Gavin McStay
@gavinmcstay.bsky.social
I study mitochondria and love doing science outreach. I direct biomed news, a platform to help find the latest biomedical research using machine learning. Senior lecturer at Liverpool John Moores University
Reposted by Gavin McStay
Have you popped into @storyhouselive.bsky.social recently? If so, you might have spotted us on the Christmas listings!
Be sure to join us for our last talk of 2025.
We're talking Christmas Movies and the science of storytelling
facebook.com/events/s/chr...
Be sure to join us for our last talk of 2025.
We're talking Christmas Movies and the science of storytelling
facebook.com/events/s/chr...
November 24, 2025 at 1:39 PM
Have you popped into @storyhouselive.bsky.social recently? If so, you might have spotted us on the Christmas listings!
Be sure to join us for our last talk of 2025.
We're talking Christmas Movies and the science of storytelling
facebook.com/events/s/chr...
Be sure to join us for our last talk of 2025.
We're talking Christmas Movies and the science of storytelling
facebook.com/events/s/chr...
Reposted by Gavin McStay
Explore the newest issue of the weekly digest on the analytical and computational methods for small molecule analysis:
biomed.news/bims-metlip/...
In collaboration with @biomednews.bsky.social
biomed.news/bims-metlip/...
In collaboration with @biomednews.bsky.social
a woman in a library with a tote bag that says ' nlg ' on it
ALT: a woman in a library with a tote bag that says ' nlg ' on it
media.tenor.com
November 23, 2025 at 6:13 PM
Explore the newest issue of the weekly digest on the analytical and computational methods for small molecule analysis:
biomed.news/bims-metlip/...
In collaboration with @biomednews.bsky.social
biomed.news/bims-metlip/...
In collaboration with @biomednews.bsky.social
Reposted by Gavin McStay
📢Last 2 weeks of #immunometabolism discoveries @biomednews.bsky.social ⬇️⬇️
biomed.news/bims-imicid/...
biomed.news/bims-imicid/...
Exciting to have a paper in the collection!
An inherited mitochondrial DNA mutation remodels inflammatory cytokine responses in macrophages and in vivo in mice
biomed.news/bims-imicid/...
biomed.news/bims-imicid/...
Exciting to have a paper in the collection!
An inherited mitochondrial DNA mutation remodels inflammatory cytokine responses in macrophages and in vivo in mice
November 23, 2025 at 1:05 PM
📢Last 2 weeks of #immunometabolism discoveries @biomednews.bsky.social ⬇️⬇️
biomed.news/bims-imicid/...
biomed.news/bims-imicid/...
Exciting to have a paper in the collection!
An inherited mitochondrial DNA mutation remodels inflammatory cytokine responses in macrophages and in vivo in mice
biomed.news/bims-imicid/...
biomed.news/bims-imicid/...
Exciting to have a paper in the collection!
An inherited mitochondrial DNA mutation remodels inflammatory cytokine responses in macrophages and in vivo in mice
Reposted by Gavin McStay
🧬 New #BiomedNews report out in Mutant #p53 and anti-cancer therapies.
Two recent papers highlight how specific TP53 mutations drive tumor behavior and reveal new therapeutic vulnerabilities.
biomed.news/bims-p53act/...
@biomednews.bsky.social
Two recent papers highlight how specific TP53 mutations drive tumor behavior and reveal new therapeutic vulnerabilities.
biomed.news/bims-p53act/...
@biomednews.bsky.social
bims-p53act 2025-11-23 papers
biomed.news
November 23, 2025 at 11:18 AM
🧬 New #BiomedNews report out in Mutant #p53 and anti-cancer therapies.
Two recent papers highlight how specific TP53 mutations drive tumor behavior and reveal new therapeutic vulnerabilities.
biomed.news/bims-p53act/...
@biomednews.bsky.social
Two recent papers highlight how specific TP53 mutations drive tumor behavior and reveal new therapeutic vulnerabilities.
biomed.news/bims-p53act/...
@biomednews.bsky.social
Reposted by Gavin McStay
This week's (on time) selection of articles and #preprints on #proteostasis thanks to @biomednews.bsky.social -- biomed.news/bims-proteo/...
