Franziska Knolle
@franziskaknolle.bsky.social
Cognitive, clinical, computational neuroscience: I study how we understand language and make decisions, and what happens in the brain if things go wrong.
https://franziskaknolle.com
https://www.tum.de
https://www.mri.tum.de
https://franziskaknolle.com
https://www.tum.de
https://www.mri.tum.de
Pinned
I am very excited to share our new preprint together with @Isabella Goodwin, @Kelly Diederen, @Emily Hird,
@veithweilnhammer.bsky.social, and @Marta Garrido! Where does predictive processing stand in psychosis research - revisiting Sterzer et al (2018) seven years later. 🧠🔍?
osf.io/preprints/ps...
@veithweilnhammer.bsky.social, and @Marta Garrido! Where does predictive processing stand in psychosis research - revisiting Sterzer et al (2018) seven years later. 🧠🔍?
osf.io/preprints/ps...
🚨lf you’re based in Munich and have a daughter or friends with one, this might be interesting to them! Experience a day as a neuroscientist 🧠💡we’re very excited to show the girls around and introduce them to our work!!! 🤩 www.girls-day.de/.oO/Show/tum...
Angebot: Ein Tag als Neurowissenschaftlerin
München | 23. April 2026, 09:00 | TUM Klinikum, Neuroradiologie, München mit Dr. Franziska Knolle
www.girls-day.de
November 25, 2025 at 2:04 PM
🚨lf you’re based in Munich and have a daughter or friends with one, this might be interesting to them! Experience a day as a neuroscientist 🧠💡we’re very excited to show the girls around and introduce them to our work!!! 🤩 www.girls-day.de/.oO/Show/tum...
Reposted by Franziska Knolle
What aspects of language are universal, and which are due to familiarity? A @nature.com paper finds that while STG shows shared responses to basic speech sounds, only native language boosts encoding of word boundaries + sound-sequence stats 🧪 www.nature.com/articles/s41...
Shared and language-specific phonological processing in the human temporal lobe - Nature
The human superior temporal gyrus processes acoustic–phonetic properties of speech regardless of whether the language is familiar to the listener, but only encodes word boundaries and language-sp...
www.nature.com
November 24, 2025 at 8:26 PM
What aspects of language are universal, and which are due to familiarity? A @nature.com paper finds that while STG shows shared responses to basic speech sounds, only native language boosts encoding of word boundaries + sound-sequence stats 🧪 www.nature.com/articles/s41...
Reposted by Franziska Knolle
“Our findings challenge the conventional focus on low-dimensional coding subspaces as a sufficient framework for understanding neural computations, demonstrating that dimensions previously considered task-irrelevant and accounting for little variance can have a critical role in driving behavior.”
Neural dynamics outside task-coding dimensions drive decision trajectories through transient amplification
Most behaviors involve neural dynamics in high-dimensional activity spaces. A common approach is to extract dimensions that capture task-related variability, such as those separating stimuli or choice...
www.biorxiv.org
November 23, 2025 at 1:38 PM
“Our findings challenge the conventional focus on low-dimensional coding subspaces as a sufficient framework for understanding neural computations, demonstrating that dimensions previously considered task-irrelevant and accounting for little variance can have a critical role in driving behavior.”
Reposted by Franziska Knolle
Qualities of felt presence are described
November 13, 2025 at 12:57 PM
Qualities of felt presence are described
Reposted by Franziska Knolle
🥳!!NEW PREPRINT!!🥳
We show that the tendency to compress complex social information into priors about social structures becomes more pronounced during adolescence.
osf.io/preprints/ps...
I am soooooo excited to share this work, together with @mkwittmann.bsky.social and @yongling.bsky.social.
We show that the tendency to compress complex social information into priors about social structures becomes more pronounced during adolescence.
osf.io/preprints/ps...
I am soooooo excited to share this work, together with @mkwittmann.bsky.social and @yongling.bsky.social.
