Jerome Epsztein
@jeromeepsztein.bsky.social
Neurobiologist interested in spatial cognition and navigation
Research director at INSERM
Team leader "Neuronal mechanisms of spatial cognition" at INMED in Marseille
Research director at INSERM
Team leader "Neuronal mechanisms of spatial cognition" at INMED in Marseille
Pinned
Happy to share our new paper with Mathilde Nordlund and Julie Koenig out @currentbiology.bsky.social. We used virtual reality in mice to study hippocampal distance coding. Our results suggest a primary contribution of grid cells to distance over cue-dependent place cell coding.
shorturl.at/63yFo
shorturl.at/63yFo
Reposted by Jerome Epsztein
Joli papier sur les bases neurales du timing; compatible avec l'hypothèse (je simplifie) que le cortex compte le temps qui passe et le striatum intègre la durée écoulée, permettant de générer une action au bon timing.
Nature research paper: Integrator dynamics in the cortico-basal ganglia loop for flexible motor timing
go.nature.com/4oX2rmq
go.nature.com/4oX2rmq
Integrator dynamics in the cortico-basal ganglia loop for flexible motor timing - Nature
How the mouse frontal cortex and striatum interact to implement integrator dynamics controlling movement timing is explored.
go.nature.com
November 25, 2025 at 7:01 AM
Joli papier sur les bases neurales du timing; compatible avec l'hypothèse (je simplifie) que le cortex compte le temps qui passe et le striatum intègre la durée écoulée, permettant de générer une action au bon timing.
Reposted by Jerome Epsztein
***Publication alert***
"Pathological tau alters head direction signaling and induces spatial orientation"
www.cell.com/cell-reports...
"Pathological tau alters head direction signaling and induces spatial orientation"
www.cell.com/cell-reports...
November 21, 2025 at 11:59 PM
***Publication alert***
"Pathological tau alters head direction signaling and induces spatial orientation"
www.cell.com/cell-reports...
"Pathological tau alters head direction signaling and induces spatial orientation"
www.cell.com/cell-reports...
Reposted by Jerome Epsztein
BTSP in V2
Rapid neocortical network modifications via dendritic plateau potential induced plasticity https://www.biorxiv.org/content/10.1101/2025.11.19.689338v1
November 20, 2025 at 11:46 PM
BTSP in V2
Reposted by Jerome Epsztein
BTSP in V1
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Plateau potentials are instructive signals for behavioral timescale synaptic plasticity in the neocortex
Learning occurs via the adjustment of synaptic weights across a variety of timescales. The mechanisms supporting these processes, from single-shot to iterative learning, are unclear. The prevailing mo...
www.biorxiv.org
November 20, 2025 at 11:50 PM
BTSP in V1
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Jerome Epsztein
🧠 The hippocampus isn’t a one-way circuit. It’s a multilane system for learning & memory. Join us tomorrow to explore how parallel processing emerges from cell diversity.
📍MIN28 | Nov 18 | 9:30–12:00 | Rm 6B. Co-chaired with @flaviodonato82.bsky.social
#SfN2025 @SfNtweets
📍MIN28 | Nov 18 | 9:30–12:00 | Rm 6B. Co-chaired with @flaviodonato82.bsky.social
#SfN2025 @SfNtweets
November 18, 2025 at 12:12 AM
🧠 The hippocampus isn’t a one-way circuit. It’s a multilane system for learning & memory. Join us tomorrow to explore how parallel processing emerges from cell diversity.
📍MIN28 | Nov 18 | 9:30–12:00 | Rm 6B. Co-chaired with @flaviodonato82.bsky.social
#SfN2025 @SfNtweets
📍MIN28 | Nov 18 | 9:30–12:00 | Rm 6B. Co-chaired with @flaviodonato82.bsky.social
#SfN2025 @SfNtweets
Reposted by Jerome Epsztein
The changes we experience may be the source of our subjective experience of time.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Time, space, memory and brain–body rhythms - Nature Reviews Neuroscience
Understanding how the brain represents experienced time and how representations of space and time are integrated to form episodic memories has been a goal of much neuroscientific research. In this Per...
www.nature.com
November 14, 2025 at 2:32 PM
The changes we experience may be the source of our subjective experience of time.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Jerome Epsztein
Relative phase of membrane potential theta oscillations between individual hippocampal neurons code space https://www.biorxiv.org/content/10.1101/2025.11.14.688496v1
November 15, 2025 at 8:15 AM
Relative phase of membrane potential theta oscillations between individual hippocampal neurons code space https://www.biorxiv.org/content/10.1101/2025.11.14.688496v1
Reposted by Jerome Epsztein
1. New preprint resolving a conundrum in systems neuroscience with an AI scientist, and humans Reilly Tilbury, Dabin Kwon, @haydari.bsky.social, @jacobmratliff.bsky.social, @bio-emergent.bsky.social, @carandinilab.net, @kevinjmiller.bsky.social, @neurokim.bsky.social
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Characterizing neuronal population geometry with AI equation discovery
The visual cortex contains millions of neurons, whose combined activity forms a population code representing visual stimuli. There is, however, a discrepancy between our understanding of this code at ...