Highlight - @drsimoncook.bsky.social RAF inhibitors activate the integrated stress response by direct activation of GCN2 www.nature.com/articles/s41...
Highlight - @drsimoncook.bsky.social RAF inhibitors activate the integrated stress response by direct activation of GCN2 www.nature.com/articles/s41...
bims-proteo 2025-11-23 papers
biomed.news
November 23, 2025 at 9:30 AM
This week's (on time) selection of articles and #preprints on #proteostasis thanks to @biomednews.bsky.social -- biomed.news/bims-proteo/...
Highlight - @drsimoncook.bsky.social RAF inhibitors activate the integrated stress response by direct activation of GCN2 www.nature.com/articles/s41...
Highlight - @drsimoncook.bsky.social RAF inhibitors activate the integrated stress response by direct activation of GCN2 www.nature.com/articles/s41...
Reposted by Gavin McStay
Latest issue of curated #engineeredlivingmaterials feed:
biomed.news/bims-enlima/... #ELMs
via @biomednews.bsky.social #livingmaterials
includes research on: 3D necroprinting, self-assembling protein materials, directed self-assembly of 3D interconnected networks & more 🧪
biomed.news/bims-enlima/... #ELMs
via @biomednews.bsky.social #livingmaterials
includes research on: 3D necroprinting, self-assembling protein materials, directed self-assembly of 3D interconnected networks & more 🧪
3D necroprinting: Leveraging biotic material as the nozzle for 3D printing
Dead mosquitoes find new life as ultrafine 3D printer nozzles, enabling sustainable microscale manufacturing.
doi.org
November 23, 2025 at 8:53 AM
Latest issue of curated #engineeredlivingmaterials feed:
biomed.news/bims-enlima/... #ELMs
via @biomednews.bsky.social #livingmaterials
includes research on: 3D necroprinting, self-assembling protein materials, directed self-assembly of 3D interconnected networks & more 🧪
biomed.news/bims-enlima/... #ELMs
via @biomednews.bsky.social #livingmaterials
includes research on: 3D necroprinting, self-assembling protein materials, directed self-assembly of 3D interconnected networks & more 🧪
Reposted by Gavin McStay
Ho ho ho, happy Sunday egg-ficionados! Here is another great issue of #cebooc: biomed.news/bims-cebooc/...
Highlight: pubmed.ncbi.nlm.nih.gov/41241715/
Runner-up: pubmed.ncbi.nlm.nih.gov/41271398/
Thanks @biomednews.bsky.social for preselecting!
Highlight: pubmed.ncbi.nlm.nih.gov/41241715/
Runner-up: pubmed.ncbi.nlm.nih.gov/41271398/
Thanks @biomednews.bsky.social for preselecting!
November 23, 2025 at 8:01 AM
Ho ho ho, happy Sunday egg-ficionados! Here is another great issue of #cebooc: biomed.news/bims-cebooc/...
Highlight: pubmed.ncbi.nlm.nih.gov/41241715/
Runner-up: pubmed.ncbi.nlm.nih.gov/41271398/
Thanks @biomednews.bsky.social for preselecting!
Highlight: pubmed.ncbi.nlm.nih.gov/41241715/
Runner-up: pubmed.ncbi.nlm.nih.gov/41271398/
Thanks @biomednews.bsky.social for preselecting!
Reposted by Gavin McStay
Good Sunday, all. What a great week for #cancermetabolism and #mitochondrialbiology. Find here a selection of groundbreaking discoveries: biomed.news/bims-camemi/... @biomednews.bsky.social #keepreading
"Trying to define yourself is like trying to bite your own teeth."-Alan Watts
"Trying to define yourself is like trying to bite your own teeth."-Alan Watts
November 23, 2025 at 6:51 AM
Good Sunday, all. What a great week for #cancermetabolism and #mitochondrialbiology. Find here a selection of groundbreaking discoveries: biomed.news/bims-camemi/... @biomednews.bsky.social #keepreading
"Trying to define yourself is like trying to bite your own teeth."-Alan Watts
"Trying to define yourself is like trying to bite your own teeth."-Alan Watts
Reposted by Gavin McStay
Delayed weekly selection of articles on #proteostasis thanks to @biomednews.bsky.social -- biomed.news/bims-proteo/...