November 21, 2025 at 4:02 PM
🥳!!NEW PREPRINT!!🥳
We show that the tendency to compress complex social information into priors about social structures becomes more pronounced during adolescence.
osf.io/preprints/ps...
I am soooooo excited to share this work, together with @mkwittmann.bsky.social and @yongling.bsky.social.
We show that the tendency to compress complex social information into priors about social structures becomes more pronounced during adolescence.
osf.io/preprints/ps...
I am soooooo excited to share this work, together with @mkwittmann.bsky.social and @yongling.bsky.social.
Reposted by Franziska Knolle
Individuals with schizophrenia exhibit region-specific reductions in dendritic spine densities across cortical regions involved in visual-spatial working memory. ja.ma/48dYiTW
November 21, 2025 at 12:00 PM
Individuals with schizophrenia exhibit region-specific reductions in dendritic spine densities across cortical regions involved in visual-spatial working memory. ja.ma/48dYiTW
Reposted by Franziska Knolle
Really excited about this 5-year project starting, funded by @wellcometrust.bsky.social, where we will combine ✨computational modelling✨ with causal intervention techniques such as ✨tFUS✨ to study the neurocognitive mechanisms of repetitive negative thoughts 🚀 led by @mikebrowning.bsky.social
Repetitive negative thoughts will be investigated using a range of cutting-edge brain science techniques as part of a new study led by the Department of Psychiatry, University of Oxford and funded by Wellcome @wellcometrust.bsky.social 👇
tinyurl.com/364es88k
tinyurl.com/364es88k
November 21, 2025 at 1:38 PM
Really excited about this 5-year project starting, funded by @wellcometrust.bsky.social, where we will combine ✨computational modelling✨ with causal intervention techniques such as ✨tFUS✨ to study the neurocognitive mechanisms of repetitive negative thoughts 🚀 led by @mikebrowning.bsky.social
Reposted by Franziska Knolle
There are 3 Oxford-based post doc positions for this Wellcome Trust project that will be advertised soon!
If you have experinece in neurostimulation (tms/tus) and/or modelling of cogneuro data in humans do contact one of us (me, @mkflugge.bsky.social @lilweb.bsky.social, Jacinta OShea) to discuss!
If you have experinece in neurostimulation (tms/tus) and/or modelling of cogneuro data in humans do contact one of us (me, @mkflugge.bsky.social @lilweb.bsky.social, Jacinta OShea) to discuss!
Repetitive negative thoughts will be investigated using a range of cutting-edge brain science techniques as part of a new study led by the Department of Psychiatry, University of Oxford and funded by Wellcome @wellcometrust.bsky.social 👇
tinyurl.com/364es88k
tinyurl.com/364es88k
November 20, 2025 at 12:21 PM
There are 3 Oxford-based post doc positions for this Wellcome Trust project that will be advertised soon!
If you have experinece in neurostimulation (tms/tus) and/or modelling of cogneuro data in humans do contact one of us (me, @mkflugge.bsky.social @lilweb.bsky.social, Jacinta OShea) to discuss!
If you have experinece in neurostimulation (tms/tus) and/or modelling of cogneuro data in humans do contact one of us (me, @mkflugge.bsky.social @lilweb.bsky.social, Jacinta OShea) to discuss!
Reposted by Franziska Knolle
Thrilled to share our new paper, out now in @natneuro.nature.com, uncovering how estradiol, the most potent estrogen, modulates reinforcement learning and reward prediction errors across biological levels. www.nature.com/articles/s41...
#blueprint 1/7
#blueprint 1/7
Estrogen modulates reward prediction errors and reinforcement learning - Nature Neuroscience
Dopamine encoding of reward prediction errors naturally fluctuates over females’ reproductive cycles with estrogenic signaling due to reduced expression of dopamine reuptake proteins.
www.nature.com
November 11, 2025 at 2:41 PM
Thrilled to share our new paper, out now in @natneuro.nature.com, uncovering how estradiol, the most potent estrogen, modulates reinforcement learning and reward prediction errors across biological levels. www.nature.com/articles/s41...
