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Institute of Science and Technology Austria (ISTA) @istaresearch.bsky.social · 17h

Join us for the Austrian Cryo-EM Symposium from Nov 11–12 at ISTA! Top speakers, cutting-edge cryo-EM, and a chance to explore Vienna & the ISTA campus. Register now 👉 cryoem-symposium.pages.ist.ac.at/registration/

#cryoEM

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Kenneth Ehses @denkenny.bsky.social · 2d

✨Excited that the main project of my PhD is now available as a pre-print on #bioRxiv

Here, we used #CryoET to visualise mitochondrial proteostatic stress and together with SPA #CryoEM shed light into the functional cycle of the Hsp60:10 chaperone system. #TeamTomo

🔗 www.biorxiv.org/content/10.1...

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Julius Brennecke @juliusbrennecke.bsky.social · 5d

The Vienna BioCenter PhD Program application deadline is approaching: October 10!

Join one of Europe’s premier life science campuses, home to cutting-edge research across all areas of biology.
Apply and start your scientific journey in Vienna!

training.vbc.ac.at/phd-program/

#PhD #LifeSciences

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Josh Hardy @joshuamhardy.bsky.social · 12d

I am thrilled to release ProteinDJ: a high-performance and modular protein design pipeline. Our open-source workflow incorporates #RFdiffusion, #ProteinMPNN, #FAMPNN, #AlphaFold2 and #Boltz-2. It is a fast, free, and fun way to design proteins (1/5)
doi.org/10.1101/2025.09.24.678028 #proteindesign

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Haselbach Lab @haselbachlab.bsky.social · 14d

Finally! This was really missing.

RCSB Protein Data Bank @rcsbpdb.bsky.social · 14d

wwPDB has introducing the first 3DEM Model-Map percentile slider (based on Q-score) to validation reports

Introducing the first 3DEM Model-Map percentile slider to the wwPDB validation report

Introducing the latest wwPDB Percentile slider based on the Q-score model-map validation metric

www.rcsb.org

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David Balchin @davidbalchin.bsky.social · 21d

Our article on human multidomain protein biogenesis is now published in @natsmb.nature.com
www.nature.com/articles/s41...

The human ribosome modulates multidomain protein biogenesis by delaying cotranslational domain docking - Nature Structural & Molecular Biology

By studying dynamic folding intermediates on the human ribosome, Pellowe et al. show that newly made domains help each other to fold but do not stably interact until synthesis is complete, avoiding in...

www.nature.com

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Edouard Hannezo @ehannezo.bsky.social · 21d

Core achievement unlocked!! Congrats to Fabrizio amd all authors!!

Institute of Science and Technology Austria (ISTA) @istaresearch.bsky.social · 22d

Who knew that the perfect pasta sauce could lead to a Nobel Prize? Congrats to ISTA postdoc Fabrizio Olmeda and collaborators for winning the Ig Nobel Prize with their research on mastering Cacio e Pepe. Bravo! 🍝 🎉

Getting hungry? Here´s the recipe for delicious research: https://bit.ly/42vlpHm

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Jack Bravo @jpkbravo.bsky.social · 25d

Join us for the Austrian Cryo-EM Symposium Nov 11–12 at @istaresearch.bsky.social!

Top speakers, cutting-edge cryo-EM, and a chance to explore Vienna & the ISTA campus.

Register now 👉 cryoem-symposium.pages.ist.ac.at #cryoEM #teamtomo

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Laura Lorenzo Orts @lorenzoorts.bsky.social · 25d

I am excited to announce that I will be moving to IMB Mainz next year! The Winter call for the IPP PhD program is now open; if you are interested in maternal #mRNA regulation and #translation in early vertebrate development, please apply! Deadline: 16 October.

More info: www.imb.de/students-pos...

Laura Lorenzo Orts

IMB Mainz

www.imb.de

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Haselbach Lab @haselbachlab.bsky.social · 27d

Wow this seems to be a major breakthrough can’t wait to test it on all the small stuff we could never solve

Oli Clarke @olibclarke.bsky.social · 28d

This one is a bit of a departure from the usual and definitely a work in progress!

We found that by using ab initio reconstruction at very high res, in very small steps, we could crack some small structures that had eluded us - e.g. 39kDa iPKAc (EMPIAR-10252), below.

Read on for details... 1/x

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Haselbach Lab @haselbachlab.bsky.social · 28d

Thanks to @horizonsmolbio.bsky.social for inviting me! It has been a real pleasure

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Haselbach Lab @haselbachlab.bsky.social · 28d

It was wonderful to be back in Göttingen and see so many friendly and familiar faces. Still a city of vibrant science.

