Lightnews — Scholar-powered news

Reposted by Yi Feng

Artologica aka Michele Banks @artologica.net · 2d

Twittering Machine, Paul Klee, 1922, gouache, ink and watercolor on paper

abstract painting with birdlike creatures on a blue ground

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Inigo Martincorena @imartincorena.bsky.social · 2d

A short thread. For years, I have been surprised by how much confusion our discovery of clones carrying cancer-driver mutations in normal tissues has caused in the cancer community. Typical questions like: (1) if you see these mutations in normal cells, are they really cancer drivers?... [1/4]

Inigo Martincorena @imartincorena.bsky.social · 3d

Our latest work is out in Nature today. In this paper, we introduce an improved version of NanoSeq, a duplex sequencing protocol with <5 errors per billion bp in single DNA molecules, and use it to study the somatic mutation landscape of oral epithelium in >1000 people www.nature.com/articles/s41...

Somatic mutation and selection at population scale - Nature

A new version of nanorate DNA sequencing, with an error rate lower than five errors per billion base pairs and compatible with whole-exome and targeted capture, enables epidemiological-scale studies of somatic mutation and selection and the generation of high-resolution selection maps across coding and non-coding sites for many genes.

www.nature.com

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The Francis Crick Institute @crick.ac.uk · 2d

We're now recruiting early career group leaders at the Crick to lead ambitious research programmes and explore bold scientific questions.

Hear our Director, Edith Heard, explain why the Crick is a unique place for curiosity-driven research.

Apply now ➡️ www.crick.ac.uk/careers-stud...

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Wilhelm Palm @wilhelmpalm.bsky.social · 2d

Just out in @science.org: Together with the lab of @johanneszuber.bsky.social, we used sequential in-vitro/in-vivo screens to decipher metabolic adaptations in tumors. We find that acidosis is a dominant factor that shapes energy metabolism and stress resilience. www.science.org/doi/10.1126/...

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James Briscoe @jamesbriscoe.bsky.social · 10d

Meet the 2025 cohort of @dev-journal.bsky.social Pathway to Independence fellows

Read about the scientific visions of eight dev bio post-docs entering the academic job market

journals.biologists.com/dev/article/...

Pathway to Independence: a forecast for the future of developmental biology

ABSTRACT. In 2022, Development launched its Pathway to Independence (PI) programme, aimed at supporting postdocs as they transition to their first independent position. In 2025, we welcome our third c...

journals.biologists.com

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Matthew Freeman @mjafreeman.bsky.social · Sep 1

Are you a postdoc interested in the mechanisms of disease?

Do you have a great record and an exciting vision?

Come and start your own lab @dunnschool.bsky.social by applying for sponsorship for early career fellowships.

Deadline 30th September...pass it on!

www.path.ox.ac.uk/work-with-us...

Group Leader Career Development Fellowships - Dunn School

Are you an early career researcher interested in the cell or molecular mechanisms underlying disease? Do you have an outstanding record and an innovative research plan?

www.path.ox.ac.uk

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Development @dev-journal.bsky.social · Jul 28

Transitions in development – an interview with Jeffrey Farrell

@jeffreyafarrell.bsky.social talks about becoming a group leader, his insights on advocacy for developmental biology and his belief in unifying single-cell biology with classical approaches.

journals.biologists.com/dev/article/...

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Jeff Farrell @jeffreyafarrell.bsky.social · Jul 29

Hey friends - Daniocell is experiencing a temporary outage right now. The NICHD server it is hosted on got dropped from the NIH’s firewall list & so currently can’t be accessed outside the NIH. The relevant IT teams are working to resolve it. Sorry for any inconvenience. It’ll be back soon!!

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Ferenc Mueller @ferencmueller.bsky.social · Jul 13

#IZFC2025 #zebrafish #DANIO-CODE data coordination centre is back online. Note changed address: danio-code-dcc.genereg.net

DANIO-CODE DCC

This Data Coordination Center allows DANIO-CODE consortium members to submit and view their data sets annotated with standard metadata nomenclatures.

danio-code-dcc.genereg.net

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Shawn Burgess @burgesslab.bsky.social · Jul 31

Wrote a big review with my friend and colleague @varshneylab.social on the state-of-the-art in CRISPR used experimentally in vivo. We wanted to focus on their use in experimental vertebrate animals (apparently passé now but we persist).

CRISPR-based functional genomics tools in vertebrate models - Experimental & Molecular Medicine

Recent advances in DNA sequencing have allowed scientists to gather vast amounts of genetic data, but understanding what those sequences actually do requires additional tools that allow scientists to ...

www.nature.com

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Sally Lowell @cellysally.bsky.social · Jul 28

Speaker update for our Generative Biology workshop: we are delighted to have @nmoris.bsky.social join us. See full list of speakers on the attached flyer or on our website.

Apply by 15th August. Places available for short talks.

royalsociety.org/science-even...

Flyer for Royal Society Generative Biology workshop. Full list of speakers can also be found on the website linked to in the post.

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Nonia Pariente @npariente.bsky.social · Jul 30

Respiratory infections reactivate dormant metastatic breast cancer cells in mouse lungs, correlating with evidence in humans that #SARS-CoV-2 infection increases the risk of cancer-related mortality & lung metastasis

😎 biology but double whammy for cancer patients

www.nature.com/articles/s41...
🧪

Respiratory viral infections awaken metastatic breast cancer cells in lungs - Nature

Mouse models show that respiratory infections from viruses such as influenza and SARS-CoV-2 can trigger metastasis of dormant breast cancer cells in the lungs, a finding supported by epidemiological d...

www.nature.com

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Pablo J. Sáez @pjsaez.bsky.social · Jul 8

This is why we love #cellmigration

#Leukocytes: #Neutrophils (cyan) #Macrophages (orange) chemotaxis.