#blueprint 1/7
#blueprint 1/7
Reposted by Franziska Knolle
New paper! Brains stretch representations along task-relevant dimensions. Spike timing is important.
www.nature.com/articles/s41...
#neuroscience
www.nature.com/articles/s41...
#neuroscience
Adaptive stretching of representations across brain regions and deep learning model layers - Nature Communications
How the brain adapts its representations to prioritize task-relevant information remains unclear. Here, the authors show that both monkey brains and deep learning models stretch neural representations...
www.nature.com
November 21, 2025 at 2:44 PM
New paper! Brains stretch representations along task-relevant dimensions. Spike timing is important.
www.nature.com/articles/s41...
#neuroscience
www.nature.com/articles/s41...
#neuroscience
Reposted by Franziska Knolle
Interested in the evolution of human language? Check out our new paper in @science.org where we synthesize latest findings and outline a multifaceted, bio-cultural approach for studying how language evolved. Super proud of this work, and hoping it leads to exciting new research! tinyurl.com/ykacvanp
November 21, 2025 at 9:47 AM
Interested in the evolution of human language? Check out our new paper in @science.org where we synthesize latest findings and outline a multifaceted, bio-cultural approach for studying how language evolved. Super proud of this work, and hoping it leads to exciting new research! tinyurl.com/ykacvanp
Reposted by Franziska Knolle
Happy to share my new paper published in @nathumbehav.nature.com: A critical look at statistical power in computational modeling studies, particularly those based on model selection.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
November 17, 2025 at 6:13 PM
Happy to share my new paper published in @nathumbehav.nature.com: A critical look at statistical power in computational modeling studies, particularly those based on model selection.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Franziska Knolle
My paper is out!
Computational modeling of error patterns during reward-based learning show evidence that habit learning (value free!) supplements working memory in 7 human data sets.
rdcu.be/eQjLN
Computational modeling of error patterns during reward-based learning show evidence that habit learning (value free!) supplements working memory in 7 human data sets.
rdcu.be/eQjLN
A habit and working memory model as an alternative account of human reward-based learning
Nature Human Behaviour - In this study, Collins proposes an alternative dual-process (working memory and habit) model of reinforcement learning in humans.
rdcu.be
November 17, 2025 at 5:18 PM
My paper is out!
Computational modeling of error patterns during reward-based learning show evidence that habit learning (value free!) supplements working memory in 7 human data sets.
rdcu.be/eQjLN
Computational modeling of error patterns during reward-based learning show evidence that habit learning (value free!) supplements working memory in 7 human data sets.
rdcu.be/eQjLN
Reposted by Franziska Knolle
The Change from 2020 tab is particularly interesting, given the narratives about what happened.
November 18, 2025 at 3:29 AM
The Change from 2020 tab is particularly interesting, given the narratives about what happened.
Reposted by Franziska Knolle
Then we have a new paper led by Nazia Jassim @naziajassim.bsky.social on the neurochemical markers of uncertainty processing and links to trait anxiety: www.nature.com/articles/s41...
@natcomms.nature.com
@natcomms.nature.com
Computational signatures of uncertainty are reflected in motor cortex excitatory neurochemistry - Nature Communications
Using computational modelling and neurochemical analysis, this study shows how motor cortex excitatory signals guide belief updating and adaptive learning in uncertain environments.
www.nature.com
November 13, 2025 at 12:13 PM
Then we have a new paper led by Nazia Jassim @naziajassim.bsky.social on the neurochemical markers of uncertainty processing and links to trait anxiety: www.nature.com/articles/s41...
@natcomms.nature.com
@natcomms.nature.com
Reposted by Franziska Knolle
First up, this paper led by Bronagh McCoy: journals.plos.org/ploscompbiol...
When noise and volatility are independently manipulated people behave differently depending on their anxious traits.
