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Reposted

Avezov lab @avezovlab.bsky.social · 4h

New preprint from our lab! ER geometry sets the tempo of neuronal bursting via Ca²⁺ store-refill—revealing selective neuronal vulnerability to ER-structure problems. Thread to follow.🧠⚡️

www.biorxiv.org/content/10.1...

#Neurodegeneration #NeuroCellBiology #Calcium #bioRxiv

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Reposted

Xinnan Wang Lab @xinnanwanglab.bsky.social · 14d

Our new review is out! Likely once an independent organism, mitochondria have retained a striking degree of autonomy. We discuss their capacity to sense within—a process we refer to as mitochondrial inside-out signaling. Written by talented @furkanoflaz.bsky.social @signscaztl.bsky.social

Waggoner Lab @labwaggoner.bsky.social · 14d

Review @cp-cellchembiol.bsky.social @xinnanwanglab.bsky.social @stanforduniversity.bsky.social
Sensing within: Mitochondrial inside-out signal transduction
www.cell.com/cell-chemica...

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Reposted

Joachim Goedhart @joachimgoedhart.bsky.social · 28d

We have updated our preprint "A green lifetime biosensor for calcium that remains bright over its full dynamic range" with some new data - including this photo showing the difference in color for the Turquoise and Green lifetime probe. www.biorxiv.org/content/10.1...

Figure 1. The excitation and emission peaks of G-Ca-FLITS are red-shifted relative to Tq-Ca-FLITS. (A) The
excitation and emission spectra show in lighter lines the calcium-free state (10 mM EGTA) and the darker
lines the calcium-bound state (39 μM free Ca2+). The Tq-Ca-FLITS is shown as a reference and was reported
before (van der Linden et al., 2021). Spectra are normalized to the maximum of the calcium-free state for
G-Ca-FLITS. (B) The photo shows the fluorescence from tubes of purified biosensors when excited with UV
(312 nm).

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Reposted

Gerry Hammond @gerryhammond.bsky.social · 28d

Announcing our new PA biosensor, PILS-Nir1 – seen here in HeLa cells during PLC activation #lipidtime #phospholipids

Read the OA paper in JCB

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Reposted

Journal of Cell Biology @jcb.org · May 13

Shun-ichi Yamashita, Ritsuko Arai, Tomotake Kanki, Satoshi Waguri et al. show that the #mitophagy receptors BNIP3 and NIX are required for tight attachment & expansion of the isolation membrane along the mitochondrial surface rupress.org/jcb/article/...

#Autophagy #Mitochondria

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furkanoflaz.bsky.social @furkanoflaz.bsky.social · May 13

Thank you!

furkanoflaz.bsky.social @furkanoflaz.bsky.social · May 12

I’m happy to share that my latest PhD work is published in
@embojournal.org
! We demonstrate a fundamental role for Annexin A5 in regulating mitochondrial calcium signaling and apoptosis. www.embopress.org/doi/full/10....

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Reposted

Nature @nature.com · Mar 31

A brain-reading implant that translates neural signals into audible speech has allowed a woman with paralysis to hear what she intends to say nearly instantly

https://go.nature.com/3QStZtI

Brain implant translates thoughts to speech in an instant

Improvements to brain–computer interfaces are bringing the technology closer to natural conversation speed.

go.nature.com

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Reposted

Joachim Goedhart @joachimgoedhart.bsky.social · Mar 24

NitrOFF: An engineered fluorescent biosensor to illuminate nitrate transport in living cells by Sheel Dodani and team: www.biorxiv.org/content/10.1...

Figure 1. Directed evolution of NreA-EGFP to NitrOFF.

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Reposted

Christian Frezza @frezzalab.bsky.social · Mar 21

In-cell architecture of the mitochondrial respiratory chain | Science www.science.org/doi/10.1126/...

In-cell architecture of the mitochondrial respiratory chain

Mitochondria regenerate adenosine triphosphate (ATP) through oxidative phosphorylation. This process is carried out by five membrane-bound complexes collectively known as the respiratory chain, workin...

www.science.org

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Reposted

Kai Johnsson @kjohnsson.bsky.social · Feb 7

Check out our new fluorescent probe for imaging f-actin dynamics: 𝗦𝗶𝗥-𝗫𝗔𝗰𝘁𝗶𝗻: 𝗔 𝗳𝗹𝘂𝗼𝗿𝗲𝘀𝗰𝗲𝗻𝘁 𝗽𝗿𝗼𝗯𝗲 𝗳𝗼𝗿 𝗶𝗺𝗮𝗴𝗶𝗻𝗴 𝗮𝗰𝘁𝗶𝗻 𝗱𝘆𝗻𝗮𝗺𝗶𝗰𝘀 𝗶𝗻 𝗹𝗶𝘃𝗲 𝗰𝗲𝗹𝗹𝘀 www.biorxiv.org/content/10.1...
Thank you @veselin-nasufovic.bsky.social

SiR-XActin: A fluorescent probe for imaging actin dynamics in live cells

Imaging actin-dependent processes in live cells is important for understanding numerous biological processes. However, currently used natural-product based fluorescent probes for actin filaments affec...

www.biorxiv.org

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Reposted

Franck Polleux @franckp.bsky.social · Dec 18

Delighted to highlight our new paper in
@natureportfolio.bsky.social entitled 'Synaptic basis of feature selectivity in hippocampal neurons' (thread below 👇): www.nature.com/articles/s41...

Synaptic basis of feature selectivity in hippocampal neurons - Nature

A temporally asymmetric synaptic plasticity kernel results from bidirectional modifications of synaptic weights around the induction of a place field.

www.nature.com

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Reposted

Xinnan Wang Lab @xinnanwanglab.bsky.social · Jan 28

Beautiful paper on mitochondrial DNA (mtDNA) stress sensing, from our postdoc Alva Sainz @signscaztl.bsky.social of her Ph.D work in the Shadel lab!

Journal of Cell Biology @jcb.org · Jan 27

New: Sainz, Shadel et al. @salkinstitute.bsky.social investigate mitochondrial respiration-independent signaling induced by acute mtDNA depletion and uncover a role for FAM43A in a CHK2-dependent mitochondrial stress signaling pathway. https://buff.ly/40MBmIW
#mitochondria

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