www.biorxiv.org
November 14, 2025 at 6:07 PM
1. New preprint resolving a conundrum in systems neuroscience with an AI scientist, and humans Reilly Tilbury, Dabin Kwon, @haydari.bsky.social, @jacobmratliff.bsky.social, @bio-emergent.bsky.social, @carandinilab.net, @kevinjmiller.bsky.social, @neurokim.bsky.social
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Jerome Epsztein
The Primate Hippocampus Constructs a Temporal Scaffold Anchored to Behavioral Events https://www.biorxiv.org/content/10.1101/2025.11.12.687961v1
November 12, 2025 at 5:16 PM
The Primate Hippocampus Constructs a Temporal Scaffold Anchored to Behavioral Events https://www.biorxiv.org/content/10.1101/2025.11.12.687961v1
Reposted by Jerome Epsztein
Visual landmark coding and dynamic coupling with path integration circuits in area 29e of the rodent parahippocampal cortex https://www.biorxiv.org/content/10.1101/2025.11.11.687899v1
November 12, 2025 at 3:17 PM
Visual landmark coding and dynamic coupling with path integration circuits in area 29e of the rodent parahippocampal cortex https://www.biorxiv.org/content/10.1101/2025.11.11.687899v1
Reposted by Jerome Epsztein
Our lab is looking for a postdoc! We have interesting projects and cutting-edge techniques such as Neuropixels Opto, Light Beads Microscopy and more. We would be delighted to receive your application. Deadline is 25 November 2025. More info here:
www.ucl.ac.uk/cortexlab/po...
www.ucl.ac.uk/cortexlab/po...
November 12, 2025 at 3:41 PM
Our lab is looking for a postdoc! We have interesting projects and cutting-edge techniques such as Neuropixels Opto, Light Beads Microscopy and more. We would be delighted to receive your application. Deadline is 25 November 2025. More info here:
www.ucl.ac.uk/cortexlab/po...
www.ucl.ac.uk/cortexlab/po...
Reposted by Jerome Epsztein
A yr ago, I wrote a piece about what is becoming a quasi-obsession in neuroscience: internal models/representations. I’m kind of stuck and not sure what to do with it. Meanwhile, I came across 2 excellent "critical" papers on the same topic by @olivia.science and @smellosopher.bsky.social 🙏💪 :
November 11, 2025 at 11:10 AM
A yr ago, I wrote a piece about what is becoming a quasi-obsession in neuroscience: internal models/representations. I’m kind of stuck and not sure what to do with it. Meanwhile, I came across 2 excellent "critical" papers on the same topic by @olivia.science and @smellosopher.bsky.social 🙏💪 :
Reposted by Jerome Epsztein
Reposted by Jerome Epsztein
REM sleep reduces subthreshold depolarization in cortical pyramidal neurons in a region-specific manner: doi.org/10.1016/j.ce...
"NMDA receptors drive subthreshold depolarization specifically during REM sleep."
"NMDA receptors drive subthreshold depolarization specifically during REM sleep."
November 9, 2025 at 8:56 PM
REM sleep reduces subthreshold depolarization in cortical pyramidal neurons in a region-specific manner: doi.org/10.1016/j.ce...
"NMDA receptors drive subthreshold depolarization specifically during REM sleep."
"NMDA receptors drive subthreshold depolarization specifically during REM sleep."
Reposted by Jerome Epsztein
No GPS in the head? Path integration by entorhinal grid cells without the grid pattern. Interesting paper from Heidelberg. www.nature.com/articles/s41...
Grid cells accurately track movement during path integration-based navigation despite switching reference frames - Nature Neuroscience
Grid cells do not maintain a stable pattern during a self-motion-based task, but track animal movement in multiple local reference frames and reanchor to task-relevant objects, thus estimating local r...
www.nature.com
October 30, 2025 at 4:03 PM
No GPS in the head? Path integration by entorhinal grid cells without the grid pattern. Interesting paper from Heidelberg. www.nature.com/articles/s41...
Reposted by Jerome Epsztein
The projections still fall short of the 60% reduction in emissions needed to prevent global temperatures from rising by more than 1.5 degrees Celsius above preindustrial levels.
UN Says Emissions Will Drop In The Next 10 Years But Not ‘Fast Enough’—Bill Gates Urges New Approach
The projections still fall short of the 60% reduction in emissions needed to prevent global temperatures from rising by more than 1.5 degrees Celsius above preindustrial levels.
www.forbes.com
October 28, 2025 at 10:55 AM
The projections still fall short of the 60% reduction in emissions needed to prevent global temperatures from rising by more than 1.5 degrees Celsius above preindustrial levels.