Highlight - Pooled overexpression screening identifies PIPPI as a novel microprotein involved in the ER stress response academic.oup.com/nar/article/...
Highlight - Pooled overexpression screening identifies PIPPI as a novel microprotein involved in the ER stress response academic.oup.com/nar/article/...
bims-proteo 2025-11-16 papers
biomed.news
November 21, 2025 at 7:46 PM
Delayed weekly selection of articles on #proteostasis thanks to @biomednews.bsky.social -- biomed.news/bims-proteo/...
Highlight - Pooled overexpression screening identifies PIPPI as a novel microprotein involved in the ER stress response academic.oup.com/nar/article/...
Highlight - Pooled overexpression screening identifies PIPPI as a novel microprotein involved in the ER stress response academic.oup.com/nar/article/...
Reposted by Gavin McStay
Rich collections of papers on #mitochondrialdisease from the last 2 weeks! 📚
biomed.news/bims-mitdis/...
biomed.news/bims-mitdis/...
@biomednews.bsky.social @mitoscientist.bsky.social
@gavinmcstay.bsky.social
Demethoxy-CoQ and NUDT5 in nucleotide synthesis
www.nature.com/articles/s42...
biomed.news/bims-mitdis/...
biomed.news/bims-mitdis/...
@biomednews.bsky.social @mitoscientist.bsky.social
@gavinmcstay.bsky.social
Demethoxy-CoQ and NUDT5 in nucleotide synthesis
www.nature.com/articles/s42...
Uridine-sensitized screening identifies demethoxy-coenzyme Q and NUDT5 as regulators of nucleotide synthesis - Nature Metabolism
A uridine-sensitized CRISPR-Cas9 screening identifies demethoxy-CoQ as an alternative electron acceptor in the absence of CoQ, and NUDT5 as a regulator of de novo pyrimidine synthesis via its interact...
www.nature.com
November 23, 2025 at 11:59 AM
Rich collections of papers on #mitochondrialdisease from the last 2 weeks! 📚
biomed.news/bims-mitdis/...
biomed.news/bims-mitdis/...
@biomednews.bsky.social @mitoscientist.bsky.social
@gavinmcstay.bsky.social
Demethoxy-CoQ and NUDT5 in nucleotide synthesis
www.nature.com/articles/s42...
biomed.news/bims-mitdis/...
biomed.news/bims-mitdis/...
@biomednews.bsky.social @mitoscientist.bsky.social
@gavinmcstay.bsky.social
Demethoxy-CoQ and NUDT5 in nucleotide synthesis
www.nature.com/articles/s42...
Reposted by Gavin McStay
Latest analytical and computational methods for small molecule analysis is here:
biomed.news/bims-metlip/...
Selected for all the researchers in the metabolomics and lipidomics fields in collaboration with Biomed News.
biomed.news/bims-metlip/...
Selected for all the researchers in the metabolomics and lipidomics fields in collaboration with Biomed News.
a man in a suit is sitting in a chair holding a piece of paper and says you don t wanna miss this
ALT: a man in a suit is sitting in a chair holding a piece of paper and says you don t wanna miss this
media.tenor.com
November 16, 2025 at 8:12 PM
Latest analytical and computational methods for small molecule analysis is here:
biomed.news/bims-metlip/...
Selected for all the researchers in the metabolomics and lipidomics fields in collaboration with Biomed News.
biomed.news/bims-metlip/...
Selected for all the researchers in the metabolomics and lipidomics fields in collaboration with Biomed News.
It was great to hear about #Chester and the River Dee tonight at @chesterscibar.bsky.social. There was a bit of history, georgraphy, ecology, engineering - all things that scibar loves
#DYK The Dee is the most managed river in Europe?
More water is extracted from the Dee than from the whole of the Lake District!
More water is extracted from the Dee than from the whole of the Lake District!
