Jacob S. Aday
@jacobsaday.bsky.social
Experimental psychologist researching psychedelics at UMich | Michigan Psychedelic Center (M-PsyC) | Chronic Pain and Fatigue Research Center (CPFRC) | he/him
https://scholar.google.com/citations?user=gFOCwBIAAAAJ&hl=en
https://scholar.google.com/citations?user=gFOCwBIAAAAJ&hl=en
Reposted by Jacob S. Aday
🚨Publication alert! 🚨
Why does stress drive psychopathology & transdiagnostic disease?
We present the Allostatic Triage Model of Psychopathology (ATP Model), which explains stress-induced transdiagnostic disease pathogenesis through a bioenergetic lens.
www.sciencedirect.com/science/arti...
Why does stress drive psychopathology & transdiagnostic disease?
We present the Allostatic Triage Model of Psychopathology (ATP Model), which explains stress-induced transdiagnostic disease pathogenesis through a bioenergetic lens.
www.sciencedirect.com/science/arti...
October 20, 2025 at 3:59 PM
🚨Publication alert! 🚨
Why does stress drive psychopathology & transdiagnostic disease?
We present the Allostatic Triage Model of Psychopathology (ATP Model), which explains stress-induced transdiagnostic disease pathogenesis through a bioenergetic lens.
www.sciencedirect.com/science/arti...
Why does stress drive psychopathology & transdiagnostic disease?
We present the Allostatic Triage Model of Psychopathology (ATP Model), which explains stress-induced transdiagnostic disease pathogenesis through a bioenergetic lens.
www.sciencedirect.com/science/arti...
Reposted by Jacob S. Aday
Our latest manuscript (from www.omarlab.org) is now published and available online --
Long lasting enhancement in reversal learning after a single psychedelic dose
pmc.ncbi.nlm.nih.gov/articles/PMC...
Long lasting enhancement in reversal learning after a single psychedelic dose
pmc.ncbi.nlm.nih.gov/articles/PMC...
Single-dose psychedelic enhances cognitive flexibility and reversal learning in mice weeks after administration
Psychedelic compounds have demonstrated remarkable therapeutic potential for treating neuropsychiatric disorders by promoting sustained neuroplasticity in the prefrontal cortex (PFC). Cognitive flexib...
pmc.ncbi.nlm.nih.gov
August 13, 2025 at 1:32 PM
Our latest manuscript (from www.omarlab.org) is now published and available online --
Long lasting enhancement in reversal learning after a single psychedelic dose
pmc.ncbi.nlm.nih.gov/articles/PMC...
Long lasting enhancement in reversal learning after a single psychedelic dose
pmc.ncbi.nlm.nih.gov/articles/PMC...
Reposted by Jacob S. Aday
Reframing Psychedelic Regulation: Tools, not Treatments
In this new article, we propose to regulate psychedelics as psychotherapeutic treatment tools rather than as treatments in their own right.
The use of anesthetics as treatment tools in surgery is a useful analogy.
In this new article, we propose to regulate psychedelics as psychotherapeutic treatment tools rather than as treatments in their own right.
The use of anesthetics as treatment tools in surgery is a useful analogy.
June 16, 2025 at 12:03 PM
Reframing Psychedelic Regulation: Tools, not Treatments
In this new article, we propose to regulate psychedelics as psychotherapeutic treatment tools rather than as treatments in their own right.
The use of anesthetics as treatment tools in surgery is a useful analogy.
In this new article, we propose to regulate psychedelics as psychotherapeutic treatment tools rather than as treatments in their own right.
The use of anesthetics as treatment tools in surgery is a useful analogy.
Reposted by Jacob S. Aday
Last year, @jacobsaday.bsky.social and @trpr-ucsf.bsky.social asked: "Psychedelic assisted psychotherapy: where is the psychotherapy research?"
link.springer.com/article/10.1...
How soon can we say "here it comes"?
link.springer.com/article/10.1...
How soon can we say "here it comes"?
May 14, 2025 at 5:12 AM
Last year, @jacobsaday.bsky.social and @trpr-ucsf.bsky.social asked: "Psychedelic assisted psychotherapy: where is the psychotherapy research?"
link.springer.com/article/10.1...
How soon can we say "here it comes"?
link.springer.com/article/10.1...
How soon can we say "here it comes"?