Reposted by Jerome Epsztein
Happy to share our new paper with Mathilde Nordlund and Julie Koenig out @currentbiology.bsky.social. We used virtual reality in mice to study hippocampal distance coding. Our results suggest a primary contribution of grid cells to distance over cue-dependent place cell coding.
shorturl.at/63yFo
shorturl.at/63yFo
September 11, 2025 at 1:23 PM
Happy to share our new paper with Mathilde Nordlund and Julie Koenig out @currentbiology.bsky.social. We used virtual reality in mice to study hippocampal distance coding. Our results suggest a primary contribution of grid cells to distance over cue-dependent place cell coding.
shorturl.at/63yFo
shorturl.at/63yFo
Reposted by Jerome Epsztein
La @socneuro.bsky.social a publié avec plusieurs Sociétés savantes et Associations de patients une tribune dans Le Monde « Budget 2026 : La taxation des expérimentations animales mettrait en péril la recherche en France » : www.lemonde.fr/sciences/art...
#plf2026 @sneuroendo.bsky.social
#plf2026 @sneuroendo.bsky.social
Budget 2026 : « La taxation des expérimentations animales mettrait en péril la recherche en France »
TRIBUNE. Dans une tribune au « Monde », des représentants de sociétés savantes, de fondations, d’associations et de réseaux scientifiques mettent en garde contre le dépôt d’amendements au projet de lo...
www.lemonde.fr
October 28, 2025 at 5:05 PM
La @socneuro.bsky.social a publié avec plusieurs Sociétés savantes et Associations de patients une tribune dans Le Monde « Budget 2026 : La taxation des expérimentations animales mettrait en péril la recherche en France » : www.lemonde.fr/sciences/art...
#plf2026 @sneuroendo.bsky.social
#plf2026 @sneuroendo.bsky.social
Reposted by Jerome Epsztein
Dentate spikes comprise a continuum of relative input strength from the lateral and medial entorhinal cortex. https://www.biorxiv.org/content/10.1101/2025.10.27.684857v1
October 28, 2025 at 8:15 AM
Dentate spikes comprise a continuum of relative input strength from the lateral and medial entorhinal cortex. https://www.biorxiv.org/content/10.1101/2025.10.27.684857v1
Reposted by Jerome Epsztein
Let’s use a good occasion to break my Bluesky shyness 😅 — a new article just came out!
This one goes back to data from the very start of my PhD, and I’m so happy to see it finally published 🧠
👉 onlinelibrary.wiley.com/doi/full/10.... 🧵1/5
This one goes back to data from the very start of my PhD, and I’m so happy to see it finally published 🧠
👉 onlinelibrary.wiley.com/doi/full/10.... 🧵1/5
October 27, 2025 at 10:32 AM
Let’s use a good occasion to break my Bluesky shyness 😅 — a new article just came out!
This one goes back to data from the very start of my PhD, and I’m so happy to see it finally published 🧠
👉 onlinelibrary.wiley.com/doi/full/10.... 🧵1/5
This one goes back to data from the very start of my PhD, and I’m so happy to see it finally published 🧠
👉 onlinelibrary.wiley.com/doi/full/10.... 🧵1/5
Reposted by Jerome Epsztein
Various theoretical properties derived for gamma oscillations based on canonical E-SOM-PV microcircuit connectivity using mean-field modelling, which moves beyond classic Wilson-Cowan models in important ways
biorxiv.org/content/10.1... - w. Farzin Tahvili & Matteo Di Volo
biorxiv.org/content/10.1... - w. Farzin Tahvili & Matteo Di Volo
A mean-field model of neural networks with PV and SOM interneurons reveals connectivity-based mechanisms of gamma oscillations
Classic theoretical models of cortical oscillations are based on the interactions between two populations of excitatory and inhibitory neurons. Nevertheless, experimental studies and network simulatio...
biorxiv.org
October 24, 2025 at 11:02 AM
Various theoretical properties derived for gamma oscillations based on canonical E-SOM-PV microcircuit connectivity using mean-field modelling, which moves beyond classic Wilson-Cowan models in important ways
biorxiv.org/content/10.1... - w. Farzin Tahvili & Matteo Di Volo
biorxiv.org/content/10.1... - w. Farzin Tahvili & Matteo Di Volo
Reposted by Jerome Epsztein
New preprint from Satoshi Kuroki & Sébastien Royer
Grid cells encode reward distance during path integration in cue-rich environments
www.researchsquare.com/article/rs-7...
Grid cells encode reward distance during path integration in cue-rich environments
www.researchsquare.com/article/rs-7...
October 22, 2025 at 9:43 AM
New preprint from Satoshi Kuroki & Sébastien Royer
Grid cells encode reward distance during path integration in cue-rich environments
www.researchsquare.com/article/rs-7...
Grid cells encode reward distance during path integration in cue-rich environments
www.researchsquare.com/article/rs-7...