November 11, 2025 at 10:47 PM
It was great to hear about #Chester and the River Dee tonight at @chesterscibar.bsky.social. There was a bit of history, georgraphy, ecology, engineering - all things that scibar loves
Reposted by Gavin McStay
A new collection of papers on #mitochondrialdisease from #week45! 📚 💚
biomed.news/bims-mitdis/...
@biomednews.bsky.social @gavinmcstay.bsky.social @mitoscientist.bsky.social
Mito complex III-derived ROS amplify immunometab changes in astrocytes and promote dementia
www.nature.com/articles/s42...
biomed.news/bims-mitdis/...
@biomednews.bsky.social @gavinmcstay.bsky.social @mitoscientist.bsky.social
Mito complex III-derived ROS amplify immunometab changes in astrocytes and promote dementia
www.nature.com/articles/s42...
Mitochondrial complex III-derived ROS amplify immunometabolic changes in astrocytes and promote dementia pathology - Nature Metabolism
Barnett et al. disentangle the differential contribution of mitochondrial complex I- and complex III-derived ROS to astrocytic function, with CIII-derived ROS being a major driver of neuroinflammatory...
www.nature.com
November 9, 2025 at 12:53 PM
A new collection of papers on #mitochondrialdisease from #week45! 📚 💚
biomed.news/bims-mitdis/...
@biomednews.bsky.social @gavinmcstay.bsky.social @mitoscientist.bsky.social
Mito complex III-derived ROS amplify immunometab changes in astrocytes and promote dementia
www.nature.com/articles/s42...
biomed.news/bims-mitdis/...
@biomednews.bsky.social @gavinmcstay.bsky.social @mitoscientist.bsky.social
Mito complex III-derived ROS amplify immunometab changes in astrocytes and promote dementia
www.nature.com/articles/s42...
Reposted by Gavin McStay
Here are the papers of the last 3 weeks on interference of viral infections with metabolic and redox pathways of host cells:
biomed.news/bims-mevinf/...
biomed.news/bims-mevinf/...
biomed.news/bims-mevinf/...
As always, many thanks to Biomed.news, @gavinmcstay.bsky.social
, Thomas Krichel
biomed.news/bims-mevinf/...
biomed.news/bims-mevinf/...
biomed.news/bims-mevinf/...
As always, many thanks to Biomed.news, @gavinmcstay.bsky.social
, Thomas Krichel
bims-mevinf 2025-11-02 papers
biomed.news
November 3, 2025 at 7:25 PM
Here are the papers of the last 3 weeks on interference of viral infections with metabolic and redox pathways of host cells:
biomed.news/bims-mevinf/...
biomed.news/bims-mevinf/...
biomed.news/bims-mevinf/...
As always, many thanks to Biomed.news, @gavinmcstay.bsky.social
, Thomas Krichel
biomed.news/bims-mevinf/...
biomed.news/bims-mevinf/...
biomed.news/bims-mevinf/...
As always, many thanks to Biomed.news, @gavinmcstay.bsky.social
, Thomas Krichel
Reposted by Gavin McStay
The weekly Metabolism driving cancer organotropism (biomed.news/bims-metorg/...) and Metabolites-driven PTMs focusing on cancer (biomed.news/bims-prolim/...) at @biomednews.bsky.social are out ☺️
bims-metorg 2025-11-02 papers
biomed.news
November 3, 2025 at 8:27 AM
The weekly Metabolism driving cancer organotropism (biomed.news/bims-metorg/...) and Metabolites-driven PTMs focusing on cancer (biomed.news/bims-prolim/...) at @biomednews.bsky.social are out ☺️
Reposted by Gavin McStay
A new collection of papers related to #mitochondrialdisease from #week44! 📚 💚
biomed.news/bims-mitdis/...
@biomednews.bsky.social @mitoscientist.bsky.social @gavinmcstay.bsky.social
Super mitochondria-enriched extracellular vesicles enable enhanced mito transfer
www.nature.com/articles/s41...
biomed.news/bims-mitdis/...
@biomednews.bsky.social @mitoscientist.bsky.social @gavinmcstay.bsky.social
Super mitochondria-enriched extracellular vesicles enable enhanced mito transfer
www.nature.com/articles/s41...