Reposted by Jacob S. Aday
Psychedelics could play a leading role in mental health care. But if approval is rushed without necessary guardrails in place, there will be a backlash, and these drugs will be relegated to the fringes of alternative health. That would be a tragic missed opportunity. www.nytimes.com/2025/04/28/o...
Opinion | How the American Right Learned to Love Psychedelics (Gift Article)
A once left-wing psychedelic movement has become tightly entwined with the Trump administration.
www.nytimes.com
April 28, 2025 at 12:30 PM
Psychedelics could play a leading role in mental health care. But if approval is rushed without necessary guardrails in place, there will be a backlash, and these drugs will be relegated to the fringes of alternative health. That would be a tragic missed opportunity. www.nytimes.com/2025/04/28/o...
Reposted by Jacob S. Aday
🚨 Postdoc Opportunity in Psychedelic Science
Join a leading psychedelic research team at Johns Hopkins @jhpsychedelics.bsky.social. Design and lead experimental studies & clinical trials.
Work with David Yaden, PhD & Sandeep Nayak, MD & others
-Salary: Middling
-Apply: [email protected]
-Pls share!
Join a leading psychedelic research team at Johns Hopkins @jhpsychedelics.bsky.social. Design and lead experimental studies & clinical trials.
Work with David Yaden, PhD & Sandeep Nayak, MD & others
-Salary: Middling
-Apply: [email protected]
-Pls share!
April 15, 2025 at 4:28 PM
🚨 Postdoc Opportunity in Psychedelic Science
Join a leading psychedelic research team at Johns Hopkins @jhpsychedelics.bsky.social. Design and lead experimental studies & clinical trials.
Work with David Yaden, PhD & Sandeep Nayak, MD & others
-Salary: Middling
-Apply: [email protected]
-Pls share!
Join a leading psychedelic research team at Johns Hopkins @jhpsychedelics.bsky.social. Design and lead experimental studies & clinical trials.
Work with David Yaden, PhD & Sandeep Nayak, MD & others
-Salary: Middling
-Apply: [email protected]
-Pls share!
“Addressing blinding in classic psychedelic studies with innovative active placebos” is out now in the International Journal of Neuropsychopharmacology.
Co-first authored with Otto Simonsson, alongside Cyril D’Souza and Emmanuelle Schindler
academic.oup.com/ijnp/advance...
Co-first authored with Otto Simonsson, alongside Cyril D’Souza and Emmanuelle Schindler
academic.oup.com/ijnp/advance...
Addressing blinding in classic psychedelic studies with innovative active placebos
AbstractRationale. Classic psychedelics show promise as a treatment for various neuropsychiatric disorders. However, weak blinding integrity in trials has
academic.oup.com
April 17, 2025 at 5:01 PM
“Addressing blinding in classic psychedelic studies with innovative active placebos” is out now in the International Journal of Neuropsychopharmacology.
Co-first authored with Otto Simonsson, alongside Cyril D’Souza and Emmanuelle Schindler
academic.oup.com/ijnp/advance...
Co-first authored with Otto Simonsson, alongside Cyril D’Souza and Emmanuelle Schindler
academic.oup.com/ijnp/advance...
Reposted by Jacob S. Aday
We are thrilled to announce the launch of the 2025 Psychedelic Community Survey, a research project for the psychedelic community. Participation is completely anonymous. Please share the survey invitation and link with anyone you think might be interested in participating.
Understanding experiences with psychedelics
The most powerful, simple and trusted way to gather experience data. Start your journey to experience management and try a free account today.
umich.qualtrics.com
April 7, 2025 at 9:57 PM
We are thrilled to announce the launch of the 2025 Psychedelic Community Survey, a research project for the psychedelic community. Participation is completely anonymous. Please share the survey invitation and link with anyone you think might be interested in participating.
Reposted by Jacob S. Aday
New pre-print out 🌍✨🌌
'Learning from Boundlessness: Psychedelic induced awe and epistemic shifts towards a holistic worldview'
doi.org/10.21203/rs....
We explored how awe during psychedelic experiences relates to lasting shifts in sense of self, other, and reality
'Learning from Boundlessness: Psychedelic induced awe and epistemic shifts towards a holistic worldview'
doi.org/10.21203/rs....
We explored how awe during psychedelic experiences relates to lasting shifts in sense of self, other, and reality
Learning from Boundlessness: Psychedelic induced awe and epistemic shifts towards a holistic worldview
Psychedelic substances are increasingly recognized for their potential to catalyse transformative shifts in worldviews. Central to these transformations are states of awe, a self-transcendent, epistem...
doi.org
April 7, 2025 at 6:46 AM
New pre-print out 🌍✨🌌
'Learning from Boundlessness: Psychedelic induced awe and epistemic shifts towards a holistic worldview'
doi.org/10.21203/rs....