I couldn't share it before the retirement of @zebrafishrock.bsky.social, but cool #microscopy in #zebrafish continue to rock !

#scicomm #scisky @cellcommlab.bsky.social @focalplane.bsky.social 🧪🔬

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Patrick Murphy @pjmurphy249.bsky.social · Jul 8

Please RT: Published today, a super fun collaboration w/ @fanjumeng.bsky.social and Marnie Halpern's lab to establish methods for transgene mapping in zebrafish - TransTag enables simple and efficient transgene mapping in zebrafish via tagmentation: Cell Reports Methods www.cell.com/cell-reports...

TransTag enables simple and efficient transgene mapping in zebrafish via tagmentation

Meng et al. develop a method called TransTag for simple and efficient mapping of Tol2-based transgenes in zebrafish. TransTag robustly identifies transgene insertion sites and offers an alignment-free...

www.cell.com

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fanjumeng.bsky.social @fanjumeng.bsky.social · Jul 8

New study online today! We present a method to identify insertion sites of Tol2 transgenes in zebrafish #zebrafish #Tol2 #Transgene www.cell.com/cell-reports...

TransTag enables simple and efficient transgene mapping in zebrafish via tagmentation

Meng et al. develop a method called TransTag for simple and efficient mapping of Tol2-based transgenes in zebrafish. TransTag robustly identifies transgene insertion sites and offers an alignment-free...

www.cell.com

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Zebrafish Rock! @zebrafishrock.bsky.social · Jun 2

Abstract deadline for #ZDM18 in Boston ends tonight (EST) for those to be considered for oral talks. More details here: www.zdmsociety.org/zdm18-abstra... #ZebrafishMeeting

ZDM18 Abstract Submission — ZDMS

www.zdmsociety.org

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Elizabeth McKenna @elizsmckenna.bsky.social · May 27

Now online in Cancer Discovery: Detection of Cancers Three Years Prior to Diagnosis Using Plasma Cell-Free DNA - by Yuxuan Wang, Nickolas Papadopoulos, Elizabeth Platz, Bert Vogelstein, and colleagues doi.org/10.1158/2159...

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Yi Feng @fengfishlab.bsky.social · May 27

This happens tomorrow, still time to register, free webinar, cutting edge zebrafish cancer model stories! Come join us!

Yi Feng @fengfishlab.bsky.social · May 13

Free Webinar - Cancer research using zebrafish models, #ZDMS 2025 Cancer RIG Meet-up on Wednesday 28 May (10-11.30AM EST) exciting stories by rising stars of zebrafish cancer research field us06web.zoom.us/meeting/regi....

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Zebrafish Rock! @zebrafishrock.bsky.social · May 16

There’s now a MedakaBase paper that you can cite, courtesy of @kurakulabmsm.bsky.social 🐠

🔗 to MedakaBase: medakabase.nbrp.jp

bioRxiv Genomics @biorxiv-genomic.bsky.social · May 16

Empowering medaka fish biology with versatile genomic resources in MedakaBase https://www.biorxiv.org/content/10.1101/2025.05.13.653297v1

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Zebrafish Rock! @zebrafishrock.bsky.social · May 16

Check out the latest microscopy preprints including our recent favorite tool (LUCID) from #WeinsteinLab 🔥

🔗 to preprint: www.biorxiv.org/content/10.1...

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Shawn Burgess @burgesslab.bsky.social · May 15

Some exciting news! NCBI has finished the annotation pipeline for our new #zebrafish reference sequence GRCz12tu:
www.ncbi.nlm.nih.gov/refseq/annot...

This is a big step up in data depth and quality and should be super helpful going forward.

Danio rerio Annotation ReportTwitterFacebookLinkedInGitHubNCBI Insights BlogTwitterFacebookYoutube

www.ncbi.nlm.nih.gov

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Zebrafish Rock! @zebrafishrock.bsky.social · May 13

#ZebrafishMeeting, for those interested!

Yi Feng @fengfishlab.bsky.social · May 13

Free Webinar - Cancer research using zebrafish models, #ZDMS 2025 Cancer RIG Meet-up on Wednesday 28 May (10-11.30AM EST) exciting stories by rising stars of zebrafish cancer research field us06web.zoom.us/meeting/regi....

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Yi Feng @fengfishlab.bsky.social · May 13

Free Webinar - Cancer research using zebrafish models, #ZDMS 2025 Cancer RIG Meet-up on Wednesday 28 May (10-11.30AM EST) exciting stories by rising stars of zebrafish cancer research field us06web.zoom.us/meeting/regi....

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Isabella Cisneros @isabellaclsci.bsky.social · Apr 25

In this very cool 1-2 punch from the Weinstein lab, start by reading Miranda & co’s awesome pre-print about a novel epigenetic reporter and follow it up with @jimmykjm.bsky.social’s pre-print using it to characterize epigenetic reprogramming during fin regeneration: www.biorxiv.org/content/10.1...

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Journal of Experimental Medicine @jem.org · Apr 15

@zebrafish007.bsky.social, @zebrafishmk.bsky.social et al. #WeinsteinLab describe a previously uncharacterized external, experimentally accessible secondary lymphoid organ in the #zebrafish located above the pectoral fin. rupress.org/jem/article/...

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