Super mitochondria-enriched extracellular vesicles enable enhanced mitochondria transfer - Nature Communications
In mitochondria transplantation, the limited activity and yield of mitochondria constrain their clinical application for mitochondrial diseases. Here, authors develop a method for producing mitochondr...
www.nature.com
November 2, 2025 at 12:33 PM
A new collection of papers related to #mitochondrialdisease from #week44! 📚 💚
biomed.news/bims-mitdis/...
@biomednews.bsky.social @mitoscientist.bsky.social @gavinmcstay.bsky.social
Super mitochondria-enriched extracellular vesicles enable enhanced mito transfer
www.nature.com/articles/s41...
biomed.news/bims-mitdis/...
@biomednews.bsky.social @mitoscientist.bsky.social @gavinmcstay.bsky.social
Super mitochondria-enriched extracellular vesicles enable enhanced mito transfer
www.nature.com/articles/s41...
Reposted by Gavin McStay
Opportunity for lab-based medicinal chemist/chemical biologist at The Francis Crick Institute (London UK) ref: R2461 | closing: 11-Nov-2025 #MedChem #ChemBiol #SynChem #ChemJobs #UKChemJobs #chemsky 🧪
crick.wd3.myworkdayjobs.com/External/job...
crick.wd3.myworkdayjobs.com/External/job...
Senior Laboratory Research Scientist - Medicinal Chemist/Chemical Biologist
Salary for this Role: From £45,700 with benefits, subject to skills & experience Job Title: Senior Laboratory Research Scientist - Medicinal Chemist/Chemical Biologist Reports to: Christelle Soudy...
crick.wd3.myworkdayjobs.com
October 29, 2025 at 7:22 AM
Opportunity for lab-based medicinal chemist/chemical biologist at The Francis Crick Institute (London UK) ref: R2461 | closing: 11-Nov-2025 #MedChem #ChemBiol #SynChem #ChemJobs #UKChemJobs #chemsky 🧪
crick.wd3.myworkdayjobs.com/External/job...
crick.wd3.myworkdayjobs.com/External/job...
Reposted by Gavin McStay
Happy Sunday! Here's a double shot of novel methods for small molecule detection, identification, and quantification.
biomed.news/bims-metlip/...
biomed.news/bims-metlip/...
A collaboration with @biomednews.bsky.social
biomed.news/bims-metlip/...
biomed.news/bims-metlip/...
A collaboration with @biomednews.bsky.social
a black and white drawing of stacks of books and papers
ALT: a black and white drawing of stacks of books and papers
media.tenor.com
October 26, 2025 at 1:34 AM
Happy Sunday! Here's a double shot of novel methods for small molecule detection, identification, and quantification.
biomed.news/bims-metlip/...
biomed.news/bims-metlip/...
A collaboration with @biomednews.bsky.social
biomed.news/bims-metlip/...
biomed.news/bims-metlip/...
A collaboration with @biomednews.bsky.social
Reposted by Gavin McStay
Last weeks #immunometabolism discoveries @biomednews.bsky.social ⬇️⬇️⬇️
biomed.news/bims-imicid/...
Lots of excellent work inside incl.
Backtracking metabolic dynamics in single cells predicts bacterial replication in human macrophages.
biomed.news/bims-imicid/...
Lots of excellent work inside incl.
Backtracking metabolic dynamics in single cells predicts bacterial replication in human macrophages.
October 20, 2025 at 12:27 PM
Last weeks #immunometabolism discoveries @biomednews.bsky.social ⬇️⬇️⬇️
biomed.news/bims-imicid/...
Lots of excellent work inside incl.
Backtracking metabolic dynamics in single cells predicts bacterial replication in human macrophages.
biomed.news/bims-imicid/...
Lots of excellent work inside incl.
Backtracking metabolic dynamics in single cells predicts bacterial replication in human macrophages.
This years #riveroflight had a science of light theme with biology-based displays: neuron, dandelion, blueprint and within water
October 28, 2025 at 11:20 PM
This years #riveroflight had a science of light theme with biology-based displays: neuron, dandelion, blueprint and within water
Reposted by Gavin McStay
Here a selection of last week studies on #anticancer #therapy and #metabolic #reprogramming. Big thanks @biomednews.bsky.social for presorting them.