We explored how awe during psychedelic experiences relates to lasting shifts in sense of self, other, and reality
'Learning from Boundlessness: Psychedelic induced awe and epistemic shifts towards a holistic worldview'
doi.org/10.21203/rs....
We explored how awe during psychedelic experiences relates to lasting shifts in sense of self, other, and reality
Our pilot clinical trial of psilocybin-assisted therapy for fibromyalgia was published today in Frontiers in Pain Research 🙂🍄
www.frontiersin.org/journals/pai...
www.frontiersin.org/journals/pai...
Frontiers | Preliminary safety and effectiveness of psilocybin-assisted therapy in adults with fibromyalgia: an open-label pilot clinical trial
www.frontiersin.org
March 18, 2025 at 5:43 PM
Our pilot clinical trial of psilocybin-assisted therapy for fibromyalgia was published today in Frontiers in Pain Research 🙂🍄
www.frontiersin.org/journals/pai...
www.frontiersin.org/journals/pai...
Reposted by Jacob S. Aday
My lab has a position for a programmer--if you have programming skills and have recently left the NIH please contact me.
February 19, 2025 at 8:43 PM
My lab has a position for a programmer--if you have programming skills and have recently left the NIH please contact me.
Reposted by Jacob S. Aday
Newest paper: #PsychedelicScience #Psychedelics
Tripping into Treatment: Comparing Initial and Current Motivations for Psychedelic Use
Psychedelic drugs are currently being explored for their therapeutic potential for a variety of health conditions. The recent increased public interest in psychedelics necessitates empirical invest...
www.tandfonline.com
February 12, 2025 at 3:00 PM
Newest paper: #PsychedelicScience #Psychedelics
New articles from the Michigan Psychedelic Center:
"Tripping into Treatment: Comparing Initial and Current Motivations for Psychedelic Use"
"Psychedelics and chronic pain: self-reported outcomes on changed substance use patterns and health following naturalistic psychedelic use"
"Tripping into Treatment: Comparing Initial and Current Motivations for Psychedelic Use"
"Psychedelics and chronic pain: self-reported outcomes on changed substance use patterns and health following naturalistic psychedelic use"
February 11, 2025 at 6:49 PM
New articles from the Michigan Psychedelic Center:
"Tripping into Treatment: Comparing Initial and Current Motivations for Psychedelic Use"
"Psychedelics and chronic pain: self-reported outcomes on changed substance use patterns and health following naturalistic psychedelic use"
"Tripping into Treatment: Comparing Initial and Current Motivations for Psychedelic Use"
"Psychedelics and chronic pain: self-reported outcomes on changed substance use patterns and health following naturalistic psychedelic use"
Reposted by Jacob S. Aday
Just came across this fascinating 2024 DMT study I missed - participants who were interrupted during their DMT experience (by having to give ratings) showed significantly less reduction in depressive symptoms compared to those left undisturbed. Important implications for psychedelic therapy. 🧵
February 2, 2025 at 11:10 PM
Just came across this fascinating 2024 DMT study I missed - participants who were interrupted during their DMT experience (by having to give ratings) showed significantly less reduction in depressive symptoms compared to those left undisturbed. Important implications for psychedelic therapy. 🧵
Reposted by Jacob S. Aday
Latest twist in Lykos saga has it all:
✅ Takeover bid led by billionaire who took drugs with Elon + helped him buy X
✅ Potential involvement of biotech exec widely accused of price gouging
✅ But also the potential to return Lykos to its public benefit mission
psychedelicalpha.com/news/billion...
✅ Takeover bid led by billionaire who took drugs with Elon + helped him buy X
✅ Potential involvement of biotech exec widely accused of price gouging
✅ But also the potential to return Lykos to its public benefit mission
psychedelicalpha.com/news/billion...
Billionaire Investor Antonio Gracias Plots $100M Lykos Takeover with Doblin’s Backing - Psychedelic Alpha
This latest twist in the Lykos Therapeutics saga threatens a major overhaul of the company’s strategy and direction, with Musk ally and billionaire investor Antonio Gracias appearing to want to take…
psychedelicalpha.com
January 10, 2025 at 2:11 PM
Latest twist in Lykos saga has it all:
✅ Takeover bid led by billionaire who took drugs with Elon + helped him buy X
✅ Potential involvement of biotech exec widely accused of price gouging
✅ But also the potential to return Lykos to its public benefit mission
psychedelicalpha.com/news/billion...
