Lightnews — Scholar-powered news

Pei Yee @impeiyee.bsky.social · 11d

Our review "Proteostasis of immune checkpoint receptors" is out in Biochem J! @biochemsoc.bsky.social

We highlight how ubiquitylation acts as a key sorting signal, governing the fate of immune checkpoints - from the highly stable PD-L1 to the short-lived CTLA-4.
portlandpress.com/biochemj/art...

Proteostasis of immune checkpoint receptors

Immunotherapy relies on the targeting of immune checkpoint receptors and their respective ligands by specific antibodies that bind to the cell surface proteins. The pace of this highly successful clin...

portlandpress.com

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Reposted by Pei Yee

Lorenz Lab @sonjalorenzlab.bsky.social · Sep 2

Delighted to share our work on cellular ubiquitination of drug-like compounds by HUWE1 - a surprising journey! Kudos to all contributors & first authors, Barbara Orth and Pavel Pohl. Sincere thanks to @ireserra.bsky.social ‬ #NatCommun for expertly guiding the winding publishing path.
rdcu.be/eDzPk

Selective ubiquitination of drug-like small molecules by the ubiquitin ligase HUWE1

Nature Communications - Ubiquitination is a versatile modification system in eukaryotic cells. Here, the authors unveil that the ubiquitin ligase HUWE1 can modify drug-like small-molecule...

rdcu.be

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Reposted by Pei Yee

Komander Lab @komanderlab.bsky.social · Jul 11

📣 Calling all ubiquitin aficionados - one week to go before abstract deadline (July 18th)!! Join us on the coast in Lorne, Australia. www.lorneubiquitin.org
#ubiquitin

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Pei Yee @impeiyee.bsky.social · May 7

Check out our study on the rapid turnover of CTLA4, featured in JCB Immune Cell Biology 2025 Collection!

Journal of Cell Biology @jcb.org · May 5

@impeiyee.bsky.social, Clague, Urbé et al. characterize the role of #ubiquitin in the rapid turnover kinetics of the immune checkpoint protein CTLA4. rupress.org/jcb/article/...

📕 In Immune Cell Biology 2025: rupress.org/jcb/collecti...

#AAI2025

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Reposted by Pei Yee

British Society for Cell Biology @bscb-official.bsky.social · Apr 15

We are sponsoring the Scottish Cell Biology Meeting on 18th Sept. Save the date!

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Reposted by Pei Yee

Institute of Systems, Molecular and Integrative Biology @livuni-ismib.bsky.social · Apr 8

Congratulations to Dr Pei Yee Tey (@impeiyee.bsky.social) from our Department of Biochemistry, Cell and Systems Biology, winner of the British Society of Cell Biology's 2025 Raff Medal for her research.

➡️ bit.ly/42evg4V

#PhD | #BSCB | #TeamLivUni

A quote card that reads ‘"I believe this medal is more than a recognition of my research. It is testimony to the extraordinary research environment I am privileged to be part of." Dr Pei Yee Tey, Department of Biochemistry, Cell and Systems Biology’. The background is navy blue with white text and pictured to the right is a photo of Pei Yee receiving the Raff Medal on stage.

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Reposted by Pei Yee

Women in TPD & Induced Proximity @womenintpd.bsky.social · Apr 3

Induced proximity modalities at the cell surface! Comprehensive review of emerging approaches and therapeutic possibilities by Carolyn Bertozzi and colleagues at Stanford!
www.nature.com/articles/s41...

Induced proximity at the cell surface - Nature Biotechnology

Technologies to modulate induced proximity at the cell surface advance the manipulation of diverse biological responses.

www.nature.com

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Reposted by Pei Yee

ewanmacdonald.bsky.social @ewanmacdonald.bsky.social · Feb 22

Thrilled to share our latest publication! We describe a novel acid-dependent mechanism regulating clathrin-independent endocytosis. This study was a fantastic collaborative effort with the labs of Ludger Johannes, Roberto Weigert, and Satyajit Mayor. nature.com/articles/s4155….

https://nature.com/articles/s4155…

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Reposted by Pei Yee

British Society for Cell Biology @bscb-official.bsky.social · Mar 27

Ian Ganley delivering his Hooke Medal lecture on mitophagy at #biologists100

@biologists.bsky.social

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Pei Yee @impeiyee.bsky.social · Mar 27

Thank you, Pat!

Pei Yee @impeiyee.bsky.social · Mar 27

Thanks, Helen!

Pei Yee @impeiyee.bsky.social · Mar 27

No, I'm currently based in the UK.

Pei Yee @impeiyee.bsky.social · Mar 27

Thanks, Jonathan!

Reposted by Pei Yee

Laboratory for Molecular Cell Biology at UCL @lmcb-ucl.bsky.social · Mar 25

Excited to see @lmcb-ucl.bsky.social alumna Pei Yee winning the Raff PhD Medal 2025. Also a very special prize named after Professor Martin Raff, a major driving force in the development of the LMCB four-year PhD programme.

Read more about Pei Yee below 👇

British Society for Cell Biology @bscb-official.bsky.social · Mar 24

Congratulations to our 2025 Raff PhD medal winner @impeiyee.bsky.social from @liverpooluni.bsky.social

bscb.org/bscb-phd-awa...

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Pei Yee @impeiyee.bsky.social · Mar 26

Deeply honoured to receive the 2025 Raff Medal!
Huge thanks to @bscb-official.bsky.social for the recognition. This wouldn’t have been possible without the support of my supervisors, Sylvie Urbé & Mike Clague, my colleagues, collaborators, and the many mentors who inspired me along the way.