When noise and volatility are independently manipulated people behave differently depending on their anxious traits.
The relationship between anxious traits and learning about changes in stochasticity and volatility
Author summary Adapting to changes in our environment is a daily endeavour. To do so, humans and animals alike make use of feedback to guide future actions. Uncertainty in the environment can arise fr...
journals.plos.org
November 13, 2025 at 11:51 AM
First up, this paper led by Bronagh McCoy: journals.plos.org/ploscompbiol...
When noise and volatility are independently manipulated people behave differently depending on their anxious traits.
When noise and volatility are independently manipulated people behave differently depending on their anxious traits.
Reposted by Franziska Knolle
Hidden Markov Models
Speaking of HMMs, really enjoyed this paper on dynamics underlying resting state and other conditions. The idea of a baseline state from which excursions lead to more integrated states is really interesting.
doi.org/10.7554/eLif...
#neuroskyence
Speaking of HMMs, really enjoyed this paper on dynamics underlying resting state and other conditions. The idea of a baseline state from which excursions lead to more integrated states is really interesting.
doi.org/10.7554/eLif...
#neuroskyence
November 9, 2025 at 3:03 PM
Hidden Markov Models
Speaking of HMMs, really enjoyed this paper on dynamics underlying resting state and other conditions. The idea of a baseline state from which excursions lead to more integrated states is really interesting.
doi.org/10.7554/eLif...
#neuroskyence
Speaking of HMMs, really enjoyed this paper on dynamics underlying resting state and other conditions. The idea of a baseline state from which excursions lead to more integrated states is really interesting.
doi.org/10.7554/eLif...
#neuroskyence
Reposted by Franziska Knolle
Which one is more English?
November 6, 2025 at 11:58 AM
Which one is more English?
Reposted by Franziska Knolle
Correlation detection as a stimulus computable account for AV perception, causal inference & saliency maps in mammals elifesciences.org/articles/106... Image- & sound-computable population model for AV perception -> Used simulation to model psychophysical, eye-tracking & pharmacological experiments
Correlation detection as a stimulus computable account for audiovisual perception, causal inference, and saliency maps in mammals
Optimal cue integration, Bayesian Causal Inference, spatial orienting, speech illusions and other key phenomena in audiovisual perception naturally emerge from the collective behavior of a population ...
elifesciences.org
November 7, 2025 at 12:22 PM
Correlation detection as a stimulus computable account for AV perception, causal inference & saliency maps in mammals elifesciences.org/articles/106... Image- & sound-computable population model for AV perception -> Used simulation to model psychophysical, eye-tracking & pharmacological experiments
Reposted by Franziska Knolle
Last blog post by me on Open Research. This time on the value of not-for-profit/diamond open access publishers: echr.group/2025/11/05/w...
Why should I support not-for-profit publishers/diamond open access journals?
Traditional scientific publishing is a very lucrative business. For example, it has been reported that for-profit publishers (such as Elsevier, Springer-Nature, Wiley, Taylor & Francis) have pr…
echr.group
November 7, 2025 at 10:31 AM
Last blog post by me on Open Research. This time on the value of not-for-profit/diamond open access publishers: echr.group/2025/11/05/w...
Reposted by Franziska Knolle
The ICHR Special Supplement 2025 is out!
New in Schiz Bull, find work from six of our international working groups, ft. new reviews on sleep dysfunction, cog development, psychedelics, cross-cultural comparisons, & the bodily self, plus the iMAPS 2 Imagery RCT!
hallucinationconsortium.org
New in Schiz Bull, find work from six of our international working groups, ft. new reviews on sleep dysfunction, cog development, psychedelics, cross-cultural comparisons, & the bodily self, plus the iMAPS 2 Imagery RCT!
hallucinationconsortium.org
International Consortium on Hallucination Research
Visit the post for more.
hallucinationconsortium.org
November 6, 2025 at 8:55 AM
The ICHR Special Supplement 2025 is out!