✅ Takeover bid led by billionaire who took drugs with Elon + helped him buy X
✅ Potential involvement of biotech exec widely accused of price gouging
✅ But also the potential to return Lykos to its public benefit mission
psychedelicalpha.com/news/billion...
Reposted by Jacob S. Aday
Big co-1st/corresponding author paper just published in
@JAMAPsychiatry!
I just can't thank our team enough for their unwavering support on this project.
Modifying Informed Consent to Help Address Functional Unmasking in Psychedelic Clinical Trials
jamanetwork.com/journals/jam...
@JAMAPsychiatry!
I just can't thank our team enough for their unwavering support on this project.
Modifying Informed Consent to Help Address Functional Unmasking in Psychedelic Clinical Trials
jamanetwork.com/journals/jam...
Modifying Informed Consent to Help Address Functional Unmasking in Psychedelic Clinical Trials
This narrative review describes clinical trials of psychedelic or MDMA therapy and reports from the investigators on the use of modifications to informed consent in these studies.
jamanetwork.com
January 8, 2025 at 6:30 PM
Big co-1st/corresponding author paper just published in
@JAMAPsychiatry!
I just can't thank our team enough for their unwavering support on this project.
Modifying Informed Consent to Help Address Functional Unmasking in Psychedelic Clinical Trials
jamanetwork.com/journals/jam...
@JAMAPsychiatry!
I just can't thank our team enough for their unwavering support on this project.
Modifying Informed Consent to Help Address Functional Unmasking in Psychedelic Clinical Trials
jamanetwork.com/journals/jam...
Reposted by Jacob S. Aday
I spoke with Javier Muniz, MD, who just left his role as Associate Director at FDA's Division of Psychiatry, about all things psychedelics.
psychedelicalpha.com/news/inside-...
psychedelicalpha.com/news/inside-...
Inside the FDA’s Psychedelics Journey: Javier Muniz, MD on Breakthroughs, Challenges, and the Future of the Field - Psychedelic Alpha
In our latest Pα+ interview, our Editor Josh Hardman speaks with Javier Muniz, MD, who recently left his post as Associate Director at the FDA’s Division of Psychiatry. In that role, Muniz was at the…
psychedelicalpha.com
December 5, 2024 at 4:11 PM
I spoke with Javier Muniz, MD, who just left his role as Associate Director at FDA's Division of Psychiatry, about all things psychedelics.
psychedelicalpha.com/news/inside-...
psychedelicalpha.com/news/inside-...
Reposted by Jacob S. Aday
Psychopharmacology gets lots of criticism from psychotherapy/adjacent folks.
But if someone could send me therapy trials that
1. Are double-triple blind
2. Carefully document/report AEs
3. Pre-register an SAP with ITT
I would appreciate.
I will wait ….
But if someone could send me therapy trials that
1. Are double-triple blind
2. Carefully document/report AEs
3. Pre-register an SAP with ITT
I would appreciate.
I will wait ….
November 29, 2024 at 6:58 PM
Psychopharmacology gets lots of criticism from psychotherapy/adjacent folks.
But if someone could send me therapy trials that
1. Are double-triple blind
2. Carefully document/report AEs
3. Pre-register an SAP with ITT
I would appreciate.
I will wait ….
But if someone could send me therapy trials that
1. Are double-triple blind
2. Carefully document/report AEs
3. Pre-register an SAP with ITT
I would appreciate.
I will wait ….
A new preprint for my new BlueSky homies: "Major life changes following psychedelic use: A retrospective survey among people using psychedelics naturalistically"
www.researchgate.net/publication/...
www.researchgate.net/publication/...
(PDF) Major life changes following psychedelic use: A retrospective survey among people using psychedelics naturalistically
PDF | Background: Psychedelic drugs show promise in facilitating a variety of long-term psychological changes, but they may also lead to unexpected... | Find, read and cite all the research you need o...
www.researchgate.net
November 20, 2024 at 5:55 PM
A new preprint for my new BlueSky homies: "Major life changes following psychedelic use: A retrospective survey among people using psychedelics naturalistically"
www.researchgate.net/publication/...
www.researchgate.net/publication/...