British Society for Cell Biology @bscb-official.bsky.social · Mar 24

Congratulations to our 2025 Raff PhD medal winner @impeiyee.bsky.social from @liverpooluni.bsky.social

bscb.org/bscb-phd-awa...

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Reposted by Pei Yee

Sylvie Callegari @sylviecallegari.bsky.social · Mar 13

Thrilled to share the structure of dimerised human PINK1 docked to an endogenous translocase array on the mitochondrial surface, composed of two TOM complexes, bridged by a VDAC2 dimer! Published today in Science www.science.org/doi/10.1126/...

@wehi-research.bsky.social @komanderlab.bsky.social

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Pei Yee @impeiyee.bsky.social · Feb 10

Diverse routes to mitophagy governed by ubiquitylation and mitochondrial import
www.cell.com/trends/cell-...

Diverse routes to mitophagy governed by ubiquitylation and mitochondrial import

The selective removal of mitochondria by mitophagy proceeds via multiple mechanisms and is essential for human well-being. The PINK1/Parkin and NIX/BNIP3 pathways are strongly linked to mitochondrial ...

www.cell.com

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Reposted by Pei Yee

Science Magazine @science.org · Jan 24

"Research is messy. … Trying to protect students from that reality does them a disservice."

On #InternationalDayOfEducation, take a look back at this #ScienceWorkingLife on teaching students about scientific failure. https://scim.ag/3PLg8ER

Illustration of one person holding papers observing students aiming for a target, with multiple arrows missing the bullseye. The text reads: Working Life, Why I teach my students about scientific failure.

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Reposted by Pei Yee

Natalia Sanchez-Soriano @natsansor.bsky.social · Jan 17

🚀 Hot off the press! Our team findings @livuni-ismib.bsky.social on brain ageing unveil a novel connection between oxidative stress, neuronal microtubules, and the cytoskeletal protein EB1 driving neuronal atrophy. 🎉 A huge thank you to the fantastic team!
www.aginganddisease.org/EN/10.14336/...

Oxidative Stress Promotes Axonal Atrophy through Alterations in Microtubules and EB1 Function

<p>Axons are crucial for transmitting neurochemical signals. As organisms age, the ability of neurons to maintain their axons declines; hence, aged axons are more susceptible to damage or dysfunction....

www.aginganddisease.org

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Reposted by Pei Yee

Ian Prior @ianprior.bsky.social · Dec 23

Happy to see this pre-print online where we supported volume EM needs of this collaborative effort led by the Booth lab to investigate the role of the chromosome periphery in meiosis vs mitosis. #liv-srf

www.biorxiv.org/content/10.1...

@livuni-livsrf.bsky.social @livuni-ismib.bsky.social

The Chromosome Periphery is an Essential Compartment of Oocyte Chromosomes

Chromosomes and their constituent compartments are core elements of the cell division machinery. In mammalian oocytes, defects in the structure or composition of chromosomes are a leading cause of abe...

www.biorxiv.org

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Reposted by Pei Yee

Lechtenberg Lab @lechtenberglab.bsky.social · Dec 3

Excited to share our latest preprint on @biorxivpreprint.bsky.social: "The RBR E3 ubiquitin ligase HOIL-1 can ubiquitinate diverse non-protein substrates in vitro".

www.biorxiv.org/content/10.1...

The RBR E3 ubiquitin ligase HOIL-1 can ubiquitinate diverse non-protein substrates in vitro

HOIL-1 is a RING-between-RING (RBR)-family E3 ubiquitin ligase and component of the linear ubiquitin chain assembly complex (LUBAC). While most E3 ubiquitin ligases conjugate ubiquitin to protein lysi...

www.biorxiv.org

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Reposted by Pei Yee

Nature Chemical Biology @natchembio.nature.com · Jan 10

A new tool FUSEP profiles the E2-specific ubiquitome and enables systematic studies of non-lysine ubiquitin conjugation, here used to identify the existence of tyrosine ubiquitination

www.nature.com/articles/s41...

E2–Ub-R74G strategy reveals E2-specific ubiquitin conjugation profiles in live cells - Nature Chemical Biology

Shen and Yin developed a technology named FUSEP to profile the E2-specific ubiquitome that makes use of a fusion between E2 and ubiquitin carrying a R74G point mutation, which leaves an LGGG remnant f...

www.nature.com

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Reposted by Pei Yee

Wojciech Pokrzywa @wpokrzywa.bsky.social · Jan 9

Our first educational project, DEGRADATOR, is now in the Journal of Chemical Education @acspublications.bsky.social
Tested with 97 high school students, it enhances understanding of protein degradation. A step towards making molecular biology more accessible.
Read more: pubs.acs.org/doi/10.1021/...

DEGRADATOR: A Gaming Expedition Into Targeted Protein Degradation Therapies

In an era of rapid scientific advancement, the need for engaging educational tools is critical. DEGRADATOR, a 2D computer game, bridges this gap by immersing players in the ubiquitin-proteasome system...

pubs.acs.org

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Pei Yee @impeiyee.bsky.social · Jan 10

It's fantastic, we had fun playing it in the office!

Pei Yee @impeiyee.bsky.social · Dec 23

My friend Victoria is joining the knitt/crocheting challenge this December to raise funds for @cancerresearchuk.org
She created thoughtful science-inspired crochet gifts for our lab members (pics attached)
Donate here if you'd like to support her cause! fundraise.cancerresearchuk.org/page/victori...

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