New in Schiz Bull, find work from six of our international working groups, ft. new reviews on sleep dysfunction, cog development, psychedelics, cross-cultural comparisons, & the bodily self, plus the iMAPS 2 Imagery RCT!
hallucinationconsortium.org
New in Schiz Bull, find work from six of our international working groups, ft. new reviews on sleep dysfunction, cog development, psychedelics, cross-cultural comparisons, & the bodily self, plus the iMAPS 2 Imagery RCT!
hallucinationconsortium.org
Reposted by Franziska Knolle
This is 🤯
All publicly available. Looks like an amazing new histology-based human probabilistic atlas and parcellation tool.
#neuroskyence #mri #brainmapping
A probabilistic histological atlas of the human brain for MRI segmentation | Nature share.google/5AD0iW7pxgb4...
All publicly available. Looks like an amazing new histology-based human probabilistic atlas and parcellation tool.
#neuroskyence #mri #brainmapping
A probabilistic histological atlas of the human brain for MRI segmentation | Nature share.google/5AD0iW7pxgb4...
A probabilistic histological atlas of the human brain for MRI segmentation - Nature
NextBrain is an open source, probabilistic atlas of the entire human brain, assembled using artificial-intelligence-enabled registration and segmentation methods to reconstruct the multimodal serial h...
share.google
November 6, 2025 at 5:35 AM
This is 🤯
All publicly available. Looks like an amazing new histology-based human probabilistic atlas and parcellation tool.
#neuroskyence #mri #brainmapping
A probabilistic histological atlas of the human brain for MRI segmentation | Nature share.google/5AD0iW7pxgb4...
All publicly available. Looks like an amazing new histology-based human probabilistic atlas and parcellation tool.
#neuroskyence #mri #brainmapping
A probabilistic histological atlas of the human brain for MRI segmentation | Nature share.google/5AD0iW7pxgb4...
Reposted by Franziska Knolle
Thrilled to share my very first publication, in Translational Psychiatry! 🧠🧪
We used invasive brain mapping to identify personalized neuromodulation targets for treatment-refractory OCD.
Read it here 👉 www.nature.com/articles/s41...
#OCD #DBS #Neuroscience #Research
We used invasive brain mapping to identify personalized neuromodulation targets for treatment-refractory OCD.
Read it here 👉 www.nature.com/articles/s41...
#OCD #DBS #Neuroscience #Research
Invasive brain mapping identifies personalized therapeutic neuromodulation targets that suppress OCD network activity - Translational Psychiatry
Translational Psychiatry - Invasive brain mapping identifies personalized therapeutic neuromodulation targets that suppress OCD network activity
www.nature.com
November 4, 2025 at 12:41 PM
Thrilled to share my very first publication, in Translational Psychiatry! 🧠🧪
We used invasive brain mapping to identify personalized neuromodulation targets for treatment-refractory OCD.
Read it here 👉 www.nature.com/articles/s41...
#OCD #DBS #Neuroscience #Research
We used invasive brain mapping to identify personalized neuromodulation targets for treatment-refractory OCD.
Read it here 👉 www.nature.com/articles/s41...
#OCD #DBS #Neuroscience #Research
Reposted by Franziska Knolle
Introducing CorText: a framework that fuses brain data directly into a large language model, allowing for interactive neural readout using natural language.
tl;dr: you can now chat with a brain scan 🧠💬
1/n
tl;dr: you can now chat with a brain scan 🧠💬
1/n
November 3, 2025 at 3:17 PM
Introducing CorText: a framework that fuses brain data directly into a large language model, allowing for interactive neural readout using natural language.
tl;dr: you can now chat with a brain scan 🧠💬
1/n
tl;dr: you can now chat with a brain scan 🧠💬
1/n
Reposted by Franziska Knolle
What he said: 💯 🎯
November 1, 2025 at 6:55 PM
What he said: 💯 🎯