V good studies in this issue, have a look
biomed.news/bims-meract/...
V good studies in this issue, have a look
biomed.news/bims-meract/...
a man with glasses and a beard is making a perfect choice face
ALT: a man with glasses and a beard is making a perfect choice face
media.tenor.com
October 26, 2025 at 10:27 PM
Here a selection of last week studies on #anticancer #therapy and #metabolic #reprogramming. Big thanks @biomednews.bsky.social for presorting them.
V good studies in this issue, have a look
biomed.news/bims-meract/...
V good studies in this issue, have a look
biomed.news/bims-meract/...
Reposted by Gavin McStay
Great collections of papers on #mitochondrialdisease from #week42 and #week43! 📚
biomed.news/bims-mitdis/...
biomed.news/bims-mitdis/...
@biomednews.bsky.social @gavinmcstay.bsky.social @mitoscientist.bsky.social
Mito & psy stress regulation of FGF21 in humans
www.nature.com/articles/s42...
biomed.news/bims-mitdis/...
biomed.news/bims-mitdis/...
@biomednews.bsky.social @gavinmcstay.bsky.social @mitoscientist.bsky.social
Mito & psy stress regulation of FGF21 in humans
www.nature.com/articles/s42...
Mitochondrial and psychosocial stress-related regulation of FGF21 in humans - Nature Metabolism
FGF21 levels increase in response to acute mental stress in individuals with impaired mitochondrial OxPhos capacity, and correlate with stress-related neuroendocrine hormones and trait-level psychosoc...
www.nature.com
October 26, 2025 at 10:36 AM
Great collections of papers on #mitochondrialdisease from #week42 and #week43! 📚
biomed.news/bims-mitdis/...
biomed.news/bims-mitdis/...
@biomednews.bsky.social @gavinmcstay.bsky.social @mitoscientist.bsky.social
Mito & psy stress regulation of FGF21 in humans
www.nature.com/articles/s42...
biomed.news/bims-mitdis/...
biomed.news/bims-mitdis/...
@biomednews.bsky.social @gavinmcstay.bsky.social @mitoscientist.bsky.social
Mito & psy stress regulation of FGF21 in humans
www.nature.com/articles/s42...
Reposted by Gavin McStay
This week's selection of articles on #proteostasis thanks to @biomednews.bsky.social -- biomed.news/bims-proteo/...
Highlight: ITCH regulates Golgi integrity and proteotoxicity in neurodegeneration www.science.org/doi/10.1126/...
Highlight: ITCH regulates Golgi integrity and proteotoxicity in neurodegeneration www.science.org/doi/10.1126/...
bims-proteo 2025-10-26 papers
biomed.news
October 26, 2025 at 7:42 AM
This week's selection of articles on #proteostasis thanks to @biomednews.bsky.social -- biomed.news/bims-proteo/...
Highlight: ITCH regulates Golgi integrity and proteotoxicity in neurodegeneration www.science.org/doi/10.1126/...
Highlight: ITCH regulates Golgi integrity and proteotoxicity in neurodegeneration www.science.org/doi/10.1126/...
Reposted by Gavin McStay
Good Sunday, all! Here is an exciting selection of papers in #cancermetabolism and #mitochondrialbiology: biomed.news/bims-camemi/...
@biomednews.bsky.social #keepreading
"Inside us there is something that has no name, that something is what we are."-José Saramago
@biomednews.bsky.social #keepreading
"Inside us there is something that has no name, that something is what we are."-José Saramago
October 26, 2025 at 6:25 AM
Good Sunday, all! Here is an exciting selection of papers in #cancermetabolism and #mitochondrialbiology: biomed.news/bims-camemi/...
@biomednews.bsky.social #keepreading
"Inside us there is something that has no name, that something is what we are."-José Saramago
@biomednews.bsky.social #keepreading
"Inside us there is something that has no name, that something is what we are."-José Saramago
A wonderful play depicting the life of Alan Turing. His impacts on the world are great but his life ended so tragically
October 22, 2025 at 9:52 PM
A wonderful play depicting the life of Alan Turing. His impacts on the world are great but his life ended so tragically