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cryoEM papers @cryoempapers.bsky.social · Sep 6

Structural basis of NSD2 degradation via targeted recruitment of SCF-FBXO22 pubmed.ncbi.nlm.nih.gov/40909644/ #cryoem

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Itai Yanai @itaiyanai.bsky.social · Jul 29

🚀 Today we're launching the 'Night Science Institute', a non-for-profit organization to lead a cultural shift in science! You may say we're dreamers 😉, but we think we're not the only ones. Perhaps today you will join us to make the Day Science and Night Science parts of the process live as one!

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Jack Bravo @jpkbravo.bsky.social · Jul 25

Thrilled to announce the nexy Austrian Cryo-EM Symposium, taking place 11th-12th November at @istaresearch.bsky.social, with speakers inc. @grigoriefflab.bsky.social, @oliveiramann.bsky.social, @bjgreber.bsky.social @svenklumpe.bsky.social @sebastianglatt.bsky.social ‪‬https://tinyurl.com/cryo2025

Austrian Cryo-EM Symposium

cryoem-symposium.pages.ist.ac.at

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Haselbach Lab @haselbachlab.bsky.social · Jul 4

Great Day for science in Heidelberg - really sad for the VBC we will certainly miss you here.

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Span Lab FAU @spanlabfau.bsky.social · May 25

Great work highlighting how important it is to carry out experimental structure determination instead relying on AlphaFold predictions. #crystallography #structure #biology #chemistry

www.nature.com/articles/s41...

AlphaFold predictions are valuable hypotheses and accelerate but do not replace experimental structure determination - Nature Methods

An analysis of AlphaFold protein structure predictions shows that while in many cases the predictions are highly accurate, there are also many instances where the predicted structures or parts of pred...

www.nature.com

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Haselbach Lab @haselbachlab.bsky.social · May 25

Indeed it was a rather eventful meeting with a lot of great science

Thibault Mayor @cellsandprots.bsky.social · May 24

I survived the 2025 EMBO protein quality control meeting - it was amazing despite a defective projector on day 1, and epileptic crisis on day 2, a black out in day 3, and we all got a shaky wake up call ~6am on day 5 by an earthquake… never a dull moment but most importantly great science

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Arjen Jakobi @cryotud.bsky.social · May 22

We are happy to release LocScale2.0: a tool for context-aware, confidence-weighted cryoEM map optimisation.

Taking two half maps as input, LcoScale-2.0 produces feature-enhanced maps along with a robust confidence score that guides objective map interpretation.

cryotud.github.io/locscale/

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Lorenz Grundmann @lgrundmann.bsky.social · May 15

The 'RNA meets Protein Decay' @embo.org workshop was really a blast. Thanks to everyone for the lively discussions!
I am especially honoured that my poster was awarded with one of the two poster prizes 😇

Pauli Group (posts by Andi Pauli) @pauligroup.bsky.social · May 15

The 2nd edition of the @embo.org workshop 'RNA meets Protein Decay', this time here in Vienna @impvienna.bsky.social, came to an end. Thanks to everyone who came and contributed to the great vibe of sharing science, discussing ideas and connecting with each other!

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Itai Yanai @itaiyanai.bsky.social · May 15

It was amazing to do a Night Science workshop today at the Karolinska Institute in Stockholm!

Gustavo Monasterio Ocares @gamonasterioo.bsky.social · May 15

Still buzzing after the Night Science workshop at KI — 6+ hours of creative thinking with @itaiyanai.bsky.social (#NightSciencepodcast)

Loved the deep dive into day science (structured, hypothesis-driven) vs night science (exploratory, intuitive). A brilliant way to rethink how we do science.

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Di Jiang @dijiang319.bsky.social · May 15

@science.org 🧫🧬❄️🔬 Molecular basis of influenza ribonucleoprotein complex assembly and processive RNA synthesis | Science www.science.org/doi/10.1126/...
@yiweichang.bsky.social www.yiweichanglab.org @jiwasa.bsky.social #virology #Influenza #Cryo-EM #StructuralBiology #RNA #polymerase

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Haselbach Lab @haselbachlab.bsky.social · May 15

Congrats to @lgrundmann.bsky.social for winning a poster award at #EMBORNAmeetsproteindecay

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Max Fürst @maxfus.bsky.social · May 3

If u ever had to depict proteins as schematics in papers, u know the dilemma: how to create a pretty “blob”?
If structure ends up big & central, u’ll render it with PyMol et al, but for a truly schematic depiction u want a biorender-style icon, but for YOUR protein.
Think I’ve finally found a way.

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Sergio Cruz-León @sergiocruzleon.bsky.social · Apr 11

Excited to share our preprint on the molecular architecture of heterochromatin in human cells 🧬🔬w/ @jpkreysing.bsky.social, @johannesbetz.bsky.social,
@marinalusic.bsky.social, Turoňová lab, @hummerlab.bsky.social @becklab.bsky.social @mpibp.bsky.social

🔗 Preprint here tinyurl.com/3a74uanv

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