.bsky.social, we significantly enhanced the tinyplot integration.
🔗 Read more: easystats.github.io/modelbased/a...
Thanks to @gmcd.bsky.social, we significantly enhanced the tinyplot integration.
🔗 Read more: easystats.github.io/modelbased/a...
Plotting estimated marginal means with tinyplot
easystats.github.io
December 13, 2025 at 2:38 AM
Use of {tinyplot} is very nice.
But, I'd love to see examples that don't use variables like
c("e16sex", "c172code", "e42dep")
But, I'd love to see examples that don't use variables like
c("e16sex", "c172code", "e42dep")
Reposted by Frank Harrell
Weekend reads: Springer Nature retracts papers using ‘bonkers’ dataset; preprint server welcomes AI authors; ethics editors’ COI disclosures ‘insufficient’
Weekend reads: Springer Nature retracts papers using ‘bonkers’ dataset; preprint server welcomes AI authors; ethics editors’ COI disclosures ‘insufficient’
Dear RW readers, we look forward to wrapping up the week with Weekend Reads. If you enjoy it too, please consider showing your support with a tax-deductible donation. I support retraction wat…
retractionwatch.com
December 13, 2025 at 12:58 PM
Weekend reads: Springer Nature retracts papers using ‘bonkers’ dataset; preprint server welcomes AI authors; ethics editors’ COI disclosures ‘insufficient’